LOCUS       NM_001082476            4757 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus NADPH dependent diflavin oxidoreductase 1 (Ndor1),
            transcript variant 1, mRNA.
ACCESSION   NM_001082476 XM_001472503 XM_001476860
VERSION     NM_001082476.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4757)
  AUTHORS   Zhu,X., Xu,B., Lian,A., Zhang,X., Wang,Y., Zhang,Y., Zhang,L.,
            Ma,J., Gao,S. and Jin,G.
  TITLE     Menin orchestrates macrophage reprogramming to maintain the
            pulmonary immune homeostasis
  JOURNAL   Cell Rep 44 (1), 115219 (2025)
   PUBMED   39817905
REFERENCE   2  (bases 1 to 4757)
  AUTHORS   Burrows,K., Ngai,L., Chiaranunt,P., Watt,J., Popple,S., Forde,B.,
            Denha,S., Olyntho,V.M., Tai,S.L., Cao,E.Y., Tejeda-Garibay,S.,
            Koenig,J.F.E., Mayer-Barber,K.D., Streutker,C.J., Hoyer,K.K.,
            Osborne,L.C., Liu,J., O'Mahony,L. and Mortha,A.
  TITLE     A gut commensal protozoan determines respiratory disease outcomes
            by shaping pulmonary immunity
  JOURNAL   Cell 188 (2), 316-330 (2025)
   PUBMED   39706191
REFERENCE   3  (bases 1 to 4757)
  AUTHORS   Strobel,M.R., Zhou,Y., Qiu,L., Hofer,A.M. and Chen,X.
  TITLE     Temporal ablation of the ciliary protein IFT88 alters normal
            brainwave patterns
  JOURNAL   Sci Rep 15 (1), 347 (2025)
   PUBMED   39747370
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4757)
  AUTHORS   Bowman,R.L., Dunbar,A.J., Mishra,T., Xiao,W., Waarts,M.R.,
            Maestre,I.F., Eisman,S.E., Cai,L., Mowla,S., Shah,N., Youn,A.,
            Bennett,L., Fontenard,S., Gounder,S., Gandhi,A., Bowman,M.,
            O'Connor,K., Zaroogian,Z., Sanchez-Vela,P., Martinez Benitez,A.R.,
            Werewski,M., Park,Y., Csete,I.S., Krishnan,A., Lee,D., Boorady,N.,
            Potts,C.R., Jenkins,M.T., Cai,S.F., Carroll,M.P., Meyer,S.E.,
            Miles,L.A., Ferrell,P.B. Jr., Trowbridge,J.J. and Levine,R.L.
  TITLE     In vivo models of subclonal oncogenesis and dependency in
            hematopoietic malignancy
  JOURNAL   Cancer Cell 42 (11), 1955-1969 (2024)
   PUBMED   39532065
REFERENCE   5  (bases 1 to 4757)
  AUTHORS   Moeller,J. and Meier,D.T.
  TITLE     Ablation of PC1/3 in POMC-Expressing Tissues but Not in Immune
            Cells Induces Sepsis Hypersensitivity
  JOURNAL   J Endocr Soc 8 (11), bvae171 (2024)
   PUBMED   39435302
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4757)
  AUTHORS   Lapinski,P.E., Bauler,T.J., Brown,E.J., Hughes,E.D., Saunders,T.L.
            and King,P.D.
  TITLE     Generation of mice with a conditional allele of the p120 Ras
            GTPase-activating protein
  JOURNAL   Genesis 45 (12), 762-767 (2007)
   PUBMED   18064675
REFERENCE   7  (bases 1 to 4757)
  AUTHORS   Ruzankina,Y., Pinzon-Guzman,C., Asare,A., Ong,T., Pontano,L.,
            Cotsarelis,G., Zediak,V.P., Velez,M., Bhandoola,A. and Brown,E.J.
  TITLE     Deletion of the developmentally essential gene ATR in adult mice
            leads to age-related phenotypes and stem cell loss
  JOURNAL   Cell Stem Cell 1 (1), 113-126 (2007)
   PUBMED   18371340
REFERENCE   8  (bases 1 to 4757)
  AUTHORS   Lum,J.J., Bui,T., Gruber,M., Gordan,J.D., DeBerardinis,R.J.,
            Covello,K.L., Simon,M.C. and Thompson,C.B.
  TITLE     The transcription factor HIF-1alpha plays a critical role in the
            growth factor-dependent regulation of both aerobic and anaerobic
            glycolysis
  JOURNAL   Genes Dev 21 (9), 1037-1049 (2007)
   PUBMED   17437992
REFERENCE   9  (bases 1 to 4757)
  AUTHORS   Gruber,M., Hu,C.J., Johnson,R.S., Brown,E.J., Keith,B. and
            Simon,M.C.
  TITLE     Acute postnatal ablation of Hif-2alpha results in anemia
  JOURNAL   Proc Natl Acad Sci U S A 104 (7), 2301-2306 (2007)
   PUBMED   17284606
REFERENCE   10 (bases 1 to 4757)
  AUTHORS   Chen,Y.X., Yan,J., Keeshan,K., Tubbs,A.T., Wang,H., Silva,A.,
            Brown,E.J., Hess,J.L., Pear,W.S. and Hua,X.
  TITLE     The tumor suppressor menin regulates hematopoiesis and myeloid
            transformation by influencing Hox gene expression
  JOURNAL   Proc Natl Acad Sci U S A 103 (4), 1018-1023 (2006)
   PUBMED   16415155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732309.9 and AK019617.1.
            
            On Nov 18, 2011 this sequence version replaced NM_001082476.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019617.1, SRR9219379.33708.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AL732309.9         147896-148046       c
            152-2154            AK019617.1         149-2151
            2155-4757           AL732309.9         137445-140047       c
FEATURES             Location/Qualifiers
     source          1..4757
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.1 cM"
     gene            1..4757
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /note="NADPH dependent diflavin oxidoreductase 1"
                     /db_xref="GeneID:78797"
                     /db_xref="MGI:MGI:1926047"
     exon            1..198
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1860
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /EC_number="1.6.-.-"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NADPH-dependent FMN and FAD-containing oxidoreductase;
                     Tg(UBC-cre)1Ejb; Tg(UBC-cre/ESR1)1Ejb"
                     /codon_start=1
                     /product="NADPH-dependent diflavin oxidoreductase 1
                     isoform 1"
                     /protein_id="NP_001075945.1"
                     /db_xref="CCDS:CCDS38069.1"
                     /db_xref="GeneID:78797"
                     /db_xref="MGI:MGI:1926047"
                     /translation="MQVPQLLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYS
                     VANLIREPLVIFVCATTGQGDPPDNMKNFWRFIFRKSLPSSSLCQMDFAVLGLGDSSY
                     AKFNFVAKKLHRRLLQLGGSALLPPCLGDDQHELGPDAAIDPWVGDLWEKIMVMYPVP
                     LDIPEIPHGVPLPSKFIFQFLQEVPSIGAEELNIASSAPQTPPSELQPFLAPVITNQR
                     VTGPQHFQDVRLIEFDITDSNISFAAGDVVFILPSNSEAHTQQFCQVLCLDPNQFFTL
                     KPREPGVPDPPGLPQPCTVWNLVSQYLDIASVPRRSFFELLACLSQHALEREKLLELS
                     SARGQEELWEYCSRPRRTILEVLCDFPHTAGAIPPDYLLDLIPRIRPRAFSIASSLLA
                     HPRRLQILVAVVKYQTRLKEPRHGLCSSWLASLNPGQAGPVRVPLWVRPGSLVFPKTP
                     DTPIIMVGAGTGVAPFRAAIQERVAHGQTGNFLFFGCRQRDQDFYWQTEWQKLEQKGW
                     LTLVTAFSREQEQKVYVQHRLRELGPLVWELLDGQGAYFYLAGNAKYLPTDVSEALMS
                     IFQEEGRLSTADASAYLARLQQTLRFQTETWA"
     exon            199..276
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            277..374
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            375..473
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            474..575
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            576..785
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            786..907
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1128
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1236
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1351
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1501
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1620
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1715
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..4757
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2321..2326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /note="hexamer: CATAAA"
     polyA_site      2341
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /note="major polyA site"
     regulatory      4728..4733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /note="hexamer: AATAAA"
     polyA_site      4757
                     /gene="Ndor1"
                     /gene_synonym="4930447P04Rik; Ndor; NR1;
                     Tg(UBC-cre/ERT2)1Ejb; Ubc-cre"
                     /note="major polyA site"
ORIGIN      
        1 ttcctgttga cagcggaagg gggaagttgg tgaggtgtgc ggttctggcc ggcgtgtgca
       61 gtaatgcagg ttccacagct cctggtgctt ttcggcagcc agactggtac agcccaggac
      121 gaggcggaga ggctgggccg tgaggcccgg cgccggcggc taggttgccg cgtgcaggct
      181 ttggactctt actccgtggc gaatctcatt agggagcccc tggtgatatt tgtttgtgcg
      241 accacaggcc aaggagaccc tcctgacaac atgaagaact tctggaggtt catattccgg
      301 aagagcctgc cgtccagctc cctctgtcaa atggattttg ctgtcctagg cctcggggat
      361 tcctcatatg ccaagttcaa ctttgtggcc aagaagctac atcgtaggct gctgcagcta
      421 ggaggcagtg cgcttctgcc cccatgtctg ggtgatgacc agcatgagct ggggcctgat
      481 gctgccattg acccctgggt aggagatctt tgggagaaga taatggttat gtacccagta
      541 ccccttgaca ttcctgagat tcctcatgga gtccccttgc cctccaagtt catctttcag
      601 tttcttcagg aggtccccag cataggggct gaggagctca acatagccag ctcagcccct
      661 cagacacccc catcagagtt acagcccttc ctggcacctg tgatcaccaa ccagagggtc
      721 actggccccc aacactttca ggatgttcgg ctgattgaat ttgacattac agactccaat
      781 atcagctttg ctgctggtga tgttgtattc attttgccct ctaactcgga ggcccacacc
      841 cagcagttct gccaagtgtt gtgcctggac cccaatcagt ttttcacact taagccacgg
      901 gaaccaggtg tccctgaccc accagggctg cctcagccct gtactgtgtg gaacctcgtg
      961 tcccagtact tggacattgc cagtgtgccc cgccgttcct tctttgagct cctggcttgt
     1021 ctctcccaac atgcgctgga gcgagagaag ctgctggaat tgagctctgc cagaggtcag
     1081 gaagagctct gggagtactg cagtcggccc cgcagaacca tcttggaggt gctatgcgac
     1141 tttccacata cagcgggtgc cattcctcca gactaccttt tggacctaat ccctcggatc
     1201 cgcccacggg ccttctccat tgcttcctcc ctactggctc atcccaggag gctacagatc
     1261 cttgtggctg tggtaaagta ccagactcgt ctgaaggagc cccgccatgg tctctgctcc
     1321 tcctggctag catccctgaa tcctgggcaa gcaggacctg tccgggtgcc tctgtgggta
     1381 cgtcctggga gcctcgtgtt cccaaaaaca ccagacacac ccattatcat ggtgggggct
     1441 ggaactggtg tggccccctt ccgagcagcc attcaggaac gagtggctca tggccaaact
     1501 ggaaacttct tgttctttgg ctgccgccag cgggatcagg acttctactg gcagactgaa
     1561 tggcagaagc tagagcagaa gggctggctg accctggtta cagccttctc ccgggagcag
     1621 gagcagaagg tatatgtgca gcaccggctt cgagagctgg ggccacttgt ctgggagctg
     1681 ctggatggcc aaggtgccta cttctaccta gcaggcaatg ctaaatattt gcctacggat
     1741 gtttcggaag cccttatgtc catttttcaa gaagaaggac gactctccac tgcagatgca
     1801 tctgcctacc ttgctaggct ccagcagaca ctgcgcttcc agactgaaac ctgggcctga
     1861 ggagccactt gctagctcac actcacatta acagctgcat tgggtagcct gctggagtct
     1921 agaaggccca ttgttacctc ttgccttcta atcccagaac actgggtaga cccacagttt
     1981 cgcttttttg gtccagctga ccaggagggc agtccttgcg tacagccaaa ctcagtggaa
     2041 cccagtgtcc catacgtagg cccagccccg gtgcagctag aactcctggt tttctctcag
     2101 accccttcat tctgccccaa atctgcattt atagtcccta ccaccaaggg cctgctaagc
     2161 cctccaaagg acatagagct gtgcgggctg cactgcccgt ctgaccccgt gctattccca
     2221 ttagtcccat aacacctgtg cagctcagct cagttgaaaa gccaccaggg accaagtctc
     2281 ctgagcattg ggaatgggca aatctgtctg tctgcaggtc cataaacatg agttaactgc
     2341 ctgggtagcc gctcacttct cttttattgc ttctagattt gagagtggtg gttgggacat
     2401 ggattatctg catctgctag tggtgggcaa agagccctcc agggcatgag cacaggcttg
     2461 tactgacagt ttagccaagc tagtcccctt ctctgatggc cacacaactc agccaagctc
     2521 atataccctt ctctcatggc caagcagaga gggcttagag agctatttat ttggaagtcc
     2581 cagccaagag ccagcatgca ctattctttc caaagaactg aaagaatgat caggtggagg
     2641 gggtgtgatt tgtgttggcc cgcccatggg cagggcctcc actgctggga aggaaaccct
     2701 gttggagcag tcagacaggt ccaagggcag ctgggcgcta aggaacctcg gttctgtctg
     2761 tcagcttgtg gaaaacaggg accagaccaa caccactctt aggcctcaga taccaagagt
     2821 tgacatgctg cggggaccca agtgaagctt acttccagtg aggtcagcaa gccgaaaggg
     2881 ttatctagag gttagtgctc aggtggatgg gtggaggcca agctctgcct ggctcctgag
     2941 ggccacacct tcatatctac aacaatccct gcagtcatcc tggagtctcc gtctacgcat
     3001 cctgacctct gttctagtgg taacctggga cctaatgaca ccagctctgt gtctactagt
     3061 tcacccggtg cttctctggg tcctgagctc ttggacccac tgtgccagct accagcagat
     3121 ggagaggatg atctcagggc ccctctgggt gccagaactc cagacagtaa accggaactg
     3181 gaggccagag acccatccgc tgccagggcc ctggagtcaa ctgtggaaga gcaggaaggt
     3241 gaggggcagg ttgtggagga ggaggaatgt cccatctgtg ctgagcctta tgggcctagt
     3301 gagcaccacc tgaccctgct aaactgtggt cacagcctgt gtgtgggctg cctacaccag
     3361 ctgttaggca tgacccccag agctgacctg ggccgtgtgt gctgtccact gtgtcgtcag
     3421 aagacaccta tgctagagtg ggagatctgt cagctgcagg aggaactgct tcgagctgat
     3481 ggaccccagc gcccaatgcg gactgcatcc gtcacagccc tgcatcctgg cccttggccc
     3541 tggggtccct tagagcaccg ctaccagctg cgcttcctgg cagggcctgt gggagggcga
     3601 agctgtctcc ccttcctgcc ctgccctccc agcctaggca cctggttgtg ggcactacgg
     3661 gaacgtggcc cctgtgcccg ccgcttgtca ctgctgagcc tactggtcct tgaactgctc
     3721 gggctggtgg tcatcttcat gccgctcctt ttactagggg tgctcttcat gctgctagac
     3781 cgttccaccc actaagcaga gcccagaatg ctggccaagc tttgaagtcc atgcacgctt
     3841 ggattctggt aatcagcaaa gacttgttat caccaatacc aagactatac atgcctaaga
     3901 gcctacgcca gccagagtgc ttacacaccc ttgcagccta gatattagct aaagccaagg
     3961 acacaaggac agcctctgaa ggagcttggc ctggcagaaa gagttgtgaa aagaacccta
     4021 tgtgcttgcc atgggcggtc atctcactgg ccacaggcag aagctgggct ataccgccag
     4081 ctcgtagtcc agctggtgag agtggacaca aatgtgtgat tccaacagtg attctgttta
     4141 tcctgagatc tgttcattgg agaaggcaag ggctgcagac tctcacctgc accagacaga
     4201 agctggtgtg tgtcctgaag gcaacagcag cagccacagt aactaccagg agaggcctgc
     4261 actgcacaag ccagccttca aaagctccca cccaacctaa gctactctca ccagagaagg
     4321 tagcccagag gagctgggat caatattgcc tttgttttgc aagggcccat ccagaccctg
     4381 aagcctccaa atgcccaagg tctagctctg ttcctagttg actctgcaat tcatgtcact
     4441 ggaccaggag ccctcacttg ggagatgcag acaaatctaa gctcacttca tggctcattg
     4501 gtgacacaat gtaaggtgta acatttcagg ctgagtccta tataacaagc ataagaaagg
     4561 ctctcagacc aggcagtggt ggcgcacacc tttgatcgca gcacttggga ggcagaggca
     4621 ggtggatttc tgagttccag gccagcctgg tctacagagc gagttccagg aggacagcca
     4681 gggctacaca gagacaccct gtctcccaaa aaaaaaaaaa agttctcaat aaacagttgt
     4741 tactgattct atcatta
//
