LOCUS       NM_028355               4321 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus NDC1 transmembrane nucleoporin (Ndc1), transcript
            variant 1, mRNA.
ACCESSION   NM_028355
VERSION     NM_028355.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4321)
  AUTHORS   Lai,T.H., Wu,Y.Y., Wang,Y.Y., Chen,M.F., Wang,P., Chen,T.M.,
            Wu,Y.N., Chiang,H.S., Kuo,P.L. and Lin,Y.H.
  TITLE     SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis
  JOURNAL   Int J Mol Sci 17 (11), 1911 (2016)
   PUBMED   27854341
  REMARK    GeneRIF: In mice sperm with mutated SEPT12, NDC1 dispersed around
            the manchette region of the sperm head and annulus, compared with
            concentrating at the sperm neck of wild-type sperm.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4321)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   3  (bases 1 to 4321)
  AUTHORS   Fairfield,H., Srivastava,A., Ananda,G., Liu,R., Kircher,M.,
            Lakshminarayana,A., Harris,B.S., Karst,S.Y., Dionne,L.A.,
            Kane,C.C., Curtain,M., Berry,M.L., Ward-Bailey,P.F., Greenstein,I.,
            Byers,C., Czechanski,A., Sharp,J., Palmer,K., Gudis,P., Martin,W.,
            Tadenev,A., Bogdanik,L., Pratt,C.H., Chang,B., Schroeder,D.G.,
            Cox,G.A., Cliften,P., Milbrandt,J., Murray,S., Burgess,R.,
            Bergstrom,D.E., Donahue,L.R., Hamamy,H., Masri,A., Santoni,F.A.,
            Makrythanasis,P., Antonarakis,S.E., Shendure,J. and Reinholdt,L.G.
  TITLE     Exome sequencing reveals pathogenic mutations in 91 strains of mice
            with Mendelian disorders
  JOURNAL   Genome Res 25 (7), 948-957 (2015)
   PUBMED   25917818
REFERENCE   4  (bases 1 to 4321)
  AUTHORS   Akiyama,K., Noguchi,J., Hirose,M., Kajita,S., Katayama,K.,
            Khalaj,M., Tsuji,T., Fairfield,H., Byers,C., Reinholdt,L., Ogura,A.
            and Kunieda,T.
  TITLE     A mutation in the nuclear pore complex gene Tmem48 causes
            gametogenesis defects in skeletal fusions with sterility (sks) mice
  JOURNAL   J Biol Chem 288 (44), 31830-31841 (2013)
   PUBMED   24045954
  REMARK    GeneRIF: A mutation in the nuclear pore complex gene Tmem48 causes
            gametogenesis defects in skeletal fusions with sterility (sks)
            mice.
REFERENCE   5  (bases 1 to 4321)
  AUTHORS   Hutchins,J.R., Toyoda,Y., Hegemann,B., Poser,I., Heriche,J.K.,
            Sykora,M.M., Augsburg,M., Hudecz,O., Buschhorn,B.A., Bulkescher,J.,
            Conrad,C., Comartin,D., Schleiffer,A., Sarov,M., Pozniakovsky,A.,
            Slabicki,M.M., Schloissnig,S., Steinmacher,I., Leuschner,M.,
            Ssykor,A., Lawo,S., Pelletier,L., Stark,H., Nasmyth,K.,
            Ellenberg,J., Durbin,R., Buchholz,F., Mechtler,K., Hyman,A.A. and
            Peters,J.M.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   6  (bases 1 to 4321)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   7  (bases 1 to 4321)
  AUTHORS   Stavru,F., Hulsmann,B.B., Spang,A., Hartmann,E., Cordes,V.C. and
            Gorlich,D.
  TITLE     NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear
            pore complexes
  JOURNAL   J Cell Biol 173 (4), 509-519 (2006)
   PUBMED   16702233
REFERENCE   8  (bases 1 to 4321)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   9  (bases 1 to 4321)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4321)
  AUTHORS   Handel,M.A., Lane,P.W., Schroeder,A.C. and Davisson,M.T.
  TITLE     New mutation causing sterility in the mouse
  JOURNAL   Gamete Res 21 (4), 409-423 (1988)
   PUBMED   3220432
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL626784.11.
            
            On Dec 13, 2019 this sequence version replaced NM_028355.3.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144734.1, BC021337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AL626784.11        50263-50364
            103-223             AL626784.11        50973-51093
            224-325             AL626784.11        53478-53579
            326-500             AL626784.11        56363-56537
            501-639             AL626784.11        57294-57432
            640-748             AL626784.11        62814-62922
            749-800             AL626784.11        63892-63943
            801-936             AL626784.11        65801-65936
            937-1029            AL626784.11        67002-67094
            1030-1111           AL626784.11        68812-68893
            1112-1267           AL626784.11        71667-71822
            1268-1507           AL626784.11        72438-72677
            1508-1623           AL626784.11        72765-72880
            1624-1674           AL626784.11        75359-75409
            1675-1738           AL626784.11        77214-77277
            1739-1839           AL626784.11        77948-78048
            1840-2000           AL626784.11        93282-93442
            2001-4321           AL626784.11        96242-98562
FEATURES             Location/Qualifiers
     source          1..4321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.18 cM"
     gene            1..4321
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /note="NDC1 transmembrane nucleoporin"
                     /db_xref="GeneID:72787"
                     /db_xref="MGI:MGI:1920037"
     exon            1..102
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2064
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /note="transmembrane protein 48"
                     /codon_start=1
                     /product="nucleoporin NDC1"
                     /protein_id="NP_082631.1"
                     /db_xref="CCDS:CCDS18438.1"
                     /db_xref="GeneID:72787"
                     /db_xref="MGI:MGI:1920037"
                     /translation="MATAASGPCAGGSPRDILWRVLGWRIVTSIVWSVVLLPVCITAF
                     IVLSSINLFHPIQWLSDSCNDFYSSQVIFHLLLLAVVIIIISIFNVEFYTVVPSISGS
                     RLALIARILHPQQLTHSFIHAAMGMAVAWCAAIMTKGQYSSLVVPCTGTESLDSPAAQ
                     TCLNEYHLFFLLSGAFMGYSYSLLYFINNMNYLPFPIIQQYKFLRFRRSLLLLVKHSC
                     VESLFMVRNFCIVYYFFGHIPKAWISTALDLHTDEQAHRPLDTIGGLLNVSLLYHVWL
                     CGVFLLVTWYSSWILFKIYATEAHVFPVQPPFAEASDECLPKVLNSNPPRIVKYLALQ
                     DLMLLSQYSPSRRQEVFSLSQPGGHPHNWTAISRECLNLLNDMTQKLVLYQEAAATNG
                     RMYSSYSVEPKKLSSAEETAFQTPKPSQTPSVPPLVKTSLFSPKLSTPNVSSPFGTPF
                     GSSVVNRMAGILDVNPFSGSPQSPQLIRRGPRLWTHTSDQQVSAISNPSPCASVTAEG
                     KTVRQPSVIYSWIQNKREQIKNFLSKRVLIMYFFSKHPEASIQAVFSDAQMHIWALEG
                     LSHLVAASFTEDRFGVVQTTLPAILHTLLTLQEAVDKYFKLPHASSKPPRASGSLVDT
                     SYKTLRFAFRASLKTAIYRITTTFGEHLNAVQASAEHQKRLQQFLEFKE"
     exon            103..223
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            224..325
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            326..500
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            501..639
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            640..748
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            749..800
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            801..936
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1029
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1111
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1267
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1507
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1623
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1674
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1738
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1839
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2000
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..4321
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /note="hexamer: AATAAA"
     polyA_site      2314
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /note="major polyA site"
     regulatory      4284..4289
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /note="hexamer: AATAAA"
     polyA_site      4321
                     /gene="Ndc1"
                     /gene_synonym="2810475A17Rik; sks; Tmem48"
                     /note="major polyA site"
ORIGIN      
        1 actctgtccc cggcacgctt gagagcgggg gccgccatct ccatggccac ggctgcgagc
       61 gggccctgcg ccggcgggtc gccgcgggac atcctttggc gcgttttggg ttggaggata
      121 gttaccagca tcgtttggtc agtagtgctt ctacccgtct gcatcacagc ctttatagtc
      181 ttaagcagca tcaatttatt ccaccctata cagtggctgt cagattcttg caatgacttc
      241 tatagttccc aagtcatctt tcacctcctg ctgctggccg tggtcattat aataataagt
      301 attttcaatg tggaattcta tacagttgtg ccctccatat ccggctccag actggccctg
      361 atagcgcgga tcctgcatcc ccagcagctc acgcactcct tcatccacgc cgcgatggga
      421 atggctgtgg cttggtgtgc ggccatcatg accaagggcc agtacagctc tctcgtggtt
      481 ccctgcactg gaactgagag cttagatagc cctgctgctc agacctgctt gaatgaatat
      541 catctgtttt tcctactgtc cggagcattc atgggctata gctatagtct tctgtatttc
      601 attaacaaca tgaattatct cccgtttcct attatacagc agtacaaatt tttgcgtttc
      661 cggagatctc tcctcttact agttaaacat agctgtgtgg aatccctgtt catggtcaga
      721 aatttctgca ttgtgtatta tttttttggc catattccca aagcatggat tagcactgct
      781 ctggaccttc acacagatga gcaggctcac aggcctcttg acacgatagg cggtctcctg
      841 aacgtctcat tactctacca cgtctggctg tgtggcgtct tcctcttggt gacttggtat
      901 agctcatgga tactcttcaa aatctatgcc accgaggcgc atgtgttccc tgttcagccg
      961 ccttttgcag aagcctcaga tgaatgcctt cctaaagtct taaacagcaa ccccccacgc
     1021 atcgtaaagt atttggcctt acaggacctg atgctgcttt ctcaatattc tccttctcgg
     1081 aggcaagaag ttttcagtct cagccaacca ggtggacatc cccacaattg gactgctatt
     1141 tcgagggagt gtttgaatct tttaaatgat atgactcaga aactggttct ctaccaagaa
     1201 gctgctgcta caaatgggag gatgtattca tcatactcag tggaacccaa gaaactgagc
     1261 tctgcagaag aaactgcttt tcagactcca aaacctagtc agacgccttc cgtgccgccg
     1321 ttagttaaaa cttcactgtt ttctccaaaa ttatctacac ccaatgtttc aagtcctttt
     1381 gggaccccgt ttggctccag cgtagtgaac cgaatggctg gaattcttga tgtaaacccc
     1441 ttctctgggt ctccccaaag tcctcagctc ataagaagag gaccgaggct gtggactcac
     1501 acttctgatc aacaagtgtc tgcaatttct aacccatctc cttgcgcctc tgttactgct
     1561 gagggtaaga cagtgagaca gcccagtgtg atctactcgt ggattcagaa taaacgagaa
     1621 cagattaaga atttcttgtc aaaacgggtg ctgataatgt actttttcag taagcaccca
     1681 gaggcctcca ttcaggctgt tttttcagat gcccaaatgc atatttgggc tttagaaggt
     1741 ctgtctcact tagtagcagc gtcatttaca gaagatagat ttggagttgt ccagaccaca
     1801 ctcccagcta tccttcatac gctgttgact ctgcaggagg ctgtcgacaa gtacttcaag
     1861 ctgcctcatg cttctagtaa accaccccga gcttcaggaa gccttgtgga cacgtcctac
     1921 aaaacattga gatttgcttt cagggcctcc ctgaaaaccg ctatctaccg tataaccacc
     1981 acgtttggtg aacatctgaa cgctgtgcag gcatctgcag aacatcagaa aagacttcag
     2041 caattcttgg agttcaaaga atagtgaagt aatataaact gtgttcatta ccctgctgat
     2101 acaactacag atgggacagt aaatgttgag cattcttgga tcagaagaga gcggactaat
     2161 tagacgcttc ctttgtcgtg gtgcttgctt tgaaaactat actttaatgg gagaaatcat
     2221 ggaaagaaat tctcagcaga ataaccgaaa actgcctttt ctgtacccag tgctttttgt
     2281 gtgtgtggta taataaaatc tttattcagt tttacaggag cgtctatggc agccgaactg
     2341 tctcttgctc atataacttg ataatgatta ttcacaattg tttgtagaat ttacttttga
     2401 aaagagtgga gccagctcag aagttaaagc aggtggtctt tcccagctgc tctaagaggt
     2461 tagctctttg taaactctca aaatacataa acttaagatt agtttgttta ctaaaggata
     2521 aaaatggtaa cggtggagaa aaactcacag taaaaatgtt gtctacagga catattttgt
     2581 taatctgtta ggttgtgttt ttgtttccag ggacaaatta aatttgcatg attgtccaaa
     2641 aagagtctcg atttacagat gttaactcta tataaaggaa tgtagaaaaa ttgaaatctt
     2701 aaggtacacg actaagcatt cacattcggg tagagcaacg tctctgagtt cactgtgtga
     2761 tgctagtgga ggatgagggc atcttgtttc ctagccaggc ttgcttgctt ttttgaaata
     2821 acattaaaca gttggcagag gttttcaaat gaggggaaaa ggagacctgg aaacttccct
     2881 ttccctacgg tttgtcttta ccaggtcaaa ttatgttgtg agtctagtct gtcttcacat
     2941 gggagcagcc tctgctgtgc taactggcta ataaaaacac agtaggccaa gctttagagc
     3001 caaaagcaca tagtcatcag ataggcaggt gaatgtcaga ggctctccgc aggagcgggt
     3061 acgccccgga tgtactgtac aggcggtcat tttatgactt atgagatcat ttctttggag
     3121 atgaaacatg ggaggtcctg ctggcagata ttcattggac cagctttggg ccaaatcctc
     3181 ctttataaat ccttttctgt tatctttttc tttaaagtca gcacagtatt gtatatgagt
     3241 cttaaatgtg atgtgtatgc ctagcctttg tcggcttcat taatgtatta catctttaca
     3301 gtagtgtatt ttagccccag atctactgcc cattcaacca gcacatggca aattataaac
     3361 gaatcccgct agccttaaaa atgtctctat gggacaattc ctcaccttaa ttgttaagtt
     3421 ttgggtcttt taagtcccct ctctaccttg tgtgtgaagt tctcttgatg tgttgtgaaa
     3481 gttgggtttc cagtgtgttg gtttcttcag atactcagag gagcctggct agataacaga
     3541 attaaagcca taggcctttt gtgtttgctg gctgcctctg actgaagcat ttcgggagac
     3601 aaatctaaat gttgtgtttc cataaagaac tgtggcatgt gtgtagctca ctaaagagag
     3661 cattcatttt aacttggact tactcctgtg aaatgtctgg tccagtttag gttcttgcct
     3721 ttcccacttc ctctgggtga aagtatattt gatagaaata tgaatctttc tggatgttct
     3781 gtgtctgagg tattgaccac accatgtctg cctgctgggg agcaggacac tgccatcccc
     3841 tcagacctgt acagtccctg gaaggtgagg ggtcattctt tttctccatt gtatattggt
     3901 gggcactctt tttttttaaa ggcacctttc ctcccgcatg caacgaggac ttgagggagg
     3961 ccagcaggag agaagcgttg gctttggtga agttgcagcc tgctgacgtg atggcctgaa
     4021 gttagccttc acaagccttt gtccctgtta gtaacaccat gctccgagcc cctctgtgtg
     4081 tgtctctagt gggacataca aagccacagg ctgcttgtgc agagtgacgg gacactcacc
     4141 cttatcctgg tgagtaggca tggagaagtc ccactcgttc ctgtgcttgg tttcttcagc
     4201 agtgttttgt atgtcttcct gttagtattt atggcagtct gcttatatcc ttctgtatat
     4261 catcagtact gaattggtag aaaaataaag tgacaattcc taactgagac tgttcatcaa
     4321 a
//
