LOCUS       XM_006496952            2771 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  PREDICTED: Mus musculus nicastrin (Ncstn), transcript variant X1,
            mRNA.
ACCESSION   XM_006496952
VERSION     XM_006496952.4
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000067.7) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Aug 8, 2019 this sequence version replaced XM_006496952.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2771
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="1"
     gene            1..2771
                     /gene="Ncstn"
                     /gene_synonym="9430068N19Rik; Aph2; D1Dau13e; Kiaa0253;
                     mKIAA0253; Nct"
                     /note="nicastrin; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 46 ESTs, 430 long SRA
                     reads, 1 Protein, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 28 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:59287"
                     /db_xref="MGI:MGI:1891700"
     CDS             94..2193
                     /gene="Ncstn"
                     /gene_synonym="9430068N19Rik; Aph2; D1Dau13e; Kiaa0253;
                     mKIAA0253; Nct"
                     /codon_start=1
                     /product="nicastrin isoform X1"
                     /protein_id="XP_006497015.1"
                     /db_xref="GeneID:59287"
                     /db_xref="MGI:MGI:1891700"
                     /translation="MPRSLFKAQPPHQPSKGTGLCGGNSVERKIYIPLNKTAPCVRLL
                     NATHQIGCQSSISGDTGVIHVVEKEEDLKWVLTDGPNPPYMVLLEGKLFTRDVMEKLK
                     GTTSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLWNELGNG
                     LAYEDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHAVISTA
                     TCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSVGLEPDVRVVVAATRLDSRS
                     FFWNVAPGAESAVASFVTQLAAAEALHKAPDVTTLSRNVMFVFFQGETFDYIGSSRMV
                     YDMENGKFPVRLENIDSFVELGQVALRTSLDLWMHTDPMSQKNESVKNQVEDLLATLE
                     KSGAGVPEVVLRRLAQSQALPPSSLQRFLRARNISGVVLADHSGSFHNRYYQSIYDTA
                     ENINVTYPEWQSPEEDLNFVTDTAKALANVATVLARALYELAGGTNFSSSIQADPQTV
                     TRLLYGFLVRANNSWFQSILKHDLRSYLDDRPLQHYIAVSSPTNTTYVVQYALANLTG
                     KATNLTREQCQDPSKVPNESKDLYEYSWVQGPWNSNRTERLPQCVRSTVRLARALSPA
                     FELSQWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSTLVFSLIVTYCINA
                     KADVLFVAPREPGAVSY"
ORIGIN      
        1 acataagttc ctcctttgcc tggacctgca tttccttagt tctctccagc ccttttctgg
       61 gtttccagcc tgattctctt caacctttct cgcatgcctc gttctctgtt taaagcccag
      121 ccaccccatc agccatcaaa agggacagga ttgtgtgggg gaaactcagt ggagaggaaa
      181 atctacattc ccttaaataa aacagctcct tgtgtccgcc tgctcaacgc cactcatcag
      241 attggctgcc agtcttcaat tagtggggat acaggggtta tccatgtagt ggagaaagaa
      301 gaagacctga agtgggtgtt gaccgatggc cccaaccccc cttacatggt tctgctggag
      361 ggcaagctct tcaccagaga tgtaatggag aagctgaagg gaacaaccag tagaatcgct
      421 ggtcttgccg tgactctagc caagcccaac tcaacttcaa gcttctctcc tagtgtgcag
      481 tgcccaaatg atgggtttgg tatttactcc aactcctacg ggccagagtt tgctcactgc
      541 aagaaaacac tgtggaatga actgggcaac ggcttggctt atgaagactt tagtttcccc
      601 atctttcttc ttgaagatga gaacgaaacc aaggtcatca agcagtgcta tcaagatcac
      661 aacctgggtc agaatggctc tgcaccaagc ttcccattgt gtgctatgca gctcttctca
      721 cacatgcacg ccgtcatcag cactgccacc tgcatgcggc gcagcttcat ccagagcacc
      781 ttcagcatca acccagaaat cgtctgtgac cccttatccg actacaacgt atggagcatg
      841 cttaagccta taaatacatc tgtgggacta gaacctgacg tcagggttgt ggttgcggcc
      901 acacggctgg atagccggtc ctttttctgg aatgtggccc caggggctga aagtgctgta
      961 gcctcctttg tcactcagct ggctgcagct gaagctttgc acaaggcacc tgatgtgacc
     1021 actctatccc gaaatgtgat gtttgtcttc ttccaggggg aaacttttga ctacattggc
     1081 agctcacgga tggtctatga tatggagaac ggcaagtttc ccgtgcggct cgagaacatt
     1141 gactccttcg tggagctggg acaggtggcc ctaagaactt cactagatct ctggatgcac
     1201 acagatccca tgtctcagaa aaatgagtct gtgaaaaacc aggtggagga tcttctggcc
     1261 actctggaga agagcggtgc tggtgtccct gaagttgtcc tgaggagact ggcccagtcc
     1321 caggcccttc caccttcgtc tctacaacga tttcttcggg ctcgaaacat ctctggcgtg
     1381 gtcctggctg accactctgg ctccttccac aatcggtatt accagagcat ttatgacacg
     1441 gctgagaaca ttaatgtgac ctatcctgag tggcagagcc cagaagagga cctcaacttt
     1501 gtgacagaca ctgccaaggc actggcgaat gtggccacag tgctggcgcg tgcactgtat
     1561 gagcttgcag gaggaaccaa cttcagcagc tccatccagg ctgatcccca gacagttaca
     1621 cgtctgctct atgggttcct ggttagagct aacaactcat ggtttcagtc gatcttgaaa
     1681 catgacctaa ggtcctattt ggatgacagg cctcttcaac actacatcgc cgtctccagc
     1741 cctaccaaca cgacttacgt tgtgcagtac gccttggcaa acctgactgg caaggcgacc
     1801 aacctcaccc gagagcagtg ccaggatcca agtaaagtcc caaatgagag caaggattta
     1861 tatgaatact cgtgggtaca aggcccttgg aattccaaca ggacagagag gctcccacag
     1921 tgtgtgcgct ccacagtgcg actggccagg gccttgtccc ctgcctttga actgagtcag
     1981 tggagctcca cagaatactc tacgtgggcg gagagccgct ggaaagacat ccaagctcgg
     2041 atattcctaa ttgccagcaa agagcttgag ttcatcacgc tgatcgtggg cttcagcacc
     2101 cttgtcttct ccctcatcgt cacctactgc atcaatgcca aagccgacgt ccttttcgtt
     2161 gctccccgag agccaggagc tgtgtcttac tgaagaggac tctagctctc cctgcctgct
     2221 ctgaacttta cttcccagac caggtgtccg gctgggaaca aaccactaat ttgtcactgg
     2281 actgtctctg ggcctgctta gacggggatt gacacacaga atggaactgt gagtggagag
     2341 atgaataagt tgccccccca gccccccttc ccatttgttt ctccttctct aatcccaggg
     2401 actatggtag agacttgctg ctcctaactc cccagttacc caccctcctc tgccctttct
     2461 cgggatacct tctgtccttc catcctgccc tgtactgccc tctgactcca ctgtcacccg
     2521 acacccctcc cccatattca gccacctgct gcaccaggaa gagggtgtga aagattgtgc
     2581 atctgcattc aactaccctg aacccttagg gaagaaatgg attccctggc tgagccagtg
     2641 tctctttccc actgtccttt ctccaggtgt gcagatggca tgttagtgtg ggcacgctgt
     2701 taagtgggta tcccacctcc agcccacagt gctcagttgt actttttatt attaaactat
     2761 aattatctat t
//
