LOCUS       NM_001360744             639 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase subunit AB1 (Ndufab1),
            transcript variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001360744 XM_006508200
VERSION     NM_001360744.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 639)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 639)
  AUTHORS   Zhang,R., Hou,T., Cheng,H. and Wang,X.
  TITLE     NDUFAB1 protects against obesity and insulin resistance by
            enhancing mitochondrial metabolism
  JOURNAL   FASEB J 33 (12), 13310-13322 (2019)
   PUBMED   31530015
  REMARK    GeneRIF: Skeletal muscle-specific ablation of NDUFAB1 disrupts
            glucose homeostasis and results in obesity and insulin resistance.
REFERENCE   3  (bases 1 to 639)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 639)
  AUTHORS   Boniecki,M.T., Freibert,S.A., Muhlenhoff,U., Lill,R. and Cygler,M.
  TITLE     Structure and functional dynamics of the mitochondrial Fe/S cluster
            synthesis complex
  JOURNAL   Nat Commun 8 (1), 1287 (2017)
   PUBMED   29097656
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 639)
  AUTHORS   Gakh,O., Ranatunga,W., Smith,D.Y. 4th, Ahlgren,E.C.,
            Al-Karadaghi,S., Thompson,J.R. and Isaya,G.
  TITLE     Architecture of the Human Mitochondrial Iron-Sulfur Cluster
            Assembly Machinery
  JOURNAL   J Biol Chem 291 (40), 21296-21321 (2016)
   PUBMED   27519411
REFERENCE   6  (bases 1 to 639)
  AUTHORS   Wirtz,S. and Schuelke,M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 639)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 639)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010307.1 and AC124379.3.
            
            On Feb 10, 2018 this sequence version replaced XM_006508200.3.
            
            Transcript Variant: This variant (3) differs in the 3' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152995.1, AK151719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-637               AK010307.1         2-638
            638-639             AC124379.3         58851-58852
FEATURES             Location/Qualifiers
     source          1..639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.38 cM"
     gene            1..639
                     /gene="Ndufab1"
                     /gene_synonym="2210401F17Rik; 2310039H15Rik;
                     2610003B19Rik; 8kDa; 9130423F15Rik; ACP; CI-SDAP; SDAP"
                     /note="NADH:ubiquinone oxidoreductase subunit AB1"
                     /db_xref="GeneID:70316"
                     /db_xref="MGI:MGI:1917566"
     exon            1..194
                     /gene="Ndufab1"
                     /gene_synonym="2210401F17Rik; 2310039H15Rik;
                     2610003B19Rik; 8kDa; 9130423F15Rik; ACP; CI-SDAP; SDAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..497
                     /gene="Ndufab1"
                     /gene_synonym="2210401F17Rik; 2310039H15Rik;
                     2610003B19Rik; 8kDa; 9130423F15Rik; ACP; CI-SDAP; SDAP"
                     /note="acyl carrier protein, mitochondrial;
                     NADH-ubiquinone oxidoreductase 9.6 kDa subunit; NADH
                     dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1"
                     /codon_start=1
                     /product="acyl carrier protein, mitochondrial precursor"
                     /protein_id="NP_001347673.1"
                     /db_xref="CCDS:CCDS21809.1"
                     /db_xref="GeneID:70316"
                     /db_xref="MGI:MGI:1917566"
                     /translation="MASRVLCACVRRLPAAFAPLPRLPTLALARPLSTTLCPEGIRRR
                     PGALQSALALAQVPGTVTHLCRQYSDAPPLTLDGIKDRVLYVLKLYDKIDPEKLSVNS
                     HFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE"
     exon            195..317
                     /gene="Ndufab1"
                     /gene_synonym="2210401F17Rik; 2310039H15Rik;
                     2610003B19Rik; 8kDa; 9130423F15Rik; ACP; CI-SDAP; SDAP"
                     /inference="alignment:Splign:2.1.0"
     exon            318..405
                     /gene="Ndufab1"
                     /gene_synonym="2210401F17Rik; 2310039H15Rik;
                     2610003B19Rik; 8kDa; 9130423F15Rik; ACP; CI-SDAP; SDAP"
                     /inference="alignment:Splign:2.1.0"
     exon            406..505
                     /gene="Ndufab1"
                     /gene_synonym="2210401F17Rik; 2310039H15Rik;
                     2610003B19Rik; 8kDa; 9130423F15Rik; ACP; CI-SDAP; SDAP"
                     /inference="alignment:Splign:2.1.0"
     exon            506..639
                     /gene="Ndufab1"
                     /gene_synonym="2210401F17Rik; 2310039H15Rik;
                     2610003B19Rik; 8kDa; 9130423F15Rik; ACP; CI-SDAP; SDAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      618..623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufab1"
                     /gene_synonym="2210401F17Rik; 2310039H15Rik;
                     2610003B19Rik; 8kDa; 9130423F15Rik; ACP; CI-SDAP; SDAP"
                     /note="hexamer: AATAAA"
     polyA_site      639
                     /gene="Ndufab1"
                     /gene_synonym="2210401F17Rik; 2310039H15Rik;
                     2610003B19Rik; 8kDa; 9130423F15Rik; ACP; CI-SDAP; SDAP"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcatc ctgggttggc gtagccatgg cgtctcgtgt cctctgcgcc tgtgtccgcc
       61 gcctgcccgc ggccttcgcg ccgctgcccc ggcttcccac gttggccttg gcgcggccgc
      121 tcagcaccac cctatgccct gagggaatcc ggaggagacc cggggctctg cagtccgcct
      181 tggcgctcgc gcaggtgcct ggaacagtca cacatttgtg ccgccagtac agtgacgcac
      241 ccccactgac gttagacgga atcaaggacc gagttctgta tgtcttgaaa ctctatgata
      301 agattgatcc agaaaagctc tccgtaaatt ctcattttat gaaggacctg ggcttagaca
      361 gtttggacca agtggaaatt attatggcca tggaagacga atttgggttt gaaattcctg
      421 atatagatgc agagaagtta atgtgtccac aagaaattgt agattacatt gcagataaga
      481 aggatgtgta tgaataaagt atcagagcct tcttcctcac tgtgaggact ccagaggaca
      541 cacgatggca tcgtggccga ctgacagcgg ctctgttcaa cttgtattta aattgtctga
      601 gtgttttacc cgttaaaaat aaatctatta caaaactag
//
