LOCUS       NM_010877               3590 bp    mRNA    linear   ROD 24-MAR-2023
DEFINITION  Mus musculus neutrophil cytosolic factor 2 (Ncf2), mRNA.
ACCESSION   NM_010877 XM_006529235
VERSION     NM_010877.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3590)
  AUTHORS   Idol RA, Bhattacharya S, Huang G, Song Z, Huttenlocher A, Keller NP
            and Dinauer MC.
  TITLE     Neutrophil and Macrophage NADPH Oxidase 2 Differentially Control
            Responses to Inflammation and to Aspergillus fumigatus in Mice
  JOURNAL   J Immunol 209 (10), 1960-1972 (2022)
   PUBMED   36426951
REFERENCE   2  (bases 1 to 3590)
  AUTHORS   Bhattacharya S, Idol RA, Yang W, Rojas Marquez JD, Li Y, Huang G,
            Beatty WL, Atkinson JJ, Brumell JH, Bagaitkar J, Magee JA and
            Dinauer MC.
  TITLE     Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in
            mice
  JOURNAL   Blood 139 (19), 2855-2870 (2022)
   PUBMED   35357446
REFERENCE   3  (bases 1 to 3590)
  AUTHORS   Kong M, Chen X, Lv F, Ren H, Fan Z, Qin H, Yu L, Shi X and Xu Y.
  TITLE     Serum response factor (SRF) promotes ROS generation and hepatic
            stellate cell activation by epigenetically stimulating NCF1/2
            transcription
  JOURNAL   Redox Biol 26, 101302 (2019)
   PUBMED   31442911
  REMARK    GeneRIF: we propose that SRF integrates transcriptional activation
            of NCF1/NCF2 and ROS production to promote liver fibrosis.
REFERENCE   4  (bases 1 to 3590)
  AUTHORS   van der Weyden L, Speak AO, Swiatkowska A, Clare S, Schejtman A,
            Santilli G, Arends MJ and Adams DJ.
  TITLE     Pulmonary metastatic colonisation and granulomas in NOX2-deficient
            mice
  JOURNAL   J Pathol 246 (3), 300-310 (2018)
   PUBMED   30062795
REFERENCE   5  (bases 1 to 3590)
  AUTHORS   Wang SM, Lim SW, Wang YH, Lin HY, Lai MD, Ko CY and Wang JM.
  TITLE     Astrocytic CCAAT/Enhancer-binding protein delta contributes to
            reactive oxygen species formation in neuroinflammation
  JOURNAL   Redox Biol 16, 104-112 (2018)
   PUBMED   29499563
  REMARK    GeneRIF: we found that ROS formation and expression of p47(phox)
            and p67(phox), subunits of NADPH oxidase, were increased in AppTg
            mice but attenuated in AppTg/Cebpd(-/-) mice. Cebpd can up-regulate
            p47(phox) and p67(phox) transcription via a direct binding on their
            promoters, which results in an increase in intracellular oxidative
            stress
REFERENCE   6  (bases 1 to 3590)
  AUTHORS   Baehner RL, Millar-Groff S and Bringas P.
  TITLE     Developmental expression of NADPH phagocytic oxidase components in
            mouse embryos
  JOURNAL   Pediatr Res 46 (2), 152-157 (1999)
   PUBMED   10447107
REFERENCE   7  (bases 1 to 3590)
  AUTHORS   Mizuki K, Kadomatsu K, Hata K, Ito T, Fan QW, Kage Y, Fukumaki Y,
            Sakaki Y, Takeshige K and Sumimoto H.
  TITLE     Functional modules and expression of mouse p40(phox) and p67(phox),
            SH3-domain-containing proteins involved in the phagocyte NADPH
            oxidase complex
  JOURNAL   Eur J Biochem 251 (3), 573-582 (1998)
   PUBMED   9490028
REFERENCE   8  (bases 1 to 3590)
  AUTHORS   Jackson SH, Malech HL, Kozak CA, Lomax KJ, Gallin JI and Holland
            SM.
  TITLE     Cloning and functional expression of the mouse homologue of p47phox
  JOURNAL   Immunogenetics 39 (4), 272-275 (1994)
   PUBMED   8119734
REFERENCE   9  (bases 1 to 3590)
  AUTHORS   Francke U, Hsieh CL, Foellmer BE, Lomax KJ, Malech HL and Leto TL.
  TITLE     Genes for two autosomal recessive forms of chronic granulomatous
            disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1)
  JOURNAL   Am J Hum Genet 47 (3), 483-492 (1990)
   PUBMED   2393022
REFERENCE   10 (bases 1 to 3590)
  AUTHORS   Fasano,O., Birnbaum,D., Edlund,L., Fogh,J. and Wigler,M.
  TITLE     New human transforming genes detected by a tumorigenicity assay
  JOURNAL   Mol Cell Biol 4 (9), 1695-1705 (1984)
   PUBMED   6092933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY097838.1, BC076609.1 and AK036379.1.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_010877.6.
            
            On or before Aug 27, 2015 this sequence version replaced
            XM_006529235.2, NM_010877.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               BY097838.1         1-147
            148-2855            BC076609.1         108-2815
            2856-3590           AK036379.1         1863-2597
FEATURES             Location/Qualifiers
     source          1..3590
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 65.05 cM"
     gene            1..3590
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /note="neutrophil cytosolic factor 2"
                     /db_xref="GeneID:17970"
                     /db_xref="MGI:MGI:97284"
     exon            1..361
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            362..1310
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1393
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1502
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1637
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1745
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1805
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1849
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1991
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2060
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2136
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2159
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2311
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2423
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2601
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..3590
                     /gene="Ncf2"
                     /gene_synonym="Ncf-2; NOXA2; p67phox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tattcagcac tctcccggag gtccctgact ctggctgtgc tctctctccc acacagctat
       61 aataaactct ctcctccacc atatctggga acagtcatgt tccttttcct ttcttatttc
      121 ttttctttct ttttcttttt tttttttccc attcagagtg tgtttctaac tcgtcacact
      181 cttccttttc ctgtgatgac aaggtcggtg tgaagctttg tgtttcgagc ttgacaggat
      241 ctagatgagc ctcaggtcac acctctgagg gatcgtctgc cttaggttaa ctgaggtaga
      301 gcatctgcta tgaaaagtga ccaggacttg ggtcctccct gcataaagag aagaaggcta
      361 cagactagtg aactcattag tcatcaacac gaggagtcat gtcttcagct tctcacagac
      421 agacagagcg atggtaattg ctgtcatgtc tgccgcccaa tttggatatc tacaagaaac
      481 tggaccctca tgaattccct tgaagtaagc tcagacctga atggacactg aagattctcc
      541 atcctgtctc agaaatatgt agcatgcttc ctccccaccc acagatttaa aaacaaaaca
      601 gtcagtgtag tggctgcaca tctatcactc cagaaattca aagtctgagg ccggagtact
      661 gggagttcag acaagcctgg gttacatccc tagacccaga gcctgagagg accagagcta
      721 gcaagtcttc caagggtgaa aaagagtcaa gtacaggacc aggcccagac ctgctgaggt
      781 ccccctgacc tgaggctccc acagagggtg tgggaagcag acatgtagga ggtgcccagg
      841 acatagaaga agctcttaga ggaactgacc agcccacggc aggctgctct gatgtacttc
      901 ctctttccca gccagcctcc tccagccctc ttctctcctt ccttttctct ctcatgctag
      961 tttatgcgtc agttcctgaa cgatggggaa acttcctgac gctacgaagt cgcccaaagg
     1021 gaggctagac cccattctgc gcgctaggct gggaccttga agcctggagc gcctacccgg
     1081 cagctctgag agagacacct tgaactacca tcctgccttc tggtaagcac ctaaccatgt
     1141 ccctggctga ggccatcaga ctctggaatg aaggggtgct cgcagccgac aagaaggact
     1201 ggaagggtgc cctggaggcc ttcagcgagg tgcaggaccc ccactcgagg atttgcttca
     1261 acataggctg cgtgaacact atcctggaaa acttgcaggc agccgagcag gccttcacca
     1321 aaagcatcaa cagagacaag cactctgcag tggcctactt ccagagagga atgctctact
     1381 acagaatgga gaagtacgac cttgctatca aagaccttaa agaggccttg acgcagcttc
     1441 gtgggaacca gctgatagac tacaagatcc tggggctgca gttcaagctg tttgcctgtg
     1501 aggtattgta caatattgct ctcatgcatg ccaagaaaga ggaatggaag aaagcagaag
     1561 agcagttggc attggcaacc aacatgaagt ccgagcccag gcattccaag atcgacaagg
     1621 ccatggagag catctggaag cagaagctgt tcgagcccgt ggtgatccct gtgggtcggc
     1681 tgttccgtcc aaatgagagg caggtggctc agctggccaa aaaggactat ctgggcaagg
     1741 ctacggttgt agcatctgtg gttcaccaag acaacttttc tggcttcgcc cctctgcagc
     1801 cacagtcagc agagcctcct cccagaccca aaaccccaga aatcttcagg gctctggaag
     1861 gtgaggcaca ccgcgtattg tttggctttg tgccggagac gccagaagag ctacaggtca
     1921 tgcctgggaa catcgtcttt gtcttgaaga agggcagtga taactgggcc acagtcatgt
     1981 tcaatggaca gaaggggctt gtcccctgca actacctgga gccagttgag cttcggattc
     2041 accctcagtc gcagccccag gaagatacct ctccagaatc cgatattcca ccacctccta
     2101 attctagccc cccaggaaga ctccagttgt caccaggtca caagcaaaaa gagcccaagg
     2161 aactgaagct cagcgtgcct atgccttaca tgctcaaggt gcattacaaa tacacagtgg
     2221 tcatggagac gcggcttggc ctcccctaca gccagcttcg gaacatggtg tctaagaagc
     2281 tggcgctctc gccagaacac actaaactga gctaccggcg tcgggacagc cacgagcttc
     2341 tgctcctgtc cgaagaaagc atgaaggatg cctggggcca agtgaaaaac tactgcctga
     2401 ctctgtggtg tgagcatacg gtgggtgacc aaggtcttat tgatgaaccc atacaaaggg
     2461 aaaactcaga cgccagtaag cagactacgg agcctcagcc taaggagggg acccaggtgg
     2521 tagcaatctt cagttatgag gctgcccagc cagaagacct ggaatttgtg gaaggagatg
     2581 taatcctggt actgtcacat gtgaatgaag aatggctgga aggggagtgt aaagggaaag
     2641 ttggcatttt cccgaaggct tttgttgaag gatgtgcagc caagaatttg gaaggcattc
     2701 ccagagaagt ctaggatcta caaagctgaa gcaaagtgtt gtttttcccc ttgcaagact
     2761 tacccatctc tgctgtgcgc tatacagaca caccagtttg gaaatgtggc ctaacttacc
     2821 atttccctat taaaattgaa cctgtcacac agcaatatga caactcagaa gattttctta
     2881 cagatggagg agggggagac aaattttctg caaaggaaat gaaggtttgt gtgtgtgctg
     2941 gctacgtgaa tgtacttaag aattcccaga gctgcacacc aatgggcaca cctttctgct
     3001 gggaaaacag gacacccagt gtccaagtcc aacagttcag tggaaaaata attaataaag
     3061 ggttcttcct ttattaattg cttgggttcc agaagcttaa agcaaattta tatgtaatcc
     3121 tgaaggtaca cacagacaac tcattaaaaa acttaagctg cattaaagaa aaggcagatt
     3181 gaatcaggtt cccatgaagc acaccatcca gtcccaagga gaatggaact cttagaatga
     3241 cagccctttc tgtccctcag atggacaaac aggaagagaa atcaaccacc ccccagatca
     3301 cagccatcac tgttggcttt catcagattc aatggctttt ataggccaga ggatgcctct
     3361 gcctcccaag tgctgggatt aaaggcatgc gccaccactg tccagctatg gcagacattt
     3421 taagctagca tttctagaac aagtcactgg atgctaagaa aagcaaaacc catccccaag
     3481 cctacccagt tgtggccatt tttgtttctt gctgacaagt gagcagttga agttctaagc
     3541 tgtattttta ctgctatatc ctttaaggta gaataaatcc tctacacacc
//
