LOCUS       NM_001372423            2914 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus N-myc downstream regulated gene 4 (Ndrg4), transcript
            variant 4, mRNA.
ACCESSION   NM_001372423 XM_006530867
VERSION     NM_001372423.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2914)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2914)
  AUTHORS   de Groot,N.E., van den Hoogenhof,M.M.G., Najafi,A., van der
            Made,I., van der Velden,J., Beqqali,A., Pinto,Y.M. and
            Creemers,E.E.
  TITLE     Heterozygous loss of Rbm24 in the adult mouse heart increases
            sarcomere slack length but does not affect function
  JOURNAL   Sci Rep 10 (1), 7687 (2020)
   PUBMED   32376900
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2914)
  AUTHORS   Vaes,N., Lentjes,M.H.F.M., Gijbels,M.J., Rademakers,G.,
            Daenen,K.L., Boesmans,W., Wouters,K.A.D., Geuzens,A., Qu,X.,
            Steinbusch,H.P.J., Rutten,B.P.F., Baldwin,S.H., Sharkey,K.A.,
            Hofstra,R.M.W., van Engeland,M., Vanden Berghe,P. and Melotte,V.
  TITLE     NDRG4, an early detection marker for colorectal cancer, is
            specifically expressed in enteric neurons
  JOURNAL   Neurogastroenterol Motil 29 (9) (2017)
   PUBMED   28524415
  REMARK    GeneRIF: NDRG4 is exclusively expressed by central, peripheral and
            enteric neurons/nerves, suggesting a neuronal-specific role of this
            protein
REFERENCE   4  (bases 1 to 2914)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 2914)
  AUTHORS   Yang,Q., Gu,Y., Zhang,X., Wang,J.M., He,Y.P., Shi,Y., Sun,Z.G.,
            Shi,H.J. and Wang,J.
  TITLE     Uterine Expression of NDRG4 Is Induced by Estrogen and Up-Regulated
            during Embryo Implantation Process in Mice
  JOURNAL   PLoS One 11 (5), e0155491 (2016)
   PUBMED   27175791
  REMARK    GeneRIF: NDRG4 might play an important role during early pregnancy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2914)
  AUTHORS   Okuda,T., Kokame,K. and Miyata,T.
  TITLE     Differential expression patterns of NDRG family proteins in the
            central nervous system
  JOURNAL   J Histochem Cytochem 56 (2), 175-182 (2008)
   PUBMED   17998568
  REMARK    GeneRIF: These expression patterns demonstrated the cell
            type-specific and ubiquitous localization of the NDRG family
            proteins. Each NDRG may play a partially redundant role in specific
            cells in the brain.
REFERENCE   7  (bases 1 to 2914)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 2914)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   9  (bases 1 to 2914)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2914)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113951.13.
            
            On Aug 30, 2019 this sequence version replaced XM_006530867.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.101468.1,
                                           SRR1660815.90870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC113951.13        81644-81755         c
            113-207             AC113951.13        62739-62833         c
            208-252             AC113951.13        59870-59914         c
            253-358             AC113951.13        53734-53839         c
            359-479             AC113951.13        53376-53496         c
            480-542             AC113951.13        53228-53290         c
            543-603             AC113951.13        53038-53098         c
            604-690             AC113951.13        51333-51419         c
            691-747             AC113951.13        51194-51250         c
            748-851             AC113951.13        50841-50944         c
            852-908             AC113951.13        50205-50261         c
            909-960             AC113951.13        50073-50124         c
            961-1008            AC113951.13        49316-49363         c
            1009-1044           AC113951.13        49058-49093         c
            1045-1096           AC113951.13        48883-48934         c
            1097-1135           AC113951.13        47664-47702         c
            1136-2914           AC113951.13        45071-46849         c
FEATURES             Location/Qualifiers
     source          1..2914
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..2914
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /note="N-myc downstream regulated gene 4"
                     /db_xref="GeneID:234593"
                     /db_xref="MGI:MGI:2384590"
     exon            1..112
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            113..207
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            208..252
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            253..358
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            359..479
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            480..542
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            543..603
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            604..690
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            691..747
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            748..851
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            852..908
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            909..960
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1008
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1044
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1096
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1135
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..2914
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2896..2901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /note="hexamer: AATAAA"
     polyA_site      2914
                     /gene="Ndrg4"
                     /gene_synonym="D8Bwg1337e; Ndr1-rs; Ndr4; SMAP-8"
                     /note="major polyA site"
ORIGIN      
        1 gctatcccgc cgctcctctc tgcggctact gcgcgcctcg ccccgggcgg cccagcgcgc
       61 tccaccgtcg ccaagatgaa ggtgctggga cacaggctcc aactgctgac agggcttctg
      121 ctccacgacg tgaccatggc agggctgcag gagctgcgat ttcctgagga gaagcccctg
      181 ctccgcggcc aggatgccac tgagatggat aaccctgacg ccttcctctc aattgtggac
      241 acagactgga aggaacatga catcgagacg ccttatggac ttctgcatgt ggtgatccgg
      301 ggctctccca aagggaaccg cccagccatc ctcacctacc atgatgtggg tctcaatcac
      361 aagctgtgct tcaacacctt cttcaacttt gaggacatgc aggagatcac caaacacttt
      421 gtggtgtgcc acgtggatgc ccctgggcag caggtgggag cgtcacagtt ccctcagggg
      481 taccagttcc cctccatgga gcagctggcc gccatgctcc cgagtgtggt acagcacttt
      541 gggtttaagt acgtgattgg cattggagtg ggagccggag cctacgtgct ggccaagttt
      601 gcactcatct tccctgacct ggtggagggg ctggtgttga tgaacattga ccccaacggc
      661 aaaggctgga ttgactgggc tgccaccaag ctctctggct tgaccagcac tttaccagac
      721 actgtactct cccatctctt cagccaggag gagctggtga acaacacgga gctggtgcag
      781 agctaccggc agcagatctc aaacgtggtg aaccaggcca acctgcagct cttctggaac
      841 atgtacaaca gccgcagaga ccttgatatt aaccgacctg ggacggtgcc caatgccaag
      901 acactccgct gcccagtgat gctggtagtc ggagataatg cacctgctga ggaaggggtg
      961 gttgagtgta actccaaact ggacccaacc actacgacct tcctgaagat ggcagattct
     1021 ggtggtcttc ctcaggtgac acaaccaggg aagctgactg aggccttcaa gtacttcctg
     1081 caaggcatgg gctacattgc acacttgaag gaccgaaggc tgagtggagg agcagtgccc
     1141 tcagccagca tgacccgcct cgcacgctca cgtaccgcgt ccctcaccag cgccagttcc
     1201 gtggacggca gccgccctca gccctgcgcc cactcagaca gcagtgaggg gatgggccag
     1261 gtcaaccaca ccatggaggt gtcctgctga agccctcgtc ctgcccatga tgcccgctta
     1321 cctgccccca ggtcccactg ccatctctgc accggctcat cttcccttta gttttatttt
     1381 tgtgagagtg aaggggagga aatggggtta cttctctttt atttaaaaag aaatgagggg
     1441 atccaccttg ggacagcaca gcacaacagt cttagatggt gtgaggggct cgccttacac
     1501 actcctgtct cactcagtgt ggcccctccc ctctgcccag ctggggcgtg gccaggatag
     1561 ttagatacag tactgaagaa agcccagccc agcccctgga tctggcagat gtgaggtttg
     1621 aagatggtgg gtagtgagct aaagctctga tgtgagtggg agtcagacca gtgggcagcc
     1681 ttggacctta agagtgtccc tttcctgtaa cccttgcatc aagcacacct attctaatag
     1741 tagaagtgac agtcatgagg atggtagcca caagagggcg ctctagacag acagccattt
     1801 tcctggtgct ctctgggcag gacaggtggt gtaaggccag ccaggctgaa gaatatggag
     1861 aaccctgaca tgggggcagg aacccccata ccctgccacc acagggcctt gtcccaccct
     1921 gaggcaaagg tcacctggtc tcttgtccct gttggcagag gttaaaatgt tgattgctgt
     1981 gtatgctgtg tgtagcccct gagaacttca tgattaccca tccctttgga agctggcagg
     2041 tactgtaggt ccctcttgtc ccagatttca ccaagtattt gtcacagtgc cctggtcaac
     2101 ttgggccagt gtgtcacaga caatacttga gaagtgagct tgttagaaag acacagatgg
     2161 gaagatacaa tgacctctgc ttgctggagg ggctggagat tgcctggccc ttgggtggga
     2221 aatgggccat cctcaaacaa aggttccatg cctcctacag cccacaacta tgcccgccat
     2281 ctcaccaagt aggcgctcac agcctggcca ttggtttcat ctgctctcat ccccagagag
     2341 gagagaaagc actaagtgtg tatatgggga gtggggatga tgtatgtggt attgtatggg
     2401 tgttctgagg caagaggaca cccacatcca tttatctgtg gcacatgccg cccctttctg
     2461 taactgtaag ccatttctag actgctctgg agtccagtgg agtgtttcct atccccggtt
     2521 cagttcactc acgtgcttcc gtgaatactg aatgtgactg tttagaggtg gtagaactaa
     2581 tcccttactg tagatagcac tccaagtatt ggacatcttt ttgctgtgtt cttaagatat
     2641 ctataaatac ctatacatta tatatatata tatatgtatg tatatcaggt cctccttcct
     2701 gtatgtggtt tcccattggt agttgtcttc tctttggtca agatgaactt ttaatggagt
     2761 tcattatttt cctctctgta caaagttaag agcctaattt tgtgtattct gtttggtggc
     2821 tgataaagag actttgagat tacaaaatgc aaaacaaaaa tccttgatat agaaagttaa
     2881 ctgtgcagaa aaactaataa agaaattaag tcta
//
