LOCUS       NM_031186               5446 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus N-deacetylase/N-sulfotransferase (heparan
            glucosaminyl) 3 (Ndst3), transcript variant 1, mRNA.
ACCESSION   NM_031186
VERSION     NM_031186.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5446)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5446)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5446)
  AUTHORS   Yin,Y., Wang,A., Feng,L., Wang,Y., Zhang,H., Zhang,I., Bany,B.M.
            and Ma,L.
  TITLE     Heparan Sulfate Proteoglycan Sulfation Regulates Uterine
            Differentiation and Signaling During Embryo Implantation
  JOURNAL   Endocrinology 159 (6), 2459-2472 (2018)
   PUBMED   29688404
  REMARK    GeneRIF: An essential role for Heparin sulfate proteoglycan
            sulfation via NDST1,2,3 in modulating signal transduction during
            mouse implantation.
REFERENCE   4  (bases 1 to 5446)
  AUTHORS   Paul,A., Crow,M., Raudales,R., He,M., Gillis,J. and Huang,Z.J.
  TITLE     Transcriptional Architecture of Synaptic Communication Delineates
            GABAergic Neuron Identity
  JOURNAL   Cell 171 (3), 522-539 (2017)
   PUBMED   28942923
REFERENCE   5  (bases 1 to 5446)
  AUTHORS   Liu,C., Gu,S., Sun,C., Ye,W., Song,Z., Zhang,Y. and Chen,Y.
  TITLE     FGF signaling sustains the odontogenic fate of dental mesenchyme by
            suppressing beta-catenin signaling
  JOURNAL   Development 140 (21), 4375-4385 (2013)
   PUBMED   24067353
REFERENCE   6  (bases 1 to 5446)
  AUTHORS   Yabe,T., Hata,T., He,J. and Maeda,N.
  TITLE     Developmental and regional expression of heparan sulfate
            sulfotransferase genes in the mouse brain
  JOURNAL   Glycobiology 15 (10), 982-993 (2005)
   PUBMED   15944372
REFERENCE   7  (bases 1 to 5446)
  AUTHORS   Wang,L., Fuster,M., Sriramarao,P. and Esko,J.D.
  TITLE     Endothelial heparan sulfate deficiency impairs L-selectin- and
            chemokine-mediated neutrophil trafficking during inflammatory
            responses
  JOURNAL   Nat Immunol 6 (9), 902-910 (2005)
   PUBMED   16056228
REFERENCE   8  (bases 1 to 5446)
  AUTHORS   Ford-Perriss,M., Guimond,S.E., Greferath,U., Kita,M., Grobe,K.,
            Habuchi,H., Kimata,K., Esko,J.D., Murphy,M. and Turnbull,J.E.
  TITLE     Variant heparan sulfates synthesized in developing mouse brain
            differentially regulate FGF signaling
  JOURNAL   Glycobiology 12 (11), 721-727 (2002)
   PUBMED   12460940
REFERENCE   9  (bases 1 to 5446)
  AUTHORS   Grobe,K. and Esko,J.D.
  TITLE     Regulated translation of heparan sulfate N-acetylglucosamine
            N-deacetylase/n-sulfotransferase isozymes by structured
            5'-untranslated regions and internal ribosome entry sites
  JOURNAL   J Biol Chem 277 (34), 30699-30706 (2002)
   PUBMED   12070138
REFERENCE   10 (bases 1 to 5446)
  AUTHORS   Aikawa,J., Grobe,K., Tsujimoto,M. and Esko,J.D.
  TITLE     Multiple isozymes of heparan sulfate/heparin GlcNAc
            N-deacetylase/GlcN N-sulfotransferase. Structure and activity of
            the fourth member, NDST4
  JOURNAL   J Biol Chem 276 (8), 5876-5882 (2001)
   PUBMED   11087757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160531.16, AC124005.13 and BC079622.1.
            
            [WARNING] On Apr 12, 2024 this sequence was replaced by
            NM_031186.4.
            
            On Jun 14, 2014 this sequence version replaced NM_031186.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF221095.1, BC112404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1137              AC160531.16        63340-64476
            1138-1225           AC160531.16        101477-101564
            1226-1380           AC160531.16        107704-107858
            1381-1566           AC160531.16        128786-128971
            1567-1695           AC160531.16        134248-134376
            1696-1878           AC124005.13        17934-18116
            1879-1975           AC124005.13        19722-19818
            1976-2099           AC124005.13        23103-23226
            2100-2274           AC124005.13        27338-27512
            2275-2445           AC124005.13        30976-31146
            2446-2555           AC124005.13        33140-33249
            2556-2658           AC124005.13        48832-48934
            2659-2780           AC124005.13        51088-51209
            2781-5446           BC079622.1         2652-5317
FEATURES             Location/Qualifiers
     source          1..5446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 54.58 cM"
     gene            1..5446
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /note="N-deacetylase/N-sulfotransferase (heparan
                     glucosaminyl) 3"
                     /db_xref="GeneID:83398"
                     /db_xref="MGI:MGI:1932544"
     exon            1..1137
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..2778
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /EC_number="2.8.2.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bifunctional heparan sulfate
                     N-deacetylase/N-sulfotransferase 3; N-heparan sulfate
                     sulfotransferase 3; glucosaminyl
                     N-deacetylase/N-sulfotransferase 3"
                     /codon_start=1
                     /product="bifunctional heparan sulfate
                     N-deacetylase/N-sulfotransferase 3 isoform 1"
                     /protein_id="NP_112463.2"
                     /db_xref="CCDS:CCDS17818.1"
                     /db_xref="GeneID:83398"
                     /db_xref="MGI:MGI:1932544"
                     /translation="MSFIMKPHRHFQRTLILLATFCMVSIIISAYYLYSGYKQESEVS
                     GRASEVDCGDLQHIPSRLMEVRRTMISDASRTDPTVLVFVESQYSSLGQDIIMMLESI
                     RFHYHTEIAPGKGDLPALTDNVKGKYVLIIYENILKYINMDSWNRSLLDKYCIEYGVG
                     IIGFHKTSEKNLQSFQFRGFPFSISGNLAVKDCCINPHSPLLRVTKSSKLDRGSLPGT
                     DWTVFQINHSTYQPVIFAKVKTPENLSPPISKHAFYATIIHDLGLHDGIQRVLFGNNL
                     NFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTRMNTNDVKALLDTQN
                     LLRTQITNFTFNLGFSGKFYHTGTEEEDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHN
                     ESSLIEQMILNKKFALEHGIPTDMGYAVSPHHSGVYPVHVQLYEAWKKVWNIKITSTE
                     EYPHLKPARYRRGFIHKNIMVLPRQTCGLFTHTIFYKEYPGGPRELDKSIHGGELFFT
                     VVLNPISIFMTHLSNYGNDRLGLYTFVNLANFVQTWTNLRLQTLPPAQLAHKYFELFP
                     DQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLVIGPQKTGTTALCLFLIMHPSILSN
                     SPSPKSFEEVQFFNRNNYHRGIDWYMDFFPVPSNVTTDFLFEKSANYFHSEDAPKRAA
                     SLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFSFYEVISAGPNAPWELRTLQK
                     RCLVPGWYANHIERWLVYFPPFQLLIIDGQQLRTTPATVMDEVQKFLGVSPHYNYSEA
                     LTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRAFLSSYYRDHNVELSKLLHR
                     LGQPLPSWLRQELQKVR"
     exon            1138..1225
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1380
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1566
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1695
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1878
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1975
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2099
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2274
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2445
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2555
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2658
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..5423
                     /gene="Ndst3"
                     /gene_synonym="4921531K01Rik; 4930511P15Rik; N-HSST 3;
                     NDST-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgtgtttc ctgtgagtcc agatgtgtga tccagatatg ctgcaatggt gacataaact
       61 gttgactgag actaggagcg tgcctgaaac tccatccctc ctcctattat tttttaatgg
      121 tgcttctact ggaatagtca acaaagtgca cccaacatga gttttatcat gaaacctcac
      181 agacactttc agagaacact gattctgctt gccacctttt gtatggtaag cattattatt
      241 tctgcttact acctgtacag cggctacaaa caggaaagtg aagtctccgg gcgggcttcg
      301 gaagtggact gtggtgacct ccagcacata ccatccaggc tgatggaagt gaggaggaca
      361 atgatttccg atgcttcaag gacagacccc acagtcctgg tgtttgtgga gagccagtac
      421 tcatcccttg gtcaagacat cattatgatg ctagaatcca tccggttcca ttatcacact
      481 gaaatcgctc ctggaaaagg agatcttccg gcacttacag acaatgtgaa gggcaaatat
      541 gttctcatta tatatgagaa tattctaaag tatataaaca tggactcttg gaatagaagc
      601 cttttagata aatactgtat agagtatggt gtgggtatca ttggattcca taaaaccagt
      661 gagaaaaatc tacagagctt tcagttcagg ggcttcccct tttccataag tggaaacctg
      721 gcagtaaaag attgctgtat taatcctcac tccccactcc ttcgtgtgac caaatcatcc
      781 aagctggaca gaggttctct acctggaact gactggacag tttttcagat taaccactcc
      841 acctaccagc cagtaatatt tgccaaagtt aagactccag aaaacctttc tcctcccatc
      901 tctaaacatg cattttatgc cactatcata cacgacctgg ggcttcatga cgggatccag
      961 cgagttcttt ttggcaacaa cttgaacttc tggctacaca agctcatctt catagacgcc
     1021 atctccttct tgtcggggaa gaggctgaca ctgtccttgg acaggtacat ccttgtggac
     1081 attgacgaca tatttgtagg gaaggagggc acaaggatga acaccaatga tgtgaaggcc
     1141 ctgcttgaca ctcagaatct tttgcgcaca caaatcacaa attttacatt caaccttgga
     1201 ttttcaggga aattttatca cacaggaact gaagaggaag atgaagggga tgattgtctg
     1261 ctgggttctg tggacgagtt ctggtggttt cctcacatgt ggagtcacat gcagccccac
     1321 ctcttccaca atgagtcgtc tttaatagag cagatgattc tcaacaaaaa gtttgcctta
     1381 gagcacggca tccctaccga tatgggatat gcagtgtccc ctcaccattc aggtgtctac
     1441 cctgtccatg ttcagcttta tgaggcctgg aagaaggttt ggaatattaa aatcaccagc
     1501 actgaagaat atccacatct gaaaccagct agatatcgga gaggcttcat tcacaaaaac
     1561 atcatggttc tcccaagaca aacctgtggg ctcttcaccc acacaatttt ctacaaggag
     1621 tatccagggg gtcccaggga actggacaag agtattcatg gaggggagct cttcttcact
     1681 gtggttctca acccaatcag tattttcatg acccatttgt ctaactatgg aaacgaccga
     1741 ctgggattat atacatttgt gaatctagcc aattttgtgc agacctggac caacctgcgt
     1801 cttcagacct tgcctccagc tcagctggct cacaagtatt ttgagctctt tcctgatcag
     1861 aaagaccctc tctggcagaa cccctgtgat gacaaacgcc acagagacat ttggtctaaa
     1921 gagaaaacct gcgatcgttt accaaaattc ttggtaatag gaccccagaa aactggtacc
     1981 actgccttgt gtctgttcct gattatgcat ccttccatcc ttagtaactc ccccagccca
     2041 aaatcctttg aggaggtaca gttctttaat agaaataact accacagggg gattgattgg
     2101 tacatggatt tcttcccagt cccatctaat gtcaccactg actttctgtt tgagaagagt
     2161 gctaattact tccattcaga ggacgctccc aagagggctg cttctctagt cccgaaagcc
     2221 aaaatcatca ccatactcat tgacccgtca gaccgagcgt actcctggta tcagcatcag
     2281 cgatcccatg aagaccctgc agctctgaaa tttagcttct atgaagtgat ctctgctggg
     2341 cccaatgcac cctgggaact ccgaaccctg cagaagagat gcctggtccc tgggtggtat
     2401 gccaaccaca tcgagagatg gcttgtttat ttccctccat ttcagttgct aatcattgat
     2461 ggacagcagc taagaactac ccctgcgaca gtgatggatg aagtccagaa gtttctagga
     2521 gtctcacctc attataatta ctccgaagct ttaacgtttg attctcataa aggcttctgg
     2581 tgtcagctgc tggaagaagg gaaaacaaaa tgccttggga agagtaaagg aagaaaatac
     2641 cccccgatgg actctgatag cagagcgttt ctgtccagct actaccgcga ccacaacgtg
     2701 gagctctcga agctgctgca caggctgggg cagcctctgc cctcctggct gagacaggag
     2761 ctgcagaaag tgaggtagca tggagaaaag aagcagacct catctagagc tcacagacga
     2821 cactaccaaa aagctgtgga acacatacct ctgcatcaca gaaaacgagc aaggctcttc
     2881 catgtgctgg catgtggatg attgtggagg gtcaggcata aaatatatat atatctttaa
     2941 gaagcttcca ggcctatggc cttcctctta acccttatct gatttgtgtg gaacagcaac
     3001 caacataaat tttaaaacaa aacagaaaac agaaacactg acgcagtcct gtaccatttc
     3061 atagtaatat ttacaatttt gtatatttcg gctacagttg ttatttctgt agatttctgg
     3121 accactattt gactgtaaaa atgttttctg actcgattct gtgaagtagc ctataaacat
     3181 cacgatggag aattacaagt gtcggaaaat gctgccagca taggccatgg ctgtgtgaga
     3241 gcagggtcgg ggagcaatct gtggactttg tctccaaaca gggaagcaaa gggggtggtt
     3301 ctccttgtac atagtccagc gagctcgtgc tgatgtagct ctgtattgta aacttggcag
     3361 acagcaaaca gtaacacatc cttacatcaa aatactgaac attaatggca gagtattgac
     3421 taaatcctct gagaaagaga actggtgaac ttctaaagat acgccataca gatacataaa
     3481 aatacactga gaactctttg ctttctgatg taagctgccg gtctattctg gccacctcca
     3541 gttgcaccga aatgcatgtg gagcctgcag gaagtattct ctctgagtca gagtgacctt
     3601 taaatttgca gagcagagac tggagaaatg gctccacagt ggggggcact gactcttctt
     3661 ctagaggact caggtttaaa tcccagcacc cacatggcag ctcacaactg cctgtatctc
     3721 ccaagatctg acactctcac atagacaaac atacaggcaa aacaccaatg cacataaaat
     3781 aaaggttaaa aaattaattt aaagtcctca taaatgagca gagcagctgc tgaacaaact
     3841 tattaactgg aaactaagga cagttccttg agctgcttaa agtactcaga tttaaattat
     3901 tgcaaaactg tgtttttcca ggtaatccca aagcaaactg tgtaatatac aggcttgtgg
     3961 gacaatggac tcatatacaa attttcatct aatatataaa acgatggttg tgcttcgagg
     4021 tggaacaagc aggtgaagta ccatgatgga ggatacctcg catattgccc acatctttgc
     4081 ccaacaacag aacattgcca actgtatgaa ctacctacga taagaatcac agggagtaca
     4141 aagatgagca tagctcagga aatatatcta atttaaatta gacacgtgat gagtgaagga
     4201 ttcgaaacaa gagtacggga gatcacactt tcctgtgtta gtatagactt aatcttgtat
     4261 tgtgattgac ccatatgtaa acataaggag aatgttcctc gctgtgactg cacacaattc
     4321 tagaaagtat tctataaggt gtgtttagag acacaatatg ccacaaaacc aaaggcctga
     4381 atacgtctat ctgtcatttc agtgcacaaa acggtactct tgcagctatt tgccagttta
     4441 aaaaacaaaa acaaaaaaga atgaagcacc cccactcgcg ctgcttaatt ccttacatcc
     4501 ttattcccac aattaccagt ttctctaaag tttttccatc ttttatgaac tcaaagaata
     4561 cagtgacttt tttttaaagc acataccgga aagagttggc taaacaacca aattttaaga
     4621 gccctgattg agaggccaaa tcaaaataca gtgaaaggac tcttccctcc taaccgctgc
     4681 cactttggca gtgacacctg ccatgcccag cggggaaatc acccctcaca tccacgtcca
     4741 ttaatttaag aaaattggct caaggggtca taagacccag cgctccagct gttacagtct
     4801 cactggtgac agtgtgtcag ctcaggaaat aagctgacat acatctccac atttgaacct
     4861 ctgtagataa attggctact gacatccttt aatgtaggga gacagtgcct gtaaaataaa
     4921 tggcaaaaaa tagcacttat aatgaatcag aaaaaaaaga gagagaaacg gtattccgac
     4981 ctgctcattc ccaagtccat gtcagatgcc gtgtagacca gcagcccttt caaagggttt
     5041 tgaccactgg gcgtgtcaaa gaggcagctc ccaattcagg agggcaacca cacatctcac
     5101 actgtgagct ccagctggcc attatgctac cctgaaatcg acagaagtcc aggagaaaag
     5161 aatgggagag aacatgattc caaactagct ttgtatagaa ttcccttttt cctgacttat
     5221 aatacggggc ttcctcagga agaaatgaaa tggttatttc aatgtttata gctataatat
     5281 tcttgtcatt cacattgaat gaaaactact gggaacattt ttttctctgg gttttttaaa
     5341 aggaaaacaa aaaacccctc tatataattc taaaagtggc atgatacctc atatgtataa
     5401 caataaactg gtaagaaaat agaaaaaaaa aaaaaaaaaa aaaaaa
//
