LOCUS       NM_010882               1652 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus necdin, MAGE family member (Ndn), mRNA.
ACCESSION   NM_010882
VERSION     NM_010882.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1652)
  AUTHORS   Zietek,M.M., Jaszczyk,A., Stankiewicz,A.M. and Sampino,S.
  TITLE     Prenatal gene-environment interactions mediate the impact of
            advanced maternal age on mouse offspring behavior
  JOURNAL   Sci Rep 14 (1), 31733 (2024)
   PUBMED   39738558
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1652)
  AUTHORS   Li,X., Zhang,Y., Hu,Y., Tang,X., Gong,Z., Lu,R.B. and Li,J.D.
  TITLE     Prader-Willi syndrome protein necdin regulates the
            nucleocytoplasmic distribution and dopaminergic neuron development
  JOURNAL   Sci Rep 14 (1), 31605 (2024)
   PUBMED   39738217
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1652)
  AUTHORS   Dong,Y., Lu,R., Cao,H., Zhang,J., Wu,X., Deng,Y. and Li,J.D.
  TITLE     Deficiency in Prader-Willi syndrome gene necdin leads to attenuated
            cardiac contractility
  JOURNAL   iScience 27 (6), 109974 (2024)
   PUBMED   38832028
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1652)
  AUTHORS   Amato,E. Jr., Taroc,E.Z.M. and Forni,P.E.
  TITLE     Illuminating the terminal nerve: Uncovering the link between GnRH-1
            neuron and olfactory development
  JOURNAL   J Comp Neurol 532 (3), e25599 (2024)
   PUBMED   38488687
REFERENCE   5  (bases 1 to 1652)
  AUTHORS   Liang,F., Li,B., Xu,Y., Gong,J., Zheng,S., Zhang,Y. and Wang,Y.
  TITLE     Identification and characterization of Necdin as a target for the
            Cockayne syndrome B protein in promoting neuronal differentiation
            and maintenance
  JOURNAL   Pharmacol Res 187, 106637 (2023)
   PUBMED   36586641
  REMARK    GeneRIF: Identification and characterization of Necdin as a target
            for the Cockayne syndrome B protein in promoting neuronal
            differentiation and maintenance.
REFERENCE   6  (bases 1 to 1652)
  AUTHORS   MacDonald,H.R. and Wevrick,R.
  TITLE     The necdin gene is deleted in Prader-Willi syndrome and is
            imprinted in human and mouse
  JOURNAL   Hum Mol Genet 6 (11), 1873-1878 (1997)
   PUBMED   9302265
  REMARK    GeneRIF: The necdin gene is imprinted, with preferential expression
            from the paternal allele in human and mouse.
REFERENCE   7  (bases 1 to 1652)
  AUTHORS   Hayashi,Y., Matsuyama,K., Takagi,K., Sugiura,H. and Yoshikawa,K.
  TITLE     Arrest of cell growth by necdin, a nuclear protein expressed in
            postmitotic neurons
  JOURNAL   Biochem Biophys Res Commun 213 (1), 317-324 (1995)
   PUBMED   7639751
REFERENCE   8  (bases 1 to 1652)
  AUTHORS   Aizawa,T., Maruyama,K., Kondo,H. and Yoshikawa,K.
  TITLE     Expression of necdin, an embryonal carcinoma-derived nuclear
            protein, in developing mouse brain
  JOURNAL   Brain Res Dev Brain Res 68 (2), 265-274 (1992)
   PUBMED   1394972
REFERENCE   9  (bases 1 to 1652)
  AUTHORS   Maruyama,K., Usami,M., Aizawa,T. and Yoshikawa,K.
  TITLE     A novel brain-specific mRNA encoding nuclear protein (necdin)
            expressed in neurally differentiated embryonal carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 178 (1), 291-296 (1991)
   PUBMED   2069569
REFERENCE   10 (bases 1 to 1652)
  AUTHORS   Prieto,J., Takei,F., Gendelman,R., Christenson,B., Biberfeld,P. and
            Patarroyo,M.
  TITLE     MALA-2, mouse homologue of human adhesion molecule ICAM-1 (CD54)
  JOURNAL   Eur J Immunol 19 (9), 1551-1557 (1989)
   PUBMED   2571505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU080413.1, AK135444.1 and BY669518.1.
            
            On Oct 25, 2006 this sequence version replaced NM_010882.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 9302265
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AU080413.1         12-56
            46-1648             AK135444.1         2-1604
            1649-1652           BY669518.1         372-375
FEATURES             Location/Qualifiers
     source          1..1652
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 34.36 cM"
     gene            1..1652
                     /gene="Ndn"
                     /gene_synonym="Peg6"
                     /note="necdin, MAGE family member"
                     /db_xref="GeneID:17984"
                     /db_xref="MGI:MGI:97290"
     exon            1..1652
                     /gene="Ndn"
                     /gene_synonym="Peg6"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1109
                     /gene="Ndn"
                     /gene_synonym="Peg6"
                     /codon_start=1
                     /product="necdin"
                     /protein_id="NP_035012.2"
                     /db_xref="CCDS:CCDS21326.1"
                     /db_xref="GeneID:17984"
                     /db_xref="MGI:MGI:97290"
                     /translation="MSEQSKDLSDPNFAAEVPDCEMQDSDAVPVGIPPPASLAANLAG
                     PPCAPEGPMAAQQASPPPEERIEDVDPKILQQAAEEGRAHQPQSPARPIPAPPAPAQL
                     VQKAHELMWYVLVKDQKRMVLWFPDMVKEVMGSYKKWCRSILRRTSVILARVFGLHLR
                     LTNLHTMEFALVKALSPEELDRVALNNRMPMTGLLLMILSLIYVKGRGAREGAVWNVL
                     RILGLRPWKKHSTFGDVRKIITEEFVQQNYLKYQRVPHIEPPEYEFFWGSRANREITK
                     MQIMEFLARVFKKDPQAWPSRYREALEQARALREANLAAQAPRSSVSED"
     regulatory      1628..1633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndn"
                     /gene_synonym="Peg6"
                     /note="hexamer: AATAAA"
     polyA_site      1652
                     /gene="Ndn"
                     /gene_synonym="Peg6"
                     /note="major polyA site"
ORIGIN      
        1 cccgcccgcc cgctgctgcg gaaggcgcag tgctcagtaa agcgcacttc ctctgctggt
       61 ctccaccgag ggagtgcccg ctccaagagc tccaagccgc atcggtcctg ctctgatccg
      121 aaggcgcaga catgtcggaa caaagtaagg acctgagcga ccctaacttt gcagccgagg
      181 tccccgactg tgagatgcag gacagcgatg ccgttccggt ggggatccct cctcccgctt
      241 ctctggccgc taacctcgca gggccaccgt gcgctcccga aggccctatg gcagcccaac
      301 aggcctcgcc accgcccgaa gaacggatag aagatgttga ccctaaaatc ctgcagcagg
      361 ccgcagagga gggccgcgcc caccagcccc agagtccagc ccggccgatc ccagcaccgc
      421 cagcccctgc ccagctggtg cagaaggcgc acgagctcat gtggtacgtg ttggtgaagg
      481 accagaagag gatggtcctc tggtttccag acatggtgaa agaggtcatg ggcagctaca
      541 agaaatggtg cagaagcatc ctcaggcgca ccagcgtcat cctcgccaga gtgttcgggc
      601 tgcacctgag gctgaccaat ctccacacca tggagtttgc cctggtcaaa gccctcagcc
      661 cagaggagct agacagggtg gcgctcaaca accgtatgcc catgacaggc ctcctgctca
      721 tgatcctgag cctcatctat gtgaagggcc gcggggccag agagggtgcg gtctggaatg
      781 tgctgcgcat cctggggctg aggccctgga agaagcactc caccttcgga gacgtgagga
      841 agataatcac cgaggagttc gtccagcaga attacctgaa gtaccagcgt gtgccccaca
      901 tcgagcctcc cgagtacgag ttcttctggg ggtccagagc taaccgtgaa atcaccaaga
      961 tgcagatcat ggagttcctg gccagagtct tcaagaaaga tccccaggcg tggccttccc
     1021 gatacaggga ggctctggag caggccagag ctctgcggga ggctaatctt gctgcccagg
     1081 ccccccgcag cagtgtctct gaggactaaa aaggtccagg ggcacactga tagtttctga
     1141 cccatactag ggctgtgtaa gggtggggtt gagtcattag agtatcccaa atccacagtg
     1201 cagtatttca tgtataattt ttaagttttc catacagtgc ttttgtacct tgtaatgcta
     1261 ttcatttgtg tactcgtgta gtgtttaaga ttgatgcatg tgtgataagt atttggtact
     1321 ttcacttttg tgctttcgtg catttttgta caagagatgt gctgtgctaa acttgtgaaa
     1381 tacattgagg tgttctgtat cttgttcttt gtatgggact gatgatctgt atcgacaaag
     1441 aaggccctgg agagttagca ggacttaaca gcaacgcaga cctgagcaag agaaaggtca
     1501 aggcctttct ccatatgact tcaactggca caggaagcat ccatgtggaa tggactgatt
     1561 tgaactggac tgttctcagt gtaggcactt agcacccttt acaaaacatg tatgcaaccc
     1621 caccataaat aaacgttaaa atgagcatta aa
//
