LOCUS       NM_145518               2674 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase core subunit S1
            (Ndufs1), transcript variant 4, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_145518
VERSION     NM_145518.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2674)
  AUTHORS   Dong,L., Luo,L., Wang,Z., Lian,S., Wang,M., Wu,X., Fan,J., Zeng,Y.,
            Li,S., Lv,S., Yang,Y., Chen,R., Shen,E., Yang,W., Li,C. and Wang,K.
  TITLE     Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial
            ROS accumulation and cytotoxic autophagy arrest in hepatocellular
            carcinoma
  JOURNAL   Free Radic Biol Med 220, 111-124 (2024)
   PUBMED   38697493
  REMARK    GeneRIF: Targeted degradation of NDUFS1 by agrimol B promotes
            mitochondrial ROS accumulation and cytotoxic autophagy arrest in
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 2674)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   3  (bases 1 to 2674)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2674)
  AUTHORS   Kenny,T.C., Khan,A., Son,Y., Yue,L., Heissel,S., Sharma,A.,
            Pasolli,H.A., Liu,Y., Gamazon,E.R., Alwaseem,H., Hite,R.K. and
            Birsoy,K.
  TITLE     Integrative genetic analysis identifies FLVCR1 as a plasma-membrane
            choline transporter in mammals
  JOURNAL   Cell Metab 35 (6), 1057-1071 (2023)
   PUBMED   37100056
REFERENCE   5  (bases 1 to 2674)
  AUTHORS   Qi,B., Song,L., Hu,L., Guo,D., Ren,G., Peng,T., Liu,M., Fang,Y.,
            Li,C., Zhang,M. and Li,Y.
  TITLE     Cardiac-specific overexpression of Ndufs1 ameliorates cardiac
            dysfunction after myocardial infarction by alleviating
            mitochondrial dysfunction and apoptosis
  JOURNAL   Exp Mol Med 54 (7), 946-960 (2022)
   PUBMED   35817848
  REMARK    GeneRIF: Cardiac-specific overexpression of Ndufs1 ameliorates
            cardiac dysfunction after myocardial infarction by alleviating
            mitochondrial dysfunction and apoptosis.
REFERENCE   6  (bases 1 to 2674)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   7  (bases 1 to 2674)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (bases 1 to 2674)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 2674)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2674)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY709888.1, AK036926.1 and AV444601.1.
            
            On May 9, 2009 this sequence version replaced NM_145518.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006660.1, AK142711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               BY709888.1         2-138
            138-2654            AK036926.1         3-2519
            2655-2674           AV444601.1         267-286
FEATURES             Location/Qualifiers
     source          1..2674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.29 cM"
     gene            1..2674
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /note="NADH:ubiquinone oxidoreductase core subunit S1"
                     /db_xref="GeneID:227197"
                     /db_xref="MGI:MGI:2443241"
     exon            1..237
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            238..303
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2426
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /EC_number="7.1.1.2"
                     /note="NADH-ubiquinone oxidoreductase 75 kDa subunit,
                     mitochondrial; CI-75kD; complex I-75kD; NADH dehydrogenase
                     (ubiquinone) Fe-S protein 1"
                     /codon_start=1
                     /product="NADH-ubiquinone oxidoreductase 75 kDa subunit,
                     mitochondrial precursor"
                     /protein_id="NP_663493.2"
                     /db_xref="CCDS:CCDS14996.1"
                     /db_xref="GeneID:227197"
                     /db_xref="MGI:MGI:2443241"
                     /translation="MLRIPIKRALIGLSNSPKGYVRTTGTAASNLIEVFVDGQSVMVE
                     PGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNI
                     LTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAV
                     EDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSEL
                     SGNVIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPR
                     MHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQNFE
                     GNAVAAIAGGLVDAEALVALKDLLNKVDSDNLCTEEIFPTEGAGTDLRSNYLLNTTIA
                     GVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPK
                     ILQDIASGRHSFCEVLKDAKKPMVVLGSSALQRDDGAAILVAVSNMVQKIRVTTGVAA
                     EWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKMLFLLGADGGCITRQDLPKDCFI
                     VYQGHHGDVGAPMADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIR
                     ALSEIAGITLPYDTLDQVRNRLEEVSPNLVRYDDIEETNYFQQASELAKLVNQEVLAD
                     PLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC"
     exon            304..395
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            396..503
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            504..580
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            581..662
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            663..793
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            794..979
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1114
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1229
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1375
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1504
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1634
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1795
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1950
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2126
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2261
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2334
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2665
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2626..2631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2659
                     /gene="Ndufs1"
                     /gene_synonym="5830412M15Rik; 9930026A05Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggtccaagt cgtcttctcc gcttcctccc gggctcgctc tcggaaattg ccgaacaggt
       61 ccgaagacgg ggaaaaacag tcgaatctgt gtttctagtc cctcctggct ttccgtcctc
      121 caggtcgggc tgacagaggt tgccgtggcc gccatattga cttagcggcc agggttttga
      181 ggggtcaggg agacccggac aggtccgcgg aactactcgg tgggctccgg aggaaagcca
      241 tcatgttaag gatacctata aaaagggcct tgataggcct ttctaattct cctaaaggat
      301 atgttcgcac aactggcaca gcagcaagta acttgattga agtatttgtt gatggtcagt
      361 ctgtcatggt ggaaccagga accactgttc tgcaggcttg cgagaaggtc ggcatgcaaa
      421 tccctcgatt ctgttaccat gaaaggttgt ctgttgctgg aaattgcagg atgtgcctgg
      481 tagagattga gaaagctcca aaggttgtcg ctgcttgtgc tatgcctgta atgaagggct
      541 ggaatatctt gacaaactcg gaaaaatcta agaaagccag agaaggtgtg atggagttct
      601 tattagcaaa tcacccattg gattgtccta tttgtgacca gggaggtgaa tgtgatctgc
      661 aggaccagtc catgatgttt ggaagtgata ggagccgatt tctagagggg aagcgtgctg
      721 tggaggacaa gaacattggg cccctagtaa agaccatcat gactagatgc atccagtgta
      781 cccggtgcat caggtttgca agtgagattg caggagtaga tgatttggga acaacaggaa
      841 gaggaaatga catgcaagtt ggcacataca ttgaaaaaat gtttatgtct gaactgtctg
      901 ggaatgtcat tgatatctgc cctgtagggg ccctaacctc taagccttat gcctttactg
      961 cccggccttg ggaaacaaga aagacagagt ccattgatgt aatggatgca gtgggaagta
     1021 acattgtggt tagcacaaga actggagagg taatgaggat tttgccaaga atgcatgaag
     1081 atattaatga agaatggatc tctgataaaa ccaggtttgc ttatgatgga ctaaaacgtc
     1141 aaagacttac tgaaccaatg gtcagaaacg aaaaagggct tttaacttat acctcctggg
     1201 aagatgcact ctctcgtgta gctggaatgt tacagaattt tgaaggcaat gctgtggcag
     1261 cgattgcagg aggcttggtg gatgctgaag ccttagtagc tctgaaagac ttgcttaata
     1321 aagttgactc tgacaactta tgcactgaag agatcttccc cactgaagga gctggtacag
     1381 acttacgttc caattatctt ctcaatacca caattgctgg tgtggaagaa gcagatgttg
     1441 ttcttctagt tggtacaaat ccacgttttg aggcaccgct gtttaatgct agaattagaa
     1501 agagctggct tcataatgac ttaaaagtgg ccctcatcgg tagtccagtg gacctcactt
     1561 acagatacga ccatctagga gactctccta aaattctgca agacattgct tcagggaggc
     1621 attcattctg cgaggtctta aaggatgcta aaaaaccaat ggtggtttta ggcagttctg
     1681 cactccagag agatgatgga gcagcaattc ttgtagctgt gtccaacatg gtacaaaaga
     1741 ttcgagtgac aaccggtgtt gctgcagagt ggaaagttat gaatattctg cataggattg
     1801 caagccaggt agctgctttg gaccttggct ataaacctgg ggtagaagcg attaggaaga
     1861 accctcccaa aatgctgttt cttctgggag cagatggagg ttgtatcacg cgacaggact
     1921 tgccaaagga ttgtttcatt gtttatcaag gacaccatgg tgatgttggt gctcccatgg
     1981 ctgatgttat tctcccaggg gctgcttaca cagaaaagtc tgctacttat gtcaatactg
     2041 agggcagagc tcagcaaacc aaagtagcag tgacgcctcc tggcttggca cgagaagact
     2101 ggaaaatcat aagagctctc tctgagattg caggtatcac tcttccatat gacactctgg
     2161 atcaagtaag gaaccgtctt gaagaggtct ctcctaatct ggttcgatat gatgatattg
     2221 aagaaactaa ttactttcag caagcaagtg agcttgccaa gctagtaaac caggaggttc
     2281 ttgctgaccc actcgttcca cctcagctaa ctataaaaga cttctatatg acagactcca
     2341 ttagcagagc ctcacagaca atggccaagt gtgtcaaagc tgtcaccgag ggcgctcagg
     2401 cagtagagga gccgtccata tgctgagaca tctaacaggg accctttttg ctacagacag
     2461 taaatggaca ttgctgtaat cccttataag ttaatgtttt ccaacatgag tctgaatgat
     2521 gtaatattta aagttatact atgcttatcc gaaaatggta ttgtacttat caaaaatcct
     2581 ggcagtttaa aatgtatgta attgtgtgca agcattaact agtttaataa aactatcatt
     2641 ttctctttca tgttaaaaac actgaaaaaa aaaa
//
