LOCUS       NM_010878               2467 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus non-catalytic region of tyrosine kinase adaptor
            protein 1 (Nck1), transcript variant 1, mRNA.
ACCESSION   NM_010878
VERSION     NM_010878.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2467)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2467)
  AUTHORS   Golding,A.P., Ferrier,B., New,L.A., Lu,P., Martin,C.E., Shata,E.,
            Jones,R.A., Moorehead,R.A. and Jones,N.
  TITLE     Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary
            Gland Development
  JOURNAL   J Mammary Gland Biol Neoplasia 28 (1), 19 (2023)
   PUBMED   37479911
  REMARK    GeneRIF: Distinct Requirements for Adaptor Proteins NCK1 and NCK2
            in Mammary Gland Development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2467)
  AUTHORS   Diab,A.M., Wigerius,M., Quinn,D.P., Qi,J., Shahin,I., Paffile,J.,
            Krueger,K., Karten,B., Krueger,S.R. and Fawcett,J.P.
  TITLE     NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic
            Spine, Synapse, and Memory Formation
  JOURNAL   J Neurosci 43 (6), 885-901 (2023)
   PUBMED   36535770
  REMARK    GeneRIF: NCK1 Modulates Neuronal Actin Dynamics and Promotes
            Dendritic Spine, Synapse, and Memory Formation.
REFERENCE   4  (bases 1 to 2467)
  AUTHORS   Bywaters,B.C., Pedraza,G., Trache,A. and Rivera,G.M.
  TITLE     Endothelial NCK2 promotes atherosclerosis progression in male but
            not female Nck1-null atheroprone mice
  JOURNAL   Front Cardiovasc Med 9, 955027 (2022)
   PUBMED   36035930
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2467)
  AUTHORS   Fernandez-Pisonero,I., Clavain,L., Robles-Valero,J.,
            Lorenzo-Martin,L.F., Caloto,R., Nieto,B., Garcia-Macias,C.,
            Oeste,C.L., Sanchez-Martin,M., Abad,A., Hortal,A., Caballero,D.,
            Gonzalez,M., Dosil,M., Alarcon,B. and Bustelo,X.R.
  TITLE     A hotspot mutation targeting the R-RAS2 GTPase acts as a potent
            oncogenic driver in a wide spectrum of tumors
  JOURNAL   Cell Rep 38 (11), 110522 (2022)
   PUBMED   35294890
REFERENCE   6  (bases 1 to 2467)
  AUTHORS   Grimm,J., Sachs,M., Britsch,S., Di Cesare,S., Schwarz-Romond,T.,
            Alitalo,K. and Birchmeier,W.
  TITLE     Novel p62dok family members, dok-4 and dok-5, are substrates of the
            c-Ret receptor tyrosine kinase and mediate neuronal differentiation
  JOURNAL   J Cell Biol 154 (2), 345-354 (2001)
   PUBMED   11470823
REFERENCE   7  (bases 1 to 2467)
  AUTHORS   Chen,M., She,H., Davis,E.M., Spicer,C.M., Kim,L., Ren,R., Le
            Beau,M.M. and Li,W.
  TITLE     Identification of Nck family genes, chromosomal localization,
            expression, and signaling specificity
  JOURNAL   J Biol Chem 273 (39), 25171-25178 (1998)
   PUBMED   9737977
REFERENCE   8  (bases 1 to 2467)
  AUTHORS   Park,D.
  TITLE     Cloning, sequencing, and overexpression of SH2/SH3 adaptor protein
            Nck from mouse thymus
  JOURNAL   Mol Cells 7 (2), 231-236 (1997)
   PUBMED   9163738
REFERENCE   9  (bases 1 to 2467)
  AUTHORS   Ren,R., Mayer,B.J., Cicchetti,P. and Baltimore,D.
  TITLE     Identification of a ten-amino acid proline-rich SH3 binding site
  JOURNAL   Science 259 (5098), 1157-1161 (1993)
   PUBMED   8438166
REFERENCE   10 (bases 1 to 2467)
  AUTHORS   Margolis,B., Silvennoinen,O., Comoglio,F., Roonprapunt,C.,
            Skolnik,E., Ullrich,A. and Schlessinger,J.
  TITLE     High-efficiency expression/cloning of epidermal growth
            factor-receptor-binding proteins with Src homology 2 domains
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8894-8898 (1992)
   PUBMED   1409582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY096444.1, CJ171968.1 and AK053155.1.
            
            On May 12, 2016 this sequence version replaced NM_010878.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF043259.1, BC002015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BY096444.1         2-21
            21-401              CJ171968.1         1-381
            402-2467            AK053155.1         118-2183
FEATURES             Location/Qualifiers
     source          1..2467
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 52.69 cM"
     gene            1..2467
                     /gene="Nck1"
                     /gene_synonym="6330586M15Rik; D230010O13Rik; Nck; Nck-1"
                     /note="non-catalytic region of tyrosine kinase adaptor
                     protein 1"
                     /db_xref="GeneID:17973"
                     /db_xref="MGI:MGI:109601"
     exon            1..140
                     /gene="Nck1"
                     /gene_synonym="6330586M15Rik; D230010O13Rik; Nck; Nck-1"
                     /inference="alignment:Splign:2.1.0"
     exon            141..384
                     /gene="Nck1"
                     /gene_synonym="6330586M15Rik; D230010O13Rik; Nck; Nck-1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..1097
                     /gene="Nck1"
                     /gene_synonym="6330586M15Rik; D230010O13Rik; Nck; Nck-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..2467
                     /gene="Nck1"
                     /gene_synonym="6330586M15Rik; D230010O13Rik; Nck; Nck-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1744..1749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nck1"
                     /gene_synonym="6330586M15Rik; D230010O13Rik; Nck; Nck-1"
                     /note="hexamer: AATAAA"
     polyA_site      1766
                     /gene="Nck1"
                     /gene_synonym="6330586M15Rik; D230010O13Rik; Nck; Nck-1"
                     /note="major polyA site"
     polyA_site      1808
                     /gene="Nck1"
                     /gene_synonym="6330586M15Rik; D230010O13Rik; Nck; Nck-1"
ORIGIN      
        1 ggttgcgcgc gccccgcccc tctccgagag ctacgcggcg gcgcagcaca ggcctcgtgc
       61 ggtaacggca tccgggcagc cgcggtggcg tcccggtgcg gtcctcaggt gactggagcc
      121 gagggctcgg cggagggaag tgttgacgct gctgaaagat ggctgaagaa gtggtggtgg
      181 tggccaaatt tgattatgtg gcacagcagg aacaagagct ggatatcaag aagaatgagc
      241 gattatggct cctggatgac tctaaatcct ggtggcgagt tcgaaattcc atgaataaaa
      301 caggttttgt cccttctaac tatgtggaaa gaaaaaacag tgctcggaaa gcatctattg
      361 ttaaaaacct gaaggacacc ttaggtattg gaaaagtgaa aagaaaaccc agtgttccag
      421 atactgcatc tcctgctgat gatagctttg ttgatccagg agaacgtctc tatgacctta
      481 acatgcctgc ttttgtgaaa tttaactaca tggctgagag agaggatgag ttgtcattga
      541 taaaagggac caaggtgatc gtcatggaga aatgcagtga tggatggtgg cgtggcagct
      601 acaacggaca aattggatgg tttccttcaa actatgtaac tgaagaaggt gacagtcctt
      661 tgggtgatca tgtaggttct ctgtcagaga aattagcagc agttgtcaat aacctaaata
      721 cgggtcaagt attgcatgtt gtacaggctc tttacccgtt tagctcatcc aatgatgaag
      781 aactcaattt tgagaaaggc gatgtaatgg atgttattga aaagccggaa aatgacccag
      841 agtggtggaa atgcaggaaa atcaatggca tggttggcct ggtgccaaaa aactacgtta
      901 ccattatgca aaacaatcca ttaacctcag gtttggaacc atctcctcca caatgtgatt
      961 acattaggcc ttcactcact gggaagtttg ctggcaatcc ttggtattat ggcaaagtca
     1021 ccaggcacca ggcagaaatg gcattaaatg aaagagggca tgaaggagac ttcctcattc
     1081 gtgacagtga atcttcgcca aatgatttct cagtatcact aaaagcacaa gggaaaaaca
     1141 agcattttaa agtccagctg aaagagactg tttactgcat tgggcagcgg aaattcagca
     1201 ccatggagga acttgtagaa cattacaaaa aggcaccgat ctttacaagt gagcaaggag
     1261 aaaaattata tctcgtcaag catttgtctt gatagtgctc gtcagcagtg actgttccac
     1321 agctttaact ggtcatgtaa ctggagactg agaaagtgct gggccaattg tacttgcttg
     1381 gaaagtgctg tttctaacta tatgagaatt gactataata catgagtatt tttgttataa
     1441 ctcagcccat acgtatatac tacatatgca gtgcatctct atagaagagt tctttattct
     1501 tggtcttact gttttctttg ctgtttttct ctttccttcc aacaatgaag gttttgtatt
     1561 ctgaaacgaa taatttggtt caaaatcttt atatggaaga attcttttat tgctgtttct
     1621 ttatttcctt gtaaagatat cctgttctcc catagttcct cttcacataa aattatatct
     1681 atatggcata tgataaagga cattcttgta aagtgttaat cttttctgtg actaaatagc
     1741 aataataaac agaaaataag aaattatttt cagatattgc atctgtcaca agccattgta
     1801 aatatcaagt atgttgtttg tgccttaatt tttaacaatc cattcattgt atccaaaaga
     1861 caccagataa taggttagaa aacataattt atagccattt taaacaaaaa tacaagaatt
     1921 tagggagtgt cccccacacc tcaagtaccc cctttcacgg gattattcat gagaagagag
     1981 cagtttgggc agttggctct tgaaatgaaa tgaatgttcc ttaggttctt tgatcaagta
     2041 tggtctatag attgtgccat atttatgcca ctgtgaaata agccatagtc aagtttgggg
     2101 aatacagtag acaatgagat atgtaacttt ttttcctttc taaacatcac taattcctca
     2161 tgtcagtaat ttaaggtttt caacttttca ccatcctgat ccagtatctg atcagattta
     2221 ctggaaaaca acaacatttt tcgacactat tgaatattaa acccaaggat acacatgaaa
     2281 agcaggtgtt ctgcgctgag tgggtcccct agcccctcgt tacttatctt ctagtttctt
     2341 taactgggag acacactgaa gtgatgtgct atggttaggt aaacagtatt atctaaaatt
     2401 ttctgtttgt catctagtac tttgtgtgtg tgaatgagaa actaaaatac tgagtctgct
     2461 gttggtc
//
