LOCUS       NM_030729               2870 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus NCK interacting protein with SH3 domain (Nckipsd),
            mRNA.
ACCESSION   NM_030729
VERSION     NM_030729.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2870)
  AUTHORS   Oh Y, Lee W, Kim SH, Lee S, Kim BC, Lee KH, Kim SH and Song WK.
  TITLE     SPIN90 Deficiency Ameliorates Amyloid beta Accumulation by
            Regulating APP Trafficking in AD Model Mice
  JOURNAL   Int J Mol Sci 23 (18), 10563 (2022)
   PUBMED   36142484
  REMARK    GeneRIF: SPIN90 Deficiency Ameliorates Amyloid beta Accumulation by
            Regulating APP Trafficking in AD Model Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2870)
  AUTHORS   You E, Huh YH, Lee J, Ko P, Jeong J, Keum S, Kim J, Kwon A, Song WK
            and Rhee S.
  TITLE     Downregulation of SPIN90 promotes fibroblast activation via
            periostin-FAK-ROCK signaling module
  JOURNAL   J Cell Physiol 234 (6), 9216-9224 (2019)
   PUBMED   30341913
  REMARK    GeneRIF: SPIN90 depletion activates FAK/ROCK signaling, induced by
            Postn expression, which is critical for myofibroblastic
            differentiation on soft matrices mimicking the mechanical
            environment of a normal tissue.
REFERENCE   3  (bases 1 to 2870)
  AUTHORS   Kim DH, Kang M, Kim CH, Huh YH, Cho IH, Ryu HH, Chung KH, Park CS,
            Rhee S, Lee YS and Song WK.
  TITLE     SPIN90 Modulates Long-Term Depression and Behavioral Flexibility in
            the Hippocampus
  JOURNAL   Front Mol Neurosci 10, 295 (2017)
   PUBMED   28979184
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2870)
  AUTHORS   You E, Huh YH, Kwon A, Kim SH, Chae IH, Lee OJ, Ryu JH, Park MH,
            Kim GE, Lee JS, Lee KH, Lee YS, Kim JW, Rhee S and Song WK.
  TITLE     SPIN90 Depletion and Microtubule Acetylation Mediate Stromal
            Fibroblast Activation in Breast Cancer Progression
  JOURNAL   Cancer Res 77 (17), 4710-4722 (2017)
   PUBMED   28652253
  REMARK    GeneRIF: Low SPIN90 expression is associated with Breast Cancer.
REFERENCE   5  (bases 1 to 2870)
  AUTHORS   Tan J, Chen XJ, Shen CL, Zhang HX, Tang LY, Lu SY, Wu WT, Kuang Y,
            Fei J and Wang ZG.
  TITLE     Lacking of palladin leads to multiple cellular events changes which
            contribute to NTD
  JOURNAL   Neural Dev 12 (1), 4 (2017)
   PUBMED   28340616
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2870)
  AUTHORS   Lu TC, He JC, Wang ZH, Feng X, Fukumi-Tominaga T, Chen N, Xu J,
            Iyengar R and Klotman PE.
  TITLE     HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting
            with diaphanous interacting protein
  JOURNAL   J Biol Chem 283 (13), 8173-8182 (2008)
   PUBMED   18234668
  REMARK    GeneRIF: identification of a new interaction between Nef and
            diaphanous interacting protein (DIP), a recently described
            regulator of Rho and Rac signaling
REFERENCE   7  (bases 1 to 2870)
  AUTHORS   Kim Y, Kim S, Lee S, Kim SH, Kim Y, Park ZY, Song WK and Chang S.
  TITLE     Interaction of SPIN90 with dynamin I and its participation in
            synaptic vesicle endocytosis
  JOURNAL   J Neurosci 25 (41), 9515-9523 (2005)
   PUBMED   16221862
REFERENCE   8  (bases 1 to 2870)
  AUTHORS   Lemon WJ, Bernert H, Sun H, Wang Y and You M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
REFERENCE   9  (bases 1 to 2870)
  AUTHORS   Fukuoka M, Suetsugu S, Miki H, Fukami K, Endo T and Takenawa T.
  TITLE     A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding
            protein, WISH, induces Arp2/3 complex activation independent of
            Cdc42
  JOURNAL   J Cell Biol 152 (3), 471-482 (2001)
   PUBMED   11157975
REFERENCE   10 (bases 1 to 2870)
  AUTHORS   de Bernard M, Moschioni M, Napolitani G, Rappuoli R and Montecucco
            C.
  TITLE     The VacA toxin of Helicobacter pylori identifies a new intermediate
            filament-interacting protein
  JOURNAL   EMBO J 19 (1), 48-56 (2000)
   PUBMED   10619843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC168054.4.
            
            [WARNING] On May 16, 2023 this sequence was replaced by
            NM_030729.5.
            
            On Mar 21, 2007 this sequence version replaced NM_030729.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064818.1, AK134725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               AC168054.4         85877-86151
            276-385             AC168054.4         88543-88652
            386-590             AC168054.4         89046-89250
            591-681             AC168054.4         89376-89466
            682-1172            AC168054.4         89716-90206
            1173-1343           AC168054.4         91446-91616
            1344-1430           AC168054.4         91762-91848
            1431-1569           AC168054.4         91927-92065
            1570-1650           AC168054.4         92164-92244
            1651-1779           AC168054.4         92425-92553
            1780-1872           AC168054.4         92657-92749
            1873-2045           AC168054.4         92844-93016
            2046-2870           AC168054.4         95039-95863
FEATURES             Location/Qualifiers
     source          1..2870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..2870
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /note="NCK interacting protein with SH3 domain"
                     /db_xref="GeneID:80987"
                     /db_xref="MGI:MGI:1931834"
     exon            1..275
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2249
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /note="Wiskott-Aldrich syndrome homolog binding protein;
                     VIP54; N-WASP-binding protein; SH3 adapter protein SPIN90;
                     54 kDa VacA-interacting protein; 90 kDa N-WASP-interacting
                     protein; 90 kDa SH3 protein interacting with Nck;
                     wiskott-Aldrich syndrome protein-binding protein WISH;
                     WASP-interacting SH3-domain protein; mDia interacting
                     protein-1"
                     /codon_start=1
                     /product="NCK-interacting protein with SH3 domain"
                     /protein_id="NP_109654.2"
                     /db_xref="CCDS:CCDS23538.1"
                     /db_xref="GeneID:80987"
                     /db_xref="MGI:MGI:1931834"
                     /translation="MYRALYAFRSAEPNAMAFAAGETFLVLERSSTHWWLAARARSGE
                     TGYVPPAYLHRLQGMEQDVLQAIDRAIEAVHNTAMRDGGKYSLEQRGVLQKLIHHRKE
                     TLSRRGTSASSATVMTPSTSDHHLDAAVSRQPNGVCRTGFERQHSLPSSEHLGTDGAL
                     YQVPPQPRRAAPTTPPPPVKRRDREALVISGSGGRTAIPSGGSSVSSGSSASSTSMDT
                     LYTGSSPSELGPSCSPTPPPVPRRGAHTTVSQPQPSPSKAPSPEPPTEEVAAETNSTP
                     DDLEAQDALSPETTEEKAAAETVVPRTIGAELMELVRRNTGLSHELCRVAIGVVVGHI
                     QATVPASSPIMEQVLLSLVEGKDLSTALPSGQVCHDQQRLEVIFADLARRKDDAQQRS
                     WALYEDEDVIRCYLEELLHILTDADPEVCKKMCKRSDFESVLALVAYYQMEHRASLRL
                     LLLKCFGAMCSLDAAIISTLVSSVLPVELARDMQTDTQDHQKLCYSALVLAMVFSMGE
                     AVPYAHYEHLGTPFAQFLLSIVEDGLPMDTTEQLPDLCMNLLLALNLHLTAPEQNVIM
                     AALSRHTNVKIFSEKLLLLLNRGDDPVRIFRHEPQPPHSVLKFLQDVFSSSATAAIFY
                     HTDMMALIDITVRQIADLSPGDKLRMEYLSLMHAVVRSTPYLQHRHRLSDLQATLRRI
                     LTEEEASPQCQMDRMIVQEMYKEFPDLGEVPS"
     exon            276..385
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     exon            386..590
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     exon            591..681
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     exon            682..1172
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1343
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1430
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1569
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1650
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1779
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1872
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2045
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2870
                     /gene="Nckipsd"
                     /gene_synonym="AF3P21; DIP1; ORF1; SPIN90; Wasbp; WASLBP;
                     WISH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaagcgcc gggcggcgcg gcactcaggg cctggcttcc cggcaccgca accttcgtcg
       61 cgtacccagc cccggcgctt cgcggcccgg cccggcccgg cctcatgtac cgcgcgctgt
      121 atgcgttccg ctccgcggag ccgaacgcca tggcgttcgc tgcaggcgag accttcctgg
      181 tgctggagcg cagcagcacg cactggtggt tagcagcacg ggcgcgcagt ggcgagaccg
      241 ggtacgtgcc gcctgcctac ctgcatcgcc tgcagggcat ggaacaagat gtcctccaag
      301 ctattgaccg tgccattgag gctgtgcaca acacagccat gcgagatggc ggcaagtaca
      361 gcctggaaca gcgtggagtc cttcagaagc ttatccatca ccggaaagaa accttgtctc
      421 gaagaggcac ctcagcttcc agtgctacgg ttatgacccc atccaccagt gaccaccatt
      481 tggacgctgc tgtatctaga cagcccaatg gggtgtgtcg aactgggttt gaacggcagc
      541 atagcctgcc cagttctgag catcttggga cagatggagc cctctaccag gttccaccac
      601 agcctcgacg agcagctcct accaccccac ccccaccggt gaagcgccga gaccgtgagg
      661 ccctggtgat ctcagggagt ggtggccgca cagccatacc ctctggaggt agttctgtgt
      721 ctagtggctc atcagccagc agcacctcca tggacacact ctatactggc tccagcccct
      781 ctgagctagg tcccagctgc tcacccacac ccccgccggt acctcgccga ggggcccaca
      841 ctactgtgtc ccagccccag ccctctccct ccaaggcacc atcccctgag ccccctacgg
      901 aggaggtggc agctgagaca aactcaaccc ctgatgactt ggaagctcag gatgccctga
      961 gcccagagac cacagaggag aaggcagccg ctgagacagt tgtgccaagg accattgggg
     1021 cagagctgat ggaactcgtg cggagaaaca ccggtctaag ccatgagtta tgccgtgtag
     1081 ccatcggcgt cgtggtgggt cacatccagg ccaccgtgcc agccagctca cctatcatgg
     1141 agcaggtcct cctctcgctg gtagaaggca aggacctgag cacagcccta ccctcagggc
     1201 aggtctgcca cgaccagcag agactggaag tgatttttgc agacctggct cgaagaaagg
     1261 atgacgccca gcagcgcagc tgggcgctgt acgaggacga ggacgtcatc cgctgctatc
     1321 tggaagaact gctgcacatc ctgacggatg cagatcccga agtttgcaag aaaatgtgca
     1381 aaaggagtga ttttgagtct gtcctagcct tggtggccta ttaccaaatg gaacaccgag
     1441 cgtctctacg gctgctgctc ctcaagtgtt tcggtgccat gtgcagccta gatgcagcga
     1501 tcatctccac tctggtgtct tccgtgctgc ctgtggaatt ggcacgggac atgcagaccg
     1561 acacgcagga ccaccagaag ctctgttact ctgccctcgt cctggccatg gtcttctcca
     1621 tgggagaggc ggtaccctac gcacactatg aacacctggg tacacccttt gcccagttcc
     1681 tactaagcat cgttgaggat ggccttccaa tggacaccac ggagcagctg ccagacctct
     1741 gcatgaacct gcttctggct ctcaacctgc acctgacagc tcctgagcag aatgtcatca
     1801 tggctgcctt gagcagacac accaatgtga agatcttctc tgagaagctg cttctgcttc
     1861 tgaacagagg ggacgaccct gtgcgtatct tcagacatga gccccagcca ccacactctg
     1921 tcctcaagtt cctgcaggat gtgttcagca gctctgccac agccgccatc ttctaccaca
     1981 cagacatgat ggcgcttatt gacatcactg tgcgccagat cgcagacctg tcacctggag
     2041 acaagctacg catggagtac ctctccctga tgcatgctgt ggtccgctcc acgccctacc
     2101 tgcagcaccg acatcggctg tcagacctgc aggctacact gcggcgcatc ctgactgagg
     2161 aagaggcctc accccagtgc cagatggacc gtatgattgt ccaagagatg tacaaggaat
     2221 tcccggacct gggagaggtt cccagctagc acttctcttt actcccttct ctgcagccct
     2281 gggagggtgc agagaactca ggggcttggc tctaaggatg ttctgcaccg acactgcgag
     2341 gtgataaaag attagaaggg acctgagccg ggccccttac ctaaaggaga gtcagggtaa
     2401 ggggccagat gtaggattgg ggaccacagt ctgggaactg tattggggca gaggaaatgc
     2461 gcaaggctga ataccctctg tttgctggta ggctgcctct tcagcatgcc acccccatcc
     2521 cccactccca tgtgcatacc cagagtcctg ctgctgctcc aggctgggct gctgccatcc
     2581 ctacctgctg tctggtctga gtcttgaccc tcagcaagcc atgtccttag ggtgagggag
     2641 gcaccttctg ccagctctgt tctttgcctt agctttgcag tgagtgttgc tcatgtgcag
     2701 cccttccccc atagggactg ctgtcccctg accccctgct ttcagcccca gaggccttgg
     2761 ccagactgtt gccttgaaag tgggatccta gagacaggcc atccgtcctg cagccccatg
     2821 gaacaggatg atggtgctga gaaagccaat gatagaatct attttctctg
//
