LOCUS       NM_144892               3151 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nuclear receptor coactivator 5 (Ncoa5), mRNA.
ACCESSION   NM_144892
VERSION     NM_144892.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3151)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3151)
  AUTHORS   Zhang,Y., Luo,Y., Liu,X., Kiupel,M., Li,A., Wang,H., Mi,Q.S. and
            Xiao,H.
  TITLE     NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently
            Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma
  JOURNAL   Cell Mol Gastroenterol Hepatol 17 (1), 1-27 (2024)
   PUBMED   37734594
  REMARK    GeneRIF: NCOA5 Haploinsufficiency in Myeloid-Lineage Cells
            Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular
            Carcinoma.
REFERENCE   3  (bases 1 to 3151)
  AUTHORS   Zhang,Y., Liu,X., Sun,K., Luo,Y., Yang,J., Li,A., Kiupel,M.,
            Fenske,S., Biel,M., Mi,Q.S., Wang,H. and Xiao,H.
  TITLE     Hyperpolarization-activated cyclic nucleotide-gated cation channel
            3 promotes HCC development in a female-biased manner
  JOURNAL   Cell Rep 42 (10), 113157 (2023)
   PUBMED   37733590
REFERENCE   4  (bases 1 to 3151)
  AUTHORS   Williams,M., Liu,X., Zhang,Y., Reske,J., Bahal,D., Gohl,T.G.,
            Hollern,D., Ensink,E., Kiupel,M., Luo,R., Das,R. and Xiao,H.
  TITLE     NCOA5 deficiency promotes a unique liver protumorigenic
            microenvironment through p21WAF1/CIP1 overexpression, which is
            reversed by metformin
  JOURNAL   Oncogene 39 (19), 3821-3836 (2020)
   PUBMED   32203160
  REMARK    GeneRIF: NCOA5 deficiency promotes a unique liver protumorigenic
            microenvironment through p21(WAF1/CIP1) overexpression, which is
            reversed by metformin.
REFERENCE   5  (bases 1 to 3151)
  AUTHORS   Gao,S., Zhang,Y., Yang,C., Perez,G.I. and Xiao,H.
  TITLE     NCOA5 Haplo-insufficiency Results in Male Mouse Infertility through
            Increased IL-6 Expression in the Epididymis
  JOURNAL   Sci Rep 9 (1), 15525 (2019)
   PUBMED   31664153
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3151)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3151)
  AUTHORS   Gao,S., Li,A., Liu,F., Chen,F., Williams,M., Zhang,C., Kelley,Z.,
            Wu,C.L., Luo,R. and Xiao,H.
  TITLE     NCOA5 haploinsufficiency results in glucose intolerance and
            subsequent hepatocellular carcinoma
  JOURNAL   Cancer Cell 24 (6), 725-737 (2013)
   PUBMED   24332041
REFERENCE   8  (bases 1 to 3151)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3151)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 3151)
  AUTHORS   Sauve,F., McBroom,L.D., Gallant,J., Moraitis,A.N., Labrie,F. and
            Giguere,V.
  TITLE     CIA, a novel estrogen receptor coactivator with a bifunctional
            nuclear receptor interacting determinant
  JOURNAL   Mol Cell Biol 21 (1), 343-353 (2001)
   PUBMED   11113208
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC017152.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017152.1, SRR1660817.24942.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3151
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.32 cM"
     gene            1..3151
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /note="nuclear receptor coactivator 5"
                     /db_xref="GeneID:228869"
                     /db_xref="MGI:MGI:2385165"
     exon            1..97
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            98..164
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1866
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /note="NCoA-5; coactivator independent of AF-2"
                     /codon_start=1
                     /product="nuclear receptor coactivator 5"
                     /protein_id="NP_659141.1"
                     /db_xref="CCDS:CCDS17068.1"
                     /db_xref="GeneID:228869"
                     /db_xref="MGI:MGI:2385165"
                     /translation="MNTAPSRPSPTRRDPYSFGDSRDTRRDRSPIRGSPRREPRDGRN
                     GRDARDSRDIRDPRDLRDRRDSRDIRDHRDSRSVREARDLRDFRDFRDLRDSRDFRDH
                     RDPVYDRYRDIRDSRDPLYRREGSYDRYLRVDDYCRRKDDSYFDRYRDSFDGRGPPGP
                     ESQSRAKERLKREERRREELYRRYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGR
                     KVRDLGMVVDLIFLNTEVSLSQALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQ
                     EHRNMPQADAMVLVARNYERYKNDCREKEREEIARQAAKMANDAILQERDRGGPEEGG
                     RGGHPPAIQSLINLLADNRYLTAEETDKIINYLRERKERLLRSSADSLPGPISRQPLG
                     AASGSSLKSQPSSQPLQSGQVLPSATPTPAAPPTSQQELQAKILSLFNSGAVAANSSS
                     ASPSVATGSSQNQNFSTAANSQPQQRPQASGNQPPNIVGQAGSARNMGPRPGAPSQGL
                     FGQPSSRLAPASTMASQRPVSSTGINFDNPSVQKALDTLIQSGPALSHLVSQTAAQVG
                     RPQAPMGSYQRHY"
     exon            165..491
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            492..628
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            629..755
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            756..955
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1276
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..3091
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3072..3077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /note="hexamer: ATTAAA"
     polyA_site      3091
                     /gene="Ncoa5"
                     /gene_synonym="CIA"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctttgt cctacggcgg gcaggtgggc agaggccgag gcggcagcgg cgggcctgag
       61 gcggaggagc ggcggggagg cggccacgcc ggtagcgata ttaataaggc agcggaaaga
      121 agaaatatga atacggctcc atcaagaccc agccccacac gaagggatcc ctatagcttt
      181 ggagatagtc gcgatacaag gcgtgatcgc tctccaattc gaggaagtcc aaggagagaa
      241 cccagggatg gcagaaatgg ccgggatgcc cgtgatagca gagacattcg agatcctcgg
      301 gatttgcggg accgcagaga cagcagggac attcgggatc acagagacag cagaagtgta
      361 cgtgaagccc gggacctgag ggattttcgg gactttcgtg atctaagaga ctctagagat
      421 tttcgagatc atcgagaccc tgtgtatgac agatacagag atataagaga ttccagagac
      481 cctttgtaca ggagagaagg ctcatatgac cgttatctga gggtggatga ctattgccgg
      541 aggaaggatg actcgtactt tgaccggtac agagatagct ttgatggacg gggccctcct
      601 ggcccagaga gtcaatctcg agcaaaagag cgtttgaaac gtgaggaacg acgtagagag
      661 gagctttatc gtcggtattt tgaggagatc cagcgacgct ttgatgctga gaggcctgtg
      721 gattgctcag ttattgtggt caacaaacag actaaagact atgctgagtc tgtggggagg
      781 aaggtgcgag acctgggcat ggtcgtggac ctgatcttcc tcaacacaga ggtgtccctc
      841 tcacaagcgc tggaggatgt cagcagagga ggctctccct tcgccattgt catcacccag
      901 cagcaccaga ttcaccgttc ctgcacagtc aacatcatgt tcggaacacc acaagagcat
      961 cgcaacatgc cccaggcaga tgccatggtg ctggtggcca gaaattacga gcgctacaag
     1021 aatgactgtc gagaaaagga acgtgaggag attgcccgac aggcagccaa aatggctaat
     1081 gacgccatcc tccaggaaag agatcgtggg ggccctgaag agggaggtcg tggagggcac
     1141 cctccagcta tccagagcct catcaacctc ctggcagata acagatacct cactgccgag
     1201 gagacggaca agatcatcaa ctacctgcgc gagcggaagg agcggctcct gaggagcagc
     1261 gccgactctc tgcctggccc gatttcccgc cagccactcg gggcggcctc gggttcctcg
     1321 ctgaagtcac aaccaagttc acaaccgctt cagagcggcc aagtgctccc ttctgctaca
     1381 cccactccag ccgcaccccc cacctcccag caagagcttc aggccaaaat cctcagcctc
     1441 ttcaatagtg gcgcggttgc ggccaacagc agctctgcat ccccctcagt ggctaccgga
     1501 agctcccaga accagaattt ttccacagca gcaaacagcc agcctcagca aagaccgcag
     1561 gcctcaggaa atcagcctcc aaacattgtg ggacaggcag ggtctgctcg gaacatgggc
     1621 cctaggcctg gggctccttc ccaagggctc tttggtcagc cttccagtcg cctggcaccc
     1681 gccagcacca tggctagcca gaggcctgta tcttccacag gtattaactt tgacaatcca
     1741 agtgtacaaa aggctctgga caccctgatt cagagtggcc ctgccctttc ccacctggtt
     1801 agccaaactg cagcacaggt ggggcggccc caggccccca tgggatctta ccagaggcat
     1861 tactgaggct ctactggtct actgttccta gccccaccct tccctggccc ctcctacttc
     1921 atcctaagta gagttgtttg gaagtgttcg aaacactttc caggtcaaca tcaaatatcc
     1981 taagtttctc tcaccactcc ttcctgcggc tgttgcttat cacttatcag aatcagaact
     2041 tagactgcat tcggggctgg atcttttgtt tgggtagaag ataagtgttc tgggatctgg
     2101 gctcagcttc tgtctgggat cgctctggca cctgcctggc agatttggag gaacaggaag
     2161 aagccaagcg cagctgccct atgggaacac catttctgga ggcagtggtc atagccttag
     2221 ttttcacctc cacagcagcc agagctgcgt cctgcctggc tcccagtgaa gccaggtggt
     2281 cttggcagac agtgtcatca ttgttccatc agagaataga actccaagga ctcaagagtg
     2341 atttctctgg actgtgaagt gccatgtggc agccagagaa gagaggactc ttgtgactgc
     2401 atcagagtgg tcccttgaag ttggtttggt ttcgtatttt ttattttcct ggagggtctg
     2461 cagacaagtg agcagctctc ttggcacttt gacatgaact gtgactctgg ggcccactgc
     2521 tctccacagc gttagctgca cctttctctc cggctgcacc tcatgcagtc agcactgggg
     2581 gcagctccag gctctggagc tggacacctt ggtggtccgt gatttctttt gagccccagg
     2641 cttttgtttt cattcagact cttgttctgt tttctgatga gcaggagacg gggaccactt
     2701 gatggtagac tgtggtagtt gggtatgttc tcatacagaa gagcattcgt gtaacttctg
     2761 agacagggtg atgtttagag aagggctctg gctgctgccc tgaatggagc cagaggaaga
     2821 agcgcctttt cctttgggaa aggctgctca ttaaatgaag tgaggatcag gtcaggggag
     2881 ggtcaggcct ggctgggcgg caagagtgct aactccagtc cagtccctgc cagaggctga
     2941 gcaaaccagt ttcaaaagct aagtccccaa atggcagcag tttatgttct gatctgtttg
     3001 tgttatacgg tgggtccccc tccccctttg gaactcttgt gttgttgata aaatgaaata
     3061 attacttttt aattaaaatg aaaaagtcag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3121 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
