LOCUS       NM_023317               2306 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus nudE neurodevelopment protein 1 (Nde1), transcript
            variant a, mRNA.
ACCESSION   NM_023317
VERSION     NM_023317.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Chomiak,A.A., Guo,Y., Kopsidas,C.A., McDaniel,D.P., Lowe,C.C.,
            Pan,H., Zhou,X., Zhou,Q., Doughty,M.L. and Feng,Y.
  TITLE     Nde1 is required for heterochromatin compaction and stability in
            neocortical neurons
  JOURNAL   iScience 25 (6), 104354 (2022)
   PUBMED   35601919
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Das,B.K., Gogoi,J., Kannan,A., Gao,L., Xing,W., Mohan,S. and
            Zhao,H.
  TITLE     The Cytoplasmic Dynein Associated Protein NDE1 Regulates
            Osteoclastogenesis by Modulating M-CSF and RANKL Signaling Pathways
  JOURNAL   Cells 11 (1), 13 (2021)
   PUBMED   35011575
  REMARK    GeneRIF: The Cytoplasmic Dynein Associated Protein NDE1 Regulates
            Osteoclastogenesis by Modulating M-CSF and RANKL Signaling
            Pathways.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   Petsouki,E., Gerakopoulos,V., Szeto,N., Chang,W., Humphrey,M.B. and
            Tsiokas,L.
  TITLE     FBW7 couples structural integrity with functional output of primary
            cilia
  JOURNAL   Commun Biol 4 (1), 1066 (2021)
   PUBMED   34518642
  REMARK    GeneRIF: FBW7 couples structural integrity with functional output
            of primary cilia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Telley,L., Agirman,G., Prados,J., Amberg,N., Fievre,S., Oberst,P.,
            Bartolini,G., Vitali,I., Cadilhac,C., Hippenmeyer,S., Nguyen,L.,
            Dayer,A. and Jabaudon,D.
  TITLE     Temporal patterning of apical progenitors and their daughter
            neurons in the developing neocortex
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073041
REFERENCE   6  (bases 1 to 2306)
  AUTHORS   Feng,Y. and Walsh,C.A.
  TITLE     Mitotic spindle regulation by Nde1 controls cerebral cortical size
  JOURNAL   Neuron 44 (2), 279-293 (2004)
   PUBMED   15473967
  REMARK    GeneRIF: Nde1 is essential for centrosome duplication and mitotic
            spindle assembly.
REFERENCE   7  (bases 1 to 2306)
  AUTHORS   Cahana,A., Jin,X.L., Reiner,O., Wynshaw-Boris,A. and O'Neill,C.
  TITLE     A study of the nature of embryonic lethality in LIS1-/- mice
  JOURNAL   Mol Reprod Dev 66 (2), 134-142 (2003)
   PUBMED   12950100
REFERENCE   8  (bases 1 to 2306)
  AUTHORS   Toyo-oka,K., Shionoya,A., Gambello,M.J., Cardoso,C., Leventer,R.,
            Ward,H.L., Ayala,R., Tsai,L.H., Dobyns,W., Ledbetter,D.,
            Hirotsune,S. and Wynshaw-Boris,A.
  TITLE     14-3-3epsilon is important for neuronal migration by binding to
            NUDEL: a molecular explanation for Miller-Dieker syndrome
  JOURNAL   Nat Genet 34 (3), 274-285 (2003)
   PUBMED   12796778
REFERENCE   9  (bases 1 to 2306)
  AUTHORS   Sasaki,S., Shionoya,A., Ishida,M., Gambello,M.J., Yingling,J.,
            Wynshaw-Boris,A. and Hirotsune,S.
  TITLE     A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the
            developing and adult nervous system
  JOURNAL   Neuron 28 (3), 681-696 (2000)
   PUBMED   11163259
REFERENCE   10 (bases 1 to 2306)
  AUTHORS   Feng,Y., Olson,E.C., Stukenberg,P.T., Flanagan,L.A., Kirschner,M.W.
            and Walsh,C.A.
  TITLE     LIS1 regulates CNS lamination by interacting with mNudE, a central
            component of the centrosome
  JOURNAL   Neuron 28 (3), 665-679 (2000)
   PUBMED   11163258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY308148.1, AK012830.1 and AF322073.1.
            
            On Jan 29, 2008 this sequence version replaced NM_023317.1.
            
            Transcript Variant: This variant (a) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.162288.1, AK037289.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                BY308148.1         2-72
            72-2204             AK012830.1         2-2134
            2205-2306           AF322073.1         2111-2212
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 9.7 cM"
     gene            1..2306
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /note="nudE neurodevelopment protein 1"
                     /db_xref="GeneID:67203"
                     /db_xref="MGI:MGI:1914453"
     exon            1..94
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            95..218
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1170
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /note="isoform a is encoded by transcript variant a;
                     nuclear distribution protein nudE homolog 1; nuclear
                     distribution gene E homolog 1"
                     /codon_start=1
                     /product="nuclear distribution protein nudE homolog 1
                     isoform a"
                     /protein_id="NP_075806.2"
                     /db_xref="CCDS:CCDS37263.2"
                     /db_xref="GeneID:67203"
                     /db_xref="MGI:MGI:1914453"
                     /translation="MEDSGKTFESEEEETNYWRDLAMTYKQRAENTQEELREFQEGSR
                     EYEAELEAQLQQIETRNRDLLSENNRLRMELESVKEKFEMQHSEGYRQISALEDDLAQ
                     TKAIKDQLQKYIRELEQANDDLERAKRATIMSLEDFEQRLNQAIERNAFLESELDEKE
                     NLLESVQRLKDEARDLRQELAVQQKQDKPRTPMPGSGQAKRTDMAVQATGSVPSTPVA
                     HRGPSSGLNTPGMFRRGLDSSTSGTPLTPAARISALNIVGDLLRKVGALESKLASCRN
                     FMYDQSPSRTSGPASGRGTKNRDGVDRRPGSTSVGDKGSGKRLEFGKPASEPASPALP
                     SAQGVVKLLL"
     exon            219..372
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            373..521
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            522..658
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            659..838
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            839..930
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1076
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..2287
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /note="hexamer: AATAAT"
     polyA_site      2287
                     /gene="Nde1"
                     /gene_synonym="2810027M15Rik; mNudE; Nude"
                     /note="major polyA site"
ORIGIN      
        1 atgggaggcg cgcaccgcgc agtaccggcg aggctggagg gcaagaaagg cctgccggcc
       61 cgcgcctcgc tggaatcgtc gccgcccggg ctggacatca tgccacagga agagtgagct
      121 tttgcccatt ttaccatgga ggactcggga aagacctttg aatcagagga ggaagaaaca
      181 aactattgga gagacctggc catgacctac aaacagaggg cagagaatac tcaggaagaa
      241 ctcagagagt tccaggaagg aagccgagaa tacgaagctg aattggaggc tcagctgcag
      301 cagattgaaa ccaggaaccg ggacctcttg tcagagaata accgccttcg catggagctg
      361 gagtctgtga aggagaagtt tgagatgcag cactcagagg gttaccggca gatctcagcc
      421 ttggaggatg acctggcgca gacgaaagcc attaaagacc aactgcagaa atacattagg
      481 gaactggaac aagccaatga tgacctggaa agagccaaac gagccacaat catgtccctg
      541 gaagactttg agcagcgttt gaatcaagcc attgaaagaa atgccttcct agagagtgag
      601 ctggatgaga aggagaatct tctagaatct gtgcagaggc tgaaggatga agcccgagat
      661 ctgcggcagg aattggctgt gcaacagaag caagacaagc cccggacacc catgccaggc
      721 tcagggcaag ccaagaggac agacatggct gtgcaggcca caggctctgt accgtctact
      781 ccagtagctc accgaggacc tagctctggt ttgaacacac caggaatgtt cagacgtggt
      841 ctggacagct ccactagtgg gacgccactc acacctgcag cccggatatc agccctaaac
      901 atcgttgggg acctgcttcg gaaagttggg gccctggagt ccaagctagc atcatgcagg
      961 aacttcatgt atgatcagtc cccaagccgg acaagtgggc cagcctcagg acgaggaacc
     1021 aaaaacagag atggtgttga cagaaggcca ggcagtacca gtgtgggcga taaagggtca
     1081 ggaaaacgct tggagtttgg gaagccagcc tcagagccag catcaccagc gctaccatcc
     1141 gcccagggtg tggtcaagct tttgctttag gaccaatgag aactgcgccc tcccctgtct
     1201 tccttacttt atagtcggct tttagtcgct ttattttcaa ggtagtttga gaaataagag
     1261 ccagtatcac cagcgttcac tttgtgccgt gtagcctaaa ctgactacgg ctggtggtgg
     1321 tggccttggc atcatccctg tgatgtggct cagtccctag cagtgtgtgt catggaaatg
     1381 agctcacaca cacacagaca ccccgcacaa ggcagctcta acgtatgatg ccactggctt
     1441 cctagagttt taatggcctc cagaggtgtt ttgctcagga gctctctgca gcctgcttcc
     1501 agctgaagct gtcttctgga acattctcct ggtgctttta cagcatgatc aaattgtatc
     1561 taggactggg agattacaga ggcaaaaaaa ggctttatta aactatggtc atgtaccttt
     1621 gacactttaa cgctgtctgc ctcttaagtc agtgggagac tatcctctat cgataaaccc
     1681 tgactcctgt ttttcttgag atcccttccc tgatgttggg gtggcatgtg catcaagaca
     1741 ctggacaact tgcgttgcac tggcctttgt tacatcatcc ctaagaacag aacttcatcc
     1801 agccagctgg gcttcattca gacaccatag agcaaccagg gtggtaaagc cggagatgga
     1861 gctcaccgcc agacgcgccc tcgggatgtg gaaagaccag cacaggctct gcaaatgcca
     1921 gctcgtctct catctctggg gtgtagcgct gccccacact tcagtgcaca atgagaaaag
     1981 cacactaata ccagagcttg gcacccttca ctggctacta acttattttc tagttgatgg
     2041 gtaaaactgg cctagagttg gacctagaac ttttcgtgtg ctactgacat tacaaggtga
     2101 ttttaagctg ctggctattt gttctcctta gacataataa cctggggaaa gatggacttt
     2161 attttttata agaaataaaa taaaaccaaa agaaatccct gctcaataga tgtgcgtcct
     2221 ttcatgtctg tgcacagggc catgaagttt gtttttaacc aagtaataaa ataattgaac
     2281 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
