LOCUS       NM_026703                795 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase subunit A8 (Ndufa8),
            mRNA.
ACCESSION   NM_026703
VERSION     NM_026703.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 795)
  AUTHORS   Fu,Q., Lv,R., Wang,S., Wang,W., Li,Y., Qiu,G., Chen,X. and Sun,C.
  TITLE     Ndufa8 promotes white fat Browning by improving mitochondrial
            respiratory chain complex I function to ameliorate obesity by in
            vitro and in vivo
  JOURNAL   Cell Signal 122, 111340 (2024)
   PUBMED   39127135
  REMARK    GeneRIF: Ndufa8 promotes white fat Browning by improving
            mitochondrial respiratory chain complex I function to ameliorate
            obesity by in vitro and in vivo.
REFERENCE   2  (bases 1 to 795)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   3  (bases 1 to 795)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 795)
  AUTHORS   Yao,Y., Liu,Q., Adrianto,I., Wu,X., Glassbrook,J., Khalasawi,N.,
            Yin,C., Yi,Q., Dong,Z., Geissmann,F., Zhou,L. and Mi,Q.S.
  TITLE     Histone deacetylase 3 controls lung alveolar macrophage development
            and homeostasis
  JOURNAL   Nat Commun 11 (1), 3822 (2020)
   PUBMED   32732898
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 795)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 795)
  AUTHORS   Wirtz,S. and Schuelke,M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773525.5.
            
            On Apr 25, 2018 this sequence version replaced NM_026703.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI871940.1, CX242850.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL773525.5         100316-100462       c
            148-311             AL773525.5         95474-95637         c
            312-477             AL773525.5         90836-91001         c
            478-795             AL773525.5         87448-87765         c
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.13 cM"
     gene            1..795
                     /gene="Ndufa8"
                     /gene_synonym="0610033L03Rik; CI-19kD; CI-PGIV"
                     /note="NADH:ubiquinone oxidoreductase subunit A8"
                     /db_xref="GeneID:68375"
                     /db_xref="MGI:MGI:1915625"
     exon            1..147
                     /gene="Ndufa8"
                     /gene_synonym="0610033L03Rik; CI-19kD; CI-PGIV"
                     /inference="alignment:Splign:2.1.0"
     exon            148..311
                     /gene="Ndufa8"
                     /gene_synonym="0610033L03Rik; CI-19kD; CI-PGIV"
                     /inference="alignment:Splign:2.1.0"
     exon            312..477
                     /gene="Ndufa8"
                     /gene_synonym="0610033L03Rik; CI-19kD; CI-PGIV"
                     /inference="alignment:Splign:2.1.0"
     exon            478..795
                     /gene="Ndufa8"
                     /gene_synonym="0610033L03Rik; CI-19kD; CI-PGIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      774..779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufa8"
                     /gene_synonym="0610033L03Rik; CI-19kD; CI-PGIV"
                     /note="hexamer: ATTAAA"
     polyA_site      793
                     /gene="Ndufa8"
                     /gene_synonym="0610033L03Rik; CI-19kD; CI-PGIV"
                     /note="major polyA site"
ORIGIN      
        1 agatggtacc gggcagtctt ggccagccaa aggggacttg aaggagacgg gcgacacggc
       61 cgagggcacc tggtcagggt cgcggctacc gccgtcatgc cggggatagt ggagctgcca
      121 actctggaag agctgaaagt ggaggaggtg aaagtcagct cagctgtgct taaagctgcc
      181 gcccatcact atggggctca gtgcgataaa accaataagg agtttatgct gtgccgctgg
      241 gaagagaagg acccaaggcg ctgcctgaag gagggcaagc tggtcaacgg ctgtgcgctg
      301 aacttcttca ggcagataaa gagtcactgt gcggagcctt tcacagagta ctggacttgc
      361 cttgattact ccaacatgca gctgtttcgt cactgccgcc agcagcaggc aaagtttgac
      421 cagtgtgtgc tggacaaact gggctgggtg aggccggacc tggggcagtt gtctaaggtc
      481 accaaagtga aaacagatcg tcctttgcca gagaatcctt atcactcaag agcaaggcca
      541 gagcccaacc ctgtgattga aggggatctg aaacccgcca agcacggcac ccgctttttt
      601 ttctggaccg tgtagagatg ggttgacggt ccacacttgg tcacctcggt catgcgccca
      661 gacaacagac gacgaaaaca cccgtgccga tctcgtgttc tttcctggat cacagacatt
      721 aacaaaaaag ttaatttatg tgacttggca gttattctat acatttcctg tccattaaaa
      781 attttaaagg aaaca
//
