LOCUS       NM_001033305             682 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase subunit B6 (Ndufb6),
            mRNA.
ACCESSION   NM_001033305 XM_131359 XM_896303 XM_910217 XM_921580
VERSION     NM_001033305.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 682)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 682)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 682)
  AUTHORS   Wirtz,S. and Schuelke,M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 682)
  AUTHORS   Acin-Perez,R., Fernandez-Silva,P., Peleato,M.L., Perez-Martos,A.
            and Enriquez,J.A.
  TITLE     Respiratory active mitochondrial supercomplexes
  JOURNAL   Mol Cell 32 (4), 529-539 (2008)
   PUBMED   19026783
REFERENCE   5  (bases 1 to 682)
  AUTHORS   Kruse,S.E., Watt,W.C., Marcinek,D.J., Kapur,R.P., Schenkman,K.A.
            and Palmiter,R.D.
  TITLE     Mice with mitochondrial complex I deficiency develop a fatal
            encephalomyopathy
  JOURNAL   Cell Metab 7 (4), 312-320 (2008)
   PUBMED   18396137
REFERENCE   6  (bases 1 to 682)
  AUTHORS   Wiley,S.E., Murphy,A.N., Ross,S.A., van der Geer,P. and Dixon,J.E.
  TITLE     MitoNEET is an iron-containing outer mitochondrial membrane protein
            that regulates oxidative capacity
  JOURNAL   Proc Natl Acad Sci U S A 104 (13), 5318-5323 (2007)
   PUBMED   17376863
REFERENCE   7  (bases 1 to 682)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY233633.1, AK146762.1 and
            CK794473.1.
            
            On Aug 20, 2015 this sequence version replaced NM_001033305.2.
            
            Summary: This gene encodes a subunit of complex I (NADH:ubiquinone
            oxidoreductase) of the mitochondrial respiratory chain. This
            complex functions in electron transport and generation of a proton
            gradient across the inner mitochondrial membrane to drive ATP
            synthesis. Data from human cell lines suggests that the encoded
            subunit may be required for electron transfer activity. [provided
            by RefSeq, Aug 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK794473.1, CD774546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BY233633.1         1-53
            54-587              AK146762.1         3-536
            588-682             CK794473.1         538-632
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 20.24 cM"
     gene            1..682
                     /gene="Ndufb6"
                     /gene_synonym="CI-B17; Gm137"
                     /note="NADH:ubiquinone oxidoreductase subunit B6"
                     /db_xref="GeneID:230075"
                     /db_xref="MGI:MGI:2684983"
     exon            1..264
                     /gene="Ndufb6"
                     /gene_synonym="CI-B17; Gm137"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..471
                     /gene="Ndufb6"
                     /gene_synonym="CI-B17; Gm137"
                     /note="complex I-B17; NADH-ubiquinone oxidoreductase B17
                     subunit; NADH dehydrogenase (ubiquinone) 1 beta
                     subcomplex, 6"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 beta
                     subcomplex subunit 6"
                     /protein_id="NP_001028477.1"
                     /db_xref="CCDS:CCDS18045.1"
                     /db_xref="GeneID:230075"
                     /db_xref="MGI:MGI:2684983"
                     /translation="MSGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPRRMWPLE
                     RFWDNFLRDGAVWKNMVFKAYRSSLFAVSHVLIPMWFVHYYVKYHMATKPYTIVSSKP
                     RIFPGDTILETGEVIPPMRDFPDQHH"
     exon            265..357
                     /gene="Ndufb6"
                     /gene_synonym="CI-B17; Gm137"
                     /inference="alignment:Splign:2.1.0"
     exon            358..402
                     /gene="Ndufb6"
                     /gene_synonym="CI-B17; Gm137"
                     /inference="alignment:Splign:2.1.0"
     exon            403..659
                     /gene="Ndufb6"
                     /gene_synonym="CI-B17; Gm137"
                     /inference="alignment:Splign:2.1.0"
     regulatory      564..569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufb6"
                     /gene_synonym="CI-B17; Gm137"
                     /note="hexamer: AATAAA"
     polyA_site      588
                     /gene="Ndufb6"
                     /gene_synonym="CI-B17; Gm137"
                     /note="major polyA site"
     regulatory      635..640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufb6"
                     /gene_synonym="CI-B17; Gm137"
                     /note="hexamer: AGTAAA"
     polyA_site      659
                     /gene="Ndufb6"
                     /gene_synonym="CI-B17; Gm137"
ORIGIN      
        1 gcgccgcttc caggcgcctc aaggtcgctt tgcggagcgg gaggggcagg tcagtgaccg
       61 gtcctgtgta ggctcgtcgg caacatgtca gggtacacgc cggatgagaa gctgcggctg
      121 cagcagctgc gggagctaag gagacgatgg ctgaaggacc aggagctgag tccccgggag
      181 cccgtgttgc ccccgcgcag gatgtggccc ctggagcgat tctgggataa ctttttgcgg
      241 gacggggccg tgtggaagaa catggtcttt aaggcgtacc gctccagtct cttcgctgtt
      301 tctcatgtgc ttatacctat gtggtttgtt cactattatg tcaaatatca tatggctact
      361 aaaccataca ccattgttag ctcgaagccc aggatatttc caggtgatac aattctggag
      421 actggagaag taattccacc aatgagagat tttcctgatc aacatcattg aagagtcctt
      481 aaaaacttaa cagacttgtg taacagcaca agtatgttcc taaagtgctg tatttactga
      541 atctgtttcc tggaaaagta attaataaag cttattctca gagtgttatc actgtccgtg
      601 ttactgtcca aaggttctat gatttgagac taacagtaaa aagacaaata ctaaacagaa
      661 aaaaaaaaaa aaaaaaaaaa aa
//
