LOCUS       NM_022996               1796 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus Nedd4 family interacting protein 1 (Ndfip1),
            transcript variant 2, mRNA.
ACCESSION   NM_022996 XM_001052153 XM_985952 XM_988154
VERSION     NM_022996.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1796)
  AUTHORS   Fu,X., Qu,L., Xu,H. and Xie,J.
  TITLE     Ndfip1 protected dopaminergic neurons via regulating mitochondrial
            function and ferroptosis in Parkinson's disease
  JOURNAL   Exp Neurol 375, 114724 (2024)
   PUBMED   38365133
  REMARK    GeneRIF: Ndfip1 protected dopaminergic neurons via regulating
            mitochondrial function and ferroptosis in Parkinson's disease.
REFERENCE   2  (bases 1 to 1796)
  AUTHORS   Hsu,W.L., Ma,Y.L., Chen,Y.C., Liu,Y.C., Cheng,K.M. and Lee,E.H.Y.
  TITLE     Identification of Ndfip1 as a novel negative regulator for spatial
            memory formation associated with increased ubiquitination of Beclin
            1 and PTEN
  JOURNAL   PLoS One 18 (4), e0283908 (2023)
   PUBMED   37023120
  REMARK    GeneRIF: Identification of Ndfip1 as a novel negative regulator for
            spatial memory formation associated with increased ubiquitination
            of Beclin 1 and PTEN.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1796)
  AUTHORS   Tang,Y.L., Zhu,L., Yang,H.F., Tao,Y., Lu,W. and Cheng,H.
  TITLE     Research progress on the role of Ndfip1 (Nedd4 family interacting
            protein 1) in immune cells
  JOURNAL   Allergol Immunopathol (Madr) 51 (1), 77-83 (2023)
   PUBMED   36617825
  REMARK    GeneRIF: Research progress on the role of Ndfip1 (Nedd4 family
            interacting protein 1) in immune cells.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1796)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1796)
  AUTHORS   Gorla,M., Santiago,C., Chaudhari,K., Layman,A.A.K., Oliver,P.M. and
            Bashaw,G.J.
  TITLE     Ndfip Proteins Target Robo Receptors for Degradation and Allow
            Commissural Axons to Cross the Midline in the Developing Spinal
            Cord
  JOURNAL   Cell Rep 26 (12), 3298-3312 (2019)
   PUBMED   30893602
REFERENCE   6  (bases 1 to 1796)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   7  (bases 1 to 1796)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1796)
  AUTHORS   Harvey,K.F., Shearwin-Whyatt,L.M., Fotia,A., Parton,R.G. and
            Kumar,S.
  TITLE     N4WBP5, a potential target for ubiquitination by the Nedd4 family
            of proteins, is a novel Golgi-associated protein
  JOURNAL   J Biol Chem 277 (11), 9307-9317 (2002)
   PUBMED   11748237
REFERENCE   9  (bases 1 to 1796)
  AUTHORS   Geschwind,D.H., Ou,J., Easterday,M.C., Dougherty,J.D.,
            Jackson,R.L., Chen,Z., Antoine,H., Terskikh,A., Weissman,I.L.,
            Nelson,S.F. and Kornblum,H.I.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   10 (bases 1 to 1796)
  AUTHORS   Jolliffe,C.N., Harvey,K.F., Haines,B.P., Parasivam,G. and Kumar,S.
  TITLE     Identification of multiple proteins expressed in murine embryos as
            binding partners for the WW domains of the ubiquitin-protein ligase
            Nedd4
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 557-565 (2000)
   PUBMED   11042109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134576.3.
            
            On Sep 26, 2017 this sequence version replaced NM_022996.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020359.1, AF220209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AC134576.3         142917-143186
            271-358             AC134576.3         166927-167014
            359-489             AC134576.3         171701-171831
            490-577             AC134576.3         175565-175652
            578-702             AC134576.3         176315-176439
            703-769             AC134576.3         180065-180131
            770-875             AC134576.3         184555-184660
            876-1796            AC134576.3         188287-189207
FEATURES             Location/Qualifiers
     source          1..1796
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 20.32 cM"
     gene            1..1796
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /note="Nedd4 family interacting protein 1"
                     /db_xref="GeneID:65113"
                     /db_xref="MGI:MGI:1929601"
     exon            1..270
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..873
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /note="Nedd4 WW binding protein 5; NEDD4 WW domain-binding
                     protein 5"
                     /codon_start=1
                     /product="NEDD4 family-interacting protein 1"
                     /protein_id="NP_075372.1"
                     /db_xref="CCDS:CCDS37789.1"
                     /db_xref="GeneID:65113"
                     /db_xref="MGI:MGI:1929601"
                     /translation="MALALAALAAVEPACGSGYQQLQNEEEPGEPEQTAGDAPPPYSS
                     ITAESAAYFDYKDESGFPKPPSYNVATTLPSYDEAERTKTEATIPLVPGRDEDFVGRD
                     DFDDTDQLRIGNDGIFMLTFFMAFLFNWIGFFLSFCLTTSAAGRYGAISGFGLSLIKW
                     ILIVRFSTYFPGYFDGQYWLWWVFLVLGFLLFLRGFINYAKVRKMPETFSNLPRTRVL
                     FIY"
     exon            271..358
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            359..489
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            490..577
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            578..702
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            703..769
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            770..875
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1796
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /note="hexamer: AATAAA"
     polyA_site      1784
                     /gene="Ndfip1"
                     /gene_synonym="0610010M22Rik; N4wbp5"
                     /note="major polyA site"
ORIGIN      
        1 gtcgtcgtcg tccccgcctc ctccccaggg gccgcggcgg agccttggcg gacgcgctca
       61 gtgccggagg agaacgtctc agcgtcggca gcgtccgtcc acacacgccc cggcgcgtac
      121 ctttcggcct cccggcgacc cccagccgcg gcgctcgcgc ccgatcagct ctctcgctcg
      181 ccctccttcc ctgaggcccg ctgcgccatg gccttggcgt tggcggcgct ggcggccgtg
      241 gagccggcct gcggcagcgg gtaccagcag ttgcagaatg aagaggagcc tggggaacct
      301 gagcagactg caggtgatgc tcctccacca tacagcagca tcacggcaga gagtgcagca
      361 tattttgact acaaagatga atctggattt ccaaagcccc catcgtataa tgtggctaca
      421 acactgccca gttatgacga ggctgagaga accaagactg aagctacgat ccctttggtt
      481 cctggaagag atgaagattt tgtgggccgg gatgattttg atgatactga ccagctgagg
      541 ataggaaacg atgggatttt tatgttaact tttttcatgg cattcctctt caactggatt
      601 gggtttttct tgtctttttg cctgaccacc tcagctgcgg gaaggtatgg ggccatctca
      661 ggatttggtc tttctctaat taagtggatc cttattgtca ggttttccac ctatttccct
      721 ggatactttg atggccagta ctggctctgg tgggtgttct tggttttagg ctttctcctg
      781 tttctcagag gatttatcaa ttacgcaaaa gttcggaaga tgccagaaac tttctcaaat
      841 ctccccagga ccagagttct ctttatttat taaagatgtt ttctggcaaa ggcttcctgc
      901 actgatgaag tcccctgaga agcgagagca cctgcaggaa gtgaatcacc accagaatgg
      961 aggaacagtc acctgcttta aaaaataaag tactgttgaa aaagatcatt tctctctatt
     1021 tgttcctagg tgtaaaatgt taatagttaa tgcagaattc tgtaatcatc gaatcattag
     1081 tggttaatgt ttgaaaaagc tcttgcaatc aagtctgtga tgtattatta ataatgcctt
     1141 atatattgtt tgtagtcatt ttaaatagca tgagccatgt ccctgtagtc agtagggggc
     1201 aatcttgctt tattcatcct ccatctcaaa gaagatttga aattacagat tagtgtaagc
     1261 tatgtatacg gctggctgtt tgaaaggggt tttctcaaaa gtcaaaactt tggttatgac
     1321 agcatttctg cacatagtcc atatttcctg ttcaaattaa tctagaaata tgtttaattg
     1381 tactgtgtgt gaacacctgg aagcaaaacc atagtgcaaa gttcattgta gtgttaccaa
     1441 aaaatgttct caattagtaa ataagcatta atttttcata gtctacattc agaaattacc
     1501 ttttcattct gtagttctgt gtagttcata taaaatggaa agggcaaaga caagattcag
     1561 attaaatatt aaatattatt ctggaagctg gctagactct cagagggtca ggaacacaga
     1621 attagtttgg aacttttgag aggatcccta gcattctgta ctccttgctt tcacaactgt
     1681 tataatgtag aatgatgtgc ttgctgccca agtgctagtt cactttggtt gctatattaa
     1741 actgtaaata caatagaaca ttaataaatg tctcttgtgt agcacctttt actgta
//
