LOCUS       NM_019744               3348 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus nuclear receptor coactivator 4 (Ncoa4), transcript
            variant 1, mRNA.
ACCESSION   NM_019744
VERSION     NM_019744.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3348)
  AUTHORS   He,X., Wang,Z., Ge,Q., Sun,S., Li,R. and Wang,B.
  TITLE     Lactylation of nuclear receptor coactivator 4 promotes
            ferritinophagy and glycolysis of neuronal cells after cerebral
            ischemic injury
  JOURNAL   Neuroreport 35 (14), 895-903 (2024)
   PUBMED   39166386
  REMARK    GeneRIF: Lactylation of nuclear receptor coactivator 4 promotes
            ferritinophagy and glycolysis of neuronal cells after cerebral
            ischemic injury.
REFERENCE   2  (bases 1 to 3348)
  AUTHORS   Wang,X., Xu,L., Meng,Y., Chen,F., Zhuang,J., Wang,M., An,W.,
            Han,Y., Chu,B., Chai,R., Liu,W. and Wang,H.
  TITLE     FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea Spiral
            Ganglion Neuron Ferroptosis via Ferritinophagy
  JOURNAL   Adv Sci (Weinh) 11 (40), e2402671 (2024)
   PUBMED   39206719
  REMARK    GeneRIF: FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea
            Spiral Ganglion Neuron Ferroptosis via Ferritinophagy.
REFERENCE   3  (bases 1 to 3348)
  AUTHORS   Li,K., Wang,A., Diao,Y. and Fan,S.
  TITLE     Oxidative medicine and cellular longevity the role and mechanism of
            NCOA4 in ferroptosis induced by intestinal ischemia reperfusion
  JOURNAL   Int Immunopharmacol 133, 112155 (2024)
   PUBMED   38688134
  REMARK    GeneRIF: Oxidative medicine and cellular longevity the role and
            mechanism of NCOA4 in ferroptosis induced by intestinal ischemia
            reperfusion.
REFERENCE   4  (bases 1 to 3348)
  AUTHORS   Du,J., Yu,L., Yang,X., Shao,F., Xia,J., Jin,W., Zhang,Y., Lei,G.,
            Wang,Y., Li,Y. and Zhang,J.
  TITLE     Regulation of NCOA4-mediated iron recycling ameliorates
            paraquat-induced lung injury by inhibiting ferroptosis
  JOURNAL   Cell Commun Signal 22 (1), 146 (2024)
   PUBMED   38388414
  REMARK    GeneRIF: Regulation of NCOA4-mediated iron recycling ameliorates
            paraquat-induced lung injury by inhibiting ferroptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3348)
  AUTHORS   Ma,Z., Lu,H., Feng,X., Du,T., Li,J., Zhang,Q., Gu,X., Shao,Y.,
            Jing,X. and Su,C.
  TITLE     Nrf2 protects against cartilage endplate degeneration through
            inhibiting NCOA4-mediated ferritinophagy
  JOURNAL   Int J Mol Med 53 (2) (2024)
   PUBMED   38063237
  REMARK    GeneRIF: Nrf2 protects against cartilage endplate degeneration
            through inhibiting NCOA4-mediated ferritinophagy.
REFERENCE   6  (bases 1 to 3348)
  AUTHORS   Wu,X., Chen,F., Sahin,A., Albarracin,C., Pei,Z., Zou,X., Singh,B.,
            Xu,R., Daniels,G., Li,Y., Wei,J., Blake,M., Schneider,R.J.,
            Cowin,P. and Lee,P.
  TITLE     Distinct function of androgen receptor coactivator ARA70alpha and
            ARA70beta in mammary gland development, and in breast cancer
  JOURNAL   Breast Cancer Res Treat 128 (2), 391-400 (2011)
   PUBMED   20814820
  REMARK    GeneRIF: High ARA70alpha inhibited cell proliferation, and that
            ARA70beta promotes proliferation in breast cancer.
REFERENCE   7  (bases 1 to 3348)
  AUTHORS   Kollara,A. and Brown,T.J.
  TITLE     Variable expression of nuclear receptor coactivator 4 (NcoA4)
            during mouse embryonic development
  JOURNAL   J Histochem Cytochem 58 (7), 595-609 (2010)
   PUBMED   20354146
  REMARK    GeneRIF: Results demonstrate ubiquitous NcoA4 expression throughout
            development and suggest that this coactivator may play a role in
            modulating nuclear receptor activity, particularly that of the aryl
            hydrocarbon receptor, during development.
REFERENCE   8  (bases 1 to 3348)
  AUTHORS   Ligr,M., Li,Y., Zou,X., Daniels,G., Melamed,J., Peng,Y., Wang,W.,
            Wang,J., Ostrer,H., Pagano,M., Wang,Z., Garabedian,M.J. and Lee,P.
  TITLE     Tumor suppressor function of androgen receptor coactivator
            ARA70alpha in prostate cancer
  JOURNAL   Am J Pathol 176 (4), 1891-1900 (2010)
   PUBMED   20167864
  REMARK    GeneRIF: ARA70alpha functions as a tumor suppressor gene
REFERENCE   9  (bases 1 to 3348)
  AUTHORS   Siriett,V., Nicholas,G., Berry,C., Watson,T., Hennebry,A.,
            Thomas,M., Ling,N., Sharma,M. and Kambadur,R.
  TITLE     Myostatin negatively regulates the expression of the steroid
            receptor co-factor ARA70
  JOURNAL   J Cell Physiol 206 (1), 255-263 (2006)
   PUBMED   16110473
  REMARK    GeneRIF: Data suggest that myostatin decreases the activity of
            androgen receptors (AR) by down-regulating the expression of ARA70,
            a known stimulating co-factor of AR
REFERENCE   10 (bases 1 to 3348)
  AUTHORS   Beckers,J., Herrmann,F., Rieger,S., Drobyshev,A.L., Horsch,M.,
            Hrabe de Angelis,M. and Seliger,B.
  TITLE     Identification and validation of novel ERBB2 (HER2, NEU) targets
            including genes involved in angiogenesis
  JOURNAL   Int J Cancer 114 (4), 590-597 (2005)
   PUBMED   15609325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154532.3.
            
            On Mar 24, 2022 this sequence version replaced NM_019744.4.
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 2. Both variants 1 and 2 encode the same
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147036.1, AK014479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC154532.3         122983-123013       c
            32-186              AC154532.3         117903-118057       c
            187-327             AC154532.3         116362-116502       c
            328-416             AC154532.3         116110-116198       c
            417-525             AC154532.3         115808-115916       c
            526-615             AC154532.3         115315-115404       c
            616-759             AC154532.3         114272-114415       c
            760-1776            AC154532.3         111850-112866       c
            1777-1917           AC154532.3         111432-111572       c
            1918-3348           AC154532.3         109552-110982       c
FEATURES             Location/Qualifiers
     source          1..3348
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.4 cM"
     gene            1..3348
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /note="nuclear receptor coactivator 4"
                     /db_xref="GeneID:27057"
                     /db_xref="MGI:MGI:1350932"
     exon            1..31
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            32..186
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1923
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="nuclear receptor coactivator 4 isoform a"
                     /protein_id="NP_062718.2"
                     /db_xref="CCDS:CCDS36863.1"
                     /db_xref="GeneID:27057"
                     /db_xref="MGI:MGI:1350932"
                     /translation="MNTSLEQSGCYSNRETLLRCSDARRELELAIGGVLRAEQQIKDN
                     LREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLYWLMGQFNCL
                     IHQLEYTQNKDLANQVSVCLERLGSLALKPEDSTVLLFEADTSALRQTITTFGSLKTI
                     QIPEHLMAHASSSSIGPFLEKRGYIQVPEQKSASSGTAVSLSEWLLVSKPAIGLQAPY
                     VPSTNPQDWLIPKQTSENSQTSARACSFFSDAWGNLKGLENWLLNSHQQEIAGKPSSS
                     KCNSHCSTSSFSPEAEKAEDVELLDQDELDLSDWLVTPQEPCELEKPVDGSWETSEKF
                     KLLFQVFREPYNVSDWLVKPDSCTNCQGNQPRGVEIENLGNLKCLNDHLEAKKSVSVP
                     GATISDGWLAQNHQDTWKVEEVCKANEPCTSFAECVCDDNCEKEAMYKWLLKKGGKDK
                     NGMPMEPKSEPEKHRESLTLWLCPSRNELTEQAKAPKAMAPARIADSFHVIKNSSLSE
                     WLMGPTCKGGPKDVPNTEERAGKEMLQSSMATSWCPFNTADWVLPGKKVGSLSQFPSG
                     EDKWLLRKKAQEAFLNSPLQEERNFRPDCYGLPAVCDLFACMQLKVDKEKWLYRTPLQ
                     M"
     exon            187..327
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            328..416
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            417..525
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            526..615
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            616..759
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1776
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1917
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..3348
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3325..3330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /note="hexamer: ATTAAA"
     polyA_site      3348
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /note="major polyA site"
ORIGIN      
        1 agcagttttc gtcgcggggc cagactacct ggaacagtga gcagaatgaa cacatccctg
       61 gaacagagtg gctgctacag taatagagaa actcttctga ggtgcagtga tgcaaggagg
      121 gagctggagc ttgctattgg tggagtactt cgggctgaac agcaaattaa agataattta
      181 cgagaggtaa aagctcagat tcacagctgc ataagtcgcc acctggaatg ccttcggagc
      241 cgagaggtgt ggctcaatga acaggtcgat ctcatctatc agcttaaaga ggagacactg
      301 cagcagcagg ctcagcagct ctattggcta atgggccaat tcaattgtct tattcatcaa
      361 ctggagtata ctcagaacaa agatcttgcc aatcaagtct ctgtgtgctt ggagagactg
      421 ggcagtttgg ccctgaagcc tgaagattca actgtcctac tctttgaagc agatacatct
      481 gctctgcgcc agaccatcac cacatttgga tcccttaaga ccattcaaat ccctgagcat
      541 ctgatggctc acgcgagctc ctcaagtatt gggcctttcc tagagaaaag aggctatatc
      601 caggtgccag agcagaagtc agcatccagt ggcacagctg tatctctgag tgagtggctt
      661 cttgtaagca aacctgccat tggtcttcag gctccttatg tacccagtac caacccacag
      721 gactggctta tcccaaaaca gacttcagag aatagtcaga cttctgccag agcctgcagt
      781 ttcttcagcg atgcctgggg caatctgaag ggcttagaaa attggctcct taacagtcat
      841 caacaagaaa ttgctggaaa accaagttcc tcaaaatgta acagccattg tagcaccagt
      901 tctttctctc ctgaagctga aaaggctgaa gatgtagagc tccttgatca agacgagctg
      961 gacctgtctg attggttggt gactcctcag gaaccctgtg agctggagaa gcctgtggat
     1021 ggcagctggg aaaccagcga gaagtttaaa ctcttgttcc aggtgttcag agagccctac
     1081 aatgtgagtg attggcttgt caagcctgac tcctgtacca actgtcaggg caaccagcct
     1141 agaggtgtgg agattgagaa cctgggcaat ctgaaatgcc taaatgacca cttggaggcc
     1201 aaaaaatcag tgtcggtccc cggcgcaaca atcagcgacg gctggcttgc ccagaaccat
     1261 caggacacat ggaaagtaga ggaagtgtgt aaagccaacg agccctgcac cagttttgca
     1321 gagtgtgtgt gtgatgacaa ctgtgagaag gaagccatgt ataaatggct tctgaagaag
     1381 ggaggaaagg acaagaatgg aatgcctatg gaacctaaat ctgagcctga gaaacacaga
     1441 gagtccctga cactgtggct ctgcccttcc agaaatgagc taacagaaca agctaaggca
     1501 cccaaggcta tggctcctgc tagaattgct gattccttcc acgtcataaa gaatagttcc
     1561 ttgtcagagt ggcttatggg gcctacgtgc aaaggaggcc ctaaggacgt gcctaataca
     1621 gaggagagag ctggcaaaga gatgcttcaa agctccatgg ccacttcctg gtgtcccttt
     1681 aacactgccg actgggtttt accaggaaag aaagtgggaa gcctcagcca gttcccctct
     1741 ggagaagata agtggctact tcgaaagaag gcacaggaag catttcttaa ttcaccccta
     1801 caagaagaac gtaactttcg ccccgactgt tacggcctcc cagcagtttg tgatctcttt
     1861 gcctgtatgc agcttaaggt tgataaagaa aaatggctgt acagaactcc tctacagatg
     1921 tgaaggaaca gactaccaga atcgagcagc tttcctgcag attattgcac atccttgagc
     1981 tgagtgactg cgatttgcca aaccattgtg cattccaagc ctgactagtc agcttagttc
     2041 ctctcctgct tagttttgaa ctagtaaaca gaagtcataa actatgagtt aagtctgtga
     2101 aagaggcttc aagtggaggt gattcattct tttgaaagcc gtaacgtgcg taacttgatc
     2161 aactcccgta ctagaaacca catcccggta cacaggcctt taccagcttt tctacagcca
     2221 acactagttt taaaagtgaa atattcctat atcaagtgtg ttaatgtgtt caaggtaata
     2281 agttctctaa catttgtctt ttagctgttt ctcattacag gcttctagag atttgaaaat
     2341 tttttttgtt cagttgatat atagaatatt tcacacaaat agttaacctt gccaatacag
     2401 tatatttttc cctactaaat gtctattagt tatattgcaa attttgatac tcatcagata
     2461 tttagcctac ataccatttc taacatttct catttggaag aaattaagct attatagttg
     2521 ttgcctttat ttctttccag tatccagtga gctctttgaa agggactttg ttttaagacc
     2581 actcttaggg cagtcagagc tcttaaagtc ctacaaacct cggctttaac taaagtgaac
     2641 cctaaagcag aaaggtaaaa agtgttagga atgcagtacc cgaaccactg gtcatcctaa
     2701 ggatttcttg gtgcatcctg tgtaaatgga agctgagctt gacacctggt gctcttaact
     2761 agggataaag tcaatgtcct gttacttcaa gcacagcatc ctgaacctcc taaagtacag
     2821 tgcagtgaca tcttgattac caggctgtgc tcaacactgt gccttggagt gtctcaccga
     2881 gacttcacag aactgatatc cttgagttct gtattctaga aagcttctct aaggatttat
     2941 cttttacagt tcccaaggat aaattagttg ctttctattc tttgaactat taatattaag
     3001 cctctgaaat gcctatgcta ttggaagtac ttttgggaaa attttatggt cccatagtga
     3061 cattaccata cagctttact gaagctccaa atcatagctg aaaagaacct catattttct
     3121 tatgtccctc aagatgccac tgagtattat aaagttggta ggtaaagaca atttaaggag
     3181 cctttccaac attttaggtt gcagggaact ttgtagtttc ttttttgagg tctaacactg
     3241 tattcacatt attaaaacat aatttaagtt aatcacttgc taatgatata taaaactttc
     3301 ttttgcatta agttttaaat ctccattaaa agcataatgg acacatca
//
