LOCUS       NP_062655                190 aa            linear   ROD 02-MAY-2024
DEFINITION  neuronal calcium sensor 1 [Mus musculus].
ACCESSION   NP_062655
VERSION     NP_062655.1
DBSOURCE    REFSEQ: accession NM_019681.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 190)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 190)
  AUTHORS   Fischer,T.T., Nguyen,L.D. and Ehrlich,B.E.
  TITLE     Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal
            morphology and development
  JOURNAL   FASEB J 35 (10), e21873 (2021)
   PUBMED   34499766
  REMARK    GeneRIF: Neuronal calcium sensor 1 (NCS1) dependent modulation of
            neuronal morphology and development.
REFERENCE   3  (residues 1 to 190)
  AUTHORS   Sah,R.K., Ma,J., Bah,F.B., Xing,Z., Adlat,S., Oo,Z.M., Wang,Y.,
            Bahadar,N., Bohio,A.A., Nagi,F.H., Feng,X., Zhang,L. and Zheng,Y.
  TITLE     Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung
            Development and Prenatal Lethality
  JOURNAL   Int J Mol Sci 21 (21), 8223 (2020)
   PUBMED   33153107
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 190)
  AUTHORS   Magno,L.A.V., Tenza-Ferrer,H., Collodetti,M., Nicolau,E.S.,
            Khlghatyan,J., Del'Guidice,T., Romano-Silva,M.A. and Beaulieu,J.M.
  TITLE     Contribution of neuronal calcium sensor 1 (Ncs-1) to
            anxiolytic-like and social behavior mediated by valproate and Gsk3
            inhibition
  JOURNAL   Sci Rep 10 (1), 4566 (2020)
   PUBMED   32165725
  REMARK    GeneRIF: Contribution of neuronal calcium sensor 1 (Ncs-1) to
            anxiolytic-like and social behavior mediated by valproate and Gsk3
            inhibition.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 190)
  AUTHORS   Simons,C., Benkert,J., Deuter,N., Poetschke,C., Pongs,O.,
            Schneider,T., Duda,J. and Liss,B.
  TITLE     NCS-1 Deficiency Affects mRNA Levels of Genes Involved in
            Regulation of ATP Synthesis and Mitochondrial Stress in Highly
            Vulnerable Substantia nigra Dopaminergic Neurons
  JOURNAL   Front Mol Neurosci 12, 252 (2019)
   PUBMED   31827421
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 190)
  AUTHORS   Mora,S., Durham,P.L., Smith,J.R., Russo,A.F., Jeromin,A. and
            Pessin,J.E.
  TITLE     NCS-1 inhibits insulin-stimulated GLUT4 translocation in 3T3L1
            adipocytes through a phosphatidylinositol 4-kinase-dependent
            pathway
  JOURNAL   J Biol Chem 277 (30), 27494-27500 (2002)
   PUBMED   12011096
  REMARK    GeneRIF: PI 4-kinase functions to negatively regulate GLUT4
            translocation through its interaction with NCS-1.
REFERENCE   7  (residues 1 to 190)
  AUTHORS   Guo,W., Malin,S.A., Johns,D.C., Jeromin,A. and Nerbonne,J.M.
  TITLE     Modulation of Kv4-encoded K(+) currents in the mammalian myocardium
            by neuronal calcium sensor-1
  JOURNAL   J Biol Chem 277 (29), 26436-26443 (2002)
   PUBMED   11994284
  REMARK    GeneRIF: NCS-1 is an accessory subunit of Kv4-encoded I(to,f)
            channels that functions to regulate I(to,f) density in the
            mammalian myocardium.
REFERENCE   8  (residues 1 to 190)
  AUTHORS   Burgoyne,R.D. and Weiss,J.L.
  TITLE     The neuronal calcium sensor family of Ca2+-binding proteins
  JOURNAL   Biochem J 353 (Pt 1), 1-12 (2001)
   PUBMED   11115393
  REMARK    Review article
            Erratum:[Biochem J 2001 Mar 15;354(Pt 3):727]
REFERENCE   9  (residues 1 to 190)
  AUTHORS   Sage,C., Venteo,S., Jeromin,A., Roder,J. and Dechesne,C.J.
  TITLE     Distribution of frequenin in the mouse inner ear during
            development, comparison with other calcium-binding proteins and
            synaptophysin
  JOURNAL   Hear Res 150 (1-2), 70-82 (2000)
   PUBMED   11077193
REFERENCE   10 (residues 1 to 190)
  AUTHORS   Olafsson,P., Soares,H.D., Herzog,K.H., Wang,T., Morgan,J.I. and
            Lu,B.
  TITLE     The Ca2+ binding protein, frequenin is a nervous system-specific
            protein in mouse preferentially localized in neurites
  JOURNAL   Brain Res Mol Brain Res 44 (1), 73-82 (1997)
   PUBMED   9030700
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL732572.10.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059825.1, SRR10662772.3087590.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..190
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.81 cM"
     Protein         1..190
                     /product="neuronal calcium sensor 1"
                     /note="frequenin homolog"
                     /calculated_mol_wt=21748
     Region          22..174
                     /region_name="FRQ1"
                     /note="Ca2+-binding protein, EF-hand superfamily [Signal
                     transduction mechanisms]; COG5126"
                     /db_xref="CDD:444056"
     Region          174..190
                     /region_name="Interaction with IL1RAPL1.
                     /evidence=ECO:0000250|UniProtKB:P62166"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BNY6.3)"
     CDS             1..190
                     /gene="Ncs1"
                     /gene_synonym="9430075O15Rik; A730032G13Rik; Freq; Mfreq;
                     NCS-1"
                     /coded_by="NM_019681.3:257..829"
                     /db_xref="CCDS:CCDS15896.1"
                     /db_xref="GeneID:14299"
                     /db_xref="MGI:MGI:109166"
ORIGIN      
        1 mgksnsklkp evveeltrkt yftekevqqw ykgfikdcps gqldaagfqk iykqffpfgd
       61 ptkfatfvfn vfdenkdgri efsefiqals vtsrgtldek lrwafklydl dndgyitrne
      121 mldivdaiyq mvgntvelpe eentpekrvd rifammdkna dgkltlqefq egskadpsiv
      181 qalslydglv
//
