LOCUS       NM_025316                999 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase subunit B5 (Ndufb5),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025316 XM_912457
VERSION     NM_025316.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 999)
  AUTHORS   Wang,T., Li,X., Tao,Y., Wang,X., Li,L. and Liu,J.
  TITLE     METTL3-mediated NDUFB5 m6A modification promotes cell migration and
            mitochondrial respiration to promote the wound healing of diabetic
            foot ulcer
  JOURNAL   J Transl Med 22 (1), 643 (2024)
   PUBMED   38982516
  REMARK    GeneRIF: METTL3-mediated NDUFB5 m6A modification promotes cell
            migration and mitochondrial respiration to promote the wound
            healing of diabetic foot ulcer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 999)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   3  (bases 1 to 999)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 999)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   5  (bases 1 to 999)
  AUTHORS   Sakamoto,T., Matsuura,T.R., Wan,S., Ryba,D.M., Kim,J.U., Won,K.J.,
            Lai,L., Petucci,C., Petrenko,N., Musunuru,K., Vega,R.B. and
            Kelly,D.P.
  TITLE     A Critical Role for Estrogen-Related Receptor Signaling in Cardiac
            Maturation
  JOURNAL   Circ Res 126 (12), 1685-1702 (2020)
   PUBMED   32212902
REFERENCE   6  (bases 1 to 999)
  AUTHORS   Wirtz,S. and Schuelke,M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 999)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 999)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 999)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   10 (bases 1 to 999)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004372.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_912457.1, NM_025316.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004372.1, AK002279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 15.85 cM"
     gene            1..999
                     /gene="Ndufb5"
                     /gene_synonym="0610007D05Rik; CI-SGDH; SGDH"
                     /note="NADH:ubiquinone oxidoreductase subunit B5"
                     /db_xref="GeneID:66046"
                     /db_xref="MGI:MGI:1913296"
     exon            1..143
                     /gene="Ndufb5"
                     /gene_synonym="0610007D05Rik; CI-SGDH; SGDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..589
                     /gene="Ndufb5"
                     /gene_synonym="0610007D05Rik; CI-SGDH; SGDH"
                     /note="NADH dehydrogenase [ubiquinone] 1 beta subcomplex
                     subunit 5, mitochondrial; complex I-SGDH; NADH-ubiquinone
                     oxidoreductase SGDH subunit; NADH dehydrogenase
                     (ubiquinone) 1 beta subcomplex, 5"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 beta
                     subcomplex subunit 5, mitochondrial precursor"
                     /protein_id="NP_079592.2"
                     /db_xref="CCDS:CCDS17300.1"
                     /db_xref="GeneID:66046"
                     /db_xref="MGI:MGI:1913296"
                     /translation="MAAMSLLQRASVSALTALSCRRAGPRLGVGSFLTRSFPKTVAPV
                     RHSGDHGKRLFVVKPSLYYDARFLRLMKFYLMLTGIPVIIGITLVNIFIGEAELAEIP
                     EGYIPEHWEYYKHPISRWIARNFYDGPEKNYEKTLAILQIESEKAELRLKEQEVRRLM
                     RARGDGPWYQFPTPEKEFIDHSPKATPDN"
     exon            144..232
                     /gene="Ndufb5"
                     /gene_synonym="0610007D05Rik; CI-SGDH; SGDH"
                     /inference="alignment:Splign:2.1.0"
     exon            233..299
                     /gene="Ndufb5"
                     /gene_synonym="0610007D05Rik; CI-SGDH; SGDH"
                     /inference="alignment:Splign:2.1.0"
     exon            300..361
                     /gene="Ndufb5"
                     /gene_synonym="0610007D05Rik; CI-SGDH; SGDH"
                     /inference="alignment:Splign:2.1.0"
     exon            362..468
                     /gene="Ndufb5"
                     /gene_synonym="0610007D05Rik; CI-SGDH; SGDH"
                     /inference="alignment:Splign:2.1.0"
     exon            469..999
                     /gene="Ndufb5"
                     /gene_synonym="0610007D05Rik; CI-SGDH; SGDH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      641..646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufb5"
                     /gene_synonym="0610007D05Rik; CI-SGDH; SGDH"
                     /note="hexamer: AATAAA"
     polyA_site      671
                     /gene="Ndufb5"
                     /gene_synonym="0610007D05Rik; CI-SGDH; SGDH"
                     /note="major polyA site"
ORIGIN      
        1 ttccgtggcc ggtgtagcca tggcggccat gagcctgctg cagcgggctt cggtctccgc
       61 gctgacagcg ctgtcttgcc gccgcgctgg tcctagactc ggagtcggaa gttttctcac
      121 gcggagcttt ccgaagactg tcgctcctgt gcggcacagt ggggaccatg gcaagagact
      181 gtttgtcgtc aagccttctt tatactatga cgctcgcttc ttgaggttaa tgaaattcta
      241 ccttatgttg actgggatcc cagttataat tggcataaca ctggtgaaca tatttattgg
      301 tgaagccgag cttgcagaaa tcccagaagg ctacatccct gaacactggg agtattacaa
      361 gcatccgata tcaagatgga tcgcccggaa tttctatgat ggccctgaaa agaactacga
      421 gaaaaccctg gctatcctcc agattgaatc tgaaaaggct gagttacggt taaaggagca
      481 ggaagttcga aggctgatgc gtgcccgagg tgatggaccc tggtatcaat ttccaacccc
      541 tgaaaaggag ttcattgatc attctccaaa ggcaactcct gacaactgat gattcatttg
      601 tctgtccaag aacagtgtgt ccctctagtg ggaagaaatg aataaatact ctgtattttt
      661 gctctgatgt acacaagatt ctgtggctgg ttcttcatga ggttcaggtg atgtgttctc
      721 tgtgggcctt tcagcttcat ctgttgggat ttacagggta gtaatgaaac ctggaggtct
      781 gggaagttgt gaattcctaa agtgacactg ttgataagct gctgatgccg ttgtctggca
      841 ggtggaaggt gcagcggtcc tgtgaatatt caggaactgt agtcatctgt cattgcagat
      901 ggggcttatt tgggactact tggaatttta agttcaaaag aaatactgaa ccaaccatat
      961 aaaattatca ggaccagaat aaataaagcc ttagagttt
//
