LOCUS       NM_025358               1322 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase subunit A9 (Ndufa9),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025358 XM_982892
VERSION     NM_025358.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1322)
  AUTHORS   Ohanele,C., Peoples,J.N., Karlstaedt,A., Geiger,J.T., Gayle,A.D.,
            Ghazal,N., Sohani,F., Brown,M.E., Davis,M.E., Porter,G.A. Jr.,
            Faundez,V. and Kwong,J.Q.
  TITLE     The mitochondrial citrate carrier SLC25A1 regulates metabolic
            reprogramming and morphogenesis in the developing heart
  JOURNAL   Commun Biol 7 (1), 1422 (2024)
   PUBMED   39482367
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1322)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   3  (bases 1 to 1322)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   4  (bases 1 to 1322)
  AUTHORS   Liu,Y., Liu,Z., Ren,Z., Han,Q., Chen,X., Han,J., Qiu,G. and Sun,C.
  TITLE     NDUFA9 and its crotonylation modification promote browning of white
            adipocytes by activating mitochondrial function in mice
  JOURNAL   Int J Biochem Cell Biol 171, 106583 (2024)
   PUBMED   38657899
  REMARK    GeneRIF: NDUFA9 and its crotonylation modification promote browning
            of white adipocytes by activating mitochondrial function in mice.
REFERENCE   5  (bases 1 to 1322)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 1322)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   7  (bases 1 to 1322)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1322)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 1322)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1322)
  AUTHORS   Baumgart,E., Vanhorebeek,I., Grabenbauer,M., Borgers,M.,
            Declercq,P.E., Fahimi,H.D. and Baes,M.
  TITLE     Mitochondrial alterations caused by defective peroxisomal
            biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout
            mouse)
  JOURNAL   Am J Pathol 159 (4), 1477-1494 (2001)
   PUBMED   11583975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165085.3 and AK012366.1.
            
            On Jul 25, 2009 this sequence version replaced NM_025358.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058378.1, AK003137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC165085.3         126824-126895
            73-1208             AK012366.1         53-1188
            1209-1322           AC165085.3         153992-154105
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 61.92 cM"
     gene            1..1322
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /note="NADH:ubiquinone oxidoreductase subunit A9"
                     /db_xref="GeneID:66108"
                     /db_xref="MGI:MGI:1913358"
     exon            1..81
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1166
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
                     subunit 9, mitochondrial; CI-39kD; complex I-39kD;
                     NADH-ubiquinone oxidoreductase 39 kDa subunit; NADH
                     dehydrogenase (ubiquinone) 1 alpha subcomplex, 9"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 9, mitochondrial precursor"
                     /protein_id="NP_079634.2"
                     /db_xref="CCDS:CCDS20557.1"
                     /db_xref="GeneID:66108"
                     /db_xref="MGI:MGI:1913358"
                     /translation="MAAAVRFRVVRALPMSRPAITAAATSVFCGSSHRQLHHAVIPHG
                     KGGRSSVSGVVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDVYDIMHLRLMGDLGQ
                     LTFLEWDARDKDSIRKAVQHSNVVINLIGREWETRNFDFEDVFVNIPRAIAQASKEAG
                     VERFIHVSHLNASMKSSSKSLRSKAVGEKEVRSVFPEAIIIRPSDIFGREDRFLNHFA
                     NYRWFLAVPLVSLGFKTVKQPVYVADVSKGIVNATKDPDAVGKTFAFTGPNRYLLFHL
                     VKYIFGMTHRTFIPYPLPLFVYSWIGKLFGLSPFEPWTTKDKVERIHISDVMPTDLPG
                     LEDLGVQPTPLELKSIEVLRRHRTYRWLSSEIEETKPAKTVNY"
     exon            82..252
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            253..350
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            351..442
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            443..584
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            585..687
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            688..755
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            756..832
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            833..928
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            929..995
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1322
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1207..1212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1231
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaagcaccgg ccgtgaggca ttgtgggaga agatggcggc cgccgtccgc tttcgggttg
       61 ttagagcgct tccaatgtca cgtcctgcca ttactgcagc agccacttct gtgttctgtg
      121 gctcatccca tcgccagctt caccatgctg tcatacctca cgggaaagga ggccgctcat
      181 ctgtcagtgg agttgtggcc actgtgtttg gggctacagg attcctgggt cgatacgttg
      241 ttaaccacct tggacgaatg gggtcacaag tgatcatacc atatcggtgt gatgtatatg
      301 acatcatgca ccttcgtctg atgggtgacc tgggccagct tacctttctg gaatgggatg
      361 cacgagacaa agattctatc aggaaagcag tgcagcacag caacgtggtc atcaatctta
      421 ttgggcggga gtgggaaacc agaaactttg attttgagga tgtttttgtg aatattcctc
      481 gagcaatagc tcaggcatcc aaggaagctg gggttgagag attcattcat gtttcacacc
      541 tgaatgccag tatgaagagt tcttctaagt ccttgaggag caaggcagtg ggagagaagg
      601 aagtgagaag tgtgtttcct gaagccatca tcatacggcc gtctgacatt ttcggaaggg
      661 aggacaggtt ccttaatcac tttgcaaatt atcgttggtt tcttgctgtg cctcttgttt
      721 ctttgggctt taagacagtg aagcagccgg tgtatgttgc agatgtttcc aaggggattg
      781 ttaatgcgac taaggatcca gatgccgtag gaaaaacctt tgccttcact gggccaaacc
      841 ggtacctgct cttccacttg gtgaagtaca tctttggcat gacccatcgg accttcatcc
      901 cttacccttt gccactattt gtgtatagct ggattggcaa actctttggg ctgagtccat
      961 ttgagccctg gacgacgaag gacaaggtgg agcggataca tatctcagac gtgatgccga
     1021 ccgacctgcc tggcctggaa gatcttggtg ttcagcccac accactggag ctcaagtcca
     1081 ttgaggtgct acggcggcat cgtacctacc gatggctgtc ttctgagatc gaggaaacca
     1141 agcctgccaa gacagtcaac tattagtgtc acccaggtca cctgtgtgca gtaaaagagt
     1201 cactctatta aatatccgag gattcggtct attgcaagtg tctttcttga ctgatcagag
     1261 aggaactcac agccattcag aactgaggct tgttttctat taaataacta tatataatat
     1321 cg
//
