LOCUS       NM_001403000            3471 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus nuclear receptor coactivator 4 (Ncoa4), transcript
            variant 6, mRNA.
ACCESSION   NM_001403000
VERSION     NM_001403000.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3471)
  AUTHORS   He,X., Wang,Z., Ge,Q., Sun,S., Li,R. and Wang,B.
  TITLE     Lactylation of nuclear receptor coactivator 4 promotes
            ferritinophagy and glycolysis of neuronal cells after cerebral
            ischemic injury
  JOURNAL   Neuroreport 35 (14), 895-903 (2024)
   PUBMED   39166386
  REMARK    GeneRIF: Lactylation of nuclear receptor coactivator 4 promotes
            ferritinophagy and glycolysis of neuronal cells after cerebral
            ischemic injury.
REFERENCE   2  (bases 1 to 3471)
  AUTHORS   Wang,X., Xu,L., Meng,Y., Chen,F., Zhuang,J., Wang,M., An,W.,
            Han,Y., Chu,B., Chai,R., Liu,W. and Wang,H.
  TITLE     FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea Spiral
            Ganglion Neuron Ferroptosis via Ferritinophagy
  JOURNAL   Adv Sci (Weinh) 11 (40), e2402671 (2024)
   PUBMED   39206719
  REMARK    GeneRIF: FOXO1-NCOA4 Axis Contributes to Cisplatin-Induced Cochlea
            Spiral Ganglion Neuron Ferroptosis via Ferritinophagy.
REFERENCE   3  (bases 1 to 3471)
  AUTHORS   Li,K., Wang,A., Diao,Y. and Fan,S.
  TITLE     Oxidative medicine and cellular longevity the role and mechanism of
            NCOA4 in ferroptosis induced by intestinal ischemia reperfusion
  JOURNAL   Int Immunopharmacol 133, 112155 (2024)
   PUBMED   38688134
  REMARK    GeneRIF: Oxidative medicine and cellular longevity the role and
            mechanism of NCOA4 in ferroptosis induced by intestinal ischemia
            reperfusion.
REFERENCE   4  (bases 1 to 3471)
  AUTHORS   Du,J., Yu,L., Yang,X., Shao,F., Xia,J., Jin,W., Zhang,Y., Lei,G.,
            Wang,Y., Li,Y. and Zhang,J.
  TITLE     Regulation of NCOA4-mediated iron recycling ameliorates
            paraquat-induced lung injury by inhibiting ferroptosis
  JOURNAL   Cell Commun Signal 22 (1), 146 (2024)
   PUBMED   38388414
  REMARK    GeneRIF: Regulation of NCOA4-mediated iron recycling ameliorates
            paraquat-induced lung injury by inhibiting ferroptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3471)
  AUTHORS   Ma,Z., Lu,H., Feng,X., Du,T., Li,J., Zhang,Q., Gu,X., Shao,Y.,
            Jing,X. and Su,C.
  TITLE     Nrf2 protects against cartilage endplate degeneration through
            inhibiting NCOA4-mediated ferritinophagy
  JOURNAL   Int J Mol Med 53 (2) (2024)
   PUBMED   38063237
  REMARK    GeneRIF: Nrf2 protects against cartilage endplate degeneration
            through inhibiting NCOA4-mediated ferritinophagy.
REFERENCE   6  (bases 1 to 3471)
  AUTHORS   Wu,X., Chen,F., Sahin,A., Albarracin,C., Pei,Z., Zou,X., Singh,B.,
            Xu,R., Daniels,G., Li,Y., Wei,J., Blake,M., Schneider,R.J.,
            Cowin,P. and Lee,P.
  TITLE     Distinct function of androgen receptor coactivator ARA70alpha and
            ARA70beta in mammary gland development, and in breast cancer
  JOURNAL   Breast Cancer Res Treat 128 (2), 391-400 (2011)
   PUBMED   20814820
  REMARK    GeneRIF: High ARA70alpha inhibited cell proliferation, and that
            ARA70beta promotes proliferation in breast cancer.
REFERENCE   7  (bases 1 to 3471)
  AUTHORS   Kollara,A. and Brown,T.J.
  TITLE     Variable expression of nuclear receptor coactivator 4 (NcoA4)
            during mouse embryonic development
  JOURNAL   J Histochem Cytochem 58 (7), 595-609 (2010)
   PUBMED   20354146
  REMARK    GeneRIF: Results demonstrate ubiquitous NcoA4 expression throughout
            development and suggest that this coactivator may play a role in
            modulating nuclear receptor activity, particularly that of the aryl
            hydrocarbon receptor, during development.
REFERENCE   8  (bases 1 to 3471)
  AUTHORS   Ligr,M., Li,Y., Zou,X., Daniels,G., Melamed,J., Peng,Y., Wang,W.,
            Wang,J., Ostrer,H., Pagano,M., Wang,Z., Garabedian,M.J. and Lee,P.
  TITLE     Tumor suppressor function of androgen receptor coactivator
            ARA70alpha in prostate cancer
  JOURNAL   Am J Pathol 176 (4), 1891-1900 (2010)
   PUBMED   20167864
  REMARK    GeneRIF: ARA70alpha functions as a tumor suppressor gene
REFERENCE   9  (bases 1 to 3471)
  AUTHORS   Siriett,V., Nicholas,G., Berry,C., Watson,T., Hennebry,A.,
            Thomas,M., Ling,N., Sharma,M. and Kambadur,R.
  TITLE     Myostatin negatively regulates the expression of the steroid
            receptor co-factor ARA70
  JOURNAL   J Cell Physiol 206 (1), 255-263 (2006)
   PUBMED   16110473
  REMARK    GeneRIF: Data suggest that myostatin decreases the activity of
            androgen receptors (AR) by down-regulating the expression of ARA70,
            a known stimulating co-factor of AR
REFERENCE   10 (bases 1 to 3471)
  AUTHORS   Beckers,J., Herrmann,F., Rieger,S., Drobyshev,A.L., Horsch,M.,
            Hrabe de Angelis,M. and Seliger,B.
  TITLE     Identification and validation of novel ERBB2 (HER2, NEU) targets
            including genes involved in angiogenesis
  JOURNAL   Int J Cancer 114 (4), 590-597 (2005)
   PUBMED   15609325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154532.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.990807.1,
                                           SRR13422590.9424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC154532.3         122535-122688       c
            155-309             AC154532.3         117903-118057       c
            310-450             AC154532.3         116362-116502       c
            451-539             AC154532.3         116110-116198       c
            540-648             AC154532.3         115808-115916       c
            649-738             AC154532.3         115315-115404       c
            739-882             AC154532.3         114272-114415       c
            883-1899            AC154532.3         111850-112866       c
            1900-2040           AC154532.3         111432-111572       c
            2041-3471           AC154532.3         109552-110982       c
FEATURES             Location/Qualifiers
     source          1..3471
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.4 cM"
     gene            1..3471
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /note="nuclear receptor coactivator 4"
                     /db_xref="GeneID:27057"
                     /db_xref="MGI:MGI:1350932"
     exon            1..154
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2046
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /note="isoform 3 is encoded by transcript variant 6"
                     /codon_start=1
                     /product="nuclear receptor coactivator 4 isoform 3"
                     /protein_id="NP_001389929.1"
                     /db_xref="GeneID:27057"
                     /db_xref="MGI:MGI:1350932"
                     /translation="MAQGTVSRMNTSLEQSGCYSNRETLLRCSDARRELELAIGGVLR
                     AEQQIKDNLREVKAQIHSCISRHLECLRSREVWLNEQVDLIYQLKEETLQQQAQQLYW
                     LMGQFNCLIHQLEYTQNKDLANQVSVCLERLGSLALKPEDSTVLLFEADTSALRQTIT
                     TFGSLKTIQIPEHLMAHASSSSIGPFLEKRGYIQVPEQKSASSGTAVSLSEWLLVSKP
                     AIGLQAPYVPSTNPQDWLIPKQTSENSQTSARACSFFSDAWGNLKGLENWLLNSHQQE
                     IAGKPSSSKCNSHCSTSSFSPEAEKAEDVELLDQDELDLSDWLVTPQEPCELEKPVDG
                     SWETSEKFKLLFQVFREPYNVSDWLVKPDSCTNCQGNQPRGVEIENLGNLKCLNDHLE
                     AKKSVSVPGATISDGWLAQNHQDTWKVEEVCKANEPCTSFAECVCDDNCEKEAMYKWL
                     LKKGGKDKNGMPMEPKSEPEKHRESLTLWLCPSRNELTEQAKAPKAMAPARIADSFHV
                     IKNSSLSEWLMGPTCKGGPKDVPNTEERAGKEMLQSSMATSWCPFNTADWVLPGKKVG
                     SLSQFPSGEDKWLLRKKAQEAFLNSPLQEERNFRPDCYGLPAVCDLFACMQLKVDKEK
                     WLYRTPLQM"
     exon            155..309
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            310..450
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            451..539
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            540..648
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            649..738
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            739..882
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1899
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2040
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..3471
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3448..3453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /note="hexamer: ATTAAA"
     polyA_site      3471
                     /gene="Ncoa4"
                     /gene_synonym="ARA70; Rfg"
                     /note="major polyA site"
ORIGIN      
        1 acttgtgaaa gcaagctaga gggctgtgga ggctaaagaa tttgaactgg acttaactca
       61 agatctgtat actctttgag ataatgtgct gtgattaaaa aacccctttt cactggaaga
      121 agaaacagca agtgaaggca agaaatggct caaggaacag tgagcagaat gaacacatcc
      181 ctggaacaga gtggctgcta cagtaataga gaaactcttc tgaggtgcag tgatgcaagg
      241 agggagctgg agcttgctat tggtggagta cttcgggctg aacagcaaat taaagataat
      301 ttacgagagg taaaagctca gattcacagc tgcataagtc gccacctgga atgccttcgg
      361 agccgagagg tgtggctcaa tgaacaggtc gatctcatct atcagcttaa agaggagaca
      421 ctgcagcagc aggctcagca gctctattgg ctaatgggcc aattcaattg tcttattcat
      481 caactggagt atactcagaa caaagatctt gccaatcaag tctctgtgtg cttggagaga
      541 ctgggcagtt tggccctgaa gcctgaagat tcaactgtcc tactctttga agcagataca
      601 tctgctctgc gccagaccat caccacattt ggatccctta agaccattca aatccctgag
      661 catctgatgg ctcacgcgag ctcctcaagt attgggcctt tcctagagaa aagaggctat
      721 atccaggtgc cagagcagaa gtcagcatcc agtggcacag ctgtatctct gagtgagtgg
      781 cttcttgtaa gcaaacctgc cattggtctt caggctcctt atgtacccag taccaaccca
      841 caggactggc ttatcccaaa acagacttca gagaatagtc agacttctgc cagagcctgc
      901 agtttcttca gcgatgcctg gggcaatctg aagggcttag aaaattggct ccttaacagt
      961 catcaacaag aaattgctgg aaaaccaagt tcctcaaaat gtaacagcca ttgtagcacc
     1021 agttctttct ctcctgaagc tgaaaaggct gaagatgtag agctccttga tcaagacgag
     1081 ctggacctgt ctgattggtt ggtgactcct caggaaccct gtgagctgga gaagcctgtg
     1141 gatggcagct gggaaaccag cgagaagttt aaactcttgt tccaggtgtt cagagagccc
     1201 tacaatgtga gtgattggct tgtcaagcct gactcctgta ccaactgtca gggcaaccag
     1261 cctagaggtg tggagattga gaacctgggc aatctgaaat gcctaaatga ccacttggag
     1321 gccaaaaaat cagtgtcggt ccccggcgca acaatcagcg acggctggct tgcccagaac
     1381 catcaggaca catggaaagt agaggaagtg tgtaaagcca acgagccctg caccagtttt
     1441 gcagagtgtg tgtgtgatga caactgtgag aaggaagcca tgtataaatg gcttctgaag
     1501 aagggaggaa aggacaagaa tggaatgcct atggaaccta aatctgagcc tgagaaacac
     1561 agagagtccc tgacactgtg gctctgccct tccagaaatg agctaacaga acaagctaag
     1621 gcacccaagg ctatggctcc tgctagaatt gctgattcct tccacgtcat aaagaatagt
     1681 tccttgtcag agtggcttat ggggcctacg tgcaaaggag gccctaagga cgtgcctaat
     1741 acagaggaga gagctggcaa agagatgctt caaagctcca tggccacttc ctggtgtccc
     1801 tttaacactg ccgactgggt tttaccagga aagaaagtgg gaagcctcag ccagttcccc
     1861 tctggagaag ataagtggct acttcgaaag aaggcacagg aagcatttct taattcaccc
     1921 ctacaagaag aacgtaactt tcgccccgac tgttacggcc tcccagcagt ttgtgatctc
     1981 tttgcctgta tgcagcttaa ggttgataaa gaaaaatggc tgtacagaac tcctctacag
     2041 atgtgaagga acagactacc agaatcgagc agctttcctg cagattattg cacatccttg
     2101 agctgagtga ctgcgatttg ccaaaccatt gtgcattcca agcctgacta gtcagcttag
     2161 ttcctctcct gcttagtttt gaactagtaa acagaagtca taaactatga gttaagtctg
     2221 tgaaagaggc ttcaagtgga ggtgattcat tcttttgaaa gccgtaacgt gcgtaacttg
     2281 atcaactccc gtactagaaa ccacatcccg gtacacaggc ctttaccagc ttttctacag
     2341 ccaacactag ttttaaaagt gaaatattcc tatatcaagt gtgttaatgt gttcaaggta
     2401 ataagttctc taacatttgt cttttagctg tttctcatta caggcttcta gagatttgaa
     2461 aatttttttt gttcagttga tatatagaat atttcacaca aatagttaac cttgccaata
     2521 cagtatattt ttccctacta aatgtctatt agttatattg caaattttga tactcatcag
     2581 atatttagcc tacataccat ttctaacatt tctcatttgg aagaaattaa gctattatag
     2641 ttgttgcctt tatttctttc cagtatccag tgagctcttt gaaagggact ttgttttaag
     2701 accactctta gggcagtcag agctcttaaa gtcctacaaa cctcggcttt aactaaagtg
     2761 aaccctaaag cagaaaggta aaaagtgtta ggaatgcagt acccgaacca ctggtcatcc
     2821 taaggatttc ttggtgcatc ctgtgtaaat ggaagctgag cttgacacct ggtgctctta
     2881 actagggata aagtcaatgt cctgttactt caagcacagc atcctgaacc tcctaaagta
     2941 cagtgcagtg acatcttgat taccaggctg tgctcaacac tgtgccttgg agtgtctcac
     3001 cgagacttca cagaactgat atccttgagt tctgtattct agaaagcttc tctaaggatt
     3061 tatcttttac agttcccaag gataaattag ttgctttcta ttctttgaac tattaatatt
     3121 aagcctctga aatgcctatg ctattggaag tacttttggg aaaattttat ggtcccatag
     3181 tgacattacc atacagcttt actgaagctc caaatcatag ctgaaaagaa cctcatattt
     3241 tcttatgtcc ctcaagatgc cactgagtat tataaagttg gtaggtaaag acaatttaag
     3301 gagcctttcc aacattttag gttgcaggga actttgtagt ttcttttttg aggtctaaca
     3361 ctgtattcac attattaaaa cataatttaa gttaatcact tgctaatgat atataaaact
     3421 ttcttttgca ttaagtttta aatctccatt aaaagcataa tggacacatc a
//
