LOCUS NM_019744 3348 bp mRNA linear ROD 12-NOV-2024 DEFINITION Mus musculus nuclear receptor coactivator 4 (Ncoa4), transcript variant 1, mRNA. ACCESSION NM_019744 VERSION NM_019744.5 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 3348) AUTHORS He,X., Wang,Z., Ge,Q., Sun,S., Li,R. and Wang,B. TITLE Lactylation of nuclear receptor coactivator 4 promotes ferritinophagy and glycolysis of neuronal cells after cerebral ischemic injury JOURNAL Neuroreport 35 (14), 895-903 (2024) PUBMED 39166386 REMARK GeneRIF: Lactylation of nuclear receptor coactivator 4 promotes ferritinophagy and glycolysis of neuronal cells after cerebral ischemic injury. REFERENCE 2 (bases 1 to 3348) AUTHORS Wang,X., Xu,L., Meng,Y., Chen,F., Zhuang,J., Wang,M., An,W., Han,Y., Chu,B., Chai,R., Liu,W. and Wang,H. TITLE FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea Spiral Ganglion Neuron Ferroptosis via Ferritinophagy JOURNAL Adv Sci (Weinh) 11 (40), e2402671 (2024) PUBMED 39206719 REMARK GeneRIF: FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea Spiral Ganglion Neuron Ferroptosis via Ferritinophagy. REFERENCE 3 (bases 1 to 3348) AUTHORS Li,K., Wang,A., Diao,Y. and Fan,S. TITLE Oxidative medicine and cellular longevity the role and mechanism of NCOA4 in ferroptosis induced by intestinal ischemia reperfusion JOURNAL Int Immunopharmacol 133, 112155 (2024) PUBMED 38688134 REMARK GeneRIF: Oxidative medicine and cellular longevity the role and mechanism of NCOA4 in ferroptosis induced by intestinal ischemia reperfusion. REFERENCE 4 (bases 1 to 3348) AUTHORS Du,J., Yu,L., Yang,X., Shao,F., Xia,J., Jin,W., Zhang,Y., Lei,G., Wang,Y., Li,Y. and Zhang,J. TITLE Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis JOURNAL Cell Commun Signal 22 (1), 146 (2024) PUBMED 38388414 REMARK GeneRIF: Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis. Publication Status: Online-Only REFERENCE 5 (bases 1 to 3348) AUTHORS Ma,Z., Lu,H., Feng,X., Du,T., Li,J., Zhang,Q., Gu,X., Shao,Y., Jing,X. and Su,C. TITLE Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4-mediated ferritinophagy JOURNAL Int J Mol Med 53 (2) (2024) PUBMED 38063237 REMARK GeneRIF: Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4-mediated ferritinophagy. REFERENCE 6 (bases 1 to 3348) AUTHORS Wu,X., Chen,F., Sahin,A., Albarracin,C., Pei,Z., Zou,X., Singh,B., Xu,R., Daniels,G., Li,Y., Wei,J., Blake,M., Schneider,R.J., Cowin,P. and Lee,P. TITLE Distinct function of androgen receptor coactivator ARA70alpha and ARA70beta in mammary gland development, and in breast cancer JOURNAL Breast Cancer Res Treat 128 (2), 391-400 (2011) PUBMED 20814820 REMARK GeneRIF: High ARA70alpha inhibited cell proliferation, and that ARA70beta promotes proliferation in breast cancer. REFERENCE 7 (bases 1 to 3348) AUTHORS Kollara,A. and Brown,T.J. TITLE Variable expression of nuclear receptor coactivator 4 (NcoA4) during mouse embryonic development JOURNAL J Histochem Cytochem 58 (7), 595-609 (2010) PUBMED 20354146 REMARK GeneRIF: Results demonstrate ubiquitous NcoA4 expression throughout development and suggest that this coactivator may play a role in modulating nuclear receptor activity, particularly that of the aryl hydrocarbon receptor, during development. REFERENCE 8 (bases 1 to 3348) AUTHORS Ligr,M., Li,Y., Zou,X., Daniels,G., Melamed,J., Peng,Y., Wang,W., Wang,J., Ostrer,H., Pagano,M., Wang,Z., Garabedian,M.J. and Lee,P. TITLE Tumor suppressor function of androgen receptor coactivator ARA70alpha in prostate cancer JOURNAL Am J Pathol 176 (4), 1891-1900 (2010) PUBMED 20167864 REMARK GeneRIF: ARA70alpha functions as a tumor suppressor gene REFERENCE 9 (bases 1 to 3348) AUTHORS Siriett,V., Nicholas,G., Berry,C., Watson,T., Hennebry,A., Thomas,M., Ling,N., Sharma,M. and Kambadur,R. TITLE Myostatin negatively regulates the expression of the steroid receptor co-factor ARA70 JOURNAL J Cell Physiol 206 (1), 255-263 (2006) PUBMED 16110473 REMARK GeneRIF: Data suggest that myostatin decreases the activity of androgen receptors (AR) by down-regulating the expression of ARA70, a known stimulating co-factor of AR REFERENCE 10 (bases 1 to 3348) AUTHORS Beckers,J., Herrmann,F., Rieger,S., Drobyshev,A.L., Horsch,M., Hrabe de Angelis,M. and Seliger,B. TITLE Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis JOURNAL Int J Cancer 114 (4), 590-597 (2005) PUBMED 15609325 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154532.3. On Mar 24, 2022 this sequence version replaced NM_019744.4. Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147036.1, AK014479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-31 AC154532.3 122983-123013 c 32-186 AC154532.3 117903-118057 c 187-327 AC154532.3 116362-116502 c 328-416 AC154532.3 116110-116198 c 417-525 AC154532.3 115808-115916 c 526-615 AC154532.3 115315-115404 c 616-759 AC154532.3 114272-114415 c 760-1776 AC154532.3 111850-112866 c 1777-1917 AC154532.3 111432-111572 c 1918-3348 AC154532.3 109552-110982 c FEATURES Location/Qualifiers source 1..3348 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="14" /map="14 19.4 cM" gene 1..3348 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /note="nuclear receptor coactivator 4" /db_xref="GeneID:27057" /db_xref="MGI:MGI:1350932" exon 1..31 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /inference="alignment:Splign:2.1.0" exon 32..186 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /inference="alignment:Splign:2.1.0" CDS 46..1923 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /note="isoform a is encoded by transcript variant 1" /codon_start=1 /product="nuclear receptor coactivator 4 isoform a" /protein_id="NP_062718.2" /db_xref="CCDS:CCDS36863.1" /db_xref="GeneID:27057" /db_xref="MGI:MGI:1350932" /translation="MNTSLEQSGCYSNRETLLRCSDARRELELAIGGVLRAEQQIKDN LREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLYWLMGQFNCL IHQLEYTQNKDLANQVSVCLERLGSLALKPEDSTVLLFEADTSALRQTITTFGSLKTI QIPEHLMAHASSSSIGPFLEKRGYIQVPEQKSASSGTAVSLSEWLLVSKPAIGLQAPY VPSTNPQDWLIPKQTSENSQTSARACSFFSDAWGNLKGLENWLLNSHQQEIAGKPSSS KCNSHCSTSSFSPEAEKAEDVELLDQDELDLSDWLVTPQEPCELEKPVDGSWETSEKF KLLFQVFREPYNVSDWLVKPDSCTNCQGNQPRGVEIENLGNLKCLNDHLEAKKSVSVP GATISDGWLAQNHQDTWKVEEVCKANEPCTSFAECVCDDNCEKEAMYKWLLKKGGKDK NGMPMEPKSEPEKHRESLTLWLCPSRNELTEQAKAPKAMAPARIADSFHVIKNSSLSE WLMGPTCKGGPKDVPNTEERAGKEMLQSSMATSWCPFNTADWVLPGKKVGSLSQFPSG EDKWLLRKKAQEAFLNSPLQEERNFRPDCYGLPAVCDLFACMQLKVDKEKWLYRTPLQ M" exon 187..327 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /inference="alignment:Splign:2.1.0" exon 328..416 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /inference="alignment:Splign:2.1.0" exon 417..525 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /inference="alignment:Splign:2.1.0" exon 526..615 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /inference="alignment:Splign:2.1.0" exon 616..759 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /inference="alignment:Splign:2.1.0" exon 760..1776 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /inference="alignment:Splign:2.1.0" exon 1777..1917 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /inference="alignment:Splign:2.1.0" exon 1918..3348 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /inference="alignment:Splign:2.1.0" regulatory 3325..3330 /regulatory_class="polyA_signal_sequence" /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /note="hexamer: ATTAAA" polyA_site 3348 /gene="Ncoa4" /gene_synonym="ARA70; Rfg" /note="major polyA site" ORIGIN 1 agcagttttc gtcgcggggc cagactacct ggaacagtga gcagaatgaa cacatccctg 61 gaacagagtg gctgctacag taatagagaa actcttctga ggtgcagtga tgcaaggagg 121 gagctggagc ttgctattgg tggagtactt cgggctgaac agcaaattaa agataattta 181 cgagaggtaa aagctcagat tcacagctgc ataagtcgcc acctggaatg ccttcggagc 241 cgagaggtgt ggctcaatga acaggtcgat ctcatctatc agcttaaaga ggagacactg 301 cagcagcagg ctcagcagct ctattggcta atgggccaat tcaattgtct tattcatcaa 361 ctggagtata ctcagaacaa agatcttgcc aatcaagtct ctgtgtgctt ggagagactg 421 ggcagtttgg ccctgaagcc tgaagattca actgtcctac tctttgaagc agatacatct 481 gctctgcgcc agaccatcac cacatttgga tcccttaaga ccattcaaat ccctgagcat 541 ctgatggctc acgcgagctc ctcaagtatt gggcctttcc tagagaaaag aggctatatc 601 caggtgccag agcagaagtc agcatccagt ggcacagctg tatctctgag tgagtggctt 661 cttgtaagca aacctgccat tggtcttcag gctccttatg tacccagtac caacccacag 721 gactggctta tcccaaaaca gacttcagag aatagtcaga cttctgccag agcctgcagt 781 ttcttcagcg atgcctgggg caatctgaag ggcttagaaa attggctcct taacagtcat 841 caacaagaaa ttgctggaaa accaagttcc tcaaaatgta acagccattg tagcaccagt 901 tctttctctc ctgaagctga aaaggctgaa gatgtagagc tccttgatca agacgagctg 961 gacctgtctg attggttggt gactcctcag gaaccctgtg agctggagaa gcctgtggat 1021 ggcagctggg aaaccagcga gaagtttaaa ctcttgttcc aggtgttcag agagccctac 1081 aatgtgagtg attggcttgt caagcctgac tcctgtacca actgtcaggg caaccagcct 1141 agaggtgtgg agattgagaa cctgggcaat ctgaaatgcc taaatgacca cttggaggcc 1201 aaaaaatcag tgtcggtccc cggcgcaaca atcagcgacg gctggcttgc ccagaaccat 1261 caggacacat ggaaagtaga ggaagtgtgt aaagccaacg agccctgcac cagttttgca 1321 gagtgtgtgt gtgatgacaa ctgtgagaag gaagccatgt ataaatggct tctgaagaag 1381 ggaggaaagg acaagaatgg aatgcctatg gaacctaaat ctgagcctga gaaacacaga 1441 gagtccctga cactgtggct ctgcccttcc agaaatgagc taacagaaca agctaaggca 1501 cccaaggcta tggctcctgc tagaattgct gattccttcc acgtcataaa gaatagttcc 1561 ttgtcagagt ggcttatggg gcctacgtgc aaaggaggcc ctaaggacgt gcctaataca 1621 gaggagagag ctggcaaaga gatgcttcaa agctccatgg ccacttcctg gtgtcccttt 1681 aacactgccg actgggtttt accaggaaag aaagtgggaa gcctcagcca gttcccctct 1741 ggagaagata agtggctact tcgaaagaag gcacaggaag catttcttaa ttcaccccta 1801 caagaagaac gtaactttcg ccccgactgt tacggcctcc cagcagtttg tgatctcttt 1861 gcctgtatgc agcttaaggt tgataaagaa aaatggctgt acagaactcc tctacagatg 1921 tgaaggaaca gactaccaga atcgagcagc tttcctgcag attattgcac atccttgagc 1981 tgagtgactg cgatttgcca aaccattgtg cattccaagc ctgactagtc agcttagttc 2041 ctctcctgct tagttttgaa ctagtaaaca gaagtcataa actatgagtt aagtctgtga 2101 aagaggcttc aagtggaggt gattcattct tttgaaagcc gtaacgtgcg taacttgatc 2161 aactcccgta ctagaaacca catcccggta cacaggcctt taccagcttt tctacagcca 2221 acactagttt taaaagtgaa atattcctat atcaagtgtg ttaatgtgtt caaggtaata 2281 agttctctaa catttgtctt ttagctgttt ctcattacag gcttctagag atttgaaaat 2341 tttttttgtt cagttgatat atagaatatt tcacacaaat agttaacctt gccaatacag 2401 tatatttttc cctactaaat gtctattagt tatattgcaa attttgatac tcatcagata 2461 tttagcctac ataccatttc taacatttct catttggaag aaattaagct attatagttg 2521 ttgcctttat ttctttccag tatccagtga gctctttgaa agggactttg ttttaagacc 2581 actcttaggg cagtcagagc tcttaaagtc ctacaaacct cggctttaac taaagtgaac 2641 cctaaagcag aaaggtaaaa agtgttagga atgcagtacc cgaaccactg gtcatcctaa 2701 ggatttcttg gtgcatcctg tgtaaatgga agctgagctt gacacctggt gctcttaact 2761 agggataaag tcaatgtcct gttacttcaa gcacagcatc ctgaacctcc taaagtacag 2821 tgcagtgaca tcttgattac caggctgtgc tcaacactgt gccttggagt gtctcaccga 2881 gacttcacag aactgatatc cttgagttct gtattctaga aagcttctct aaggatttat 2941 cttttacagt tcccaaggat aaattagttg ctttctattc tttgaactat taatattaag 3001 cctctgaaat gcctatgcta ttggaagtac ttttgggaaa attttatggt cccatagtga 3061 cattaccata cagctttact gaagctccaa atcatagctg aaaagaacct catattttct 3121 tatgtccctc aagatgccac tgagtattat aaagttggta ggtaaagaca atttaaggag 3181 cctttccaac attttaggtt gcagggaact ttgtagtttc ttttttgagg tctaacactg 3241 tattcacatt attaaaacat aatttaagtt aatcacttgc taatgatata taaaactttc 3301 ttttgcatta agttttaaat ctccattaaa agcataatgg acacatca //