LOCUS       NM_010746               1463 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus natural cytotoxicity triggering receptor 1 (Ncr1),
            transcript variant 1, mRNA.
ACCESSION   NM_010746
VERSION     NM_010746.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1463)
  AUTHORS   Samper,N., Hardardottir,L., Depierreux,D.M., Song,S.C.,
            Nakazawa,A., Gando,I., Nakamura,T.Y., Sharkey,A.M., Nowosad,C.R.,
            Feske,S., Colucci,F. and Coetzee,W.A.
  TITLE     Kir6.1, a component of an ATP-sensitive potassium channel,
            regulates natural killer cell development
  JOURNAL   Front Immunol 15, 1490250 (2024)
   PUBMED   39687626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1463)
  AUTHORS   Koya,J., Tanigawa,T., Mizuno,K., Kim,H., Ito,Y., Yuasa,M.,
            Yamaguchi,K., Kogure,Y., Saito,Y., Shingaki,S., Tabata,M.,
            Murakami,K., Chiba,K., Okada,A., Shiraishi,Y., Marouf,A.,
            Lievin,R., Chaubard,S., Jaccard,A., Hermine,O., de Leval,L.,
            Tournilhac,O., Damaj,G., Gaulard,P., Couronne,L., Yasui,T.,
            Nakashima,K., Miyoshi,H., Ohshima,K. and Kataoka,K.
  TITLE     Modeling NK-cell lymphoma in mice reveals its cell-of-origin and
            microenvironmental changes and identifies therapeutic targets
  JOURNAL   Nat Commun 15 (1), 9106 (2024)
   PUBMED   39438472
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1463)
  AUTHORS   Biniaris-Georgallis,S.I., Aschman,T., Stergioula,K., Schreiber,F.,
            Jafari,V., Taranko,A., Karmalkar,T., Kasapi,A., Lenac Rovis,T.,
            Jelencic,V., Bejarano,D.A., Fabry,L., Papacharalampous,M.,
            Mattiola,I., Molgora,M., Hou,J., Hublitz,K.W., Heinrich,F.,
            Guerra,G.M., Durek,P., Patone,G., Lindberg,E.L., Maatz,H.,
            Holsken,O., Kronke,G., Mortha,A., Voll,R.E., Clarke,A.J.,
            Hauser,A.E., Colonna,M., Thurley,K., Schlitzer,A., Schneider,C.,
            Stamatiades,E.G., Mashreghi,M.F., Jonjic,S., Hubner,N.,
            Diefenbach,A., Kanda,M. and Triantafyllopoulou,A.
  TITLE     Amplification of autoimmune organ damage by NKp46-activated ILC1s
  JOURNAL   Nature 634 (8035), 952-960 (2024)
   PUBMED   39137897
  REMARK    GeneRIF: Amplification of autoimmune organ damage by
            NKp46-activated ILC1s.
REFERENCE   4  (bases 1 to 1463)
  AUTHORS   Samper,N., Harethardottir,L., Depierreux,D.M., Song,S.C.,
            Nakazawa,A., Gando,I., Nakamura,T.Y., Sharkey,A.M., Nowosad,C.R.,
            Feske,S., Colucci,F. and Coetzee,W.A.
  TITLE     Kir6.1, a component of an ATP-sensitive potassium channel,
            regulates natural killer cell development
  JOURNAL   bioRxiv (2024)
   PUBMED   39211194
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1463)
  AUTHORS   Huang,C., Zhu,W., Li,Q., Lei,Y., Chen,X., Liu,S., Chen,D.,
            Zhong,L., Gao,F., Fu,S., He,D., Li,J. and Xu,H.
  TITLE     Antibody Fc-receptor FcepsilonR1gamma stabilizes cell surface
            receptors in group 3 innate lymphoid cells and promotes
            anti-infection immunity
  JOURNAL   Nat Commun 15 (1), 5981 (2024)
   PUBMED   39013884
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1463)
  AUTHORS   Walzer,T., Blery,M., Chaix,J., Fuseri,N., Chasson,L., Robbins,S.H.,
            Jaeger,S., Andre,P., Gauthier,L., Daniel,L., Chemin,K., Morel,Y.,
            Dalod,M., Imbert,J., Pierres,M., Moretta,A., Romagne,F. and
            Vivier,E.
  TITLE     Identification, activation, and selective in vivo ablation of mouse
            NK cells via NKp46
  JOURNAL   Proc Natl Acad Sci U S A 104 (9), 3384-3389 (2007)
   PUBMED   17360655
  REMARK    GeneRIF: Mouse NKp46 triggers Natural Killer cell effector function
            and allows the detection of NK cells in situ.
REFERENCE   7  (bases 1 to 1463)
  AUTHORS   Gazit,R., Gruda,R., Elboim,M., Arnon,T.I., Katz,G., Achdout,H.,
            Hanna,J., Qimron,U., Landau,G., Greenbaum,E., Zakay-Rones,Z.,
            Porgador,A. and Mandelboim,O.
  TITLE     Lethal influenza infection in the absence of the natural killer
            cell receptor gene Ncr1
  JOURNAL   Nat Immunol 7 (5), 517-523 (2006)
   PUBMED   16565719
REFERENCE   8  (bases 1 to 1463)
  AUTHORS   Arnon,T.I., Achdout,H., Lieberman,N., Gazit,R., Gonen-Gross,T.,
            Katz,G., Bar-Ilan,A., Bloushtain,N., Lev,M., Joseph,A., Kedar,E.,
            Porgador,A. and Mandelboim,O.
  TITLE     The mechanisms controlling the recognition of tumor- and
            virus-infected cells by NKp46
  JOURNAL   Blood 103 (2), 664-672 (2004)
   PUBMED   14504081
  REMARK    GeneRIF: NKp46 interacts with both viral hemagglutinins and the
            unknown tumor ligands via different mechanisms.
REFERENCE   9  (bases 1 to 1463)
  AUTHORS   Hoelsbrekken,S.E., Nylenna,O., Saether,P.C., Slettedal,I.O.,
            Ryan,J.C., Fossum,S. and Dissen,E.
  TITLE     Cutting edge: molecular cloning of a killer cell Ig-like receptor
            in the mouse and rat
  JOURNAL   J Immunol 170 (5), 2259-2263 (2003)
   PUBMED   12594244
REFERENCE   10 (bases 1 to 1463)
  AUTHORS   Biassoni,R., Pessino,A., Bottino,C., Pende,D., Moretta,L. and
            Moretta,A.
  TITLE     The murine homologue of the human NKp46, a triggering receptor
            involved in the induction of natural cytotoxicity
  JOURNAL   Eur J Immunol 29 (3), 1014-1020 (1999)
   PUBMED   10092106
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079401.1.
            
            On Apr 5, 2007 this sequence version replaced NM_010746.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079401.1, BC042788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1463              AK079401.1         2-1464
FEATURES             Location/Qualifiers
     source          1..1463
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.5 cM"
     gene            1..1463
                     /gene="Ncr1"
                     /gene_synonym="Cd335; Ly94; NKp46"
                     /note="natural cytotoxicity triggering receptor 1"
                     /db_xref="GeneID:17086"
                     /db_xref="MGI:MGI:1336212"
     exon            1..59
                     /gene="Ncr1"
                     /gene_synonym="Cd335; Ly94; NKp46"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1003
                     /gene="Ncr1"
                     /gene_synonym="Cd335; Ly94; NKp46"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mAR-1; NK-p46; mNKp46; activating receptor 1;
                     natural killer cell p46-related protein; lymphocyte
                     antigen 94; MAR1 (mouse activating receptor 1)"
                     /codon_start=1
                     /product="natural cytotoxicity triggering receptor 1
                     isoform 1 precursor"
                     /protein_id="NP_034876.2"
                     /db_xref="CCDS:CCDS20734.1"
                     /db_xref="GeneID:17086"
                     /db_xref="MGI:MGI:1336212"
                     /translation="MLPTLTALLCLGLCLSQRINTEKETLPKPIIWAKPSIMVTNGNS
                     VNIWCQGAQSASEYQLYFEGSFFALERPKPSRSMNKVRFFISQMTSHTAGIYTCFYQS
                     GELWSKSSNPLKLVVTGLYDTPNLWVYPQPEVTLGENVTFFCQLKTATSKFFLLKERG
                     SNHIQNKYGNIQAEFPMGPVTRAHRGTYRCFGSYNDYAWSFPSEPVTLLITGGVENSS
                     LAPTDPTSSLDYWEFDLSTNESGLQKDSAFWDHTTQNLIRIGLACIILITLVWLLTED
                     WLSKRKDHEEANRLTNWECRRRWRMQHYFEEEQRNAISMMELKATPGAL"
     exon            60..95
                     /gene="Ncr1"
                     /gene_synonym="Cd335; Ly94; NKp46"
                     /inference="alignment:Splign:2.1.0"
     exon            96..380
                     /gene="Ncr1"
                     /gene_synonym="Cd335; Ly94; NKp46"
                     /inference="alignment:Splign:2.1.0"
     exon            381..659
                     /gene="Ncr1"
                     /gene_synonym="Cd335; Ly94; NKp46"
                     /inference="alignment:Splign:2.1.0"
     exon            660..710
                     /gene="Ncr1"
                     /gene_synonym="Cd335; Ly94; NKp46"
                     /inference="alignment:Splign:2.1.0"
     exon            711..758
                     /gene="Ncr1"
                     /gene_synonym="Cd335; Ly94; NKp46"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1463
                     /gene="Ncr1"
                     /gene_synonym="Cd335; Ly94; NKp46"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcagcact ggtctggcca ctggtatgct gccaacactc actgccctac tgtgccttgg
       61 gctatgtctg agccagagga tcaacactga aaaggagact ctcccgaaac ccatcatctg
      121 ggccaaaccc agcatcatgg tcacaaatgg aaactcggtg aacatctggt gtcagggggc
      181 tcagagtgct tctgagtatc aactgtactt tgaaggaagc ttttttgcct tggagagacc
      241 aaagccatcg agatcgatga ataaagttag gttcttcatt tcacaaatga cctcacatac
      301 tgcagggatc tacacctgct tctatcagag tggagagctc tggtcaaagt cgagcaaccc
      361 cctgaaactg gtagtaactg gtctgtatga cacacccaac ctctgggttt atccacagcc
      421 tgaggtaacc ttgggggaga atgttacctt cttttgccaa ctgaagactg ccacaagcaa
      481 attctttctg ctcaaggaga gaggatccaa ccacatccag aataaatatg ggaacatcca
      541 agcagagttt cccatgggcc ccgtgactag ggctcacaga gggacataca gatgttttgg
      601 ctcttacaac gactatgcat ggtcttttcc cagtgagcct gtgacactac tcatcacagg
      661 aggtgttgag aacagcagcc ttgcacctac cgaccctact tcttctcttg attattggga
      721 gtttgacctt tcaaccaatg aatcaggatt acaaaaggac tccgccttct gggatcacac
      781 aacccagaat ctcattcgaa ttggtctggc atgcataatc ctgataactc tagtatggct
      841 tttgactgaa gactggctca gcaagaggaa agatcatgaa gaggccaaca gattaacaaa
      901 ttgggaatgc aggagaagat ggagaatgca gcattacttt gaagaggaac aaagaaatgc
      961 aatatctatg atggaactga aggcaactcc tggggccttg tgagctctat gctgtaccct
     1021 ggataaagaa agagatcttt tcagaaatga aggggtagga gtgttaccaa gtttggcaaa
     1081 gcattctaaa ggacactgtg agaggaagcc tctaacagac ctctctgtct ctgctaagct
     1141 ttaagtactt taacgcttat ttactgcaag ttatactttt gatcactctg gtctttccta
     1201 gaaataactt cgttccaatg tgatggccat gggaatattt ccttcctact ttaggtctta
     1261 tcgtcatttc tttttctaat tttatttatt ttatgttgcc gggaattgaa ctcaagttgt
     1321 ctggaggagc aacaagtgct cttaactaca aaccatatct ccagctccat cctcaatatt
     1381 ttatattgtg tgtgcatgtc tgtaggatgc atgtgtgtgc acacatatgt acatatattc
     1441 tatgccatta aaatgaaggt cag
//
