LOCUS       NM_024220                693 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase subunit C2 (Ndufc2),
            mRNA.
ACCESSION   NM_024220
VERSION     NM_024220.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 693)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 693)
  AUTHORS   Wu,Y., Zhang,C., Duan,S., Li,Y., Lu,L., Bajpai,A., Yang,C., Mi,J.,
            Tian,G., Xu,F., Qi,D., Xu,Z. and Chi,X.D.
  TITLE     TEAD1, MYO7A and NDUFC2 are novel functional genes associated with
            glucose metabolism in BXD recombinant inbred population
  JOURNAL   Diabetes Obes Metab 26 (5), 1775-1788 (2024)
   PUBMED   38385898
  REMARK    GeneRIF: TEAD1, MYO7A and NDUFC2 are novel functional genes
            associated with glucose metabolism in BXD recombinant inbred
            population.
REFERENCE   3  (bases 1 to 693)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 693)
  AUTHORS   Chen,J., Liu,X., Bi,R., Liu,P. and Gong,W.
  TITLE     NDUFC2 deficiency exacerbates endothelial mesenchymal
            transformation during ischemia-reperfusion via NLRP3
  JOURNAL   Neuroreport 34 (13), 670-676 (2023)
   PUBMED   37506315
  REMARK    GeneRIF: NDUFC2 deficiency exacerbates endothelial mesenchymal
            transformation during ischemia-reperfusion via NLRP3.
REFERENCE   5  (bases 1 to 693)
  AUTHORS   Chen,Y., Wu,J., Zhang,S., Gao,W., Liao,Z., Zhou,T., Li,Y., Su,D.,
            Liu,H., Yang,X., Su,P. and Xu,C.
  TITLE     Hnrnpk maintains chondrocytes survival and function during growth
            plate development via regulating Hif1alpha-glycolysis axis
  JOURNAL   Cell Death Dis 13 (9), 803 (2022)
   PUBMED   36127325
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 693)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 693)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 693)
  AUTHORS   Wirtz,S. and Schuelke,M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 693)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 693)
  AUTHORS   Ruiz-Lozano,P., Smith,S.M., Perkins,G., Kubalak,S.W., Boss,G.R.,
            Sucov,H.M., Evans,R.M. and Chien,K.R.
  TITLE     Energy deprivation and a deficiency in downstream metabolic target
            genes during the onset of embryonic heart failure in RXRalpha-/-
            embryos
  JOURNAL   Development 125 (3), 533-544 (1998)
   PUBMED   9425147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK128102.1 and AI413456.1.
            
            On Aug 15, 2009 this sequence version replaced NM_024220.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK128102.1, AK168342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-679               CK128102.1         1-679
            680-693             AI413456.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 53.49 cM"
     gene            1..693
                     /gene="Ndufc2"
                     /gene_synonym="1810004I06Rik; 2010300P09Rik; G1"
                     /note="NADH:ubiquinone oxidoreductase subunit C2"
                     /db_xref="GeneID:68197"
                     /db_xref="MGI:MGI:1344370"
     exon            1..355
                     /gene="Ndufc2"
                     /gene_synonym="1810004I06Rik; 2010300P09Rik; G1"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..549
                     /gene="Ndufc2"
                     /gene_synonym="1810004I06Rik; 2010300P09Rik; G1"
                     /EC_number="7.1.1.2"
                     /note="CI-B14.5b; NADH dehydrogenase (ubiquinone) 1,
                     subcomplex unknown, 2; complex I-B14.5b; NADH-ubiquinone
                     oxidoreductase subunit B14.5b; 14.5b subunit of the
                     NADH-ubiquinone dehydrogenase complex"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 subunit C2"
                     /protein_id="NP_077182.1"
                     /db_xref="CCDS:CCDS21457.1"
                     /db_xref="GeneID:68197"
                     /db_xref="MGI:MGI:1344370"
                     /translation="MMNGRPGHEPLKFLPDEARSLPPPKLNDPRLVYMGLLGYCTGLM
                     DNMLRMRPVMRAGLHRQLLFVTSFVFAGYFYLKRQNYLYAVKDHDMFGYIKLHPEDFP
                     EKEKKTYAEILEPFHPVR"
     exon            356..499
                     /gene="Ndufc2"
                     /gene_synonym="1810004I06Rik; 2010300P09Rik; G1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..681
                     /gene="Ndufc2"
                     /gene_synonym="1810004I06Rik; 2010300P09Rik; G1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      659..664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufc2"
                     /gene_synonym="1810004I06Rik; 2010300P09Rik; G1"
                     /note="hexamer: ATTAAA"
     polyA_site      681
                     /gene="Ndufc2"
                     /gene_synonym="1810004I06Rik; 2010300P09Rik; G1"
                     /note="major polyA site"
ORIGIN      
        1 ggaacctcgc gtgcagaggt tgctaaggct gagcgcacag ggaagctttt gggtgctgca
       61 ccgccgtacg caatgccctt cagcctagag cgcggaggag gacggtagct cggtcacggc
      121 gtttggagtc gttgtttttc ctatagttgg agtcgaggtc aaacctctcg tggaacctgc
      181 ctcaagatga tgaacggccg gccgggccat gagcccttaa aattcttgcc ggacgaggcc
      241 cggagcctgc ccccgcccaa gctgaacgac ccgcggcttg tctacatggg cttgttgggc
      301 tactgcacgg gcctgatgga caacatgctg cggatgcgac cggtgatgag agcaggtttg
      361 caccgccagc ttctgttcgt tacgtccttt gtctttgctg gatactttta tttaaaacgt
      421 caaaactatt tgtatgctgt gaaggaccat gacatgtttg gttatataaa attacaccca
      481 gaagattttc ctgaaaaaga gaagaaaacc tatgctgaaa ttcttgagcc attccatcca
      541 gtgcgttgaa gttttcaaaa ggcttgttcc tgttcctctt caccacaacc tgaatatttt
      601 ctgagtttta tgggattttc tgtgacagtg aagtttaggt taagatgtta acactgttat
      661 taaaatagtt attacaaatc aaaaaaaaaa aaa
//
