LOCUS       NM_008679               7526 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus nuclear receptor coactivator 3 (Ncoa3), transcript
            variant 1, mRNA.
ACCESSION   NM_008679
VERSION     NM_008679.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7526)
  AUTHORS   Deng,M., Hou,Y., Liu,J., He,J., Lan,Z. and Xiao,H.
  TITLE     Mesenchymal stem cell-derived exosomes overexpressing SRC-3 protect
            mice from cerebral ischemia by inhibiting ferroptosis
  JOURNAL   Brain Res Bull 211, 110948 (2024)
   PUBMED   38614406
  REMARK    GeneRIF: Mesenchymal stem cell-derived exosomes overexpressing
            SRC-3 protect mice from cerebral ischemia by inhibiting
            ferroptosis.
REFERENCE   2  (bases 1 to 7526)
  AUTHORS   Xie,Y., Yuan,Q., Cao,X., Qiu,Y., Zeng,J., Cao,Y., Xie,Y., Meng,X.,
            Huang,K., Yi,F. and Zhang,C.
  TITLE     Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic
            Kidney Disease by Impairing Podocyte Autophagy
  JOURNAL   Adv Sci (Weinh) 11 (19), e2308378 (2024)
   PUBMED   38483947
  REMARK    GeneRIF: Deficiency of Nuclear Receptor Coactivator 3 Aggravates
            Diabetic Kidney Disease by Impairing Podocyte Autophagy.
REFERENCE   3  (bases 1 to 7526)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 7526)
  AUTHORS   Han,S.J., Jain,P., Gilad,Y., Xia,Y., Sung,N., Park,M.J., Dean,A.M.,
            Lanz,R.B., Xu,J., Dacso,C.C., Lonard,D.M. and O'Malley,B.W.
  TITLE     Steroid receptor coactivator 3 is a key modulator of regulatory T
            cell-mediated tumor evasion
  JOURNAL   Proc Natl Acad Sci U S A 120 (23), e2221707120 (2023)
   PUBMED   37253006
  REMARK    GeneRIF: Steroid receptor coactivator 3 is a key modulator of
            regulatory T cell-mediated tumor evasion.
REFERENCE   5  (bases 1 to 7526)
  AUTHORS   Lira,M.C., Rosa,F.D., Aiello,I., Machado,M.S., Palma,A.G., Paz,L.,
            Guemes,M.C.S., Burlando,S., Azurmendi,P.J., Paladino,N.,
            Costas,M.A. and Rubio,M.F.
  TITLE     NCoA3 upregulation in breast cancer-associated adipocytes elicits
            an inflammatory profile
  JOURNAL   Oncol Rep 49 (5) (2023)
   PUBMED   37026525
  REMARK    GeneRIF: NCoA3 upregulation in breast cancer-associated adipocytes
            elicits an inflammatory profile.
REFERENCE   6  (bases 1 to 7526)
  AUTHORS   O'Brien,T.W., Liu,J., Sylvester,J.E., Mougey,E.B.,
            Fischel-Ghodsian,N., Thiede,B., Wittmann-Liebold,B. and Graack,H.R.
  TITLE     Mammalian mitochondrial ribosomal proteins (4). Amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 275 (24), 18153-18159 (2000)
   PUBMED   10751423
REFERENCE   7  (bases 1 to 7526)
  AUTHORS   Ning,G., Jurecic,V., Baldini,A. and Xu,J.
  TITLE     Structure and chromosomal locations of mouse steroid receptor
            coactivator gene family
  JOURNAL   In Vitro Cell Dev Biol Anim 35 (8), 481-486 (1999)
   PUBMED   10501088
REFERENCE   8  (bases 1 to 7526)
  AUTHORS   Chen,D., Ma,H., Hong,H., Koh,S.S., Huang,S.M., Schurter,B.T.,
            Aswad,D.W. and Stallcup,M.R.
  TITLE     Regulation of transcription by a protein methyltransferase
  JOURNAL   Science 284 (5423), 2174-2177 (1999)
   PUBMED   10381882
REFERENCE   9  (bases 1 to 7526)
  AUTHORS   Xu,J., Qiu,Y., DeMayo,F.J., Tsai,S.Y., Tsai,M.J. and O'Malley,B.W.
  TITLE     Partial hormone resistance in mice with disruption of the steroid
            receptor coactivator-1 (SRC-1) gene
  JOURNAL   Science 279 (5358), 1922-1925 (1998)
   PUBMED   9506940
REFERENCE   10 (bases 1 to 7526)
  AUTHORS   Torchia,J., Rose,D.W., Inostroza,J., Kamei,Y., Westin,S.,
            Glass,C.K. and Rosenfeld,M.G.
  TITLE     The transcriptional co-activator p/CIP binds CBP and mediates
            nuclear-receptor function
  JOURNAL   Nature 387 (6634), 677-684 (1997)
   PUBMED   9192892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589902.18 and AL589873.11.
            
            On Apr 20, 2022 this sequence version replaced NM_008679.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086482.1, SRR10223969.3363.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AL589902.18        150731-150852
            123-201             AL589902.18        192979-193057
            202-306             AL589873.11        7225-7329
            307-479             AL589873.11        7552-7724
            480-580             AL589873.11        8224-8324
            581-755             AL589873.11        9835-10009
            756-941             AL589873.11        11081-11266
            942-1034            AL589873.11        11383-11475
            1035-1175           AL589873.11        12124-12264
            1176-1323           AL589873.11        12523-12670
            1324-1700           AL589873.11        14051-14427
            1701-2569           AL589873.11        14540-15408
            2570-2699           AL589873.11        16858-16987
            2700-2894           AL589873.11        18411-18605
            2895-3206           AL589873.11        18933-19244
            3207-3333           AL589873.11        19464-19590
            3334-3505           AL589873.11        20526-20697
            3506-3799           AL589873.11        25527-25820
            3800-3883           AL589873.11        27331-27414
            3884-4103           AL589873.11        28098-28317
            4104-4278           AL589873.11        28974-29148
            4279-4420           AL589873.11        29580-29721
            4421-7526           AL589873.11        29901-33006
FEATURES             Location/Qualifiers
     source          1..7526
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 86.22 cM"
     gene            1..7526
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /note="nuclear receptor coactivator 3"
                     /db_xref="GeneID:17979"
                     /db_xref="MGI:MGI:1276535"
     exon            1..122
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            123..201
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..306
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..4432
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     AIB-1; RAC-3; SRC-3; NCoA-3; CBP-interacting protein;
                     receptor-associated coactivator 3; steroid receptor
                     coactivator protein 3; amplified in breast cancer-1
                     protein homolog; thyroid hormone receptor activator
                     molecule 1"
                     /codon_start=1
                     /product="nuclear receptor coactivator 3 isoform 1"
                     /protein_id="NP_032705.2"
                     /db_xref="CCDS:CCDS38333.1"
                     /db_xref="GeneID:17979"
                     /db_xref="MGI:MGI:1276535"
                     /translation="MSGLGESSLDPLAAESRKRKLPCDAPGQGLVYSGEKWRREQESK
                     YIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISSDDDVQKADVS
                     STGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYS
                     ILHEQDRKDFLKHLPKSTVNGVSWTNENQRQKSHTFNCRMLMKTHDILEDVNASPETR
                     QRYETMQCFALSQPRAMLEEGEDLQCCMICVARRVTAPFPSSPESFITRHDLSGKVVN
                     IDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYVHGHAETPVYRFSL
                     ADGTIVSAQTKSKLFRNPVTNDRHGFISTHFLQREQNGYRPNPNPAGQGIRPPAAGCG
                     VSMSPNQNVQMMGSRTYGVPDPSNTGQMGGARYGASSSVASLTPGQSLQSPSSYQNSS
                     YGLSMSSPPHGSPGLGPNQQNIMISPRNRGSPKMASHQFSPAAGAHSPMGPSGNTGSH
                     SFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNISQPSKVSGQDSKSPLGLY
                     CEQNPVESSVCQSNSRDHPSEKESKESSGEVSETPRGPLESKGHKKLLQLLTCSSDDR
                     GHSSLTNSPLDPNCKDSSVSVTSPSGVSSSTSGTVSSTSNVHGSLLQEKHRILHKLLQ
                     NGNSPAEVAKITAEATGKDTSSTASCGEGTTRQEQLSPKKKENNALLRYLLDRDDPSD
                     VLAKELQPQADSGDSKLSQCSCSTNPSSGQEKDPKIKTETNEEVSGDLDNLDAILGDL
                     TSSDFYNNPTNGGHPGAKQQMFAGPSSLGLRSPQPVQSVRPPYNRAVSLDSPVSVGSG
                     PPVKNVSAFPGLPKQPILAGNPRMMDSQENYGANMGPNRNVPVNPTSSPGDWGLANSR
                     ASRMEPLASSPLGRTGADYSATLPRPAMGGSVPTLPLRSNRLPGARPSLQQQQQQQQQ
                     QQQQQQQQQQQQQQQQQQQMLQMRTGEIPMGMGVNPYSPAVPSNQPGSWPEGMLSMEQ
                     GPHGSQNRPLLRNSLDDLLGPPSNAEGQSDERALLDQLHTLLSNTDATGLEEIDRALG
                     IPELVNQGQALESKQDVFQGQEAAVMMDQKAALYGQTYPAQGPPLQGGFNLQGQSPSF
                     NSMMGQISQQGSFPLQGMHPRAGLVRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALEM
                     KMENPAGTAVMRPMMPQQAFFNAQMAAQQKRELMSHHLQQQRMAMMMSQPQPQAFSPP
                     PNVTASPSMDGVLAGSAMPQAPPQQFPYPANYGMGQPPEPAFGRGSSPPSAMMSSRMG
                     PSQNAMVQHPQPTPMYQPSDMKGWPSGNLARNGSFPQQQFAPQGNPAAYNMVHMNSSG
                     GHLGQMAMTPMPMSGMPMGPDQKYC"
     exon            307..479
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..580
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..755
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..941
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1034
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1175
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1323
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1700
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..2569
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2699
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2894
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3206
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3333
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3505
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3799
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            3800..3883
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            3884..4103
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            4104..4278
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4420
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     exon            4421..7526
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5208..5213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /note="hexamer: AATAAA"
     polyA_site      5227
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /note="major polyA site"
     regulatory      5733..5738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /note="hexamer: ATTAAA"
     polyA_site      5757
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
     regulatory      7508..7513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /note="hexamer: AATAAA"
     polyA_site      7526
                     /gene="Ncoa3"
                     /gene_synonym="2010305B15Rik; Actr; Aib1; bHLHe42; KAT13B;
                     p/Cip; pCip; Rac3; Src3; Tram-1; Tram1"
                     /note="major polyA site"
ORIGIN      
        1 agcggcggct gcctcagctc ctcagagcgc cggcggcggc ctcggcggag tcggtgtcgg
       61 cggccggggc tgagctgtga gtttccgatc gagaacagcg ttggggaaga tggcggcgag
      121 cggatcaaaa gatttgctga acagtggact ccgagatcgg taaaacgaag ctcttcctgc
      181 ccttcctgac caggctgtca gttgctgatc tgtgatcagg atgagtggac taggcgaaag
      241 ctctttggat ccgctggccg ctgagtctcg gaaacgcaaa ctgccctgtg atgccccagg
      301 acaggggctt gtctacagtg gtgagaagtg gcgacgggag caggagagca agtacataga
      361 ggagctggca gagctcatct ctgcaaatct cagcgacatc gacaacttca atgtcaagcc
      421 agataaatgt gccatcctaa aggagacagt gagacagata cggcaaataa aagaacaagg
      481 aaaaactatt tccagtgatg atgatgttca aaaagctgat gtgtcttcta cagggcaggg
      541 agtcattgat aaagactctt taggaccgct tttactacag gcactggatg gtttcctgtt
      601 tgtggtgaat cgagatggaa acattgtatt cgtgtcagaa aatgtcacac agtatctgca
      661 gtacaagcag gaggacctgg ttaacacaag tgtctacagc atcttacatg agcaagaccg
      721 gaaggatttt cttaaacact taccaaaatc cacagttaat ggagtttctt ggactaatga
      781 gaaccagaga caaaaaagcc atacatttaa ttgtcgtatg ttgatgaaaa cacacgacat
      841 tttggaagac gtgaatgcca gtcccgaaac acgccagaga tatgaaacaa tgcagtgctt
      901 tgccctgtct cagcctcgcg ctatgctgga agaaggagaa gacttgcagt gctgtatgat
      961 ctgcgtggct cgccgcgtga ctgcgccatt cccatccagt cctgagagct ttattaccag
     1021 acatgacctt tccggaaagg ttgtcaatat agatacaaac tcacttagat cttccatgag
     1081 gcctggcttt gaagacataa tccgaagatg tatccagagg ttcttcagtc tgaatgatgg
     1141 gcagtcatgg tcccagaagc gtcactatca agaagcttat gttcatggcc acgcagagac
     1201 ccccgtgtat cgtttctcct tggctgatgg aactattgtg agtgcgcaga caaaaagcaa
     1261 actcttccgc aatcctgtaa cgaatgatcg tcacggcttc atctcgaccc actttcttca
     1321 gagagaacag aatggataca gaccaaaccc aaatcccgca ggacaaggca tccgacctcc
     1381 tgcagcaggg tgtggcgtga gcatgtctcc aaatcagaat gtacagatga tgggcagccg
     1441 gacctatggc gtgccagacc ccagcaacac agggcagatg ggtggagcta ggtacggggc
     1501 ttctagtagc gtagcctcac tgacgccagg acaaagccta cagtcgccat cttcctatca
     1561 gaacagcagc tatgggctca gcatgagcag tcccccccac ggcagtcctg gtcttggtcc
     1621 caaccagcag aacatcatga tttcccctcg gaatcgtggc agcccaaaga tggcctccca
     1681 ccagttctct cctgctgcag gtgcacactc acccatggga ccttctggca acacagggag
     1741 ccacagcttt tctagcagct ccctcagtgc cttgcaagcc atcagtgaag gcgtggggac
     1801 ctctctttta tctactctgt cctcaccagg ccccaaactg gataattctc ccaatatgaa
     1861 tataagccag ccaagtaaag tgagtggtca ggactctaag agccccctag gcttatactg
     1921 tgaacagaat ccagtggaga gttcagtgtg tcagtcaaac agcagagatc acccaagtga
     1981 aaaagaaagc aaggagagca gtggggaggt gtcagagacg cccaggggac ctctggaaag
     2041 caaaggccac aagaaactgc tgcagttact cacgtgctcc tccgacgacc gaggccattc
     2101 ctccttgacc aactctcccc tggatccaaa ctgcaaagac tcttccgtta gtgtcaccag
     2161 cccctctgga gtgtcctcct caacatcagg gacagtgtct tccacctcca atgtgcatgg
     2221 gtctctgttg caagagaaac accggatttt gcacaagttg ctgcagaatg gcaactcccc
     2281 agcggaggtc gccaagatca ctgcagaggc cactgggaag gacacgagca gcactgcttc
     2341 ctgtggagag gggacaacca ggcaggagca gctgagtcct aagaagaagg agaataatgc
     2401 tctgcttaga tacctgctgg acagggatga ccccagtgat gtgcttgcca aagagctgca
     2461 gccccaggcc gacagtgggg acagtaaact gagtcagtgc agctgctcca ccaatcccag
     2521 ctctggccaa gagaaagacc ccaaaattaa gaccgagacg aacgaggagg tatcgggaga
     2581 cctggataat ctagatgcca ttcttggaga tttgaccagt tctgacttct acaacaatcc
     2641 tacaaatggc ggtcacccag gggccaaaca gcagatgttt gcaggaccga gttctctggg
     2701 tttgcgaagt ccacagcctg tgcagtctgt tcgtcctcca tataaccgag cggtgtctct
     2761 ggatagccct gtgtctgttg gctcaggtcc gccagtgaag aatgtcagtg ctttccctgg
     2821 gttaccaaaa cagcccatac tggctgggaa tccaagaatg atggatagtc aggagaatta
     2881 cggtgccaac atgggcccaa acagaaatgt tcctgtgaat ccgacttcct cccccggaga
     2941 ctggggctta gctaactcaa gggccagcag aatggagcct ctggcatcaa gtcccctggg
     3001 aagaactgga gccgattaca gtgccacttt acccagacct gccatggggg gctctgtgcc
     3061 taccttgcca cttcgttcta atcgactgcc aggtgcaaga ccatcgttgc agcaacagca
     3121 gcagcaacag cagcaacagc aacaacaaca gcagcaacag cagcagcaac agcagcagca
     3181 gcaacagcag cagatgcttc aaatgagaac tggtgagatt cccatgggaa tgggagtcaa
     3241 tccctatagc ccagcagtgc cgtctaacca accaggttcc tggccagagg gcatgctctc
     3301 tatggaacaa ggtcctcacg ggtctcaaaa taggcctctt cttagaaact ctctggatga
     3361 tctgcttggg ccaccttcta acgcagaggg ccagagtgac gagagagctc tgctggacca
     3421 gctgcacaca ctcctgagca acacagatgc cacaggtctg gaggagatcg acagggcctt
     3481 gggaattcct gagctcgtga atcagggaca agctttggag tccaaacagg atgttttcca
     3541 aggccaagaa gcagcagtaa tgatggatca gaaggctgca ctatatggac agacataccc
     3601 agctcagggt cctccccttc aaggaggctt taaccttcag ggacagtcac catcgtttaa
     3661 ctctatgatg ggtcagatta gccagcaagg cagctttcct ctgcaaggca tgcatcctag
     3721 agccggcctc gtgagaccaa ggaccaacac cccgaagcag ctgagaatgc agcttcagca
     3781 gaggctacag ggccagcagt ttttaaatca gagccggcag gcacttgaaa tgaaaatgga
     3841 gaaccctgct ggcactgctg tgatgaggcc catgatgccc cagcaggctt tctttaatgc
     3901 ccaaatggct gcccagcaga aacgagagct gatgagccat cacctgcagc agcagaggat
     3961 ggcgatgatg atgtcacaac cacagcctca ggccttcagc ccacctccca acgtcaccgc
     4021 ctcccccagc atggacgggg ttttggcagg ttcagcaatg ccgcaagccc ctccacaaca
     4081 gtttccatat ccagcaaatt acggaatggg acaaccacca gagccagcct ttggtcgagg
     4141 ctcgagtcct cccagtgcaa tgatgtcatc aagaatgggg ccttcccaga atgccatggt
     4201 gcagcatcct cagcccacac ccatgtatca gccttcagat atgaaggggt ggccgtcagg
     4261 gaacctggcc aggaatggct ccttccccca gcagcagttt gctccccagg ggaaccctgc
     4321 agcctacaac atggtgcata tgaacagcag cggtgggcac ttgggacaga tggccatgac
     4381 ccccatgccc atgtctggca tgcccatggg ccccgatcag aaatactgct gacatctccc
     4441 tagtgggact gactgtacag atgacactgc acaggatcat caggacgtgg cggcgagtca
     4501 ttgtctaagc atccagcttg gaagcaaggc cagcgtgacc agcagcgggg tctgtgctgt
     4561 catttgagca gagctgggtc tcgctgaagc gcactgtcta cctgatgccc tgcctctgtg
     4621 tggcaaggtg ttctgcctca tgaggatgtg attctggaga tggggtgttc gtaagcaccg
     4681 ctctcttacg tcactccctt ctgcctcgcc agccaaagtc ttcacgtaga tctagatggc
     4741 tagggtttct gtcttgcagc actggacgag ggggcacagt ctgccttctc gcgtgtcgtc
     4801 agcaagtagt tcgtgtcgct ctcctgtcca gtgcaatcag tgtttctgcg ctcttgtcct
     4861 ttacaggtgt agtccccaga gtctgtcgtc ctaggtctct cctggtgagg tccccgtacc
     4921 ctgtaattct caaggatttg tcattgatgt taaatggctt tgaagaaggg aagatgagat
     4981 ggcaatattg aattttcccg ccccaatgtg cagccaagcg cactttactg aggaagtcac
     5041 ggagaaatgc aatattcctg agggcgtgag gaatggtgaa ccacattcct gctttctgtc
     5101 tgcactaatc tgttaggaca agaacacgat tgtcgtttgt ttgtttgttg tttctttcaa
     5161 gtactggcgt caccctttgc ctatatggtg gagcaataat gctttgaaat aaacttgtga
     5221 aacccaaggc caggtcctgc actctgagtc agaagcgagc agtgcttctg tggacacact
     5281 tccttccctt tgtaaatagg atctttaaga tattgtatta tgtgaaaata tgtacatacc
     5341 ttttttgtag gccacagcag ctcattttta cagagtttgt gaagctaaat atttaacatt
     5401 gttgatttct gtaagctcca cgcagtgagg ttacaggcag cggagacatc tggaaggccc
     5461 agcctggggc agggcagcct gcagctcccc tcgtgttaca ggcctcactc tttaaaaagg
     5521 ctttttaaag ggatcatttg tttagatgta ggcatttaaa ttttttaaaa attttcttta
     5581 ccagagaact acgcactttg ttaatttgtg gggaaagaat agatatgggg aaatgagctt
     5641 taaacgaaaa cagaaaaccg ccaagagtct aaaaacaaaa ccgaagcaaa ttgattttaa
     5701 aaagaatctt gtgtttttta agcagtccat aaattaaatg ataataattt tggaaaactg
     5761 tagcccactc atcattttag gatcgatgtc tgttactagg acctgagccc cacatttagg
     5821 tcaaaggccc cgggcccttg ctgtgtgtgg tctggtgtct gcccagttct cctctggttc
     5881 agctcatagg gtctcttact acctctccgc atcagggtgc tgagctcaga accaggcctg
     5941 ccagtgccac tgagtgagag tgacaccttg gcacatgcca gcccctcctg ccacctctct
     6001 gcctcctctt ggcacctgtc ctcgtcagtg tgaagtaggg aaaccaagtg taatgccttt
     6061 atttgggtcc ttaggttcaa acagttagat ggcattaggt tagtaaacca tctgtagctt
     6121 tgtttctcca ccagccctgg tgtcattgtc cgagatccag tcaatgttta agagtcacac
     6181 gtttagccag ttgtcctcca cccccaacca cctccccccg cccccccccc ccccaaggga
     6241 gcacagcttc attctctgaa ctctctgtga gtgaagctca catttccaga agcacctgtg
     6301 gatggacttg gcttctcaac gtgctttggt catgatcagc tcactgtcct cgtttccatt
     6361 gtgtgctgtg ttttgccgct gacacccgat ctggctgggc gcggtgagcc cgccatgctt
     6421 aggtgtaggc cacagtggtg ctcttccctt aacttggaga gaccttgatt ctgccctcag
     6481 caccccagct ccaggccaac tggttggtac ccccttttta tatggggaga caaatgaagt
     6541 ttattatgtt tttatatttt ctacttactg atttttattg gtgccagttc aaaattcgga
     6601 tttcctttta atagcctctc agataatttg ttgtttttac ctgaattgtc cttaaatctt
     6661 ttttgggtca ttctctttgt actcttcttg cctacctcgc ctccactcct ccctggcccc
     6721 tctttaaacc taggtgtcct tggggcaaat ggtataaaag tattcttttc atctgctttt
     6781 atgatgtggg gacatttcca gtacctacct tttttttttt tttttttttt tttttgctga
     6841 atccaaagat atataaataa aaatgtattt tatgaagatc caaatgatat taaggcaaca
     6901 tgtttcttca aaaataaatg aagctgtact gttgctgttg gtatcagaac gctttctctc
     6961 taaactgtgc ccctgtcatt aacaggccta cccggttcat cagcattaga tgctgaggtg
     7021 ggtcggggcc agaggcagtg ggtactaggg cacataattg gcttgattca ggggtaggtg
     7081 cagctggact gtgcagagag tttccagttt acaacacgcc agtccagtcc ctttctatct
     7141 gcagtagagt gttaccagga gcagacctct aggtgagctc gaatctggcc ctgccatgaa
     7201 gcaacaggtg tgtttacctc cagtgcaggc gattaaaaac agggcggtgt tttgtttttc
     7261 tcttgcctcc tccctttttc tcttcttttg aaaataagga gttctgaaga agacggaaat
     7321 gtcactccaa gagcagtaaa ttctcaggaa ctgaccgaca ccactgagaa cacatttggg
     7381 gttaatcaca tttatataag tgtcacttaa gatggtgtca ttctttacac cgcaaggaat
     7441 ggaaaccatt cggtgactca gttgggtgag ctttggatgc cttgccgact gtctggatgc
     7501 tcttgtaaat aaaggtttct atttaa
//
