LOCUS       NM_001098789             986 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Ndufa4, mitochondrial complex associated like 2
            (Ndufa4l2), mRNA.
ACCESSION   NM_001098789 XM_001004705 XM_979012
VERSION     NM_001098789.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 986)
  AUTHORS   Mesa-Ciller,C., Turiel,G., Guajardo-Grence,A.,
            Lopez-Rodriguez,A.B., Egea,J., De Bock,K., Aragones,J. and
            Urrutia,A.A.
  TITLE     Unique expression of the atypical mitochondrial subunit NDUFA4L2 in
            cerebral pericytes fine tunes HIF activity in response to hypoxia
  JOURNAL   J Cereb Blood Flow Metab 43 (1), 44-58 (2023)
   PUBMED   35929074
  REMARK    GeneRIF: Unique expression of the atypical mitochondrial subunit
            NDUFA4L2 in cerebral pericytes fine tunes HIF activity in response
            to hypoxia.
REFERENCE   2  (bases 1 to 986)
  AUTHORS   Liu,Z., Chaillou,T., Santos Alves,E., Mader,T., Jude,B.,
            Ferreira,D.M.S., Hynynen,H., Cheng,A.J., Jonsson,W.O., Pironti,G.,
            Andersson,D.C., Kenne,E., Ruas,J.L., Tavi,P. and Lanner,J.T.
  TITLE     Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass
            and force
  JOURNAL   FASEB J 35 (12), e22010 (2021)
   PUBMED   34724256
  REMARK    GeneRIF: Mitochondrial NDUFA4L2 is a novel regulator of skeletal
            muscle mass and force.
REFERENCE   3  (bases 1 to 986)
  AUTHORS   Morarach,K., Mikhailova,A., Knoflach,V., Memic,F., Kumar,R., Li,W.,
            Ernfors,P. and Marklund,U.
  TITLE     Diversification of molecularly defined myenteric neuron classes
            revealed by single-cell RNA sequencing
  JOURNAL   Nat Neurosci 24 (1), 34-46 (2021)
   PUBMED   33288908
REFERENCE   4  (bases 1 to 986)
  AUTHORS   Moreno-Dominguez,A., Ortega-Saenz,P., Gao,L., Colinas,O.,
            Garcia-Flores,P., Bonilla-Henao,V., Aragones,J., Huttemann,M.,
            Grossman,L.I., Weissmann,N., Sommer,N. and Lopez-Barneo,J.
  TITLE     Acute O2 sensing through HIF2alpha-dependent expression of atypical
            cytochrome oxidase subunits in arterial chemoreceptors
  JOURNAL   Sci Signal 13 (615) (2020)
   PUBMED   31848220
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 986)
  AUTHORS   Xu,W.N., Zheng,H.L., Yang,R.Z., Liu,T., Yu,W., Zheng,X.F., Li,B.,
            Jiang,S.D. and Jiang,L.S.
  TITLE     Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus
            cells induced by oxidative stress via the inhibition of mitophagy
  JOURNAL   Exp Mol Med 51 (11), 1-16 (2019)
   PUBMED   31740659
  REMARK    GeneRIF: The results demonstrated that the upregulation of NDUFA4L2
            ameliorated the apoptosis of NP cells by repressing excessive
            mitophagy, which ultimately alleviated IVDD. These findings show
            for the first time that NDUFA4L2 and mitophagy may be potential
            therapeutic targets for IVDD.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 986)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   7  (bases 1 to 986)
  AUTHORS   Lim,M., Brown,H.M., Kind,K.L., Breen,J., Anastasi,M.R.,
            Ritter,L.J., Tregoweth,E.K., Dinh,D.T., Thompson,J.G. and
            Dunning,K.R.
  TITLE     Haemoglobin expression in in vivo murine preimplantation embryos
            suggests a role in oxygen-regulated gene expression
  JOURNAL   Reprod Fertil Dev 31 (4), 724-734 (2019)
   PUBMED   30482269
REFERENCE   8  (bases 1 to 986)
  AUTHORS   Tello,D., Balsa,E., Acosta-Iborra,B., Fuertes-Yebra,E., Elorza,A.,
            Ordonez,A., Corral-Escariz,M., Soro,I., Lopez-Bernardo,E.,
            Perales-Clemente,E., Martinez-Ruiz,A., Enriquez,J.A., Aragones,J.,
            Cadenas,S. and Landazuri,M.O.
  TITLE     Induction of the mitochondrial NDUFA4L2 protein by HIF-1alpha
            decreases oxygen consumption by inhibiting Complex I activity
  JOURNAL   Cell Metab 14 (6), 768-779 (2011)
   PUBMED   22100406
  REMARK    GeneRIF: Induction of the mitochondrial NDUFA4L2 protein by
            HIF-1alpha decreases oxygen consumption by inhibiting Complex I
            activity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY336656.1 and BC099496.1.
            
            On or before Jul 25, 2007 this sequence version replaced
            XM_979012.1, XM_001004705.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064011.1, AV008012.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY336656.1         3-41
            40-986              BC099496.1         1-947
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.51 cM"
     gene            1..986
                     /gene="Ndufa4l2"
                     /note="Ndufa4, mitochondrial complex associated like 2"
                     /db_xref="GeneID:407790"
                     /db_xref="MGI:MGI:3039567"
     exon            1..100
                     /gene="Ndufa4l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..307
                     /gene="Ndufa4l2"
                     /note="NADH dehydrogenase (ubiquinone) 1 alpha subcomplex,
                     4-like 2"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 4-like 2"
                     /protein_id="NP_001092259.1"
                     /db_xref="CCDS:CCDS36080.1"
                     /db_xref="GeneID:407790"
                     /db_xref="MGI:MGI:3039567"
                     /translation="MAGTSLGTRFYRQIKRHPGLIPMIGFICLGMGSAGLYLLRLALR
                     SPDVCWDRKNNPEPWNRLSPNDQYKFLAVSTDYKKLKKDRPDF"
     exon            101..189
                     /gene="Ndufa4l2"
                     /inference="alignment:Splign:2.1.0"
     exon            190..250
                     /gene="Ndufa4l2"
                     /inference="alignment:Splign:2.1.0"
     exon            251..962
                     /gene="Ndufa4l2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      937..942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufa4l2"
                     /note="hexamer: AATACA"
     polyA_site      962
                     /gene="Ndufa4l2"
                     /note="major polyA site"
ORIGIN      
        1 ggaatagaag agatccacct agaagaccag acactgggac aagatggcag gaactagtct
       61 agggacccgc ttctaccggc agataaaaag acaccctggg ctcatcccaa tgattggctt
      121 catctgcttg ggcatgggca gtgccggact ctacttgctg cgacttgccc tgcgcagtcc
      181 tgatgtctgc tgggacagaa agaacaaccc agagccctgg aaccgcctga gtcccaatga
      241 ccagtacaag ttccttgccg tttcaaccga ctacaagaag ctgaagaagg accggccaga
      301 cttctaagtc agagatctcc acgtaaatca ctctttctgc tccctgcccc agacccttgg
      361 gcgtctgtct agcagcatca gtccagcttc tgcttaaagg cccgattccc acgcaaaggg
      421 gaggccgccc cgcccccacc cgcctccctt gctcccagga gaggaaaaag cctctgaccc
      481 tcagcttgag tcccacgtgg gggaggggac tcgactgcag acgacagttg gggttgaccc
      541 aaaaacccaa gccagtcccc ctctccccct gccgctccct gctcctcctg actgggtgtg
      601 gcgcaggcta cgtgttgagc gtgtccgacg tgtgccagca gcaagcaggg gcccgagtgc
      661 cagggacgtg gcaggcccca cgtttgtttt gacagagttt tgagcagggt tcagggcggt
      721 gtctgcccag gctcgactgg gctcgtcctg ggttcccagc ctgactcgga tggggtatct
      781 ctgccatgca gtgggcttct tccctgccca agccggcagc ctccggtcaa ggacagccct
      841 cccgccttgc acctgggcag tcttgtgcct ttcccccacc cctcccttcc cttgcttctc
      901 tgtccctggg gatcaaacag aagcagccgt gggcaaaata caatttcatt taacaaattg
      961 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
