LOCUS       NM_010883               1962 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus Norrie disease (pseudoglioma) (human) (Ndp), mRNA.
ACCESSION   NM_010883
VERSION     NM_010883.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1962)
  AUTHORS   Pokrajac,N.T., Tokarew,N.J.A., Gurdita,A., Ortin-Martinez,A. and
            Wallace,V.A.
  TITLE     Meningeal macrophages inhibit chemokine signaling in pre-tumor
            cells to suppress mouse medulloblastoma initiation
  JOURNAL   Dev Cell 58 (20), 2015-2031 (2023)
   PUBMED   37774709
REFERENCE   2  (bases 1 to 1962)
  AUTHORS   Pauzuolyte,V., Patel,A., Wawrzynski,J.R., Ingham,N.J., Leong,Y.C.,
            Karda,R., Bitner-Glindzicz,M., Berger,W., Waddington,S.N.,
            Steel,K.P. and Sowden,J.C.
  TITLE     Systemic gene therapy rescues retinal dysfunction and hearing loss
            in a model of Norrie disease
  JOURNAL   EMBO Mol Med 15 (10), e17393 (2023)
   PUBMED   37642150
REFERENCE   3  (bases 1 to 1962)
  AUTHORS   Ding,J., Lee,S.J., Vlahos,L., Yuki,K., Rada,C.C., van Unen,V.,
            Vuppalapaty,M., Chen,H., Sura,A., McCormick,A.K., Tomaske,M.,
            Alwahabi,S., Nguyen,H., Nowatzke,W., Kim,L., Kelly,L., Vollrath,D.,
            Califano,A., Yeh,W.C., Li,Y. and Kuo,C.J.
  TITLE     Therapeutic blood-brain barrier modulation and stroke treatment by
            a bioengineered FZD4-selective WNT surrogate in mice
  JOURNAL   Nat Commun 14 (1), 2947 (2023)
   PUBMED   37268690
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1962)
  AUTHORS   Wang,Z., Yemanyi,F., Blomfield,A.K., Bora,K., Huang,S., Liu,C.H.,
            Britton,W.R., Cho,S.S., Tomita,Y., Fu,Z., Ma,J.X., Li,W.H. and
            Chen,J.
  TITLE     Amino acid transporter SLC38A5 regulates developmental and
            pathological retinal angiogenesis
  JOURNAL   Elife 11, e73105 (2022)
   PUBMED   36454214
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1962)
  AUTHORS   Pokrajac,N.T., Gurdita,A., Tachibana,N., Tokarew,N.J.A. and
            Wallace,V.A.
  TITLE     Three dimensional reconstruction of the mouse cerebellum in
            Hedgehog-driven medulloblastoma models to identify Norrin-dependent
            effects on preneoplasia
  JOURNAL   Commun Biol 5 (1), 569 (2022)
   PUBMED   35680976
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1962)
  AUTHORS   Richter,M., Gottanka,J., May,C.A., Welge-Lussen,U., Berger,W. and
            Lutjen-Drecoll,E.
  TITLE     Retinal vasculature changes in Norrie disease mice
  JOURNAL   Invest Ophthalmol Vis Sci 39 (12), 2450-2457 (1998)
   PUBMED   9804153
REFERENCE   7  (bases 1 to 1962)
  AUTHORS   Ruether,K., van de Pol,D., Jaissle,G., Berger,W., Tornow,R.P. and
            Zrenner,E.
  TITLE     Retinoschisislike alterations in the mouse eye caused by gene
            targeting of the Norrie disease gene
  JOURNAL   Invest Ophthalmol Vis Sci 38 (3), 710-718 (1997)
   PUBMED   9071226
REFERENCE   8  (bases 1 to 1962)
  AUTHORS   Battinelli,E.M., Boyd,Y., Craig,I.W., Breakefield,X.O. and
            Chen,Z.Y.
  TITLE     Characterization and mapping of the mouse NDP (Norrie disease)
            locus (Ndp)
  JOURNAL   Mamm Genome 7 (2), 93-97 (1996)
   PUBMED   8835523
REFERENCE   9  (bases 1 to 1962)
  AUTHORS   Berger,W., van de Pol,D., Bachner,D., Oerlemans,F., Winkens,H.,
            Hameister,H., Wieringa,B., Hendriks,W. and Ropers,H.H.
  TITLE     An animal model for Norrie disease (ND): gene targeting of the
            mouse ND gene
  JOURNAL   Hum Mol Genet 5 (1), 51-59 (1996)
   PUBMED   8789439
REFERENCE   10 (bases 1 to 1962)
  AUTHORS   Sims,K.B., Lebo,R.V., Benson,G., Shalish,C., Schuback,D.,
            Chen,Z.Y., Bruns,G., Craig,I.W., Golbus,M.S. and Breakefield,X.O.
  TITLE     The Norrie disease gene maps to a 150 kb region on chromosome
            Xp11.3
  JOURNAL   Hum Mol Genet 1 (2), 83-89 (1992)
   PUBMED   1301161
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ062577.1 and BC090623.1.
            
            On May 9, 2015 this sequence version replaced NM_010883.2.
            
            Summary: This gene encodes a secreted protein that acts a ligand
            for multiple different receptors and participates in both Wnt and
            Wnt-independant signalling. Its activity is important in vascular
            development of the eye and inner ear. Mutation of the related gene
            in humans causes Norrie syndrome. [provided by RefSeq, May 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090623.1, X92397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CJ062577.1         2-11
            11-1962             BC090623.1         1-1952
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 12.07 cM"
     gene            1..1962
                     /gene="Ndp"
                     /gene_synonym="ND; Ndph"
                     /note="Norrie disease (pseudoglioma) (human)"
                     /db_xref="GeneID:17986"
                     /db_xref="MGI:MGI:102570"
     exon            1..389
                     /gene="Ndp"
                     /gene_synonym="ND; Ndph"
                     /inference="alignment:Splign:2.1.0"
     exon            390..763
                     /gene="Ndp"
                     /gene_synonym="ND; Ndph"
                     /inference="alignment:Splign:2.1.0"
     CDS             596..991
                     /gene="Ndp"
                     /gene_synonym="ND; Ndph"
                     /note="norrin; norrie disease protein homolog"
                     /codon_start=1
                     /product="norrin precursor"
                     /protein_id="NP_035013.1"
                     /db_xref="CCDS:CCDS30034.1"
                     /db_xref="GeneID:17986"
                     /db_xref="MGI:MGI:102570"
                     /translation="MRNHVLAASISMLSLLAIMGDTDSKTDSSFLMDSQRCMRHHYVD
                     SISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLK
                     ALRLRCSGGMRLTATYRYILSCHCEECSS"
     exon            764..1939
                     /gene="Ndp"
                     /gene_synonym="ND; Ndph"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndp"
                     /gene_synonym="ND; Ndph"
                     /note="hexamer: AATAGA"
     polyA_site      1939
                     /gene="Ndp"
                     /gene_synonym="ND; Ndph"
                     /note="major polyA site"
ORIGIN      
        1 ctcatcttaa gatgctccat ggaaaagatc cgagcagtgg gcagaggctg tgagtccccg
       61 ataacgagag cgcctaacat ttccgtggta ttcccatttg ctagagcgct gctgcggcca
      121 cacgcctgat tgatatatgc ctgcaatggc acttttccat ttgacactct ccctctctct
      181 ctccctctct ctccctctct ctctctccct ctctctccct ctctctccct gggtcgctta
      241 aacaacagtc ctaacttttg tgtgttgcaa atataaaagg caagccatgt gacagaggga
      301 cagaagaaca aaagcatttg gaagtaacag gacctctttc tagctctcag aaaagtctga
      361 gaagaaagga gccctgcgtt tcccccaagc tgtgcagcac atactgctgt gatcggttgc
      421 aagtgaaaga agcaagagaa attcctgcat acaaaggaca atgacaacca gaaagcggca
      481 gccctatcct gctctggcct tgaaagggac tggatcctag gaggtggcag catttccaat
      541 ctattgtcct ctgtctccct ctgctgtttt tctggaggag tttcccttta caacaatgag
      601 aaatcatgta ctagctgcat ccatttctat gctctccctg ctggccataa tgggagatac
      661 agacagcaaa acagacagtt catttctgat ggactctcaa cgctgcatga gacaccatta
      721 tgtcgattct atcagtcacc cactgtacaa atgtagctca aagatggtgc tcctggccag
      781 atgtgagggg cactgcagcc aggcatcacg ctctgagccc ttggtgtcct tcagcactgt
      841 cctcaagcaa cctttccgtt cctcctgtca ctgctgccga ccccagactt ccaagctgaa
      901 ggctctgcgt ctgcgctgct cagggggcat gcgacttact gccacttacc ggtacatcct
      961 ctcctgtcac tgtgaggaat gcagctcctg agacttgctg atgattggct ttctgactgg
     1021 cacaaccaca ggagcagttc aacctgccag agacggactg gcaagaaaag agttaaggca
     1081 gataaagatg gagcaagtcc cataggattt tgcatattct tgtcctaaag actcaatgtg
     1141 cttttgacag aaagtgactc tgggaacttg cttttcattc ccatctcctt tccctggaag
     1201 aatttctttt ggttacttta cagattcagg catttcccct gttggctcta attgtggttt
     1261 gggtgcctga cagctctgca ttagtgggaa aatgtggggc cctgtgcaat agcatgtcag
     1321 gctgttccta tttggtgcat attagggaaa attttaccta actctcctta ggagatcttt
     1381 gcttgttgtt tcccctggtc attttggtct aagatttgcc tctaaagttt cctggtttca
     1441 agatctggac acccagtcca tggatgttta gtgaggctta ctcacagcca gctaactgct
     1501 actaaaataa ctaacacatg ggttctttta tgtgacagcg ggactcctga ccactatagt
     1561 aattattcag aagtgactga ggggatataa atgtggcaga ggaatttata atctgaagcc
     1621 ttttgtgagg aagcaggctt tcacacatac acactcaggt ggatcctgca ctgactctgg
     1681 agaaggcata cattatactt ggtgtggaga acacaccata ctcataattg agcattagtc
     1741 aagcatgtag gaatctactt gtgggtgtgc aatagcttca gccatatctt agctatatcc
     1801 acctgtctat gtgaagcttg ttgccgtagt ggtggcccga cttattgtct gaaatttttg
     1861 tttcaatata tttttggtcc tcgaagctca aattttgaag tctccccatg ttttcaaata
     1921 aaaatagagt accttcaaaa aaaaaaaaaa aaaaaaaaaa aa
//
