LOCUS       NM_001127346             646 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase complex assembly factor
            2 (Ndufaf2), transcript variant 1, mRNA.
ACCESSION   NM_001127346 XM_001476048 XM_919782
VERSION     NM_001127346.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 646)
  AUTHORS   Chen,Y., Wu,J., Zhang,S., Gao,W., Liao,Z., Zhou,T., Li,Y., Su,D.,
            Liu,H., Yang,X., Su,P. and Xu,C.
  TITLE     Hnrnpk maintains chondrocytes survival and function during growth
            plate development via regulating Hif1alpha-glycolysis axis
  JOURNAL   Cell Death Dis 13 (9), 803 (2022)
   PUBMED   36127325
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 646)
  AUTHORS   Adjobo-Hermans,M.J.W., de Haas,R., Willems,P.H.G.M., Wojtala,A.,
            van Emst-de Vries,S.E., Wagenaars,J.A., van den Brand,M.,
            Rodenburg,R.J., Smeitink,J.A.M., Nijtmans,L.G., Sazanov,L.A.,
            Wieckowski,M.R. and Koopman,W.J.H.
  TITLE     NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4-/- mice and
            Leigh syndrome patients: A stabilizing role for NDUFAF2
  JOURNAL   Biochim Biophys Acta Bioenerg 1861 (8), 148213 (2020)
   PUBMED   32335026
  REMARK    GeneRIF: NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4(-/-)
            mice and Leigh syndrome patients: A stabilizing role for NDUFAF2.
REFERENCE   3  (bases 1 to 646)
  AUTHORS   Schlehe,J.S., Journel,M.S., Taylor,K.P., Amodeo,K.D. and
            LaVoie,M.J.
  TITLE     The mitochondrial disease associated protein Ndufaf2 is dispensable
            for Complex-1 assembly but critical for the regulation of oxidative
            stress
  JOURNAL   Neurobiol Dis 58, 57-67 (2013)
   PUBMED   23702311
  REMARK    GeneRIF: These data suggest that Ndufaf2, unlike other Complex-1
            assembly factors, may be more accurately described as a chaperone
            involved in proper folding during Complex-1 assembly, since it is
            dispensable for Complex-1 maturation but not its proper function.
REFERENCE   4  (bases 1 to 646)
  AUTHORS   Hanzelka,K., Skalniak,L., Jura,J., Lenzen,S. and Gurgul-Convey,E.
  TITLE     Effects of the novel mitochondrial protein mimitin in
            insulin-secreting cells
  JOURNAL   Biochem J 445 (3), 349-359 (2012)
   PUBMED   22587331
  REMARK    GeneRIF: Mimitin overexpression increased basal and glucose-induced
            insulin secretion and prevented cytokine-mediated suppression of
            insulin secretion. Mimitin knockdown in MIN6 cells had opposite
            effects to those observed after overexpression.
REFERENCE   5  (bases 1 to 646)
  AUTHORS   Tsuneoka,M., Teye,K., Arima,N., Soejima,M., Otera,H., Ohashi,K.,
            Koga,Y., Fujita,H., Shirouzu,K., Kimura,H. and Koda,Y.
  TITLE     A novel Myc-target gene, mimitin, that is involved in cell
            proliferation of esophageal squamous cell carcinoma
  JOURNAL   J Biol Chem 280 (20), 19977-19985 (2005)
   PUBMED   15774466
REFERENCE   6  (bases 1 to 646)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 646)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 646)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 646)
  AUTHORS   Timsit,S.G., Bally-Cuif,L., Colman,D.R. and Zalc,B.
  TITLE     DM-20 mRNA is expressed during the embryonic development of the
            nervous system of the mouse
  JOURNAL   J Neurochem 58 (3), 1172-1175 (1992)
   PUBMED   1737990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103379.8 and CT025566.7.
            
            On Dec 30, 2021 this sequence version replaced NM_001127346.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF740215.1, BC116975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC103379.8         126085-126233       c
            150-239             CT025566.7         114976-115065       c
            240-280             CT025566.7         104795-104835       c
            281-646             CT025566.7         76031-76396         c
FEATURES             Location/Qualifiers
     source          1..646
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 59.63 cM"
     gene            1..646
                     /gene="Ndufaf2"
                     /gene_synonym="1810058I14Rik; mimitin; Ndufa12l"
                     /note="NADH:ubiquinone oxidoreductase complex assembly
                     factor 2"
                     /db_xref="GeneID:75597"
                     /db_xref="MGI:MGI:1922847"
     exon            1..149
                     /gene="Ndufaf2"
                     /gene_synonym="1810058I14Rik; mimitin; Ndufa12l"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..529
                     /gene="Ndufaf2"
                     /gene_synonym="1810058I14Rik; mimitin; Ndufa12l"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mimitin, mitochondrial; Myc-induced mitochondria protein;
                     MMTN; NDUFA12-like protein; myc-induced mitochondrial
                     protein; NADH dehydrogenase (ubiquinone) 1 alpha
                     subcomplex, assembly factor 2"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex assembly factor 2 isoform 1"
                     /protein_id="NP_001120818.1"
                     /db_xref="CCDS:CCDS49357.1"
                     /db_xref="GeneID:75597"
                     /db_xref="MGI:MGI:1922847"
                     /translation="MSWWSGVWRSVWSALSREVREHVGTDHLGNKYYYVAEYKNWRGQ
                     TIREKRIVEAANRKEVDYEAGDIPTEWEAWIRRTRKTPPTMEEILKNEKYREEIKIKS
                     QDFYEKDKLGKETSEELLPSPTATQVKGHASAPYFGREEPSVAPTSTGKTFQPGSWTP
                     EDGKRQSQ"
     exon            150..239
                     /gene="Ndufaf2"
                     /gene_synonym="1810058I14Rik; mimitin; Ndufa12l"
                     /inference="alignment:Splign:2.1.0"
     exon            240..280
                     /gene="Ndufaf2"
                     /gene_synonym="1810058I14Rik; mimitin; Ndufa12l"
                     /inference="alignment:Splign:2.1.0"
     exon            281..646
                     /gene="Ndufaf2"
                     /gene_synonym="1810058I14Rik; mimitin; Ndufa12l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      627..632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufaf2"
                     /gene_synonym="1810058I14Rik; mimitin; Ndufa12l"
                     /note="hexamer: AATAAA"
     polyA_site      646
                     /gene="Ndufaf2"
                     /gene_synonym="1810058I14Rik; mimitin; Ndufa12l"
                     /note="major polyA site"
ORIGIN      
        1 agaccttgag ttcggcgcag gcatgagctg gtggtccggt gtgtggcgct ctgtttggag
       61 cgccttgtcc agggaggtga gggagcacgt gggcacggac catctgggga acaaatacta
      121 ctacgtcgcc gagtacaaga actggagagg gcagactatt cgagagaaaa ggattgtaga
      181 agcagcgaac agaaaagagg tagactatga agcaggagac atcccaaccg agtgggaagc
      241 atggattaga agaacaagga agactccacc cactatggag gaaatactaa agaatgaaaa
      301 gtacagagaa gaaattaaaa taaaaagcca agatttttat gaaaaagata aactcggtaa
      361 agaaaccagt gaagaactct tgccttcacc tactgcaact caagttaaag ggcacgcctc
      421 tgccccgtat tttggaaggg aagagccctc agtggctccc accagcactg gcaagacttt
      481 tcagccaggg tcctggacgc cagaagatgg caaaagacaa agtcaatgaa tgacaaagtc
      541 aatgaatgac aaagtcaatg aatgacaaag tcaatgaatg ccctgccctg aagtcatagc
      601 attgtaagga tatggctgtt ttaacaaata aaaggttaaa agtcga
//
