LOCUS       NM_025551               1027 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus NADH:ubiquinone oxidoreductase subunit A12 (Ndufa12),
            transcript variant 1, mRNA.
ACCESSION   NM_025551
VERSION     NM_025551.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1027)
  AUTHORS   Vercellino,I. and Sazanov,L.A.
  TITLE     SCAF1 drives the compositional diversity of mammalian respirasomes
  JOURNAL   Nat Struct Mol Biol 31 (7), 1061-1071 (2024)
   PUBMED   38575788
REFERENCE   2  (bases 1 to 1027)
  AUTHORS   Sheng,X., Liu,C., Yan,G., Li,G., Liu,J., Yang,Y., Li,S., Li,Z.,
            Zhou,J., Zhen,X., Zhang,Y., Diao,Z., Hu,Y., Fu,C., Yao,B., Li,C.,
            Cao,Y., Lu,B., Yang,Z., Qin,Y., Sun,H. and Ding,L.
  TITLE     The mitochondrial protease LONP1 maintains oocyte development and
            survival by suppressing nuclear translocation of AIFM1 in mammals
  JOURNAL   EBioMedicine 75, 103790 (2022)
   PUBMED   34974310
REFERENCE   3  (bases 1 to 1027)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1027)
  AUTHORS   Adjobo-Hermans,M.J.W., de Haas,R., Willems,P.H.G.M., Wojtala,A.,
            van Emst-de Vries,S.E., Wagenaars,J.A., van den Brand,M.,
            Rodenburg,R.J., Smeitink,J.A.M., Nijtmans,L.G., Sazanov,L.A.,
            Wieckowski,M.R. and Koopman,W.J.H.
  TITLE     NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4-/- mice and
            Leigh syndrome patients: A stabilizing role for NDUFAF2
  JOURNAL   Biochim Biophys Acta Bioenerg 1861 (8), 148213 (2020)
   PUBMED   32335026
  REMARK    GeneRIF: NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4(-/-)
            mice and Leigh syndrome patients: A stabilizing role for NDUFAF2.
REFERENCE   5  (bases 1 to 1027)
  AUTHORS   Signes,A. and Fernandez-Vizarra,E.
  TITLE     Assembly of mammalian oxidative phosphorylation complexes I-V and
            supercomplexes
  JOURNAL   Essays Biochem 62 (3), 255-270 (2018)
   PUBMED   30030361
  REMARK    Review article
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138026.4.
            
            On Jun 28, 2018 this sequence version replaced NM_025551.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134765.1, C89034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC138026.4         8875-8970
            97-179              AC138026.4         9790-9872
            180-267             AC138026.4         13128-13215
            268-1027            AC138026.4         30521-31280
FEATURES             Location/Qualifiers
     source          1..1027
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 48.83 cM"
     gene            1..1027
                     /gene="Ndufa12"
                     /gene_synonym="2410011G03Rik; CI-B17.2; CIB17.2"
                     /note="NADH:ubiquinone oxidoreductase subunit A12"
                     /db_xref="GeneID:66414"
                     /db_xref="MGI:MGI:1913664"
     exon            1..96
                     /gene="Ndufa12"
                     /gene_synonym="2410011G03Rik; CI-B17.2; CIB17.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..448
                     /gene="Ndufa12"
                     /gene_synonym="2410011G03Rik; CI-B17.2; CIB17.2"
                     /EC_number="7.1.1.2"
                     /EC_number="1.6.99.3"
                     /note="isoform 1 is encoded by transcript variant 1; NADH
                     dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12;
                     13kDa differentiation-associated protein; complex I-B17.2;
                     NADH-ubiquinone oxidoreductase subunit B17.2"
                     /codon_start=1
                     /product="NADH dehydrogenase [ubiquinone] 1 alpha
                     subcomplex subunit 12 isoform 1"
                     /protein_id="NP_079827.3"
                     /db_xref="CCDS:CCDS24132.2"
                     /db_xref="GeneID:66414"
                     /db_xref="MGI:MGI:1913664"
                     /translation="MELVEVLKRGVQQVTGHGGLRGLLRVFFRANDIRIGTLVGEDKY
                     GNKYYEDNKQFFGRHRWVIYTTEMNGKNTFWDVDGSMVPPEWHRWLHCMTDDPPTTNP
                     PTARKFIWTNHKFNVSATPEQYVPYSTTRKKIHEWVPPSTPYK"
     exon            97..179
                     /gene="Ndufa12"
                     /gene_synonym="2410011G03Rik; CI-B17.2; CIB17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            180..267
                     /gene="Ndufa12"
                     /gene_synonym="2410011G03Rik; CI-B17.2; CIB17.2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..1027
                     /gene="Ndufa12"
                     /gene_synonym="2410011G03Rik; CI-B17.2; CIB17.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      518..523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufa12"
                     /gene_synonym="2410011G03Rik; CI-B17.2; CIB17.2"
                     /note="hexamer: ATTAAA"
     polyA_site      536
                     /gene="Ndufa12"
                     /gene_synonym="2410011G03Rik; CI-B17.2; CIB17.2"
                     /note="major polyA site"
     regulatory      1007..1012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndufa12"
                     /gene_synonym="2410011G03Rik; CI-B17.2; CIB17.2"
                     /note="hexamer: ATTAAA"
     polyA_site      1027
                     /gene="Ndufa12"
                     /gene_synonym="2410011G03Rik; CI-B17.2; CIB17.2"
ORIGIN      
        1 gcagatgaga atggagctgg tggaggtcct gaagcgcggc gtgcagcagg tcaccggcca
       61 cggcggcctg cggggcctcc tacgggtttt cttcagggca aatgatataa ggattggtac
      121 actggtggga gaagacaaat atggaaataa atactacgaa gacaacaagc aattttttgg
      181 ccgccaccga tgggtcatct acaccaccga gatgaacggc aaaaacacat tctgggatgt
      241 ggatggaagc atggtgcctc ctgagtggca ccgctggctt cactgcatga ctgacgaccc
      301 tccgacgact aatccaccga ctgctcgtaa attcatctgg acaaaccata aattcaatgt
      361 gtctgccact ccagagcaat acgttcctta ttccaccact agaaagaaga ttcatgaatg
      421 ggttccacct tcgacacctt acaagtgacc gcagtgaaga ctgttcctgc acttccaggc
      481 tagtgcagga ccatcctagc agctgaccat gaacttgatt aaaattgttt gacctagcag
      541 tgtcttgtgc gttcacaccg tcattcatcc cctgcaaagt agaagctcgc acatgaggga
      601 gggaggtgac tgacatagat ctctggggcg ggggatggga gtggggggtc tgaagtaaag
      661 ttcccagttc taggaaatag ccccagggga cctgtttgtg tttcatgatc ttccccgact
      721 tccatggctg gttgataagg gcaggctgca ttccaacctg agccagacat tggtaagctt
      781 cgtggagaga cacaaacacc gagtggcagc ctggctcaga ctctggtgtg gctctgtatg
      841 gaggaggtta ttggagatgt cctatttcct tccccacccc actccccctt tggttttttg
      901 agataggatt tctttatgtg gctctggatg ttttggaact cactttgtag actaggctag
      961 ccttgaactc aaaagatcta cctgcctgtg cctcccaagt gctggtatta aaaggtgtcc
     1021 actaaaa
//
