LOCUS       NM_172399               4684 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus neuron-derived neurotrophic factor (Ndnf), mRNA.
ACCESSION   NM_172399
VERSION     NM_172399.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4684)
  AUTHORS   Jiang,Y.Q., Lee,D.K., Guo,W., Li,M. and Sun,Q.
  TITLE     Hypothalamic regulation of hippocampal CA1 interneurons by the
            supramammillary nucleus
  JOURNAL   Cell Rep 43 (11), 114898 (2024)
   PUBMED   39446584
REFERENCE   2  (bases 1 to 4684)
  AUTHORS   Choi,J., Jung,S., Kim,J., So,D., Kim,A., Kim,S., Choi,S., Yoo,E.,
            Kim,J.Y., Jang,Y.C., Lee,H., Kim,J., Shin,H.S., Chae,S. and Keum,S.
  TITLE     ARNT2 controls prefrontal somatostatin interneurons mediating
            affective empathy
  JOURNAL   Cell Rep 43 (9), 114659 (2024)
   PUBMED   39180750
REFERENCE   3  (bases 1 to 4684)
  AUTHORS   Iannone,A.F., Akgul,G., Zhang,R., Wacks,S., Hussein,N.,
            Macias,C.G., Donatelle,A., Bauriedel,J.M.J., Wright,C., Abramov,D.,
            Johnson,M.A., Govek,E.E., Burre,J., Milner,T.A. and De Marco
            Garcia,N.V.
  TITLE     The chemokine Cxcl14 regulates interneuron differentiation in layer
            I of the somatosensory cortex
  JOURNAL   Cell Rep 43 (8), 114531 (2024)
   PUBMED   39058591
REFERENCE   4  (bases 1 to 4684)
  AUTHORS   Carabana,C., Sun,W., Veludo Ramos,C., Huyghe,M., Perkins,M.,
            Maillot,A., Journot,R., Hartani,F., Faraldo,M.M., Lloyd-Lewis,B.
            and Fre,S.
  TITLE     Spatially distinct epithelial and mesenchymal cell subsets along
            progressive lineage restriction in the branching embryonic mammary
            gland
  JOURNAL   EMBO J 43 (12), 2308-2336 (2024)
   PUBMED   38760574
REFERENCE   5  (bases 1 to 4684)
  AUTHORS   Hartung,J., Schroeder,A., Perez Vazquez,R.A., Poorthuis,R.B. and
            Letzkus,J.J.
  TITLE     Layer 1 NDNF interneurons are specialized top-down master
            regulators of cortical circuits
  JOURNAL   Cell Rep 43 (5), 114212 (2024)
   PUBMED   38743567
REFERENCE   6  (bases 1 to 4684)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   7  (bases 1 to 4684)
  AUTHORS   Boyle,M.P., Bernard,A., Thompson,C.L., Ng,L., Boe,A., Mortrud,M.,
            Hawrylycz,M.J., Jones,A.R., Hevner,R.F. and Lein,E.S.
  TITLE     Cell-type-specific consequences of Reelin deficiency in the mouse
            neocortex, hippocampus, and amygdala
  JOURNAL   J Comp Neurol 519 (11), 2061-2089 (2011)
   PUBMED   21491433
REFERENCE   8  (bases 1 to 4684)
  AUTHORS   Feng,W., Leach,S.M., Tipney,H., Phang,T., Geraci,M., Spritz,R.A.,
            Hunter,L.E. and Williams,T.
  TITLE     Spatial and temporal analysis of gene expression during growth and
            fusion of the mouse facial prominences
  JOURNAL   PLoS One 4 (12), e8066 (2009)
   PUBMED   20016822
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4684)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   10 (bases 1 to 4684)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029210.1 and CK618056.1.
            
            On Jul 25, 2009 this sequence version replaced NM_172399.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029210.1, AK049802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1765              AK029210.1         2-1766
            1766-1766           CK618056.1         312-312
            1767-4684           AK029210.1         1768-4685
FEATURES             Location/Qualifiers
     source          1..4684
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.29 cM"
     gene            1..4684
                     /gene="Ndnf"
                     /gene_synonym="A930038C07Rik; epidermacan"
                     /note="neuron-derived neurotrophic factor"
                     /db_xref="GeneID:68169"
                     /db_xref="MGI:MGI:1915419"
     exon            1..491
                     /gene="Ndnf"
                     /gene_synonym="A930038C07Rik; epidermacan"
                     /inference="alignment:Splign:2.1.0"
     exon            492..680
                     /gene="Ndnf"
                     /gene_synonym="A930038C07Rik; epidermacan"
                     /inference="alignment:Splign:2.1.0"
     CDS             493..2199
                     /gene="Ndnf"
                     /gene_synonym="A930038C07Rik; epidermacan"
                     /note="fibronectin type-III domain-containing protein
                     C4orf31 homolog; protein NDNF"
                     /codon_start=1
                     /product="protein NDNF precursor"
                     /protein_id="NP_765987.2"
                     /db_xref="CCDS:CCDS20207.1"
                     /db_xref="GeneID:68169"
                     /db_xref="MGI:MGI:1915419"
                     /translation="MELFYWCLLCLLLPLTSRTQKLPTRDEELFQMQIRDKEFFHDSS
                     VIPDGAEVSSYLFRDTPRRYFFMVEEDNTPLSVTVTPCDAPLEWKLSLQELHEGSSAD
                     GSGDPELLDQQKQQMTDVEGTELFSYKGNDVEYFLSSSSPSGLYQLELLSTEKDTHFK
                     VYATTTPESDQPYPELPYDPRVDVTSFGRTTVTLAWKPSPTASILKQPIEYCVVINKE
                     HNFKSLCAAETKMNADDAFMVAPKPGLDFNPFDFAHFGFPTDNLGKDRSLLAKPSPKV
                     GRHVYWRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFMVNTNTNMSTAYVGAFVRT
                     KEEAKQKTVELKDGRVTDVFVKRKGKKFLRFAPVSSHQKVTFFIHSCMDAVQVQVRRD
                     GRLLLSQNVEGIRQFQLRGKPKGKYLIRLKGNRKGASKLKILATTRPSKHAFPSLPED
                     TRIKAFDKLRTCSSVTVAWLGTQERRKFCIYRKEVDGNYSEDQKRREQNQCLGPDTRK
                     KSEKVLCKYFHSQNLQKAVTTETIRDLQPGKSYLLDVYVVGHGGHSVKYQSKIVKTRK
                     VC"
     exon            681..805
                     /gene="Ndnf"
                     /gene_synonym="A930038C07Rik; epidermacan"
                     /inference="alignment:Splign:2.1.0"
     exon            806..4684
                     /gene="Ndnf"
                     /gene_synonym="A930038C07Rik; epidermacan"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2816..2821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndnf"
                     /gene_synonym="A930038C07Rik; epidermacan"
                     /note="hexamer: ATTACA"
     polyA_site      2840
                     /gene="Ndnf"
                     /gene_synonym="A930038C07Rik; epidermacan"
                     /note="major polyA site"
     regulatory      3898..3903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndnf"
                     /gene_synonym="A930038C07Rik; epidermacan"
                     /note="hexamer: AATAAA"
     polyA_site      3919
                     /gene="Ndnf"
                     /gene_synonym="A930038C07Rik; epidermacan"
ORIGIN      
        1 acactccttg cccggagcgg cgagagagca gagcttagcg agccgcgtat gagccgccgc
       61 ctctgtggct ggtgcacggg gctctgtctc tgcagcccgc gccggcgttt agcgagccag
      121 tcgtccggca gtgccagctc cacgggcgcg ttcagtatcc tcccgccacc cagcgcccgc
      181 actgaccagc gctgtcctga gacccccggg ccggcgccgc cgtctgcgcc acttcgcagc
      241 aacttctgcg gctgcgtgtc gccggccttc tgcttgtgtt ggaagtttgc agcgcccgcc
      301 acaaagttgg gacacttggg cattacattt gccctagcgt gcacgtcccc tcggttcgtg
      361 gatcctggta tttgacatct tggtaggatc cccggacctg ggctttttcc gcaccacaca
      421 ccccccggga agaagaaaaa aaaaaccaac caaactttct tcttcccact agaaaaaaca
      481 aattctttaa ggatggagct gttctactgg tgtttgctgt gcctcctgtt accactcact
      541 tcaaggaccc agaagctgcc cacccgagat gaggaacttt ttcagatgca gatccgggat
      601 aaggaatttt ttcacgattc atctgtgatt ccagatggag ctgaagtcag cagttatctc
      661 tttagagata cacctagaag gtatttcttc atggttgagg aagataacac cccactgtca
      721 gtcacagtga caccttgcga tgcacctttg gagtggaagc ttagccttca ggagctgcat
      781 gaggggtcca gtgcagatgg atcaggtgac ccagaactac ttgaccagca gaagcagcag
      841 atgactgatg tagagggcac agaactattc tcctacaagg gcaatgatgt agagtatttt
      901 ctgtcttcaa gttccccatc tggtttgtat cagttggagc ttctttcaac agagaaagac
      961 acacatttca aagtatatgc caccaccaca ccagaatctg accagccata ccctgaatta
     1021 ccatatgacc ccagagttga tgtgacctcc tttggacgta ccacagtcac tttggcctgg
     1081 aagccaagcc ctacagcctc tatattgaaa caacccatag agtactgtgt ggtcatcaac
     1141 aaggagcaca atttcaaaag cctctgtgca gcagaaacaa agatgaatgc agatgatgcc
     1201 ttcatggtgg cgcccaaacc tggtctagac tttaacccct ttgactttgc ccattttgga
     1261 tttccaacag ataatttggg taaagatcga agcctcctgg caaagccttc tcccaaagtg
     1321 gggcgccatg tctactggag gcccaaggtt gacattcaaa aaatttgcat aggaaataaa
     1381 aacattttca cagtctctga cctgaagccc gatacccaat actactttga tgtcttcatg
     1441 gtcaatacca acaccaacat gagtacagct tatgtgggtg cctttgtcag gaccaaggag
     1501 gaggcaaaac agaagacagt ggaactcaaa gacgggaggg tcacagatgt gtttgttaaa
     1561 aggaagggga aaaagtttct acggtttgct ccagtctcct ctcaccaaaa ggtcacgttc
     1621 tttattcatt cttgtatgga tgccgttcaa gtccaagtga gaagagatgg gaggctgctt
     1681 ctgtcacaga atgtggaagg cattcggcag tttcagttaa gaggaaaacc caaaggaaaa
     1741 tacctcattc gactgaaagg caacaggaaa ggagcatcaa agctgaaaat actggcgacc
     1801 accaggccca gtaagcatgc attcccctct cttcccgaag acacaagaat caaagctttt
     1861 gacaagctac gtacctgctc ttcagttacg gtggcatggc ttggcaccca agaaaggaga
     1921 aagttttgta tctacagaaa ggaagtggat ggaaactaca gtgaagacca gaagagaaga
     1981 gagcaaaacc agtgcctagg accagacacc agaaagaaat cagagaaggt cctttgcaaa
     2041 tacttccaca gccaaaacct gcagaaagca gtgactacag agacaatcag agatctgcag
     2101 cctgggaagt cttacctgct ggatgtttac gtcgtaggac atgggggaca ctctgtgaag
     2161 tatcaaagta aaattgtgaa aacaaggaag gtctgttagt caccttgagt gaagatcagg
     2221 agaactccag gagagacatg gagtcacact gcttgtaact gactactctc gtgacaaaca
     2281 aaagttgtac ttgaaagaaa gggtaacaac atgtgtacat tgatgcttgc ctaatgtagc
     2341 atggagactt gtactcacgc acacctgtgg tacttagggt ccatctgtct aatgctggtt
     2401 aatgtcaaaa gaagagggta tctcaatgga tgccacccct tgctttgacc attgcatgaa
     2461 ctgcttctaa attattttat tacctaaaat tttaaaatat gccattcgtt gcacacattc
     2521 acaaatgcaa ataattcctc tctatagatg ttaggggaag tttatatata aatatataaa
     2581 tataaattat tttataaagt ctgttttaat tgttggtgtt tctattattg taagctatta
     2641 aattctttct ctgttaaagt atagatctaa tctaagatcg tatcaccctc taagcagtaa
     2701 tattgttgta aattcttatt tgttcagtaa aatgtttaaa tgctgtctgt atgtatctca
     2761 tgtaaaaagt tgatatacat tatattcatg tatataaaat taagaatatt agattattac
     2821 actgttcatt ttcccaagca gtactgtggt atattcaatt gcttatctgt ccttaaaacc
     2881 gtgctttttc tgtaagttgg caccaaaatt tagtcttatt tagtagctag gaggtaaatg
     2941 ttggctctct cgatctttac tggcatcaag agctggttat tcaagtctgg atttgggaac
     3001 tcaatgggag acgaagaact gtaataggct tgtttgagca tagaacaagg caaacactat
     3061 caatctgata agcgatcatt ttaaacattt attttccatt tgcttaaatt ttggcaaatc
     3121 ttttaacggc ttgctgaagc aggtgagaac cttgattagg actttcatca gtcacaacac
     3181 aatgctacat ctgctgctta caagatttat aaaacactgc tgcaggtaat tttattttga
     3241 gttttcaact gtttttaaag ttaattttag tgtaagatac aagtctagca aataacatct
     3301 gcaggctcta ccaagggagc atggggacac ttttatcctc tacagatttt acttggaaat
     3361 tccaaggcaa catgagacca taaaagcaag attcagaaat acttgtaatt gttggtcacc
     3421 taaaaccata tgactttagg agaatgttac tgcccaccat cccctttccc atttataaag
     3481 ttgaggaagt ggtagaagtg gatacaatga cactgtgaaa taccttctga catgagaagt
     3541 tgccgtttgc aaaatcctga ccctaaaccc ttacattcta tggctagagt gagaacaggc
     3601 gcaatggttc ctcttattgc tatccactgc atgccggcac agctttgctg gtgagagttc
     3661 acagcagcat ttctatgggg tataggaata ctgtggcaga gatggcgttg tatatagttc
     3721 cctatgacgt gtgttctgct taccttaagg gaaagtacaa gcgttatggc ataccctcta
     3781 aatccttggc agtaactttc agcaaaattg atccatctgt gcaatgcagg aacaacatct
     3841 gaaataactt tttggaagct gacaaccatg tacccaatgc tttatttaag cagcttcaat
     3901 aaaaggagag actgacaaat tgacactcag agaaattata ttcagctata gatgtgagaa
     3961 aagcagcttc ctaatgctgc tgagcaactt gtaagtggga ctgcagcgaa tcagattact
     4021 gctgctttga aggtctggga tcttggatac tgcctaactc tcagcatctg ggaaccaggt
     4081 tgaactgatt ttaaaacact ttgaattttc tgctaggcgt ggtagtagtt tcttcatatt
     4141 gtggacaaat acagaaattc tctaatgacc ctaggataaa aattgccttt tcaagctaag
     4201 gaaaattaaa cacacatcat gaaaggctta ctgcttataa caaagggaaa agccttgaaa
     4261 atcatgcctc actgatgtgc taagatttca ggagtatcca gtggactagg gacaaggaag
     4321 ggactcattc attcacattt tagaaataac tacacgcttg ctaatataaa agcaaaacct
     4381 ggcctacgct aatctctgag agaacaatag acactgagag ggatggtacc caatgccatg
     4441 tgtagacgga tattgagaag agaaggcttg gagatattta gctcattatc tttccttttc
     4501 aagtacaatg acagagaaag aacagaatat atttaaaaca agagaaacaa aaaataagaa
     4561 agttttgccc acacaaatgt ataccaggag acagaggcaa atggagttct gtgaatttga
     4621 gtttcagcct gatctattta atgagaccca ggcccactaa ggactacaag gtgagactca
     4681 gtgc
//
