LOCUS       NM_001408602            7265 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus nuclear receptor coactivator 1 (Ncoa1), transcript
            variant 6, mRNA.
ACCESSION   NM_001408602 XM_006515005
VERSION     NM_001408602.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7265)
  AUTHORS   Shi,L.Y., Wang,Y., Yang,Y.J., Li,Q., Yang,Z.X., Sun,L.H., Luo,F.Q.,
            He,Y.H., Zhang,S.P., Su,N., Liu,J.Q., He,Y., Guan,Y.C., Wei,Z.L.,
            Cao,Y.X. and Zhang,D.
  TITLE     NLRP4E regulates actin cap formation through SRC and CDC42 during
            oocyte meiosis
  JOURNAL   Cell Mol Biol Lett 29 (1), 68 (2024)
   PUBMED   38730334
  REMARK    GeneRIF: NLRP4E regulates actin cap formation through SRC and CDC42
            during oocyte meiosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7265)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7265)
  AUTHORS   Li,X., Wang,X., Chen,C., Zhang,E., Zhang,Y., Li,H., Lei,Y., Lou,Z.
            and Zhang,F.
  TITLE     Accumulation of NCOA1 dependent on HERC3 deficiency transactivates
            matrix metallopeptidases and promotes extracellular matrix
            degradation in intervertebral disc degeneration
  JOURNAL   Life Sci 320, 121555 (2023)
   PUBMED   36878279
  REMARK    GeneRIF: Accumulation of NCOA1 dependent on HERC3 deficiency
            transactivates matrix metallopeptidases and promotes extracellular
            matrix degradation in intervertebral disc degeneration.
REFERENCE   4  (bases 1 to 7265)
  AUTHORS   Peng,Q., Hua,Y., Xu,H., Chen,X., Xu,H., Wang,L. and Zhao,H.
  TITLE     The NCOA1-CBP-NF-kappaB transcriptional complex induces
            inflammation response and triggers endotoxin-induced myocardial
            dysfunction
  JOURNAL   Exp Cell Res 415 (2), 113114 (2022)
   PUBMED   35339471
  REMARK    GeneRIF: The NCOA1-CBP-NF-kappaB transcriptional complex induces
            inflammation response and triggers endotoxin-induced myocardial
            dysfunction.
REFERENCE   5  (bases 1 to 7265)
  AUTHORS   Guo,P., Chen,Q., Peng,K., Xie,J., Liu,J., Ren,W., Tong,Z., Li,M.,
            Xu,J., Zhang,Y., Yu,C. and Mo,P.
  TITLE     Nuclear receptor coactivator SRC-1 promotes colorectal cancer
            progression through enhancing GLI2-mediated Hedgehog signaling
  JOURNAL   Oncogene 41 (20), 2846-2859 (2022)
   PUBMED   35418691
REFERENCE   6  (bases 1 to 7265)
  AUTHORS   Sato,H., Koide,T., Masuya,H., Wakana,S., Sagai,T., Umezawa,A.,
            Ishiguro,S., Tamai,M. and Shiroishi,T.
  TITLE     A new mutation Rim3 resembling Re(den) is mapped close to retinoic
            acid receptor alpha (Rara) gene on mouse chromosome 11
  JOURNAL   Mamm Genome 9 (1), 20-25 (1998)
   PUBMED   9434940
  REMARK    Erratum:[Mamm Genome 1998 Apr;9(4):344. Tama M [corrected to Tamai
            M]]
REFERENCE   7  (bases 1 to 7265)
  AUTHORS   Torchia,J., Rose,D.W., Inostroza,J., Kamei,Y., Westin,S.,
            Glass,C.K. and Rosenfeld,M.G.
  TITLE     The transcriptional co-activator p/CIP binds CBP and mediates
            nuclear-receptor function
  JOURNAL   Nature 387 (6634), 677-684 (1997)
   PUBMED   9192892
REFERENCE   8  (bases 1 to 7265)
  AUTHORS   Yao,T.P., Ku,G., Zhou,N., Scully,R. and Livingston,D.M.
  TITLE     The nuclear hormone receptor coactivator SRC-1 is a specific target
            of p300
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10626-10631 (1996)
   PUBMED   8855229
REFERENCE   9  (bases 1 to 7265)
  AUTHORS   Kamei,Y., Xu,L., Heinzel,T., Torchia,J., Kurokawa,R., Gloss,B.,
            Lin,S.C., Heyman,R.A., Rose,D.W., Glass,C.K. and Rosenfeld,M.G.
  TITLE     A CBP integrator complex mediates transcriptional activation and
            AP-1 inhibition by nuclear receptors
  JOURNAL   Cell 85 (3), 403-414 (1996)
   PUBMED   8616895
REFERENCE   10 (bases 1 to 7265)
  AUTHORS   Zhu,Y., Qi,C., Calandra,C., Rao,M.S. and Reddy,J.K.
  TITLE     Cloning and identification of mouse steroid receptor coactivator-1
            (mSRC-1), as a coactivator of peroxisome proliferator-activated
            receptor gamma
  JOURNAL   Gene Expr 6 (3), 185-195 (1996)
   PUBMED   9041124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC241534.2, CU041254.6 and AC162932.2.
            
            On Jun 17, 2022 this sequence version replaced XM_006515005.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777535.1547020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               AC241534.2         88008-88409         c
            403-537             CU041254.6         152653-152787       c
            538-686             AC162932.2         196029-196177       c
            687-792             AC162932.2         186065-186170       c
            793-959             AC162932.2         180686-180852       c
            960-1057            AC162932.2         177449-177546       c
            1058-1235           AC162932.2         164536-164713       c
            1236-1415           AC162932.2         157354-157533       c
            1416-1511           AC162932.2         154694-154789       c
            1512-1652           AC162932.2         148092-148232       c
            1653-1800           AC162932.2         139144-139291       c
            1801-3139           AC162932.2         136578-137916       c
            3140-3320           AC162932.2         132482-132662       c
            3321-3438           AC162932.2         119770-119887       c
            3439-3607           AC162932.2         116841-117009       c
            3608-3922           AC162932.2         116362-116676       c
            3923-4024           AC162932.2         112415-112516       c
            4025-4427           AC162932.2         109275-109677       c
            4428-4602           AC162932.2         105102-105276       c
            4603-4786           AC162932.2         100880-101063       c
            4787-4876           AC162932.2         95325-95414         c
            4877-7265           AC162932.2         89030-91418         c
FEATURES             Location/Qualifiers
     source          1..7265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 2.05 cM"
     gene            1..7265
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /note="nuclear receptor coactivator 1"
                     /db_xref="GeneID:17977"
                     /db_xref="MGI:MGI:1276523"
     exon            1..402
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..537
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..686
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..792
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             704..5047
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /EC_number="2.3.1.48"
                     /note="isoform 2 is encoded by transcript variant 6;
                     steroid receptor coactivator 1; nuclear receptor
                     coactivator protein 1"
                     /codon_start=1
                     /product="nuclear receptor coactivator 1 isoform 2"
                     /protein_id="NP_001395531.1"
                     /db_xref="GeneID:17977"
                     /db_xref="MGI:MGI:1276523"
                     /translation="MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLE
                     ELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSS
                     SQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSIL
                     HVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPEDPGTENQEACQRY
                     EVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISID
                     TSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILND
                     GTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDSNSGMSIPRINPSVNP
                     GISPAHGVTRSSTLPPSNNNMVSARVNRQQSSDLNSSSSHTNSSNNQGNFGCSPGNQI
                     VANVALNQGQAGSQSSNPSLNLNNSPMEGTGIALSQFMSPRRQANSGLATRARMSNNS
                     FPPNIPTLSSPVGITSGACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSAGSPVLRQMS
                     SQNSPSRLSMQPAKAESKDSKEIASILNEMIQSDNSDNSANEGKPLDSGLLHNNDRLS
                     EGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPS
                     SHSSLTERHKILHRLLQEGSPSDITTLSVEPEKKDSVPASTAVSVSGQSQGSASIKLE
                     LDAAKKKESKDHQLLRYLLDKDEKDLRSTPNLCLDDVKVKVEKKEQMDPCNTNPTPMT
                     KPAPEEVKLESQSQFTADLDQFDQLLPTLEKAAQLPSLCETDRMDGAVTGVSIKAEVL
                     PASLQPTTARAAPRLSRLPELELEAIDNQFGQPGAGDQIPWANNTLTTINQNKPEDQC
                     ISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGL
                     DVLSERFPPQQATPPLMMEDRPTLYSQPYSSPSPTAGLSGPFQGMVRQKPSLGAMPVQ
                     VTPPRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQNRQAILNQFAA
                     NAPVGMNMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQIIQQQRAMLMRHQSF
                     GNNIPPSSGLPVQMGTPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASL
                     ATRSSMVNRGMAGNMGGQFGAGISPQMQQNVFQYPGPGLVPQGEATFAPSLSPGSSMV
                     PMPVPPPQSSLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAVQSQPAPAQPGVYNN
                     MSITVSMAGGNANIQNMNPMMGQMQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLS
                     STDLLKTDADGNQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQ
                     QKSLLQQLLTE"
     exon            793..959
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1057
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1235
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1415
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1511
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1652
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1800
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..3139
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3320
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3321..3438
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3607
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3608..3922
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3923..4024
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4025..4427
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4428..4602
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4603..4786
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4787..4876
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4877..7265
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7242..7247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /note="hexamer: AATAGA"
     polyA_site      7265
                     /gene="Ncoa1"
                     /gene_synonym="bHLHe74; KAT13A; mNRC-1; NCoA-1; NRC-1;
                     SRC-1; SRC-a; SRC1"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggcg gcggcagccg tggaggagga gaacatggcg gccgcggaga gcggctgaaa
       61 tgcctgttct tcaggccggg cgagcgggag actgacgcga ttcacctcgt cctgtcgtcc
      121 gtcggtcgga gcgcggcctc aagcccttcg gctgcagttc gctgctgttc cctcaagcac
      181 agcttgtgcc ggggtggttc tgcatccccc tgaagtgggg ggactcctgc tccggaggag
      241 gggggccgga gagccgaggc ggcggcggcg gcggcgggcc gcctgggccc cggggacggg
      301 cgccgggccg gaggagcggc ggagtccgcg gcggcgccgc cacagtcgcg agtgagcgcg
      361 gcgccgggga gcgcggccca gaggcggcgg cggcggaggc agatctgtcc atactaaagg
      421 aaatgtaact ggaactgatc tgatggtaaa accacggccc ttcagacaag atctcatagg
      481 aggagacctt gcttccaaat gaagacacca acattcagac tttctactta ttcaaagttg
      541 tccgtgtaat tgaccttaaa tgaggtgaga gcaaaccgac gagcgccatc tctggacaca
      601 ctgcattact cccccagaag ccacgctcca gagcactttg accttatcag ctttgaggac
      661 tcattatgaa caaaggagtc tcccaggtgt gaagttcatc aacatgagtg gccttgggga
      721 cagttcatca gaccctgcaa acccagactc tcataagaga aaaggatcgc catgtgacac
      781 gctggcatca agtactgaga agaggcgcag ggagcaagaa aataagtatt tagaagaact
      841 agctgaacta ctgtctgcca acatcagtga cattgacagc ttgagtgtaa aaccagataa
      901 atgcaagatt ttgaagaaga cagtagatca gatacagcta atgaagagaa tggagcaaga
      961 gaaatccacg actgatgatg acgtgcagaa gtccgacatc tcctcgagca gccaaggagt
     1021 gatagagaag gagtcgctgg gccctcttct tctggaggct ttggatggat ttttctttgt
     1081 tgtgaactgt gaaggaagaa ttgtatttgt atcagaaaat gtgaccagct acttgggtta
     1141 caatcaggaa gaattaatga ataccagcgt ctacagcata ctgcatgtgg gagatcatgc
     1201 agaatttgtc aagaatctgc taccaaaatc actagtaaat ggagttcctt ggcctcaaga
     1261 ggcaacacgc cgaaatagcc atacatttaa ctgcaggatg ctaattcacc ctccagagga
     1321 cccaggtact gagaaccaag aagcttgcca gcgctatgaa gtaatgcagt gtttcacagt
     1381 gtcacagcca aaatccatcc aagaagatgg tgaagatttc cagtcatgtc tgatttgtat
     1441 tgctcgacga ttacctcggc ctccagccat tacaggtgta gaatccttta tgaccaagca
     1501 agatactaca ggcaaaatca tctctattga cactagctcc ctgagggctg ctggcaggac
     1561 tggctgggaa gacctagtaa ggaagtgcat ctatgctttc ttccaacctc agggcagaga
     1621 gccatcttac gcccggcagc tgtttcaaga agtgatgact cgtggcactg cctccagccc
     1681 atcctataga ttcatattga atgatgggac aatgcttagc gcccacacca agtgtaaact
     1741 ttgctaccct caaagtcctg acatgcagcc tttcatcatg ggaattcata tcatcgacag
     1801 ggagcacagt gggctttctc ctcaagatga cagtaattct ggaatgtcaa ttccccgaat
     1861 aaatccctca gtcaatcctg gtatctctcc agcccatggt gtgacccgtt catccacgtt
     1921 gccaccatcc aacaacaaca tggtctctgc cagagtaaac cgccaacaga gctcagacct
     1981 caacagcagc agcagtcata ctaactctag caacaaccaa gggaactttg gatgttcacc
     2041 tggaaatcag attgtagcca atgttgcctt aaaccaggga caggcaggtt cccagagcag
     2101 caatccctct ttaaacctca ataattctcc tatggaaggt acaggaattg ccctctcaca
     2161 gttcatgtct ccgaggagac aagctaattc tggcttggca acaagggcca ggatgtcaaa
     2221 caattcattt cctccaaata ttccaacatt aagctcccca gttggcatta ctagtggtgc
     2281 ctgtaataat aataatcgat cctattcaaa tatcccagta acatctttac aaggtatgaa
     2341 tgaaggaccc aataactctg ttggcttctc tgctgggtct ccagtccttc ggcagatgag
     2401 ctcacagaat tcacctagca gattaagtat gcaaccagca aaggctgagt ccaaagacag
     2461 caaagagatt gcatccattt taaatgaaat gattcagtcc gacaacagcg acaacagtgc
     2521 taacgaaggc aagcctctgg actcaggact tctgcataac aatgacagac tctcagaagg
     2581 agacagtaaa tactctcaaa ctagtcacaa gctagtacag ctattgacta cgaccgcaga
     2641 gcagcagtta cggcatgccg acatagacac aagctgcaaa gatgtactgt cttgcactgg
     2701 tacttccagc tctgcctcct ctaacccctc aggaggtact tgtccctctt ctcacagctc
     2761 tctgactgag cggcataaaa ttctgcaccg gcttttacag gagggcagcc cctcagacat
     2821 caccactttg tctgtggaac ccgagaagaa ggacagtgtg ccagcctcta ctgctgtgtc
     2881 agtgtctgga caatcccagg ggagtgccag cataaaactg gaactggatg ctgcaaagaa
     2941 aaaagagtca aaagaccatc agctcctacg ctacctttta gacaaagatg agaaagattt
     3001 aaggtccact ccaaacctgt gcctggatga cgtaaaggtc aaagtggaga agaaagaaca
     3061 gatggatcct tgtaacacaa acccaacccc aatgaccaaa cctgctcctg aggaagttaa
     3121 actggagtcc cagagccagt ttacagctga ccttgaccag tttgatcagt tattgcccac
     3181 cctggagaag gcagcacagt tgccgagctt gtgcgagaca gacaggatgg atggtgcggt
     3241 caccggtgtc agcatcaagg cggaggtcct gccagcgtca ctccagccca ccactgccag
     3301 agctgccccc aggctgagca gattgcctga actagaatta gaagcgatcg ataaccagtt
     3361 tggacaacca ggagcggggg atcagattcc atgggcaaat aatactttga caacaataaa
     3421 tcagaataaa ccagaagacc aatgtattag ctcacagctg gatgagctcc tctgtccacc
     3481 aacaacagta gaaggaagaa acgatgagaa ggcccttctg gaacaactgg tgtctttcct
     3541 cagtggcaaa gatgaaacgg agctggctga gctagaccgg gcactgggga tcgacaagct
     3601 cgtccaggga ggcggattag atgtattatc tgagcgattt ccaccacagc aagcaacacc
     3661 acctttgatg atggaagaca gacccaccct ctattcccag ccatactcat ctccttctcc
     3721 caccgctggt ctctctggcc ctttccaagg catggtccgg cagaagcctt cactgggggc
     3781 tatgccggtt caagtaacac ctcctcgagg aaccttttca cccaacatgg gcatgcagcc
     3841 ccggcagact ctcaatagac ctccagctgc acccaaccag cttcggctgc agctgcagca
     3901 gcggctacag gggcagcagc agttgatgca ccaaaaccgg caagccatct tgaaccagtt
     3961 tgcagcaaat gctcctgttg gcatgaacat gaggtcaggc atgcagcagc agatcacacc
     4021 tcagccaccc ttgaatgctc agatgttggc ccagcgccag cgggagttgt acagtcagca
     4081 gcatcgacag aggcaaatta tacagcagca gagagccatg ctcatgaggc accaaagttt
     4141 tgggaacaac atccctcctt catctggact cccagttcaa atggggactc cccgtcttcc
     4201 tcagggtgct ccccagcagt tcccctaccc accaaactat ggtacaaacc caggaacccc
     4261 acctgcctcc accagccctt tctctcaact ggcagcaaac cctgaggcct ccttggccac
     4321 ccgcagcagc atggtgaaca gaggcatggc agggaacatg ggaggacagt ttggcgctgg
     4381 catcagtcct cagatgcagc agaatgtctt ccaatatcca ggaccaggac tagttcccca
     4441 aggtgaggcc acctttgccc catctctaag ccctgggagc tccatggtgc cgatgccagt
     4501 ccctcctcct caaagctctc tgctccagca aactccacct acttctgggt accagtcacc
     4561 agacatgaag gcctggcagc aaggaacaat gggaaacaac aatgtgttca gtcaagctgt
     4621 ccagagccag cctgcacctg cacagccagg agtgtacaac aacatgagca tcaccgtgtc
     4681 catggcaggt ggaaacgcaa acattcagaa catgaatcca atgatgggcc agatgcaaat
     4741 gagctctctg cagatgccag ggatgaatac tgtgtgctct gagcagatga atgatccagc
     4801 actgagacac acaggcctct actgcaacca gctctcgtcc actgaccttc tcaaaacaga
     4861 cgcagatgga aaccagcagg tgcagcaggt tcaggtgttt gctgacgtcc agtgtacagt
     4921 gaatctggta ggcggggacc cttacctgaa ccagcctggt ccactgggaa ctcaaaagcc
     4981 cacgtcagga ccacagaccc cccaggccca gcagaagagc ctccttcagc agctactgac
     5041 tgaataacca cttttaaagg aatgtgaaat ttaaataata gacatgcaga gttatacaaa
     5101 tatattatat atttttctga gatttttgat atctcaatct gcagccattc ttcagatcgt
     5161 agcatttgga gcaaaaaaaa aaaaaagaaa aaaaagaaaa aaagttcact tttgttggga
     5221 gattgagagg tggtgttttt gtttccttct ttgtaaaggc cttggatatt gaaaagaata
     5281 acaaggcaga acagttggac aatcttattt cttgagccaa aagttaatta ttcttatttt
     5341 tataatcagt cattggcttc ttatctggat gaaggctttt ggagggaaac caaaataaca
     5401 agaggggaag acgaagcccc acctcaccgg ctcagccctg tccctgccct ggaagaagag
     5461 cctgtggggc tttgcctgtc tgtccaccaa aggctgtcac gctcctccca ccgcagcctc
     5521 ccctcccccg gccccaggca acttgtgtgt acaatcagct tcttcaagca accctgtatc
     5581 tgtggcatca agagaatatt ttgcgtctac atatgtaccc cttctccttt ttataatgat
     5641 ggatttaaac caagatgcct ccaggaaaaa ggatgaaatt agtatattca ttcaccaagg
     5701 aatccaaaaa tgcagtttgg gggaaaatgc aataattttt gatgagatgg gtgaaggaca
     5761 agaaccaagt tctatcaatt attgtagata tgattttctg attgagtctg cggggaaggc
     5821 agcctgttct ttctgctttt actttgttaa cagcaaggta gctaaagtta tttaaaataa
     5881 aattaagttt atgatccgag tagctttttt tccttaaatc tcactgtaaa tatatttttg
     5941 atttcttgta gaaattgatt ttgttctgtt taattttatg cttttttttt tcaacctctt
     6001 ggtttttcta aatttgtgtg tgaagtataa tgttgattgg attgccatta tgtttggctg
     6061 gtaatttcat tatcccaata actgtgaggc catgtatgga tttactttgg gtctcatcaa
     6121 agtggcaccg ctggaaaaga gctattgtag ctgagctagg ggaggccacc ccagagtggc
     6181 caggctcagc tgatcaaagt gcacaggcca cttggatgaa gggaaatcag tgctcaaaga
     6241 gaatctcctt tttttttttt tttttggtct cagaataact ttgggaattt gaatttccat
     6301 cagtgcaaat gtgtttctct gctctgctcc gaggctaatt ggtaccatgt tacccccttg
     6361 ccttgttact ctgctgcatc ccttctcatc ctgcccccac ccccacctcc acctcaagaa
     6421 aggagccagc gaactgactc tagtgctagc agttgtgcta ctgaccgggc aggtgagctt
     6481 gattaaggtg tggccagagg ccaagggagt ctcccttgct aaccttgccc agcatccctg
     6541 ggcctgtgga cagcaacagt gaccttcgtc accagctacc tctgctcacg tggcagagaa
     6601 aaggccataa gaaccaatgc agacaaggag cacggactca agacttcaag gaagaagcca
     6661 tttccccagg tccttccttc tgcatctcgc cacccctggt acaaacaact ccattgaatg
     6721 gcatctactc agaaactaca ggattttgaa aatggtggaa gggctcatgt ggtagcaact
     6781 atgaaccaga aataggaccc tcagttacag acattatctt ttttagtttt gcagaaaatg
     6841 catccctgat ctcattcatt tccagcttga aagccccgcc atgttactct agttcctacc
     6901 aaaccgctct aggaggtcat ttcaattttg tttgtgataa taaacgtgca gacttcagga
     6961 agttcacctt taatttcagc attccagatg aagtttcctg acgcggcgct ttggcataag
     7021 gacctagaaa agaacagcag taaggaaagt tggagatgct aatgccctcc cctatcccca
     7081 ctgcacctta aagtatgcat gtcaccttca aggttttata attgcactgt ttgttttatg
     7141 tatgtacaga ttaaaattat tgctacattt gaggaaaata aaattgcttg cttctatgta
     7201 attcctgtca ttccacagga aattgacttt tccagctact gaatagaatt tgtttaacaa
     7261 cctca
//
