LOCUS       NM_026614                578 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase subunit A5 (Ndufa5),
            transcript variant 1, mRNA.
ACCESSION   NM_026614
VERSION     NM_026614.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 578)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 578)
  AUTHORS   Nie,H., Yu,X., He,H., Zhou,L., Li,Q., Song,C., Wang,D., Ren,T.,
            Chen,Z., Huang,H., Dai,X. and Zhou,Y.
  TITLE     Hepatocyte miR-33a mediates mitochondrial dysfunction and
            hepatosteatosis by suppressing NDUFA5
  JOURNAL   J Cell Mol Med 22 (12), 6285-6293 (2018)
   PUBMED   30324697
  REMARK    GeneRIF: Through bioinformatics prediction, we found miR-33a
            directly targeted on the 3'-UTR of NDUFA5. Dual-luciferase reporter
            analysis further confirmed the direct suppression of miR-33a on
            NDUFA5 expression
REFERENCE   3  (bases 1 to 578)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 578)
  AUTHORS   Yavari,A., Stocker,C.J., Ghaffari,S., Wargent,E.T., Steeples,V.,
            Czibik,G., Pinter,K., Bellahcene,M., Woods,A., Martinez de
            Morentin,P.B., Cansell,C., Lam,B.Y., Chuster,A., Petkevicius,K.,
            Nguyen-Tu,M.S., Martinez-Sanchez,A., Pullen,T.J., Oliver,P.L.,
            Stockenhuber,A., Nguyen,C., Lazdam,M., O'Dowd,J.F., Harikumar,P.,
            Toth,M., Beall,C., Kyriakou,T., Parnis,J., Sarma,D., Katritsis,G.,
            Wortmann,D.D., Harper,A.R., Brown,L.A., Willows,R., Gandra,S.,
            Poncio,V., de Oliveira Figueiredo,M.J., Qi,N.R., Peirson,S.N.,
            McCrimmon,R.J., Gereben,B., Tretter,L., Fekete,C., Redwood,C.,
            Yeo,G.S., Heisler,L.K., Rutter,G.A., Smith,M.A., Withers,D.J.,
            Carling,D., Sternick,E.B., Arch,J.R., Cawthorne,M.A., Watkins,H.
            and Ashrafian,H.
  TITLE     Chronic Activation of gamma2 AMPK Induces Obesity and Reduces beta
            Cell Function
  JOURNAL   Cell Metab 23 (5), 821-836 (2016)
   PUBMED   27133129
REFERENCE   5  (bases 1 to 578)
  AUTHORS   Dai,N., Zhao,L., Wrighting,D., Kramer,D., Majithia,A., Wang,Y.,
            Cracan,V., Borges-Rivera,D., Mootha,V.K., Nahrendorf,M.,
            Thorburn,D.R., Minichiello,L., Altshuler,D. and Avruch,J.
  TITLE     IGF2BP2/IMP2-Deficient mice resist obesity through enhanced
            translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial
            proteins
  JOURNAL   Cell Metab 21 (4), 609-621 (2015)
   PUBMED   25863250
REFERENCE   6  (bases 1 to 578)
  AUTHORS   Peralta,S., Torraco,A., Wenz,T., Garcia,S., Diaz,F. and Moraes,C.T.
  TITLE     Partial complex I deficiency due to the CNS conditional ablation of
            Ndufa5 results in a mild chronic encephalopathy but no increase in
            oxidative damage
  JOURNAL   Hum Mol Genet 23 (6), 1399-1412 (2014)
   PUBMED   24154540
  REMARK    GeneRIF: At the age of 11 months, mice with a central nervous
            system knockout of Ndufa5 (Ndufa5 CNS-KO) showed lethargy and loss
            of motor skills. In these mice cortices, the levels of NDUFA5
            protein were reduced to 25% of controls. Fully assembled complex I
            (CI) levels were also greatly reduced in cortex and CI activity in
            homogenates was reduced to 60% of controls.
REFERENCE   7  (bases 1 to 578)
  AUTHORS   Wirtz,S. and Schuelke,M.
  TITLE     Region-specific expression of mitochondrial complex I genes during
            murine brain development
  JOURNAL   PLoS One 6 (4), e18897 (2011)
   PUBMED   21556144
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 578)
  AUTHORS   Shimada,T., Moriuchi,R., Mori,T., Yamada,K., Ishimaru,T. and
            Katamine,S.
  TITLE     Identification of NADH dehydrogenase 1 alpha subcomplex 5 capable
            to transform murine fibroblasts and overexpressed in human cervical
            carcinoma cell lines
  JOURNAL   Biochem Biophys Res Commun 339 (3), 852-857 (2006)
   PUBMED   16329995
  REMARK    GeneRIF: The real-time RT-PCR analysis revealed that the
            expressions of the NDUFA5 mRNA, but not the ZNF9 mRNA level, were
            significantly up-regulated in all the tested cell lines derived
            from HPV-positive cervical cancer, HeLa, SW576, and CaSKi.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY253904.1, AK019301.1 and W66892.1.
            
            On Mar 1, 2018 this sequence version replaced NM_026614.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY712440.1, AK019301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BY253904.1         3-5
            4-552               AK019301.1         2-550
            553-578             W66892.1           411-436
FEATURES             Location/Qualifiers
     source          1..578
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 11.28 cM"
     gene            1..578
                     /gene="Ndufa5"
                     /gene_synonym="2900002J19Rik; CI-13kD-B"
                     /note="NADH:ubiquinone oxidoreductase subunit A5"
                     /db_xref="GeneID:68202"
                     /db_xref="MGI:MGI:1915452"
     exon            1..165
                     /gene="Ndufa5"
                     /gene_synonym="2900002J19Rik; CI-13kD-B"
                     /inference="alignment:Splign:2.1.0"
     exon            166..210
                     /gene="Ndufa5"
                     /gene_synonym="2900002J19Rik; CI-13kD-B"
                     /inference="alignment:Splign:2.1.0"
     exon            211..327
                     /gene="Ndufa5"
                     /gene_synonym="2900002J19Rik; CI-13kD-B"
                     /inference="alignment:Splign:2.1.0"
     exon            328..393
                     /gene="Ndufa5"
                     /gene_synonym="2900002J19Rik; CI-13kD-B"
                     /inference="alignment:Splign:2.1.0"
     exon            394..556
                     /gene="Ndufa5"
                     /gene_synonym="2900002J19Rik; CI-13kD-B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      533..538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufa5"
                     /gene_synonym="2900002J19Rik; CI-13kD-B"
                     /note="hexamer: ATTAAA"
     polyA_site      556
                     /gene="Ndufa5"
                     /gene_synonym="2900002J19Rik; CI-13kD-B"
                     /note="major polyA site"
ORIGIN      
        1 ggtgggcggg agctgcccct acccagcccg agcggttgga gccaagagtg ttcttaggtg
       61 actcaggggc agcatcgacg ctcgattgag cgggcttggg aaaggttccc agagggctgt
      121 gcgctggagg cgctggacgc tgtcatggcg ggcttgctga aaaagacaac tggcctggtg
      181 gggttggcgg tgtgcgacac tccacacgag aggctcacaa tattgtatac aaagactctt
      241 gatattctga agcactttcc taaacatgca gcctatagaa aatacacaga acagatcacc
      301 aacgagaagc tggatatggt caaggcggag ccagatgtta aaaaattaga agccttgctt
      361 cagggtggtg aagtggaaga ggtgattctt caggctgaaa aagaactaag tctggcaagg
      421 aaaatgttga agtggaagcc atgggagcca ttggtggaag agccgcctgc taaccagtgg
      481 aagtggccaa tatgacctca gtgtcagatg gtggatggga attaaatgtg caattaaatg
      541 ctctgtgatg ctaaaaaaaa aaaaaaaaaa aaaaaaaa
//
