LOCUS       NM_010886                513 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus Ndufa4, mitochondrial complex associated (Ndufa4),
            mRNA.
ACCESSION   NM_010886
VERSION     NM_010886.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Wang,Z., Tao,E., Chen,Y., Wang,Q., Liu,M., Wei,L., Xu,S., Chen,W.
            and Zhong,C.
  TITLE     NDUFA4 promotes the progression of head and neck paraganglioma by
            inhibiting ferroptosis
  JOURNAL   Biochem Cell Biol 101 (6), 523-530 (2023)
   PUBMED   37602474
  REMARK    GeneRIF: NDUFA4 promotes the progression of head and neck
            paraganglioma by inhibiting ferroptosis.
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Zhu,J., Xiang,X., Hu,X., Li,C., Song,Z. and Dong,Z.
  TITLE     miR-147 Represses NDUFA4, Inducing Mitochondrial Dysfunction and
            Tubular Damage in Cold Storage Kidney Transplantation
  JOURNAL   J Am Soc Nephrol 34 (8), 1381-1397 (2023)
   PUBMED   37211637
  REMARK    GeneRIF: miR-147 Represses NDUFA4, Inducing Mitochondrial
            Dysfunction and Tubular Damage in Cold Storage Kidney
            Transplantation.
REFERENCE   3  (bases 1 to 513)
  AUTHORS   Chen,Y., Wu,J., Zhang,S., Gao,W., Liao,Z., Zhou,T., Li,Y., Su,D.,
            Liu,H., Yang,X., Su,P. and Xu,C.
  TITLE     Hnrnpk maintains chondrocytes survival and function during growth
            plate development via regulating Hif1alpha-glycolysis axis
  JOURNAL   Cell Death Dis 13 (9), 803 (2022)
   PUBMED   36127325
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 513)
  AUTHORS   Li,Y., Ivica,N.A., Dong,T., Papageorgiou,D.P., He,Y., Brown,D.R.,
            Kleyman,M., Hu,G., Chen,W.W., Sullivan,L.B., Del Rosario,A.,
            Hammond,P.T., Vander Heiden,M.G. and Chen,J.
  TITLE     MFSD7C switches mitochondrial ATP synthesis to thermogenesis in
            response to heme
  JOURNAL   Nat Commun 11 (1), 4837 (2020)
   PUBMED   32973183
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 513)
  AUTHORS   Yao,Y., Liu,Q., Adrianto,I., Wu,X., Glassbrook,J., Khalasawi,N.,
            Yin,C., Yi,Q., Dong,Z., Geissmann,F., Zhou,L. and Mi,Q.S.
  TITLE     Histone deacetylase 3 controls lung alveolar macrophage development
            and homeostasis
  JOURNAL   Nat Commun 11 (1), 3822 (2020)
   PUBMED   32732898
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 513)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   7  (bases 1 to 513)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 513)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 513)
  AUTHORS   Tallquist,M.D., Yun,T.J. and Pease,L.R.
  TITLE     A single T cell receptor recognizes structurally distinct
            MHC/peptide complexes with high specificity
  JOURNAL   J Exp Med 184 (3), 1017-1026 (1996)
   PUBMED   9064319
REFERENCE   10 (bases 1 to 513)
  AUTHORS   Chen,S., Knox,R., Lewis,A.D., Friedlos,F., Workman,P., Deng,P.S.,
            Fung,M., Ebenstein,D., Wu,K. and Tsai,T.M.
  TITLE     Catalytic properties of NAD(P)H:quinone acceptor oxidoreductase:
            study involving mouse, rat, human, and mouse-rat chimeric enzymes
  JOURNAL   Mol Pharmacol 47 (5), 934-939 (1995)
   PUBMED   7746280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM951472.1, AK076036.1 and AW045432.1.
            
            On Feb 24, 2018 this sequence version replaced NM_010886.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU704539.1, BM951472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BM951472.1         16-19
            5-496               AK076036.1         2-493
            497-513             AW045432.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 5.01 cM"
     gene            1..513
                     /gene="Ndufa4"
                     /gene_synonym="MLRQ"
                     /note="Ndufa4, mitochondrial complex associated"
                     /db_xref="GeneID:17992"
                     /db_xref="MGI:MGI:107686"
     exon            1..127
                     /gene="Ndufa4"
                     /gene_synonym="MLRQ"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..334
                     /gene="Ndufa4"
                     /gene_synonym="MLRQ"
                     /codon_start=1
                     /product="cytochrome c oxidase subunit NDUFA4"
                     /protein_id="NP_035016.1"
                     /db_xref="CCDS:CCDS39427.1"
                     /db_xref="GeneID:17992"
                     /db_xref="MGI:MGI:107686"
                     /translation="MLRQILGQAKKHPSLIPLFVFIGAGGTGAALYVMRLALFNPDVS
                     WDRKNNPEPWNKLGPNEQYKFYSVNVDYSKLKKEGPDF"
     exon            128..216
                     /gene="Ndufa4"
                     /gene_synonym="MLRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            217..277
                     /gene="Ndufa4"
                     /gene_synonym="MLRQ"
                     /inference="alignment:Splign:2.1.0"
     exon            278..497
                     /gene="Ndufa4"
                     /gene_synonym="MLRQ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      478..483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufa4"
                     /gene_synonym="MLRQ"
                     /note="hexamer: AATAAA"
     polyA_site      497
                     /gene="Ndufa4"
                     /gene_synonym="MLRQ"
                     /note="major polyA site"
ORIGIN      
        1 ggacgtccgc tcagccaggt tgcagaagcg gcttagcgtg tgtcctaatc ttctctctgc
       61 gtgtaggtag gcctgtgccg caaacatgct ccgccagatc ctcgggcaag ccaagaagca
      121 tcccagcttg attcctctct tcgtatttat tggagcaggg ggtactggag cagcactgta
      181 tgtgatgcgc ttggcactgt ttaatccaga tgtcagctgg gacagaaaga acaacccaga
      241 gccatggaac aaactgggtc ccaatgaaca atataagttc tactctgtga atgtggacta
      301 cagcaaactg aagaaagaag gcccagactt ctaaactatg aagttcactg taaagctgct
      361 gataatgaag gtctttcaga agccatccgc acaattttcc acttaagcag gaaatatgtc
      421 tctgaatgca tgaaatcatg ttgatttttt ttttttttgg agtttattac actgatgaat
      481 aaatctctga aacttgaaaa aaaaaaaaaa aaa
//
