LOCUS       NM_023668               2382 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus nudE neurodevelopment protein 1 like 1 (Ndel1),
            transcript variant 1, mRNA.
ACCESSION   NM_023668
VERSION     NM_023668.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2382)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2382)
  AUTHORS   Das,B.K., Gogoi,J., Kannan,A., Gao,L., Xing,W., Mohan,S. and
            Zhao,H.
  TITLE     The Cytoplasmic Dynein Associated Protein NDE1 Regulates
            Osteoclastogenesis by Modulating M-CSF and RANKL Signaling Pathways
  JOURNAL   Cells 11 (1), 13 (2021)
   PUBMED   35011575
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2382)
  AUTHORS   Amberg,N. and Hippenmeyer,S.
  TITLE     Genetic mosaic dissection of candidate genes in mice using mosaic
            analysis with double markers
  JOURNAL   STAR Protoc 2 (4), 100939 (2021)
   PUBMED   34825212
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2382)
  AUTHORS   Kim,Y.B., Hlavaty,D., Maycock,J. and Lechler,T.
  TITLE     Roles for Ndel1 in keratin organization and desmosome function
  JOURNAL   Mol Biol Cell 32 (20), ar2 (2021)
   PUBMED   34319758
  REMARK    GeneRIF: Roles for Ndel1 in keratin organization and desmosome
            function.
REFERENCE   5  (bases 1 to 2382)
  AUTHORS   Gavrilovici,C., Jiang,Y., Kiroski,I., Sterley,T.L., Vandal,M.,
            Bains,J., Park,S.K., Rho,J.M., Teskey,G.C. and Nguyen,M.D.
  TITLE     Behavioral Deficits in Mice with Postnatal Disruption of Ndel1 in
            Forebrain Excitatory Neurons: Implications for Epilepsy and
            Neuropsychiatric Disorders
  JOURNAL   Cereb Cortex Commun 2 (1), tgaa096 (2021)
   PUBMED   33615226
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2382)
  AUTHORS   Ozeki,Y., Tomoda,T., Kleiderlein,J., Kamiya,A., Bord,L., Fujii,K.,
            Okawa,M., Yamada,N., Hatten,M.E., Snyder,S.H., Ross,C.A. and
            Sawa,A.
  TITLE     Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents
            binding to NudE-like (NUDEL) and inhibits neurite outgrowth
  JOURNAL   Proc Natl Acad Sci U S A 100 (1), 289-294 (2003)
   PUBMED   12506198
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13969]
REFERENCE   7  (bases 1 to 2382)
  AUTHORS   Ko,J., Humbert,S., Bronson,R.T., Takahashi,S., Kulkarni,A.B., Li,E.
            and Tsai,L.H.
  TITLE     p35 and p39 are essential for cyclin-dependent kinase 5 function
            during neurodevelopment
  JOURNAL   J Neurosci 21 (17), 6758-6771 (2001)
   PUBMED   11517264
REFERENCE   8  (bases 1 to 2382)
  AUTHORS   Sweeney,K.J., Prokscha,A. and Eichele,G.
  TITLE     NudE-L, a novel Lis1-interacting protein, belongs to a family of
            vertebrate coiled-coil proteins
  JOURNAL   Mech Dev 101 (1-2), 21-33 (2001)
   PUBMED   11231056
REFERENCE   9  (bases 1 to 2382)
  AUTHORS   Niethammer,M., Smith,D.S., Ayala,R., Peng,J., Ko,J., Lee,M.S.,
            Morabito,M. and Tsai,L.H.
  TITLE     NUDEL is a novel Cdk5 substrate that associates with LIS1 and
            cytoplasmic dynein
  JOURNAL   Neuron 28 (3), 697-711 (2000)
   PUBMED   11163260
REFERENCE   10 (bases 1 to 2382)
  AUTHORS   Sasaki,S., Shionoya,A., Ishida,M., Gambello,M.J., Yingling,J.,
            Wynshaw-Boris,A. and Hirotsune,S.
  TITLE     A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the
            developing and adult nervous system
  JOURNAL   Neuron 28 (3), 681-696 (2000)
   PUBMED   11163259
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY124052.1, CJ092278.1 and BC046796.1.
            
            On May 17, 2018 this sequence version replaced NM_023668.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046796.1, SRR1660817.138769.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY124052.1         3-6
            5-73                CJ092278.1         2-70
            74-2382             BC046796.1         1-2309
FEATURES             Location/Qualifiers
     source          1..2382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.09 cM"
     gene            1..2382
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /note="nudE neurodevelopment protein 1 like 1"
                     /db_xref="GeneID:83431"
                     /db_xref="MGI:MGI:1932915"
     exon            1..194
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /inference="alignment:Splign:2.1.0"
     exon            195..292
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1244
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear distribution protein nudE-like 1; protein Nudel;
                     nuclear disribution gene E like; nuclear distribution gene
                     E-like homolog 1"
                     /codon_start=1
                     /product="nuclear distribution protein nudE-like 1 isoform
                     1"
                     /protein_id="NP_076157.2"
                     /db_xref="CCDS:CCDS24870.1"
                     /db_xref="GeneID:83431"
                     /db_xref="MGI:MGI:1932915"
                     /translation="MDGEDIPDFSSLKEETAYWKELSLKYKQSFQEARDELVEFQEGS
                     RELEAELEAQLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQSYKQVSVLEDDLS
                     QTRAIKEQLHKYVRELEQANDDLERAKRATIVSLEDFEQRLNQAIERNAFLESELDEK
                     ESLLVSVQRLKDEARDLRQELAVRERQQEVTRKSAPSSPTLDCEKMDSAVQASLSLPA
                     TPVGKGTENSFPSPKAIPNGFGTSPLTPSARISALNIVGDLLRKVGALESKLAACRNF
                     AKDQASRKSYVPGSVNCGVMNSNGPECPRSGRATFFHKGAVNGFDPAPPPPGLGSSRP
                     SSAPGMLPLSV"
     exon            293..446
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /inference="alignment:Splign:2.1.0"
     exon            447..595
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /inference="alignment:Splign:2.1.0"
     exon            596..732
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /inference="alignment:Splign:2.1.0"
     exon            733..906
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /inference="alignment:Splign:2.1.0"
     exon            907..998
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1150
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..2382
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1456
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
                     /note="major polyA site"
     polyA_site      2097
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
     polyA_site      2208
                     /gene="Ndel1"
                     /gene_synonym="2600006O07Rik; MITAP1; mNudE-L; mNudel;
                     NUDEL"
ORIGIN      
        1 gtgcgtcaca gaatggcctc cgacacccag ggagcccctg acgtgtcggg gaggagcccg
       61 gtgcggggat acgcggagtg gagctcaggg ctgcggaagg gagcagagct gagcggctgg
      121 gcgggcctgg ccaggccagc ggagcagaga cgtcggccga gcggcggcga acatgcgctt
      181 ttgacacatt ggcggctttc ttgatcatgg atggtgaaga tataccggat ttttcaagtt
      241 taaaggaaga aactgcttat tggaaggaac tttccttgaa gtataagcaa agcttccagg
      301 aagctcggga tgagctagtt gagttccagg aaggaagcag agagttagaa gcagagttgg
      361 aggcacagtt agtacaggct gaacaaagaa atagagacct gcaggctgat aaccaaagac
      421 tgaagtatga agtggaggcg ttaaaggaga aactagagca tcagtatgca cagagctaca
      481 agcaggtctc agtgttagaa gatgatttaa gtcagacccg ggccattaag gagcaactgc
      541 ataagtatgt gagagagctg gagcaggcca atgatgacct ggagcgagca aaaagggcaa
      601 caatagtttc actggaagac tttgaacaaa ggctaaatca ggccattgaa cgaaatgcat
      661 tcttagaaag tgagctcgat gaaaaggaat ctttgttggt ctcagtacag aggttaaagg
      721 atgaagccag agatttaagg caagaactag cagttcggga acgacaacag gaagtgaccc
      781 gcaagtctgc ccccagctct ccaactctgg actgtgagaa gatggattct gcggtccagg
      841 cttcactctc cttgcctgca acgcctgttg ggaaaggcac agaaaacagt tttccttcac
      901 caaaagctat accaaacggc tttggaacca gtccactaac tccttctgct aggatatcag
      961 cactaaacat cgtgggagat ctcttgcgga aagtaggggc tttagaatcc aagttagccg
     1021 cttgcaggaa ctttgcaaaa gaccaagcat cccgcaaatc ttatgttcca gggagcgtta
     1081 actgtggggt aatgaacagc aatggcccag agtgcccaag gtcagggcga gcaactttct
     1141 tccataaagg ggcagtaaat ggctttgatc cagctcctcc tcctcctggg ctgggctcct
     1201 cacgcccatc gtcagcaccg ggtatgctgc ctctcagtgt gtgagtgccc ggcctccagg
     1261 tggggcccct gccctcttcc agcagcccag gacacctacg cctcgtccct cggtgcctgg
     1321 gtccagccct gtgcccctct gtccgcctct tcaccgctgg cagagggcag gctgcatgca
     1381 gtggcggctg ctgggccctg cccagcccca ggactctgcg cgatatcaat actggctatt
     1441 ttctcttctc gccgtagtgc cgttggtttc acatgattgc acttttgtgg gtcacaagtg
     1501 atacatacgt gtattactcg atcactggat gtggaagtac ccattcatca catctgcctc
     1561 atagccccca tctttgctgt gctgatagga tttagttgtg tttaggacat tgcagatctt
     1621 ctagaagttt cccctcaatc aggttgataa gaccttctaa gcttctgcca agcatcttca
     1681 gtgctcacaa tcatgtgtcc cctagcctca cccctgcagt tcaggcctgt ttctgtcaga
     1741 gtcaggaaca tctctgaatt atggaacatt gtctgtacct tctgacttta tgtaagcagt
     1801 ccattccatt gcttgtttct caaagcagcg agatacctgt ctgagctgca ggaggcaggg
     1861 gcagccggga catgggcact tcagggccga gcctctgtgt tgccttctcc tctgtcctca
     1921 gactcaggag gcaggtggca atctcctcgc cagcattcca ggccctcagt tcaatgacat
     1981 ctctcagagc atttttgttt tctcctctga aggtccatcc agttgcattg ggaagggttg
     2041 aggggcctga ttctggggct ggctaatgcc agctctcggg ggcagactgg ctaggtgttt
     2101 gtcccttgca ccctatgatt attctcatgc tgcacttact gtttacattt gttttattgt
     2161 acataggttt gtaaacatta ttgcctaaga tatttgtata taacttgggc tttgtagctt
     2221 ttatttattc agactcatat ggcatgttaa ttaatgactt acgatggtgt cctactctgg
     2281 gcagctgtat aggatcatca tgtggttaaa agaagatact tccctccaaa aaaaaatctt
     2341 ttaatgtgga aacaataaat ttcacagaaa aaaaaaaaaa aa
//
