LOCUS       NM_001360264            2124 bp    mRNA    linear   ROD 10-SEP-2023
DEFINITION  Mus musculus N-myc downstream regulated gene 2 (Ndrg2), transcript
            variant 3, mRNA.
ACCESSION   NM_001360264 XM_017316048
VERSION     NM_001360264.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2124)
  AUTHORS   Jiang T, Li Y, He S, Huang N, Du M, Zhai Q, Pu K, Wu M, Yan C, Ma Z
            and Wang Q.
  TITLE     Reprogramming astrocytic NDRG2/NF-kappaB/C3 signaling restores the
            diabetes-associated cognitive dysfunction
  JOURNAL   EBioMedicine 93, 104653 (2023)
   PUBMED   37329577
  REMARK    GeneRIF: Reprogramming astrocytic NDRG2/NF-kappaB/C3 signaling
            restores the diabetes-associated cognitive dysfunction.
REFERENCE   2  (bases 1 to 2124)
  AUTHORS   Zhao Y, Fan X, Wang Q, Zhen J, Li X, Zhou P, Lang Y, Sheng Q, Zhang
            T, Huang T, Zhao Y, Lv Z and Wang R.
  TITLE     ROS promote hyper-methylation of NDRG2 promoters in a
            DNMTS-dependent manner: Contributes to the progression of renal
            fibrosis
  JOURNAL   Redox Biol 62, 102674 (2023)
   PUBMED   36989575
  REMARK    GeneRIF: ROS promote hyper-methylation of NDRG2 promoters in a
            DNMTS-dependent manner: Contributes to the progression of renal
            fibrosis.
REFERENCE   3  (bases 1 to 2124)
  AUTHORS   Nutter CA, Kidd BM, Carter HA, Hamel JI, Mackie PM, Kumbkarni N,
            Davenport ML, Tuyn DM, Gopinath A, Creigh PD, Sznajder LJ, Wang ET,
            Ranum LPW, Khoshbouei H, Day JW, Sampson JB, Prokop S and Swanson
            MS.
  TITLE     Choroid plexus mis-splicing and altered cerebrospinal fluid
            composition in myotonic dystrophy type 1
  JOURNAL   Brain (2023) In press
   PUBMED   37143315
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 2124)
  AUTHORS   Xu J, Ji T, Li G, Zhang H, Zheng Y, Li M, Ma J, Li Y and Chi G.
  TITLE     Lactate attenuates astrocytic inflammation by inhibiting
            ubiquitination and degradation of NDRG2 under oxygen-glucose
            deprivation conditions
  JOURNAL   J Neuroinflammation 19 (1), 314 (2022)
   PUBMED   36572898
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2124)
  AUTHORS   Rosianu F, Mihaylov SR, Eder N, Martiniuc A, Claxton S, Flynn HR,
            Jalal S, Domart MC, Collinson L, Skehel M, Snijders AP, Krause M,
            Tooze SA and Ultanir SK.
  TITLE     Loss of NDR1/2 kinases impairs endomembrane trafficking and
            autophagy leading to neurodegeneration
  JOURNAL   Life Sci Alliance 6 (2), e202201712 (2022)
   PUBMED   36446521
  REMARK    GeneRIF: Loss of NDR1/2 kinases impairs endomembrane trafficking
            and autophagy leading to neurodegeneration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2124)
  AUTHORS   Mitchelmore C, Buchmann-Moller S, Rask L, West MJ, Troncoso JC and
            Jensen NA.
  TITLE     NDRG2: a novel Alzheimer's disease associated protein
  JOURNAL   Neurobiol Dis 16 (1), 48-58 (2004)
   PUBMED   15207261
REFERENCE   7  (bases 1 to 2124)
  AUTHORS   Burchfield JG, Lennard AJ, Narasimhan S, Hughes WE, Wasinger VC,
            Corthals GL, Okuda T, Kondoh H, Biden TJ and Schmitz-Peiffer C.
  TITLE     Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence
            for cross-talk with protein kinase C theta
  JOURNAL   J Biol Chem 279 (18), 18623-18632 (2004)
   PUBMED   14985363
  REMARK    GeneRIF: data identify Ndrg2 as a novel insulin-dependent
            phosphoprotein and suggest that PKC theta may inhibit insulin
            action in part by reducing its phosphorylation by Akt.
REFERENCE   8  (bases 1 to 2124)
  AUTHORS   Qu X, Zhai Y, Wei H, Zhang C, Xing G, Yu Y and He F.
  TITLE     Characterization and expression of three novel
            differentiation-related genes belong to the human NDRG gene family
  JOURNAL   Mol Cell Biochem 229 (1-2), 35-44 (2002)
   PUBMED   11936845
REFERENCE   9  (bases 1 to 2124)
  AUTHORS   Zhao W, Tang R, Huang Y, Wang W, Zhou Z, Gu S, Dai J, Ying K, Xie Y
            and Mao Y.
  TITLE     Cloning and expression pattern of the human NDRG3 gene
  JOURNAL   Biochim Biophys Acta 1519 (1-2), 134-138 (2001)
   PUBMED   11406283
REFERENCE   10 (bases 1 to 2124)
  AUTHORS   Okuda T and Kondoh H.
  TITLE     Identification of new genes ndr2 and ndr3 which are related to
            Ndr1/RTP/Drg1 but show distinct tissue specificity and response to
            N-myc
  JOURNAL   Biochem Biophys Res Commun 266 (1), 208-215 (1999)
   PUBMED   10581191
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125087.2, CX123178.1, CX239542.1, AK003364.1 and AI837300.1.
            
            [WARNING] On Oct 4, 2023 this sequence was replaced by
            NM_001360264.2.
            
            On Jan 31, 2018 this sequence version replaced XM_017316048.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.142893.1,
                                           SRR5189682.122396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC125087.2         122982-123114       c
            134-676             CX123178.1         101-643
            677-1388            CX239542.1         1-712
            1389-2112           AK003364.1         327-1050
            2113-2124           AI837300.1         19-30               c
FEATURES             Location/Qualifiers
     source          1..2124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.72 cM"
     gene            1..2124
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /note="N-myc downstream regulated gene 2"
                     /db_xref="GeneID:29811"
                     /db_xref="MGI:MGI:1352498"
     exon            1..133
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1255
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /note="isoform 3 is encoded by transcript variant 3; N-myc
                     downstream regulated 2; protein NDRG2; protein Ndr2; N-myc
                     downstream-regulated gene 2 protein"
                     /codon_start=1
                     /product="protein NDRG2 isoform 3"
                     /protein_id="NP_001347193.1"
                     /db_xref="GeneID:29811"
                     /db_xref="MGI:MGI:1352498"
                     /translation="MATMAELQEVQITEEKPLLPGQTPETAKEAELAARILLDQGQTH
                     SVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFRFGDMQEIIQNFVRVH
                     VDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYAL
                     NHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPDMILGHLFSQEELSGNSELIQ
                     KYRGIIQHAPNLENIELYWNSYNNRRDLNFERGGETTLKCPVMLVVGDQAPHEDAVVE
                     CNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTA
                     SLTSAASIDGSRSRSRTLSQSSESGTLPSGPPGHTMEVSC"
     exon            134..214
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            215..256
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            257..362
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            363..483
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            484..546
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            547..607
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            608..694
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            695..751
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            752..855
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            856..900
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            901..952
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1000
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1036
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1088
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..2124
                     /gene="Ndrg2"
                     /gene_synonym="Ndr2; SYLD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagaga gagagagaga gagattgatt ggattggata tctaggtccc tctgttgagt
       61 gcttgatagt cactgcctca gtccttttta gcccctcaag atgctgacat tggagctata
      121 gttgaaggtc atggccacca tggcagaact tcaggaggtg cagatcaccg aggagaagcc
      181 gctgttgcca ggacaaacac ccgagactgc caaggaggcc gagttagctg cccgcatcct
      241 cctggaccag ggacagactc actctgtgga gacaccttat ggctcggtca cttttactgt
      301 gtatggcacc cccaaaccca aacgcccggc gatattcacc taccatgatg taggcctcaa
      361 ctataagtct tgcttccagc cactgtttcg gttcggggat atgcaagaga tcatacagaa
      421 cttcgtgcgg gttcatgtgg atgcccctgg catggaagag ggggcgcctg tgtttcctct
      481 gggatatcag tacccatctc tggaccagct tgctgacatg attccttgca tcctgcagta
      541 cctaaatttc tctacaataa ttggagttgg tgttggagcc ggagcctaca ttctgtcgcg
      601 atatgctctg aaccacccgg acacagttga aggtcttgtt ctcatcaaca ttgatcccaa
      661 tgccaagggc tggatggact gggcagccca caagttaact ggccttacgt cttccattcc
      721 ggacatgatt cttggacatc ttttcagcca ggaagagctt tctggaaatt ctgaattgat
      781 acaaaagtac agaggtatca tccaacacgc acccaacctg gagaacattg aactctactg
      841 gaatagctac aacaaccgcc gagacctgaa ctttgagcga ggtggtgaga cgaccctcaa
      901 gtgccctgtg atgctggtgg ttggagacca agcacctcat gaagatgccg tggtggaatg
      961 taactcaaag ctggacccca cacagacctc gttcctcaag atggccgact ctggaggtca
     1021 gccacagctg actcagcccg gcaagctgac agaggctttc aagtacttcc tgcaaggcat
     1081 gggctacatg gcctcttcct gcatgactcg cctatctcgg tctcgcacag catctctgac
     1141 cagtgcagca tccatcgatg gcagtcggtc ccgatcccgc accctgtcgc agagtagcga
     1201 gtctgggact ctcccttctg gacccccagg gcacaccatg gaagtctcct gttgaatgac
     1261 cctcattgcc ttggtgtgga tcccagccct cacctcctgc aacactaatt taagaggtgt
     1321 tatcagggca ctgggccaga gtaagcaagg aaaatgggca gattgtgcag ggagatgacc
     1381 ttgatcttta attgctaccc taaccttgac ctttaacctg tgatatcctc tagctcctag
     1441 gtgaggtgtc ctaatatctc ttagagatct gggcccccta aattaccccc tcttccattt
     1501 tggtgttgag aaggcttgta tgttctctcc ctgacctagg ttctatagat gaggaacaat
     1561 gagctgttct agctgacacg gggcctccat cactccccct ctttagccca tatttgcaag
     1621 ggtaggagag agagtgtgtg tgtgttgtgt gtgtgtgtgt gtgtgtgtag ggttgatggt
     1681 gagagatggg gagctccttc cccaaagctg acagtggctt tgccttgatg tgtcaggcct
     1741 ctctgaaggc aatagtccca aatgaatgtt tatcaggaga aggtttgctg gtgggtcagt
     1801 gatccttaat gtgatagaaa tatccagcat gtaaaaagaa aggatgggag atggtggccc
     1861 gtgaagaaca gtggtaaaca cattgaagct ggggtagaag ggaggggccc gggtcctttg
     1921 gccacactaa cttggatagc tgtcagcgtg cacctaaagt gggactaagg gaaagagctt
     1981 aggtccgact gcttggggct tggcatcagg gtgggaagag ctacctcagg ctctgaccat
     2041 actgtgacgt gtagagcgtg acctcctgtc tcacacaact tctgctgtga caataaacta
     2101 tagaggaaac tgaacagcat tgtt
//
