LOCUS       NM_008678               8286 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus nuclear receptor coactivator 2 (Ncoa2), transcript
            variant a, mRNA.
ACCESSION   NM_008678
VERSION     NM_008678.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8286)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8286)
  AUTHORS   Maurya,V.K., Szwarc,M.M., Lonard,D.M., Kommagani,R., Wu,S.P.,
            O'Malley,B.W., DeMayo,F.J. and Lydon,J.P.
  TITLE     Steroid receptor coactivator-2 drives epithelial reprogramming that
            enables murine embryo implantation
  JOURNAL   FASEB J 37 (12), e23313 (2023)
   PUBMED   37962238
  REMARK    GeneRIF: Steroid receptor coactivator-2 drives epithelial
            reprogramming that enables murine embryo implantation.
REFERENCE   3  (bases 1 to 8286)
  AUTHORS   Zhong,X., Wu,H., Ouyang,C., Zhang,W., Shi,Y., Wang,Y.C., Ann,D.K.,
            Gwack,Y., Shang,W. and Sun,Z.
  TITLE     Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by
            Stimulating T-cell Activation via Upregulation of PGC-1alpha
            Critical for Mitochondrial Function
  JOURNAL   Cancer Immunol Res 11 (10), 1414-1431 (2023)
   PUBMED   37540802
  REMARK    GeneRIF: Ncoa2 Promotes CD8+ T cell-Mediated Antitumor Immunity by
            Stimulating T-cell Activation via Upregulation of PGC-1alpha
            Critical for Mitochondrial Function.
REFERENCE   4  (bases 1 to 8286)
  AUTHORS   Tanaka,M., Homme,M., Teramura,Y., Kumegawa,K., Yamazaki,Y.,
            Yamashita,K., Osato,M., Maruyama,R. and Nakamura,T.
  TITLE     HEY1-NCOA2 expression modulates chondrogenic differentiation and
            induces mesenchymal chondrosarcoma in mice
  JOURNAL   JCI Insight 8 (10), e160279 (2023)
   PUBMED   37212282
  REMARK    GeneRIF: HEY1-NCOA2 expression modulates chondrogenic
            differentiation and induces mesenchymal chondrosarcoma in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8286)
  AUTHORS   Zhang,W., Cao,X., Zhong,X., Wu,H., Shi,Y., Feng,M., Wang,Y.C.,
            Ann,D., Gwack,Y., Yuan,Y.C., Shang,W. and Sun,Z.
  TITLE     SRC2 controls CD4+ T cell activation via stimulating c-Myc-mediated
            upregulation of amino acid transporter Slc7a5
  JOURNAL   Proc Natl Acad Sci U S A 120 (18), e2221352120 (2023)
   PUBMED   37094160
  REMARK    GeneRIF: SRC2 controls CD4[+] T cell activation via stimulating
            c-Myc-mediated upregulation of amino acid transporter Slc7a5.
REFERENCE   6  (bases 1 to 8286)
  AUTHORS   Voegel,J.J., Heine,M.J., Tini,M., Vivat,V., Chambon,P. and
            Gronemeyer,H.
  TITLE     The coactivator TIF2 contains three nuclear receptor-binding motifs
            and mediates transactivation through CBP binding-dependent and
            -independent pathways
  JOURNAL   EMBO J 17 (2), 507-519 (1998)
   PUBMED   9430642
REFERENCE   7  (bases 1 to 8286)
  AUTHORS   Welch,C.L., Xia,Y.R., Hong,H., Stallcup,M.R. and Lusis,A.J.
  TITLE     Localization of the mouse glucocorticoid receptor-interacting
            protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis
  JOURNAL   Mamm Genome 8 (8), 620-621 (1997)
   PUBMED   9250876
REFERENCE   8  (bases 1 to 8286)
  AUTHORS   Torchia,J., Rose,D.W., Inostroza,J., Kamei,Y., Westin,S.,
            Glass,C.K. and Rosenfeld,M.G.
  TITLE     The transcriptional co-activator p/CIP binds CBP and mediates
            nuclear-receptor function
  JOURNAL   Nature 387 (6634), 677-684 (1997)
   PUBMED   9192892
REFERENCE   9  (bases 1 to 8286)
  AUTHORS   Hong,H., Kohli,K., Garabedian,M.J. and Stallcup,M.R.
  TITLE     GRIP1, a transcriptional coactivator for the AF-2 transactivation
            domain of steroid, thyroid, retinoid, and vitamin D receptors
  JOURNAL   Mol Cell Biol 17 (5), 2735-2744 (1997)
   PUBMED   9111344
REFERENCE   10 (bases 1 to 8286)
  AUTHORS   Hong,H., Kohli,K., Trivedi,A., Johnson,D.L. and Stallcup,M.R.
  TITLE     GRIP1, a novel mouse protein that serves as a transcriptional
            coactivator in yeast for the hormone binding domains of steroid
            receptors
  JOURNAL   Proc Natl Acad Sci U S A 93 (10), 4948-4952 (1996)
   PUBMED   8643509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052117.1, AK038781.1, AK087443.1, BU703942.1, AC091248.6,
            AK035719.1, AK042893.1, AK028964.1 and BP761474.1.
            
            On Nov 11, 2014 this sequence version replaced NM_008678.2.
            
            Transcript Variant: This variant (a) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U39060.1, AF000582.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AK052117.1         1-162
            163-818             AK038781.1         265-920
            819-2647            AK087443.1         827-2655
            2648-2827           BU703942.1         89-268
            2828-3034           AC091248.6         84101-84307
            3035-3455           BU703942.1         269-689
            3456-4598           AK035719.1         365-1507
            4599-4599           AC091248.6         102328-102328
            4600-4601           AK035719.1         1509-1510
            4602-6093           AK042893.1         341-1832
            6094-6467           AK028964.1         1920-2293
            6468-6468           AC091248.6         108299-108299
            6469-8213           AK028964.1         2295-4039
            8214-8286           BP761474.1         1-73                c
FEATURES             Location/Qualifiers
     source          1..8286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 4.12 cM"
     gene            1..8286
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /note="nuclear receptor coactivator 2"
                     /db_xref="GeneID:17978"
                     /db_xref="MGI:MGI:1276533"
     exon            1..146
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..203
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            204..308
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..4611
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /note="isoform a is encoded by transcript variant a;
                     transcriptional intermediary factor 2; glucocorticoid
                     receptor interacting protein 1; steroid receptor
                     coactivator 2"
                     /codon_start=1
                     /product="nuclear receptor coactivator 2 isoform a"
                     /protein_id="NP_032704.2"
                     /db_xref="CCDS:CCDS35515.1"
                     /db_xref="GeneID:17978"
                     /db_xref="MGI:MGI:1276533"
                     /translation="MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENK
                     YIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDV
                     SSTGQGVIDKDALGPMMLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVY
                     SILHVGDHTEFVKNLLPKSMVNGGSWSGEPPRRSSHTFNCRMLVKPLPDSEEEGHDSQ
                     EAHQKYEAMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPTLPSSESFTTRQDL
                     QGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLRQGLAFS
                     QIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQAMG
                     KPLNPISSSSPAHQALCSGNPGQDMTLGSNINFPMNGPKEQMGMPMGRFGGSGGMNHV
                     SGMQATTPQGSNYALKMNSPSQSSPGMNPGQASSVLSPRQRMSPGVAGSPRIPPSQFS
                     PAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSP
                     VNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAEASCHPEEQKGPNDSSMPQAASGD
                     RAEGHSRLHDSKGQTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGTS
                     LKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQESSSTAPGSEVTVKQEPASPKKK
                     ENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQ
                     PGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQAIINDLMQLTADSSPVPPA
                     GAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVI
                     PQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRPSMPSGEWAPQSPAVRVTCAATTGAM
                     NRPVQGGMIRNPTASIPMRANSQPGQRQMLQSQVMNIGPSELEMNMGGPQYNQQQAPP
                     NQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALR
                     NFDGLEEIDRALGIPELVSQSQAVDAEQFSSQESSIMLEQKPPVFPQQYASQAQMAQG
                     GYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQQNRQ
                     PLMNQISSVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMQQQVQQRTLM
                     MRGQGLNVTPSMVAPAGLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQ
                     SPLMSPRMAHTQSPMMQQSQANPAYQPTSDMNGWAQGSMGGNSMFSQQSPPHFGQQAN
                     TSMYSNNMNISVSMATNTGGLSSMNQMTGQMSMTSVTSVPTSGLPSMGPEQVNDPALR
                     GGNLFPNQLPGMDMIKQEGDASRKYC"
     exon            309..481
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..585
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..763
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..952
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1054
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1198
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1346
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..2616
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2827
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3034
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3250
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3380
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3381..3546
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3825
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..3903
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3904..4132
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4133..4310
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4311..4509
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4510..4599
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            4600..8267
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6068..6073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /note="hexamer: AATAAA"
     polyA_site      6092
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /note="major polyA site"
     regulatory      8191..8196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /note="hexamer: AATAAA"
     polyA_site      8247
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
                     /note="major polyA site"
     polyA_site      8267
                     /gene="Ncoa2"
                     /gene_synonym="bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C;
                     NCoA-2; SRC-2; TIF2"
ORIGIN      
        1 gagctggggg aggatctcca ttgaaataaa caaccaggca gcagttatta acacgggaac
       61 atggcggccg cagcctgggc tcccgcggcg gcggcggagg tcagcgccga cggcagcccg
      121 cacctgacgg cgtgacggcc acattgattt tcctcgcatc tggcttcact gcattggctc
      181 ttctgcactg tgtacaggca cagttgctga tatgtgttca agatgagtgg gatgggagaa
      241 aacacctctg acccgtccag ggcagagacc agaaaacgca aggaatgtcc cgaccagctc
      301 ggacccagcc ccaaaaggag cactgagaaa cggaaccgcg agcaggagaa taagtacata
      361 gaggagctgg ccgagctgat cttcgcaaac tttaatgata ttgacaactt caacttcaaa
      421 cctgacaaat gtgccatcct aaaagaaact gtgaagcaga tccgccagat caaagagcaa
      481 gagaaagcag cagctgccaa catagatgaa gtgcagaagt cagatgtgtc gtccacgggg
      541 cagggtgtca tcgacaagga tgcactgggg cccatgatgc ttgaggccct cgatgggttc
      601 ttcttcgttg tgaacctgga aggcagtgtg gtgttcgtgt cagagaatgt gacacagtat
      661 ctacggtata accaagaaga gctgatgaac aagagtgtct acagcatcct gcatgtcggg
      721 gaccacactg aatttgtcaa gaacctgctg ccaaagtcca tggtgaatgg aggatcctgg
      781 tctggagaac ctcccaggcg gagcagccat accttcaact gtcgcatgct ggtgaagcct
      841 ttgccagatt cagaagagga aggccatgat agccaggaag cccatcagaa atacgaggcg
      901 atgcagtgct tcgctgtgtc tcagcccaag tccatcaaag aggaaggcga agatttgcag
      961 tcctgcttga tttgtgtggc acgaagagtc cccatgaagg aaagaccaac tcttccctca
     1021 tcagaaagct ttaccacccg ccaggacctc caaggcaaga tcacttcact ggacactagc
     1081 accatgagag ccgccatgaa gccgggctgg gaagatctgg taagaagatg cattcagaag
     1141 ttccacacac agcatgaagg ggagtctcta tcatatgcca agaggcatca ccatgaagtt
     1201 ctgagacaag ggttggcgtt cagtcagatc tatcgttttt ctttgtctga tggcactctc
     1261 gttgctgcac aaaccaagag caaactcatc cgttctcaga ctactaatga gcctcagctt
     1321 gtaatatctt tacacatgct tcacagagag cagaatgtat gtgtaatgaa tccggatctg
     1381 actggacaag cgatggggaa gccattgaat ccaattagct ctagcagccc tgcccaccag
     1441 gccctgtgca gtgggaaccc aggtcaggac atgaccctcg gtagcaatat aaattttccc
     1501 atgaatggcc caaaggaaca aatgggcatg cctatgggca ggtttggtgg ttctgggggc
     1561 atgaaccatg tgtcaggcat gcaagcaacc actcctcagg gtagtaacta tgcactcaaa
     1621 atgaacagtc cctcgcaaag cagccccggc atgaacccgg ggcaagccag ctccgtgctc
     1681 tccccaaggc agcgcatgag ccccggcgtg gctggcagtc ctcgcatccc acccagtcag
     1741 ttttcccctg caggaagctt gcattcccct gtgggagttt gcagcagcac aggaaatagc
     1801 catagttata ccaacagttc cctcaatgca ctgcaagccc tcagcgaggg ccatggggtc
     1861 tcactcgggt cctcgctggc ttcaccggac ctaaaaatgg gcaatttgca aaactcccca
     1921 gttaatatga atcctccccc actcagcaag atgggaagct tggactccaa agactgtttt
     1981 ggactttatg gggagccctc agaaggtaca actggacaag cagaggccag ctgccatcct
     2041 gaagaacaaa aggggcccaa tgattccagc atgccccagg cggccagcgg ggacagggct
     2101 gagggacaca gccggctgca tgacagcaaa gggcagacca aactcctgca gctgctgacc
     2161 accaagtccg accagatgga gccttcaccc ttgcccagct ccttgtcgga cacaaacaag
     2221 gactcaacag ggagcttgcc tgggcctggg tccacgcatg gcacctcgct caaggagaag
     2281 cataagattt tgcacagact cttacaggac agcagttccc ctgtggactt ggccaagctg
     2341 acagcagaag ccacaggcaa agagctgagc caggagtcca gcagcacagc tcctgggtcg
     2401 gaagtgactg tcaaacagga gccagcgagc cccaagaaga aagagaatgc actactgcgc
     2461 tatttgctcg acaaagatga tactaaagat attggtttac cggaaataac ccccaaactc
     2521 gagcgactgg acagtaagac agatcctgcc agtaacacaa agttaattgc tatgaaaact
     2581 gtgaaggagg aggtgagctt tgagcccagt gaccagcctg gcagcgagct ggacaacttg
     2641 gaagagattt tggatgattt gcagaacagt cagttaccac agcttttccc agacacaagg
     2701 ccaggagctc ctactgggtc agttgacaag caagccatca tcaatgacct catgcaactc
     2761 acagctgaca gcagtcccgt cccacctgcc ggagcccaga aggcagcact gcgcatgtca
     2821 cagagcactt ttaataaccc acgaccaggg caactgggca ggttattgcc aaaccagaac
     2881 ttaccacttg acatcacttt gcaaagccca actggtgctg gacctttccc accaatcaga
     2941 aacagtagcc cctactcagt gatacctcag ccaggaatga tgggtaacca agggatgcta
     3001 ggaagccaag gaaacttagg gaacaatagc acaggaatga ttggcagcag cacttcccgg
     3061 cccagcatgc cttctgggga atgggcacca cagagtccag ctgtgagagt cacttgtgct
     3121 gctaccactg gtgccatgaa ccgaccagtc caaggaggca tgattcggaa cccaacagcc
     3181 agcatcccca tgcgagccaa cagccagcct ggccaaagac agatgcttca gtctcaggtc
     3241 atgaacatag gcccttctga gttagagatg aacatgggag gacctcagta taatcaacag
     3301 caggcccctc cgaaccaaac tgccccgtgg cctgagagca tcctgcctat agaccaggca
     3361 tcgtttgcca gccagaacag gcagcccttc ggcagctccc ctgatgacct gctgtgtcca
     3421 catcctgcag cagagtcgcc aagcgatgag ggcgctcttc ttgaccagct gtatctggcc
     3481 ttgcggaact tcgatggcct tgaggagatt gatagagctc tggggatacc agaactggtc
     3541 agccagagcc aagctgtgga tgcagagcag ttctcaagtc aggagtccag cataatgctg
     3601 gagcagaagc cccccgtttt cccacagcag tacgcatctc aggcacaaat ggcccagggt
     3661 ggctataatc ccatgcaaga tccaaacttt cacaccatgg gacagcggcc aaattacacc
     3721 acactccgta tgcagccacg gccaggcctc aggcccacag gcattgtgca gaaccagcca
     3781 aaccaactga gacttcagct tcagcaccgc ctccaagcac agcagaatcg ccagccgctt
     3841 atgaatcaga tcagcagtgt ttccaatgtg aacctgactc tgaggcctgg agtgcccact
     3901 caggctccta ttaatgcaca gatgctggcc cagaggcaga gggaaatcct caaccaacat
     3961 cttcggcaga gacagatgca gcagcaggtg cagcagcgga ctttgatgat gagaggacag
     4021 ggcttgaatg tgaccccaag catggtggct cccgctggcc taccagcagc catgagcaat
     4081 ccccggatcc cccaggccaa tgcccagcag ttcccatttc ctccgaacta cggaataagt
     4141 caacaacctg atcctggctt tactggggct acaactcccc agagtcctct aatgtctccc
     4201 cggatggcac atactcagag tcccatgatg cagcagtctc aagccaaccc agcctaccag
     4261 cccacctcag acatgaatgg atgggcacag gggagcatgg gtggaaacag catgttctca
     4321 cagcagtccc caccacactt tgggcaacaa gcaaacacca gcatgtatag taacaacatg
     4381 aacatcagtg tgtcgatggc aaccaacacg ggtggcttga gcagcatgaa ccagatgaca
     4441 ggccagatga gcatgacctc agtgacctcc gtgcctacgt caggactgcc ctccatgggt
     4501 cccgagcagg tcaatgaccc tgctctgagg ggaggcaacc ttttcccaaa ccaactgcct
     4561 ggaatggaca tgatcaagca ggagggagat gcatctcgga aatactgctg accctggaga
     4621 aactgtctgc atctttcttc aacccactgg gcttacaaac atttaccagt ctggagagct
     4681 gcgtctcttt gtgttgccac ctgacatgcc gccagttctc ccaggacata gcagcagaca
     4741 gtcgggccct gggcccgcag catagagcgt gctggcttgg ctgccaccgg aagagttgcc
     4801 tctcccgaca gcctgcagct cgcctccaga ccaacccgca gtctgttcac tgcattcacc
     4861 gtagtgcaac ttagatctcc tgcagagtaa ctgtccccag gccgacttca tccccatcag
     4921 attgaatgta tttaaatgtg tgtgtttgag gagagccatg cccttggcct gttcctgctc
     4981 ggctccagac actggtttct tgctttgttc tctgtggctc ttctgtgtaa aagatgagaa
     5041 tcttatctac aggaaagaaa ggaactttta acacagtaca acccaaggtg ttctaagctt
     5101 aaagcctgca tttgactggg atggagacag ggcagacact gtgcacagcg ctgtgtatgc
     5161 cggcacacct agtcagcaac acgtaaccga ggcagagttc tgtctccagg aaggagtgtc
     5221 ccgtcactga acagatggaa ggctcttgag agaggctgtt agcattaaca agtatctgtt
     5281 cccacttctc tctgttaaaa ccaaactagt ttcccctaaa tcatgaatca aaaagaaata
     5341 cttgtttcta aattgttttt agatcagata gtttgattgg catctcttcc cttcctctcc
     5401 ccaccttctc tcgtccctcc ctctttcatt cctttaaagt aaaaacatca acagcagcat
     5461 acaccataga gaccagggaa gcccttagga tctctcagtg ctgtgccagc cacttacagc
     5521 agcttcccag tgaccatgca tttcctatca gagaggaaca aagtcaggct gtgacatctg
     5581 cttaggtagc ctgggctgcc ccatcagctc aggcctccaa aatgagagaa cttactaatg
     5641 aaatcaacag cagacgtcac gacagatcta acctctgcca tatggggttg ttttttattt
     5701 ttggttttta gcagtgctga cgaagccgaa gttttgtaag gtacataaag atccaattta
     5761 tatgtaaaca agcaataatt taagttctga acttaagtgt tttaactgta taattttgtg
     5821 aggtatacat attgtgggat tgactcaaaa tgaggtactt cagtattaaa ttagatatct
     5881 tcatagcaat gtctcctaaa ggtgttttgt aacggctgcc aatgccttgg ttagacctga
     5941 cttgtagacg taagaccttt tgttttctaa cccttgagac tctcctcatg aatcctgtat
     6001 ctaatctata tgatatgcag ccgctgtcag aaccaagtct tgattttata tgtttatatt
     6061 ctttcttaat aaaccttaga aagacaacat tactaagcag cccactttga tggttgtttt
     6121 cttgcccact gtcggggata acctctatta actggtgtca gtttcagaca gctgcagtac
     6181 ccagaaccga gaccttttca attctcccca accttgatac acacactttc gtacctaaat
     6241 ttcagaatga tgtctttttg atgtctaaaa acaaagcatt ttataatatc tcattatcca
     6301 agctttctag gaacagagaa gattttcctt gaagtttgtt tattcctggc agggttaaaa
     6361 acatataaac taccctattt atatttatgt ctccctatat atctacagat tgtagaaata
     6421 tagaaagaga tgtgacccaa agacaaatgg tcagtcatct gaaagtgttg ctgcgtgcta
     6481 aggaactctg gaaatttgca tttccatacc tttttccact tagagaagaa tctcagtgag
     6541 ggaggtggcc caggaacagc gcttccccgt tggccaccag ttcctgtgtc tgctcgagac
     6601 tccaccaaac cattggcttg cacatctgtc ctgcaaaggg agcagataga acccagaact
     6661 ccaggccctg ccccaggagt gaggctcagg tgcactactg agctcgacct gttctcagat
     6721 aagtcagaaa tgtgaggtag gtaaaaatga cttcacacag cacaagagaa aaaggaattt
     6781 aaaacatact tgttttgtat taaatcccat ctcactgtaa catcaagcca caatatctta
     6841 cctttcagcc ttcatccaat ctcccactgc tttctaatgt tgacccggct gttagcgtag
     6901 cccatggtca tggcaaatcc tctcacaggt cagagcagcc atgaactgtg tgccatctca
     6961 tcaggaggat caatcgcatc agcaaaggca tcctgatcat gttctcagag ccagggccag
     7021 cccagcctcc cctgccatca gtattgctca cgctctgcac aacacatttg tacttggttt
     7081 tgtctgacag aacatagaat cagtgttctc ttagatgact caatgtgaaa agcgtaatgt
     7141 gaaaagtaca cacctgatcg tggttgtaaa atccatttaa gtgttcatgc aacatggtga
     7201 gttttaaaag tgaagtgtgc tgtgatacta caaccaattg actcaaagat taaagcacgc
     7261 acgcacacac acacacacat acacacgtgt atctcttacg acctgtaatg attgaaagca
     7321 atggtttttt tgcagtttaa gatgcaattt ttaatctgtg tttaaaaacg gagttcatat
     7381 gggtgtgaca cgtgaactgg gaggcacaga tccacttgca gaacccaaag atacacaatc
     7441 aattttgaaa tgcaacttaa gccattaatt gttggtgtga atttaaaatt ttctagttgt
     7501 ttatatggta gtatgctgcc gaagagcaaa gcattctctg cacaaaagaa aacactgtag
     7561 tggcttcgat tttaattaga actttctccc tggtgtttct ttatagacta aaacaaaatc
     7621 ttttaagttt ctttactaca ggtaaaagct atgtgcaaga acctcaaaat gctaaaacct
     7681 agcataatgc cttagatctg tttttaagtc ttgtatattc ctacatagct gtccaatgta
     7741 ttatatttgt atagtgaatt gtgtaaaatt tttgaataag taagtcatcg cttacccgta
     7801 tgttactgaa cagtgatgac aactcgtttc ttcaaacatt taactgtctt ctctttttcc
     7861 tttgtcattt gtgggtttta tttgtacagt tcctcatgaa gttgcatttg agatatgtgt
     7921 atatgaaaaa attatacaag ggtaaaatta agcaatatat taactatggt tcttcaggag
     7981 aaagcttaca gtgtttcagg ttgtgattta ttttcaaaac agagttgact ctgaacatca
     8041 ctttgttcat ctgcattgat gtttgtattt ctagtgtgag cagtttatgc aaaggtagat
     8101 atatacagag aaattttaaa tacatttatg caagttacta ttgctttgct gatgctattt
     8161 gcttatttga tgttaaataa tgctattgta aataaagaat ctgttgttac tgcatcattt
     8221 aataaatttt aatgccttcg ggttttacat ggctttagag attttaaaaa aaaaaaaaaa
     8281 aaaaaa
//
