LOCUS       NP_079634                377 aa            linear   ROD 07-FEB-2025
DEFINITION  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9,
            mitochondrial precursor [Mus musculus].
ACCESSION   NP_079634 XP_987986
VERSION     NP_079634.2
DBSOURCE    REFSEQ: accession NM_025358.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 377)
  AUTHORS   Ohanele,C., Peoples,J.N., Karlstaedt,A., Geiger,J.T., Gayle,A.D.,
            Ghazal,N., Sohani,F., Brown,M.E., Davis,M.E., Porter,G.A. Jr.,
            Faundez,V. and Kwong,J.Q.
  TITLE     The mitochondrial citrate carrier SLC25A1 regulates metabolic
            reprogramming and morphogenesis in the developing heart
  JOURNAL   Commun Biol 7 (1), 1422 (2024)
   PUBMED   39482367
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 377)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   3  (residues 1 to 377)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   4  (residues 1 to 377)
  AUTHORS   Liu,Y., Liu,Z., Ren,Z., Han,Q., Chen,X., Han,J., Qiu,G. and Sun,C.
  TITLE     NDUFA9 and its crotonylation modification promote browning of white
            adipocytes by activating mitochondrial function in mice
  JOURNAL   Int J Biochem Cell Biol 171, 106583 (2024)
   PUBMED   38657899
  REMARK    GeneRIF: NDUFA9 and its crotonylation modification promote browning
            of white adipocytes by activating mitochondrial function in mice.
REFERENCE   5  (residues 1 to 377)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (residues 1 to 377)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   7  (residues 1 to 377)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (residues 1 to 377)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (residues 1 to 377)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 377)
  AUTHORS   Baumgart,E., Vanhorebeek,I., Grabenbauer,M., Borgers,M.,
            Declercq,P.E., Fahimi,H.D. and Baes,M.
  TITLE     Mitochondrial alterations caused by defective peroxisomal
            biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout
            mouse)
  JOURNAL   Am J Pathol 159 (4), 1477-1494 (2001)
   PUBMED   11583975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165085.3 and AK012366.1.
            
            On Jul 25, 2009 this sequence version replaced NP_079634.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058378.1, AK003137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 61.92 cM"
     Protein         1..377
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 9, mitochondrial precursor"
                     /EC_number="7.1.1.2"
                     /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
                     subunit 9, mitochondrial; CI-39kD; complex I-39kD;
                     NADH-ubiquinone oxidoreductase 39 kDa subunit; NADH
                     dehydrogenase (ubiquinone) 1 alpha subcomplex, 9"
                     /calculated_mol_wt=38826
     transit_peptide 1..35
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q9DC69.2)"
                     /calculated_mol_wt=3717
     mat_peptide     36..377
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 9, mitochondrial. /id=PRO_0000019993"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DC69.2)"
                     /calculated_mol_wt=38826
     Region          54..326
                     /region_name="NDUFA9_like_SDR_a"
                     /note="NADH dehydrogenase (ubiquinone) 1 alpha subcomplex,
                     subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs;
                     cd05271"
                     /db_xref="CDD:187579"
     Site            order(60,62..65,84..86,129..131,144,167..169,180,184,
                     203..206)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187579"
     Site            order(180,184)
                     /site_type="active"
                     /db_xref="CDD:187579"
     Site            189
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q9DC69.2)"
     Site            370
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (Q9DC69.2)"
     CDS             1..377
                     /gene="Ndufa9"
                     /gene_synonym="1010001N11Rik"
                     /coded_by="NM_025358.3:33..1166"
                     /db_xref="CCDS:CCDS20557.1"
                     /db_xref="GeneID:66108"
                     /db_xref="MGI:MGI:1913358"
ORIGIN      
        1 maaavrfrvv ralpmsrpai taaatsvfcg sshrqlhhav iphgkggrss vsgvvatvfg
       61 atgflgryvv nhlgrmgsqv iipyrcdvyd imhlrlmgdl gqltflewda rdkdsirkav
      121 qhsnvvinli grewetrnfd fedvfvnipr aiaqaskeag verfihvshl nasmksssks
      181 lrskavgeke vrsvfpeaii irpsdifgre drflnhfany rwflavplvs lgfktvkqpv
      241 yvadvskgiv natkdpdavg ktfaftgpnr yllfhlvkyi fgmthrtfip yplplfvysw
      301 igklfglspf epwttkdkve rihisdvmpt dlpgledlgv qptplelksi evlrrhrtyr
      361 wlsseieetk paktvny
//
