LOCUS       NM_023312               1268 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase subunit A13 (Ndufa13),
            transcript variant 1, mRNA.
ACCESSION   NM_023312
VERSION     NM_023312.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1268)
  AUTHORS   Ren,J., Che,Y., Li,H., Gao,H., Wang,Y., Wang,Y., Su,H., Li,Z.,
            Li,J. and Qu,P.
  TITLE     SGK3 deficiency in macrophages suppresses angiotensin II-induced
            cardiac remodeling via regulating Ndufa13-mediated mitochondrial
            oxidative stress
  JOURNAL   Cell Mol Life Sci 81 (1), 359 (2024)
   PUBMED   39158709
  REMARK    GeneRIF: SGK3 deficiency in macrophages suppresses angiotensin
            II-induced cardiac remodeling via regulating Ndufa13-mediated
            mitochondrial oxidative stress.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1268)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1268)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   4  (bases 1 to 1268)
  AUTHORS   Wang,B., Yang,Y., Ye,J., Han,X., Yang,L., Huang,Y. and Chao,L.
  TITLE     GRIM-19 deficiency promotes macrophage polarization to the M1
            phenotype partly through glycolysis in unexplained recurrent
            spontaneous abortiondagger
  JOURNAL   Biol Reprod 110 (4), 739-749 (2024)
   PUBMED   38206868
  REMARK    GeneRIF: GRIM-19 deficiency promotes macrophage polarization to the
            M1 phenotype partly through glycolysis in unexplained recurrent
            spontaneous abortiondagger.
REFERENCE   5  (bases 1 to 1268)
  AUTHORS   Yang,L., Yang,Y., Han,X., Huang,C., Wang,Y., Jiang,D. and Chao,L.
  TITLE     GRIM19 deficiency aggravates metabolic disorder and ovarian
            dysfunction in PCOS
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167063 (2024)
   PUBMED   38360073
  REMARK    GeneRIF: GRIM19 deficiency aggravates metabolic disorder and
            ovarian dysfunction in PCOS.
REFERENCE   6  (bases 1 to 1268)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 1268)
  AUTHORS   Lufei,C., Ma,J., Huang,G., Zhang,T., Novotny-Diermayr,V., Ong,C.T.
            and Cao,X.
  TITLE     GRIM-19, a death-regulatory gene product, suppresses Stat3 activity
            via functional interaction
  JOURNAL   EMBO J 22 (6), 1325-1335 (2003)
   PUBMED   12628925
REFERENCE   8  (bases 1 to 1268)
  AUTHORS   Seo,T., Lee,D., Shim,Y.S., Angell,J.E., Chidambaram,N.V.,
            Kalvakolanu,D.V. and Choe,J.
  TITLE     Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated
            herpesvirus interacts with a cell death regulator, GRIM19, and
            inhibits interferon/retinoic acid-induced cell death
  JOURNAL   J Virol 76 (17), 8797-8807 (2002)
   PUBMED   12163600
  REMARK    GeneRIF: results collectively indicate that viral interferon
            regulatory factor 1 modulates interferon/retinoic acid-cell death
            signals via interactions with GRIM19
REFERENCE   9  (bases 1 to 1268)
  AUTHORS   Angell,J.E., Lindner,D.J., Shapiro,P.S., Hofmann,E.R. and
            Kalvakolanu,D.V.
  TITLE     Identification of GRIM-19, a novel cell death-regulatory gene
            induced by the interferon-beta and retinoic acid combination, using
            a genetic approach
  JOURNAL   J Biol Chem 275 (43), 33416-33426 (2000)
   PUBMED   10924506
REFERENCE   10 (bases 1 to 1268)
  AUTHORS   Moore,A.B., He,H., Yoshida,A., Rico,P.J., Haseman,J.K. and Dixon,D.
  TITLE     Transforming growth factor-alpha, epidermal growth factor receptor,
            and PCNA immunoexpression in uterine leiomyosarcomas and leiomyomas
            in B6C3F1 mice
  JOURNAL   Exp Toxicol Pathol 52 (3), 195-200 (2000)
   PUBMED   10930119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158564.7.
            
            On Feb 8, 2019 this sequence version replaced NM_023312.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034899.1, SRR7345562.3275072.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-678               AC158564.7         95907-96584         c
            679-869             AC158564.7         95568-95758         c
            870-948             AC158564.7         89268-89346         c
            949-1020            AC158564.7         88530-88601         c
            1021-1268           AC158564.7         88189-88436         c
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.03 cM"
     gene            1..1268
                     /gene="Ndufa13"
                     /gene_synonym="2700054G14Rik; CDA016; CGI-39; CI-B16.6;
                     GRIM-19; Grim19"
                     /note="NADH:ubiquinone oxidoreductase subunit A13"
                     /db_xref="GeneID:67184"
                     /db_xref="MGI:MGI:1914434"
     exon            1..678
                     /gene="Ndufa13"
                     /gene_synonym="2700054G14Rik; CDA016; CGI-39; CI-B16.6;
                     GRIM-19; Grim19"
                     /inference="alignment:Splign:2.1.0"
     exon            679..869
                     /gene="Ndufa13"
                     /gene_synonym="2700054G14Rik; CDA016; CGI-39; CI-B16.6;
                     GRIM-19; Grim19"
                     /inference="alignment:Splign:2.1.0"
     CDS             776..1210
                     /gene="Ndufa13"
                     /gene_synonym="2700054G14Rik; CDA016; CGI-39; CI-B16.6;
                     GRIM-19; Grim19"
                     /EC_number="7.1.1.2"
                     /note="genes associated with retinoid-IFN-induced
                     mortality 19; complex I-B16.6; cell death regulatory
                     protein GRIM-19; NADH-ubiquinone oxidoreductase B16.6
                     subunit; gene associated with retinoic-interferon-induced
                     mortality 19 protein; gene associated with retinoic and
                     IFN-induced mortality 19 protein; gene associated with
                     retinoic and interferon-induced mortality 19 protein; NADH
                     dehydrogenase (ubiquinone) 1 alpha subcomplex, 13"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 13"
                     /protein_id="NP_075801.1"
                     /db_xref="CCDS:CCDS22353.1"
                     /db_xref="GeneID:67184"
                     /db_xref="MGI:MGI:1914434"
                     /translation="MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMFAVGIGALI
                     FGYWRMMRWNQERRRLLIEDLEARIALMPLFQAEKDRRTLQILRENLEEEAIIMKDVP
                     NWKVGESVFHTTRWVPPLIGEMYGLRTKEEMSNANFGFTWYT"
     exon            870..948
                     /gene="Ndufa13"
                     /gene_synonym="2700054G14Rik; CDA016; CGI-39; CI-B16.6;
                     GRIM-19; Grim19"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1020
                     /gene="Ndufa13"
                     /gene_synonym="2700054G14Rik; CDA016; CGI-39; CI-B16.6;
                     GRIM-19; Grim19"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1268
                     /gene="Ndufa13"
                     /gene_synonym="2700054G14Rik; CDA016; CGI-39; CI-B16.6;
                     GRIM-19; Grim19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1230..1235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufa13"
                     /gene_synonym="2700054G14Rik; CDA016; CGI-39; CI-B16.6;
                     GRIM-19; Grim19"
                     /note="hexamer: AATAAA"
     polyA_site      1262
                     /gene="Ndufa13"
                     /gene_synonym="2700054G14Rik; CDA016; CGI-39; CI-B16.6;
                     GRIM-19; Grim19"
                     /note="major polyA site"
ORIGIN      
        1 ccattgcaca cttcgatgaa ctcgaaaacg tgtacgatgt gcgggtgccg tactccccgc
       61 aggatggaca gctctcgagg caggaacttg ttgacgaagt ccggaggcgc tcgccggcgg
      121 tccaccacct tgatggccac cgtcccttta tacttcttgg aggtggccac tttcaccttg
      181 gagtagctgc cctcacctat cgtgcggccc agcttatagc caagttcgct caggagtttg
      241 tcgcccgaca tggtggcgcc cggggcgcgc ggggagcagg aggcggctgc tgtcgggggg
      301 cggccggact ccaatctcgg gcctaaccca tggtgcttgg cacctgcacc cccgtgcccc
      361 catgtgccca ctcccaaggc cctacagccg cgatgacttt tattgcccgg gtaacaattt
      421 ctgccttgtg aagtgactgc gggcgtcact cggccttggg gcggggaccc tccctccccc
      481 gccccgcggg ctccctaaac ccttcttagg ctttgtgact caatcgccct taatggtcag
      541 ttcctcgtga gaagtcactg gcgaggagac tgcccactga tgtggaacag gacaagtccc
      601 tccctgaagt gatggtgctc aggtgggtgg gaaccagcct gttgcctcga gcctggctac
      661 catggctcac gaaagaaagg aacctcctgg gtgacggaac ttccgccaca ctcaaaatgg
      721 tggtcgcgcg ttgcctcact tccgctggtg gccggaagtt gcgggtcctg caagtatggc
      781 ggcgtcgaag gtgaagcagg acatgccccc gccagggggc tacggcccca tcgactacaa
      841 gcggaacctg ccccgccggg gactgtcggg gtacagcatg tttgctgtgg gcatcggggc
      901 cttgatcttt ggctactgga gaatgatgag gtggaaccag gagcgcaggc gcctgctgat
      961 tgaggacttg gaggccagga tcgccctcat gccgctcttc caggcagaga aggaccggag
     1021 gaccctgcag attctccggg aaaacctgga ggaggaagcc atcatcatga aggatgtgcc
     1081 caactggaag gtgggcgagt ctgtgttcca taccacacga tgggtgccac ccctcattgg
     1141 cgagatgtat gggttgcgca ccaaggagga gatgagcaat gccaacttcg gcttcacctg
     1201 gtacacttag ggcctgagcc aacgcacata ataaagagtg gtcaaataaa atgttgactc
     1261 tatagtga
//
