LOCUS       NM_008681               2909 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus N-myc downstream regulated gene 1 (Ndrg1), mRNA.
ACCESSION   NM_008681 NM_010884
VERSION     NM_008681.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2909)
  AUTHORS   Hoshino,T., Mukai,A., Yamashita,H., Misawa,H., Urushitani,M.,
            Tashiro,Y., Matsuzawa,S.I. and Takahashi,R.
  TITLE     NDRG1 upregulation by ubiquitin proteasome system dysfunction
            aggravates neurodegeneration
  JOURNAL   Mol Brain 17 (1), 77 (2024)
   PUBMED   39444004
  REMARK    GeneRIF: NDRG1 upregulation by ubiquitin proteasome system
            dysfunction aggravates neurodegeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2909)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2909)
  AUTHORS   Rosianu,F., Mihaylov,S.R., Eder,N., Martiniuc,A., Claxton,S.,
            Flynn,H.R., Jalal,S., Domart,M.C., Collinson,L., Skehel,M.,
            Snijders,A.P., Krause,M., Tooze,S.A. and Ultanir,S.K.
  TITLE     Loss of NDR1/2 kinases impairs endomembrane trafficking and
            autophagy leading to neurodegeneration
  JOURNAL   Life Sci Alliance 6 (2), e202201712 (2022)
   PUBMED   36446521
  REMARK    GeneRIF: Loss of NDR1/2 kinases impairs endomembrane trafficking
            and autophagy leading to neurodegeneration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2909)
  AUTHORS   Hodgson,R., Xu,X., Anzilotti,C., Deobagkar-Lele,M., Crockford,T.L.,
            Kepple,J.D., Cawthorne,E., Bhandari,A., Cebrian-Serrano,A.,
            Wilcock,M.J., Davies,B., Cornall,R.J. and Bull,K.R.
  TITLE     NDRG1 is induced by antigen-receptor signaling but dispensable for
            B and T cell self-tolerance
  JOURNAL   Commun Biol 5 (1), 1216 (2022)
   PUBMED   36357486
  REMARK    GeneRIF: NDRG1 is induced by antigen-receptor signaling but
            dispensable for B and T cell self-tolerance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2909)
  AUTHORS   Jiang,L.T., Chen,Y.H., Huang,J.H., Tong,W.F., Jin,L.J. and Li,L.X.
  TITLE     Aberrant Neuregulin 1/ErbB Signaling in Charcot-Marie-Tooth Type 4D
            Disease
  JOURNAL   Mol Cell Biol 42 (7), e0055921 (2022)
   PUBMED   35708320
REFERENCE   6  (bases 1 to 2909)
  AUTHORS   Li,J., Davidson,G., Huang,Y., Jiang,B.H., Shi,X., Costa,M. and
            Huang,C.
  TITLE     Nickel compounds act through
            phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent
            pathway to induce hypoxia inducible factor transactivation and
            Cap43 expression in mouse epidermal Cl41 cells
  JOURNAL   Cancer Res 64 (1), 94-101 (2004)
   PUBMED   14729612
  REMARK    GeneRIF: Nickel induces HIF-1 transactivation and Cap43 protein
            expression through a PI-3K/Akt-dependent and p70(S6k)-independent
            pathway.
REFERENCE   7  (bases 1 to 2909)
  AUTHORS   Taketomi,Y., Sugiki,T., Saito,T., Ishii,Si., Hisada,M.,
            Suzuki-Nishimura,T., Uchida,M.K., Moon,T.C., Chang,H.W., Natori,Y.,
            Miyazawa,S., Kikuchi-Yanoshita,R., Murakami,M. and Kudo,I.
  TITLE     Identification of NDRG1 as an early inducible gene during in vitro
            maturation of cultured mast cells
  JOURNAL   Biochem Biophys Res Commun 306 (2), 339-346 (2003)
   PUBMED   12804568
  REMARK    GeneRIF: may be a mast cell maturation-associated inducible protein
            that allows the cells to be susceptible to extracellular stimuli
            leading to degranulation
REFERENCE   8  (bases 1 to 2909)
  AUTHORS   Okuda,T. and Kondoh,H.
  TITLE     Identification of new genes ndr2 and ndr3 which are related to
            Ndr1/RTP/Drg1 but show distinct tissue specificity and response to
            N-myc
  JOURNAL   Biochem Biophys Res Commun 266 (1), 208-215 (1999)
   PUBMED   10581191
REFERENCE   9  (bases 1 to 2909)
  AUTHORS   Shimono,A., Okuda,T. and Kondoh,H.
  TITLE     N-myc-dependent repression of ndr1, a gene identified by direct
            subtraction of whole mouse embryo cDNAs between wild type and N-myc
            mutant
  JOURNAL   Mech Dev 83 (1-2), 39-52 (1999)
   PUBMED   10381566
REFERENCE   10 (bases 1 to 2909)
  AUTHORS   Lin,T.M. and Chang,C.
  TITLE     Cloning and characterization of TDD5, an androgen target gene that
            is differentially repressed by testosterone and dihydrotestosterone
  JOURNAL   Proc Natl Acad Sci U S A 94 (10), 4988-4993 (1997)
   PUBMED   9144177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY232155.1, AW611038.1, CA320478.1, AA795988.1, AK098075.1 and
            AI118620.1.
            
            On or before Mar 8, 2007 this sequence version replaced
            NM_010884.1, NM_008681.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U60593.1, AK170809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               BY232155.1         2-256
            256-606             AW611038.1         256-606
            607-911             CA320478.1         350-654
            912-1099            AA795988.1         205-392
            1100-2886           AK098075.1         1099-2885
            2887-2909           AI118620.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..2909
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 29.3 cM"
     gene            1..2909
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /note="N-myc downstream regulated gene 1"
                     /db_xref="GeneID:17988"
                     /db_xref="MGI:MGI:1341799"
     exon            1..138
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            139..219
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            220..255
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            256..361
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            362..482
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            483..545
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            546..606
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            607..693
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            694..750
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            751..854
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            855..911
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            912..963
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1011
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1047
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1099
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..2890
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /note="hexamer: AATAAA"
     polyA_site      2887
                     /gene="Ndrg1"
                     /gene_synonym="CAP43; CMT4D; DRG1; HMSNL; Ndr1; Ndrl;
                     NMSL; PROXY1; RTP; TDD5"
                     /note="major polyA site"
ORIGIN      
        1 ataaacaaac cttgccaggc taccctctcg cgttgcaggc agattgctca cccatcttcg
       61 tctccctctt cacctcccgc ggggcgctgc acctccaacc ttgtggttgg ctcctttccg
      121 tgcttgcttg ctcattaggt gtgtgatagc acggaaatgt cccgagagct acatgacgtg
      181 gacctcgctg aggtgaagcc tctggtggaa aaaggggaga gcatcactgg tctcctgcaa
      241 gagttcgatg ttcaggagca ggatattgag accctacatg gctccctgca tgtcaccctg
      301 tgtgggaccc ccaagggcaa ccgtcctgtc atcctcacgt atcacgacat cggcatgaac
      361 cacaagacct gctacaaccc cctcttcaac tctgaggaca tgcaggagat cacacaacat
      421 tttgctgtct gccatgtgga tgcccctggc caacaggatg gtgccccttc cttcccagtg
      481 gggtacatgt acccctcaat ggatcagttg gctgaaatgc ttcctggagt ccttcaccag
      541 tttgggctca agagtgtcat tggcatgggg acaggagctg gcgcctacat cctgacccgc
      601 ttcgcactca acaaccctga gatggtagag ggtctcgtgc tcatgaatgt gaacccctgt
      661 gctgaaggct ggatggactg ggctgcctct aagatctcag gatggaccca agccctgcct
      721 gacatggtgg tgtcccacct cttcggcaag gaggagatac acaacaacgt ggaggtagtg
      781 cacacgtacc gccagcacat cctcaacgac atgaacccga gcaacctaca cttattcatc
      841 agcgcctaca acagccggag agacctggag attgagcggc caatgcctgg aacccacact
      901 gtcactttgc agtgccctgc tctgctggta gttggagaca actctcctgc cgtggatgct
      961 gtggtggaat gcaattctaa attggaccca acgaagacca ccctgctcaa gatggcagac
     1021 tgtggaggcc ttcctcagat ctctcagccc gccaagcttg ctgaggcctt caagtacttt
     1081 gtgcagggca tgggatacat gccttctgcc agcatgactc gcctgatgcg gtcccgcaca
     1141 gcctctggct ccagtgtcac atccctggag ggcacccgta gccgctccca taccagcgag
     1201 ggcccccgaa gccgctcgca caccagtgag gggtcccgta gccgctccca taccagtgag
     1261 gatgcccgtc tcaacatcac ccccaactcg ggtgccaccg gaaacaatgc cgggcccaag
     1321 tccatggagg tgtcctgcta agcaatctgt gcatcagtca ccctggactg gtggcctctc
     1381 ccttagcccc caacccttgc ctgccaccct acgctaatgc ggtattaatc taaagctgct
     1441 tttgtaagaa tgaactctgg cggtggcaga cccaggctgt tctgactgcc tcctgggacc
     1501 agggtgggtg gtggtggacc aaaggcaaga agcagttcag cgtactgttc tgctaacaag
     1561 tggcctggtg gaccctctct ctaccctcag acaccaaact gccaaaacta agaaatagat
     1621 agctgtaaca ctgcctggct ccaagcccag gctgatccag cattctggtt cataggcgtt
     1681 ttgccaacct gcctacttcc tgtttcctcc ccactaaact cattcctgga aacaaacttc
     1741 tgttttgaaa ggagagagag aggcaggaaa gttgggcgcc ttattttaag tagagaaacc
     1801 aagaaaggaa gagaaaaaaa ggcagggtct agggcaggta gaggaaaaac acaacaagtc
     1861 tactaggctc acttgaagga attgatttta aagttctgga cactgaaacc cacaacctgt
     1921 ttttctggca accttttaac gtgcaagaaa aactggtaac aaaccccagg ctttatagag
     1981 aaagtgatcc agcaaatgtg gggcatcagt gatttaagac tcttgctatg cagtctactg
     2041 taccccgctc ccattccaca gtgaatgagt ggatgacacc tctgtccctc gggaagatgg
     2101 ttttgatttg ttgttgcatt ctttgaggca gagggagaac ccagcaggtg acaggggtcc
     2161 ttgtctggga tgagtcttta ggatgggaag ggtggggata gaatggccct gggattttga
     2221 ggactcatgg tagggccaag tgctagaacc tggtgggtgt gatttcattg atctggaatc
     2281 ttgtgtgact gagtcacacc ttgtctccca taattgatgt ctggcattga tttgaaactt
     2341 gatagctgaa tgtctcttaa ctggcccatc gctggttctt cagagagaac cgtatgttct
     2401 agtgggggaa ggactggttt tgggttctgt acattccacg ggaacttgct tccctctcct
     2461 gcccctcctg ctgactgggt ttgtagcatt ggcctcttaa gcaatgccag cctaatgccc
     2521 atgctccata ctactgcctt ttgattctta ctgtggctaa ccttgaacct ttcctatagg
     2581 aaatgtgatc agatcagaga cacttgatcg ttgggagtca gccctcaagg cctggcgact
     2641 tccaggatct tggagttgct agaggaaaag tagttatgcc ctataggcgg catgagagac
     2701 aagggatcag tttacctgcc aactcctacc gtggaggagg agttccactg accttgtgta
     2761 gaaagatcag gaatccaggc cagggtgatt gaatgctgac aagaaatcac tgtatatgtc
     2821 tctccagggc agtttcttaa taagatgttt gtatttattt ccagaccaat aaatttgtaa
     2881 ctttgcagtg aaaaaaaaaa aaaaaaaaa
//
