LOCUS       NM_026061                682 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase subunit B8 (Ndufb8),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026061
VERSION     NM_026061.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 682)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 682)
  AUTHORS   Tomar,A., Gomez-Velazquez,M., Gerlini,R., Comas-Armangue,G.,
            Makharadze,L., Kolbe,T., Boersma,A., Dahlhoff,M., Burgstaller,J.P.,
            Lassi,M., Darr,J., Toppari,J., Virtanen,H., Kuhnapfel,A.,
            Scholz,M., Landgraf,K., Kiess,W., Vogel,M., Gailus-Durner,V.,
            Fuchs,H., Marschall,S., Hrabe de Angelis,M., Kotaja,N., Korner,A.
            and Teperino,R.
  TITLE     Epigenetic inheritance of diet-induced and sperm-borne
            mitochondrial RNAs
  JOURNAL   Nature 630 (8017), 720-727 (2024)
   PUBMED   38839949
REFERENCE   3  (bases 1 to 682)
  AUTHORS   Shen,T., Wang,S., Huang,C., Zhu,S., Zhu,X., Li,N., Wang,H.,
            Huang,L., Ren,M., Han,Z., Ge,J., Chen,Z. and Ouyang,K.
  TITLE     Cardiac-specific deletion of heat shock protein 60 induces
            mitochondrial stress and disrupts heart development in mice
  JOURNAL   Biochem Biophys Res Commun 710, 149883 (2024)
   PUBMED   38588611
REFERENCE   4  (bases 1 to 682)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 682)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 682)
  AUTHORS   Ishihara,T., Ban-Ishihara,R., Maeda,M., Matsunaga,Y., Ichimura,A.,
            Kyogoku,S., Aoki,H., Katada,S., Nakada,K., Nomura,M., Mizushima,N.,
            Mihara,K. and Ishihara,N.
  TITLE     Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial
            fission is essential for maintenance of homogeneously active
            mitochondria during neonatal heart development
  JOURNAL   Mol Cell Biol 35 (1), 211-223 (2015)
   PUBMED   25348719
REFERENCE   7  (bases 1 to 682)
  AUTHORS   Peralta,S., Torraco,A., Wenz,T., Garcia,S., Diaz,F. and Moraes,C.T.
  TITLE     Partial complex I deficiency due to the CNS conditional ablation of
            Ndufa5 results in a mild chronic encephalopathy but no increase in
            oxidative damage
  JOURNAL   Hum Mol Genet 23 (6), 1399-1412 (2014)
   PUBMED   24154540
REFERENCE   8  (bases 1 to 682)
  AUTHORS   Francis,B.M., Yang,J., Song,B.J., Gupta,S., Maj,M., Bazinet,R.P.,
            Robinson,B. and Mount,H.T.
  TITLE     Reduced levels of mitochondrial complex I subunit NDUFB8 and linked
            complex I + III oxidoreductase activity in the TgCRND8 mouse model
            of Alzheimer's disease
  JOURNAL   J Alzheimers Dis 39 (2), 347-355 (2014)
   PUBMED   24217272
  REMARK    GeneRIF: study reports mitochondrial dysfunction in TgCRND8 mouse
            model of Alzheimer's disease and identifies the NDUFB8 subunit of
            complex I as a key target of A-beta toxicity
REFERENCE   9  (bases 1 to 682)
  AUTHORS   Wirtz,S. and Schuelke,M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 682)
  AUTHORS   Yang,H., Brosel,S., Acin-Perez,R., Slavkovich,V., Nishino,I.,
            Khan,R., Goldberg,I.J., Graziano,J., Manfredi,G. and Schon,E.A.
  TITLE     Analysis of mouse models of cytochrome c oxidase deficiency owing
            to mutations in Sco2
  JOURNAL   Hum Mol Genet 19 (1), 170-180 (2010)
   PUBMED   19837698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151478.1.
            
            On Mar 19, 2018 this sequence version replaced NM_026061.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043019.1, CF740602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC151478.1         137575-137700       c
            127-253             AC151478.1         137189-137315       c
            254-353             AC151478.1         135927-136026       c
            354-509             AC151478.1         134956-135111       c
            510-682             AC151478.1         132498-132670       c
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 37.98 cM"
     gene            1..682
                     /gene="Ndufb8"
                     /gene_synonym="2900010I05Rik; CI-ASHI"
                     /note="NADH:ubiquinone oxidoreductase subunit B8"
                     /db_xref="GeneID:67264"
                     /db_xref="MGI:MGI:1914514"
     exon            1..126
                     /gene="Ndufb8"
                     /gene_synonym="2900010I05Rik; CI-ASHI"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..602
                     /gene="Ndufb8"
                     /gene_synonym="2900010I05Rik; CI-ASHI"
                     /EC_number="1.6.99.3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; NADH dehydrogenase [ubiquinone] 1 beta
                     subcomplex subunit 8, mitochondrial; complex I-ASHI;
                     NADH-ubiquinone oxidoreductase ASHI subunit; NADH
                     dehydrogenase (ubiquinone) 1 beta subcomplex 8"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 beta
                     subcomplex subunit 8, mitochondrial isoform 1 precursor"
                     /protein_id="NP_080337.1"
                     /db_xref="CCDS:CCDS29851.1"
                     /db_xref="GeneID:67264"
                     /db_xref="MGI:MGI:1914514"
                     /translation="MAAARAAALGVRWLQRTTRGVVPLEARRAFHMTKDMLPGSYPRT
                     PEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPMLPNRSQHERDPWYQWDHSELRMNWG
                     EPIHWDLDMYIRNRVDTSPTPVSWDVMCKHLFGFVAFMVFMFWVGHVFPSYQPVGPKQ
                     YPYNNLYLERGGDPTKEPEPVVHYDI"
     exon            127..253
                     /gene="Ndufb8"
                     /gene_synonym="2900010I05Rik; CI-ASHI"
                     /inference="alignment:Splign:2.1.0"
     exon            254..353
                     /gene="Ndufb8"
                     /gene_synonym="2900010I05Rik; CI-ASHI"
                     /inference="alignment:Splign:2.1.0"
     exon            354..509
                     /gene="Ndufb8"
                     /gene_synonym="2900010I05Rik; CI-ASHI"
                     /inference="alignment:Splign:2.1.0"
     exon            510..682
                     /gene="Ndufb8"
                     /gene_synonym="2900010I05Rik; CI-ASHI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      661..666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufb8"
                     /gene_synonym="2900010I05Rik; CI-ASHI"
                     /note="hexamer: AATAAA"
     polyA_site      671
                     /gene="Ndufb8"
                     /gene_synonym="2900010I05Rik; CI-ASHI"
                     /note="major polyA site"
ORIGIN      
        1 gcttttgcgc atgtgcagag tgaaccgcgg agaaggtgaa gatggctgcc gcccgggctg
       61 cggccctggg agtccgatgg ctgcagagga caacccgggg cgtggtgcca ctggaggcac
      121 ggagagcctt ccatatgacc aaggacatgt tgccggggtc atatcctagg accccagagg
      181 aacgcgccgc ggccgccaag aagtataaca tgcgagtgga agactacgag ccataccccg
      241 atgatggcat ggggtatggc gactacccga tgctccccaa ccgatcacag catgagaggg
      301 atccgtggta tcagtgggac cactcagaac tcaggatgaa ctggggtgaa ccgatacact
      361 gggacctaga catgtacatc aggaatcgtg tggacacgtc acctacccct gtgtcctggg
      421 atgtcatgtg taaacatctc ttcggctttg tggctttcat ggttttcatg ttctgggtag
      481 ggcacgtgtt cccttcctac cagcctgtgg gtccgaagca gtacccttac aataatctgt
      541 acctggagcg gggtggtgat cctaccaaag agcctgagcc cgtggttcac tatgatatct
      601 gaggaggctt gatgggcttt ttgccctcgt tcctagaggc ttaaccataa taaaatccct
      661 aataaagctc agtgctctgg tt
//
