LOCUS       NM_019681               4036 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus neuronal calcium sensor 1 (Ncs1), mRNA.
ACCESSION   NM_019681
VERSION     NM_019681.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4036)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4036)
  AUTHORS   Fischer,T.T., Nguyen,L.D. and Ehrlich,B.E.
  TITLE     Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal
            morphology and development
  JOURNAL   FASEB J 35 (10), e21873 (2021)
   PUBMED   34499766
  REMARK    GeneRIF: Neuronal calcium sensor 1 (NCS1) dependent modulation of
            neuronal morphology and development.
REFERENCE   3  (bases 1 to 4036)
  AUTHORS   Sah,R.K., Ma,J., Bah,F.B., Xing,Z., Adlat,S., Oo,Z.M., Wang,Y.,
            Bahadar,N., Bohio,A.A., Nagi,F.H., Feng,X., Zhang,L. and Zheng,Y.
  TITLE     Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung
            Development and Prenatal Lethality
  JOURNAL   Int J Mol Sci 21 (21), 8223 (2020)
   PUBMED   33153107
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4036)
  AUTHORS   Magno,L.A.V., Tenza-Ferrer,H., Collodetti,M., Nicolau,E.S.,
            Khlghatyan,J., Del'Guidice,T., Romano-Silva,M.A. and Beaulieu,J.M.
  TITLE     Contribution of neuronal calcium sensor 1 (Ncs-1) to
            anxiolytic-like and social behavior mediated by valproate and Gsk3
            inhibition
  JOURNAL   Sci Rep 10 (1), 4566 (2020)
   PUBMED   32165725
  REMARK    GeneRIF: Contribution of neuronal calcium sensor 1 (Ncs-1) to
            anxiolytic-like and social behavior mediated by valproate and Gsk3
            inhibition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4036)
  AUTHORS   Simons,C., Benkert,J., Deuter,N., Poetschke,C., Pongs,O.,
            Schneider,T., Duda,J. and Liss,B.
  TITLE     NCS-1 Deficiency Affects mRNA Levels of Genes Involved in
            Regulation of ATP Synthesis and Mitochondrial Stress in Highly
            Vulnerable Substantia nigra Dopaminergic Neurons
  JOURNAL   Front Mol Neurosci 12, 252 (2019)
   PUBMED   31827421
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4036)
  AUTHORS   Mora,S., Durham,P.L., Smith,J.R., Russo,A.F., Jeromin,A. and
            Pessin,J.E.
  TITLE     NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1
            adipocytes through a phosphatidylinositol 4-kinase-dependent
            pathway
  JOURNAL   J Biol Chem 277 (30), 27494-27500 (2002)
   PUBMED   12011096
  REMARK    GeneRIF: PI 4-kinase functions to negatively regulate GLUT4
            translocation through its interaction with NCS-1.
REFERENCE   7  (bases 1 to 4036)
  AUTHORS   Guo,W., Malin,S.A., Johns,D.C., Jeromin,A. and Nerbonne,J.M.
  TITLE     Modulation of Kv4-encoded K(+) currents in the mammalian myocardium
            by neuronal calcium sensor-1
  JOURNAL   J Biol Chem 277 (29), 26436-26443 (2002)
   PUBMED   11994284
  REMARK    GeneRIF: NCS-1 is an accessory subunit of Kv4-encoded I(to,f)
            channels that functions to regulate I(to,f) density in the
            mammalian myocardium.
REFERENCE   8  (bases 1 to 4036)
  AUTHORS   Burgoyne,R.D. and Weiss,J.L.
  TITLE     The neuronal calcium sensor family of Ca2+-binding proteins
  JOURNAL   Biochem J 353 (Pt 1), 1-12 (2001)
   PUBMED   11115393
  REMARK    Review article
            Erratum:[Biochem J 2001 Mar 15;354(Pt 3):727]
REFERENCE   9  (bases 1 to 4036)
  AUTHORS   Sage,C., Venteo,S., Jeromin,A., Roder,J. and Dechesne,C.J.
  TITLE     Distribution of frequenin in the mouse inner ear during
            development, comparison with other calcium-binding proteins and
            synaptophysin
  JOURNAL   Hear Res 150 (1-2), 70-82 (2000)
   PUBMED   11077193
REFERENCE   10 (bases 1 to 4036)
  AUTHORS   Olafsson,P., Soares,H.D., Herzog,K.H., Wang,T., Morgan,J.I. and
            Lu,B.
  TITLE     The Ca2+ binding protein, frequenin is a nervous system-specific
            protein in mouse preferentially localized in neurites
  JOURNAL   Brain Res Mol Brain Res 44 (1), 73-82 (1997)
   PUBMED   9030700
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL732572.10.
            
            On Nov 17, 2006 this sequence version replaced NM_019681.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059825.1, SRR10662772.3087590.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AL732572.10        103027-103346
            321-345             AL732572.10        127716-127740
            346-484             AL732572.10        137770-137908
            485-563             AL732572.10        139413-139491
            564-652             AL732572.10        141251-141339
            653-730             AL732572.10        141766-141843
            731-847             AL732572.10        144391-144507
            848-4036            AL732572.10        149388-152576
FEATURES             Location/Qualifiers
     source          1..4036
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.81 cM"
     gene            1..4036
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /note="neuronal calcium sensor 1"
                     /db_xref="GeneID:14299"
                     /db_xref="MGI:MGI:109166"
     exon            1..320
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..829
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /note="frequenin homolog"
                     /codon_start=1
                     /product="neuronal calcium sensor 1"
                     /protein_id="NP_062655.1"
                     /db_xref="CCDS:CCDS15896.1"
                     /db_xref="GeneID:14299"
                     /db_xref="MGI:MGI:109166"
                     /translation="MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLD
                     AAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLR
                     WAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNA
                     DGKLTLQEFQEGSKADPSIVQALSLYDGLV"
     exon            321..345
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..484
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..563
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            564..652
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..730
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..847
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..4036
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1719
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
     regulatory      4031..4036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /note="hexamer: AATAAA"
     polyA_site      4036
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcgccg tggccgcttg caccgccaag gcctggccct cgccgggtcc ccgaggcccc
       61 ttgaaccgtc agccgcggtc gcgcagcacg ccggagcccc gcgcacggga cgcgcgggca
      121 cggccagaca aaggcgcggc cccggcccgg cccagcccgg cctgccggcc tccgcgcacc
      181 ccggcccgac ccaaccgctc ccgctgggcg ccccgagcgg gtccggcccg gggagcgggg
      241 gccgcggccg ccgagcatgg ggaaatccaa cagcaagttg aagcctgaag ttgtggagga
      301 gctgaccaga aaaacctact tcactgagaa agaagtacag cagtggtaca agggcttcat
      361 taaggactgc cccagcgggc agctggatgc cgctggcttc cagaagatct acaagcagtt
      421 cttcccattt ggagacccca ccaagttcgc cacgtttgtt ttcaacgtct tcgacgagaa
      481 caaggatggc aggattgagt tctccgagtt catccaggca ctgtcggtga cctcaagggg
      541 gaccctggat gaaaagctgc gatgggcctt caagctttat gacttggata acgatggcta
      601 catcaccagg aacgagatgc tcgacatagt ggacgccatt taccagatgg tggggaacac
      661 cgtggagctc ccagaagaag agaacacacc agagaagagg gtggaccgga tctttgccat
      721 gatggacaag aatgctgatg ggaagctgac tcttcaggag ttccaggaag gctccaaggc
      781 tgatccctcc attgtgcagg cgctgtccct ctacgatggg ctggtatagt ccaggcccag
      841 agctgtgatg tgtgggaacc actagcctct ttctgtgcca tgaggccacc gcagcctgac
      901 accgcccctg tgcccaccca gccttcctca tctccacaaa gccagccgcc cttgagcctc
      961 caggccctgg ttctcttccc ccctgccctg catccacctg ccgcctgaag ccactggttc
     1021 caatcgtcaa caacctccgc ttgtccaaaa caacgacaaa ccgaaacgga aaggctccag
     1081 ccctctgcaa aactgagcgc ccggctgtct ccctcggcag ccaccccatt cttcctgctg
     1141 tccggcctgt gtgctttctt tttttatttc aaacggacat tgtaaaagaa aacaaactac
     1201 cttctgttct aaaggatact gaccattggg agaaggcctc tgtctcagag aactcagtct
     1261 ctgcctggtc ccctgaagtg gtggtgacca gggccagtga ggctgctggc agcaagggtg
     1321 ttagtggcag tggctcacgt gataacagta ttgtgcgttt tgtggagaaa ctgagggttt
     1381 tttttatact catatataat cgaacctttt atttattggt tgttaactct tgctgctacc
     1441 ttgtgtgtct gaaactccca ggatgctggg cctccgttta catgtgcaca ccctcatcca
     1501 cctgcctgcc tcacttggga ggatggtggc ctgcagcggc caagaagcca aaaatctttt
     1561 cctctttttt ttttctcaga tactgtgccc catttttgga gaggggaagg tgggcattgc
     1621 taaatggcta atgtactgtt cccccagctt ctgccctgga gtccccaccc ctcgcctctg
     1681 ctctccttgg aatccataac actttttttc aaaaacaaac ttgaggtttt tttttttttt
     1741 tttttttttt aattttgcaa ctttaaattt gatgttaaca gcagaaagaa aatggagagc
     1801 cttgttctga gagtaggagc taggagagtg tgtccggcac acagtagaga gcgtatgaag
     1861 tgggtttccc tgcaaactgc tggcctcagc ctccctgatg ctaagaggct gggtaggtgt
     1921 ggcatgtgaa tccctctgct ctcctgccct gactgctttt tgcagtagtc ttcttcccta
     1981 ccaggagtct gagaaagaag gggtaggagg ataacaccag gccctgttgg tcctcaggac
     2041 tgggtccaga gccagagaga tggctccata cttgtcacca ggaggagcgg gcaaccatgg
     2101 cttctctggg actttgtagt ctttcccttc tcgatcagca gggctggaag gcctggtggt
     2161 tggctttgtt gatcttgtgt gattcttagc ccagagctag ggttcctgtg tttgtgacac
     2221 tgttctatgg ctgggttttc tagtctggag ggcacaggat cgtatgaatg acagtacaac
     2281 cctcatatag tctctgggca cagccttggt tgccggagtg tgtggtctgc ctcagaggct
     2341 gactgtgtct gatggcaccc cctttagccc ctctttagga tttcccagac tcttgagtcc
     2401 ctttgggctc atcctcaccc tggggagctt tccggggtga gcctctcagc tgcagaggca
     2461 gacctaagct cacagttctt gcttctagtt tgtgtaacct ctctgcccac cattgagagg
     2521 gggaaattgg ttcccggatt tttcttctgc tctgactctc ctgtaatctc cagcatactt
     2581 ctgggagacc aaaatcttcc ttgctaatga cctgtggatg agcagctgtc ccctggagga
     2641 ttgatgtccc ccatcaatag gtggctttgg ctgcctgtcc atccctgtgg tgggaatgct
     2701 tagctagtcc atgcacactc cctcttcctg ggtagaccct ttgctcatgc tgtgcccatt
     2761 gctagcccac cagatcccac agggaaattt tctttgagac ctctttgggt catcttcctg
     2821 cttgatccct gacatgtcct agagagtaga tgtggtgtca taggttgaga ggccctctct
     2881 ctggtctctg gagactcagc tgtccctctg tcagtggaca tttttggtgg catcaagacc
     2941 cagtgattcc aagctgagga gaggctcctc agctaaggtg ttcacttttt tctgtgggtc
     3001 caggcttcct ctcaggatct cggctttttg gtttgtagcc ttcagtgtgg cttttggtct
     3061 tcacagttta tgtccttggg tccaagcctc ggactttgag acagccctgg gctgcctttt
     3121 cctggcaggg tgtgggacac tgtttttgtt caaggacgcg tgctgactga tgtctgtctc
     3181 tctttcacca gcagttagct gaggcacaca gcacgcccag aatctgaggc caggcctctt
     3241 ctgtgcagcc tgaggacctc tccaagttca tttccacaga ggccccaccc catctgatgc
     3301 tgctttcttt aggggtgtgg tccagccagt gaggccaggc ccctggtacc tcggcagacc
     3361 ctcctttcta gggccaggaa tgctgtgacc ccctcttccc agcatctgct gcccaccttg
     3421 tgtcgacggt gacttgggag cctatcacga cttttcagta tctagccagg tttaaaataa
     3481 caaggcaaat gtatgcagca ttgacatctc tttctttaaa tggtctacag tttgacaggc
     3541 catttcctag gaagctgtgt ttcctttgca ctttggggga ccttgtctct tctaggagat
     3601 agtggggtgt gcagtccctg gggatccctg gcatctctcc tgagaaagcc cccactgctg
     3661 gccaagcaga aagcctccaa gattctttcc agtgtgtttc tgcatttaca tgatctaaag
     3721 atgcatgggg acgccccctg gtggtgatga gccgcagtgg cacccgggga tgcagtggtc
     3781 cagccagagg tgaggctaga ggtgggaagg ccaaggtggg ggctgtgatt tccgaggtcc
     3841 tgggccccca gccctacata tctggcagca tgcctcccac ccacacctct gctaggtcag
     3901 ctgggactgg caaggtagtt ggcataaggg cacagtggga agctttgccc tcccaacttt
     3961 aattttttaa aaaaatatct gcagaataaa tccaatggtt aatttttgaa tgaataaaag
     4021 gcttttgttg aataaa
//
