LOCUS       NM_011986               3701 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus neurochondrin (Ncdn), transcript variant 1, mRNA.
ACCESSION   NM_011986
VERSION     NM_011986.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3701)
  AUTHORS   Ojha P, Pal S and Bhattacharyya S.
  TITLE     Regulation of Metabotropic Glutamate Receptor Internalization and
            Synaptic AMPA Receptor Endocytosis by the Postsynaptic Protein
            Norbin
  JOURNAL   J Neurosci 42 (5), 731-748 (2022)
   PUBMED   34907024
  REMARK    GeneRIF: Regulation of Metabotropic Glutamate Receptor
            Internalization and Synaptic AMPA Receptor Endocytosis by the
            Postsynaptic Protein Norbin.
REFERENCE   2  (bases 1 to 3701)
  AUTHORS   Pantarelli C, Pan D, Chetwynd S, Stark AK, Hornigold K, Machin P,
            Crossland L, Cleary SJ, Baker MJ, Hampson E, Mandel A,
            Segonds-Pichon A, Walker R, van 't Veer C, Riffo-Vasquez Y,
            Okkenhaug K, Pitchford S and Welch HCE.
  TITLE     The GPCR adaptor protein norbin suppresses the neutrophil-mediated
            immunity of mice to pneumococcal infection
  JOURNAL   Blood Adv 5 (16), 3076-3091 (2021)
   PUBMED   34402884
  REMARK    GeneRIF: The GPCR adaptor protein norbin suppresses the
            neutrophil-mediated immunity of mice to pneumococcal infection.
REFERENCE   3  (bases 1 to 3701)
  AUTHORS   Pan D, Barber MA, Hornigold K, Baker MJ, Toth JM, Oxley D and Welch
            HC.
  TITLE     Norbin Stimulates the Catalytic Activity and Plasma Membrane
            Localization of the Guanine-Nucleotide Exchange Factor P-Rex1
  JOURNAL   J Biol Chem 291 (12), 6359-6375 (2016)
   PUBMED   26792863
  REMARK    GeneRIF: A novel mechanism of P-Rex1 regulation through the
            GPCR-adaptor protein Norbin.
REFERENCE   4  (bases 1 to 3701)
  AUTHORS   Wang H, Warner-Schmidt J, Varela S, Enikolopov G, Greengard P and
            Flajolet M.
  TITLE     Norbin ablation results in defective adult hippocampal neurogenesis
            and depressive-like behavior in mice
  JOURNAL   Proc Natl Acad Sci U S A 112 (31), 9745-9750 (2015)
   PUBMED   26195764
  REMARK    GeneRIF: Norbin is a regulator of adult hippocampal neurogenesis
            and that its deletion causes depressive-like behaviors.
REFERENCE   5  (bases 1 to 3701)
  AUTHORS   Oku S, Takahashi N, Fukata Y and Fukata M.
  TITLE     In silico screening for palmitoyl substrates reveals a role for
            DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in
            its targeting to Rab5-positive endosomes
  JOURNAL   J Biol Chem 288 (27), 19816-19829 (2013)
   PUBMED   23687301
  REMARK    GeneRIF: In silico screening for palmitoyl substrates reveals a
            role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin
            palmitoylation in its targeting to Rab5-positive endosomes.
REFERENCE   6  (bases 1 to 3701)
  AUTHORS   Mochizuki R, Dateki M, Yanai K, Ishizuka Y, Amizuka N, Kawashima H,
            Koga Y, Ozawa H and Fukamizu A.
  TITLE     Targeted disruption of the neurochondrin/norbin gene results in
            embryonic lethality
  JOURNAL   Biochem Biophys Res Commun 310 (4), 1219-1226 (2003)
   PUBMED   14559245
  REMARK    GeneRIF: neurochondrin/norbin gene function is essential for the
            early embryogenesis
REFERENCE   7  (bases 1 to 3701)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 3701)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3701)
  AUTHORS   Bois PR, Southgate L and Jeffreys AJ.
  TITLE     Length of uninterrupted repeats determines instability at the
            unstable mouse expanded simple tandem repeat family MMS10 derived
            from independent SINE B1 elements
  JOURNAL   Mamm Genome 12 (2), 104-111 (2001)
   PUBMED   11210178
REFERENCE   10 (bases 1 to 3701)
  AUTHORS   Ishiduka Y, Mochizuki R, Yanai K, Takatsuka M, Nonomura T, Niida S,
            Horiguchi H, Maeda N and Fukamizu A.
  TITLE     Induction of hydroxyapatite resorptive activity in bone marrow cell
            populations resistant to bafilomycin A1 by a factor with restricted
            expression to bone and brain, neurochondrin
  JOURNAL   Biochim Biophys Acta 1450 (1), 92-98 (1999)
   PUBMED   10231559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB855959.1, CD548169.1, BQ745150.1, CX568560.1, AK002938.1 and
            AL606908.10.
            
            [WARNING] On Oct 17, 2023 this sequence was replaced by
            NM_011986.5.
            
            On Jul 10, 2009 this sequence version replaced NM_011986.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154889.1, BC017126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BB855959.1         2-29
            29-570              CD548169.1         1-542
            571-1301            BQ745150.1         1-731
            1302-1395           CX568560.1         688-781
            1396-2326           AK002938.1         1-931
            2327-3701           AL606908.10        7347-8721           c
FEATURES             Location/Qualifiers
     source          1..3701
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..3701
                     /gene="Ncdn"
                     /gene_synonym="mKIAA0607; MMS10-AE; Ms10ae; norbin"
                     /note="neurochondrin"
                     /db_xref="GeneID:26562"
                     /db_xref="MGI:MGI:1347351"
     exon            1..459
                     /gene="Ncdn"
                     /gene_synonym="mKIAA0607; MMS10-AE; Ms10ae; norbin"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..2616
                     /gene="Ncdn"
                     /gene_synonym="mKIAA0607; MMS10-AE; Ms10ae; norbin"
                     /note="isoform 1 is encoded by transcript variant 1;
                     M-Sema F-associating protein of 75 kDa; neurochondrin-1;
                     neurochondrin-2; minisatellite 10ae detected by probe
                     MMS10"
                     /codon_start=1
                     /product="neurochondrin isoform 1"
                     /protein_id="NP_036116.3"
                     /db_xref="CCDS:CCDS18659.1"
                     /db_xref="GeneID:26562"
                     /db_xref="MGI:MGI:1347351"
                     /translation="MSCCDLAAAGQLGKAGIMASDCEPALNQAESRNPTLERYLGALR
                     EAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHV
                     LRALGVALLACFCSDPELASHPQVLNKIPILSTFLTARGDPDDAARRSMIDDTYQCLT
                     AVAGTPRGPRHLIAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDL
                     LAVLRGLSEDFQRAEDASKFELCQLLPLFLPPTTVPPECHRDLQAGLARILGSKLSSW
                     QRNPALKLAARLAHACGSDWIPVGSSGSKFLALLVNLACVEVRLALEETGTEVKEDVV
                     TACYALMELGIQECTRCEQSLLKEPQKVQLVSIMKEAIGAVIHYLLQVGPEKQKEPFV
                     FASVRILGAWLAEETSSLRKEVCQLLPFLVRYAKTLYEEAEEASDISQQVANLAISPT
                     TPGPSWPGDALRLLLPGWCHLTVEDGPREILIKEGAPSLLCKYFLQQWELTSPGHDTS
                     VLPDSVEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPSLVQQQGRLLLA
                     ANVATLGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSP
                     DYEGIWADLQELWFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPE
                     MVAAYQGVLVELARANRLCREAMRLQAGEETASHYRMAALEQCLSEP"
     exon            460..600
                     /gene="Ncdn"
                     /gene_synonym="mKIAA0607; MMS10-AE; Ms10ae; norbin"
                     /inference="alignment:Splign:2.1.0"
     exon            601..1569
                     /gene="Ncdn"
                     /gene_synonym="mKIAA0607; MMS10-AE; Ms10ae; norbin"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1811
                     /gene="Ncdn"
                     /gene_synonym="mKIAA0607; MMS10-AE; Ms10ae; norbin"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2036
                     /gene="Ncdn"
                     /gene_synonym="mKIAA0607; MMS10-AE; Ms10ae; norbin"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2179
                     /gene="Ncdn"
                     /gene_synonym="mKIAA0607; MMS10-AE; Ms10ae; norbin"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..3701
                     /gene="Ncdn"
                     /gene_synonym="mKIAA0607; MMS10-AE; Ms10ae; norbin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagcagcct ggagccaaga gtgggcaacg cggcgtgagc agcagcccca ggctcccgga
       61 gcatcgcgcc cggagaaaga cttcgccgct cggggccgca gcctggtgag ctcagccccc
      121 ttcaagccct cccctgcatc tcagccggag cctctccgaa ccggcgctga tcgatgccga
      181 gactccccag ggaccctatc gcgactccat cgtgccatat ctcgacatca ccgtaccctg
      241 tcgagactcc attttgtcac aacccctttc agtatttatc tatctaccta tatatttttt
      301 taaatttgcc ctatcatatt tgggggctgt ccccttcatg tcgtgatttc gctgtgatct
      361 ctccgtgaca tcaccgcgcc atcgtgaagt gtgatctcat cgctgccctg tcgttcgact
      421 tcatcaatgt cgtgttgtga cctggctgcg gcgggacagt tgggcaaggc gggcatcatg
      481 gcctcggatt gtgagccagc tctgaaccag gcagagagcc gaaaccccac cctggagcgc
      541 tacctgggag ccctccgtga ggccaagaat gacagcgagc agtttgcagc cctgctgcta
      601 gtaacgaagg cagtcaaagc aggtgacatt gatgccaaaa cccgacgtag gatctttgat
      661 gccgttgggt tcacctttcc caaccgactc ctgaccacta aggaggcacc tgatggctgc
      721 cctgaccacg ttctccgggc cctgggcgtg gccctgctgg cctgtttctg cagcgaccct
      781 gaactagcca gccatcccca ggtcctgaac aagatcccca tccttagcac attccttaca
      841 gcccgggggg accctgatga tgctgcccgc cgctccatga tcgatgacac ctaccagtgc
      901 ctgacagctg ttgcgggcac accccgaggg ccccggcacc tcattgctgg tggcaccgtg
      961 tctgccctgt gccaggcgta cctggggcat ggctacggct ttgaccaggc tctggcactc
     1021 ttggtggggc tgctggctgc tgcagagaca cagtgctgga aggaggcgga gcccgacctg
     1081 ctggctgtgt tgcgaggcct cagtgaggat ttccaaagag ccgaagatgc cagcaagttt
     1141 gagctctgcc agctgctgcc cctttttctg cccccaacaa ctgtgccccc tgaatgccac
     1201 cgagatctgc aggctgggct ggcacgaatc ctaggaagca agttgagctc ctggcagcgc
     1261 aaccctgcac tgaagctggc agcccgcctg gctcatgcct gcggctccga ctggatccca
     1321 gtgggcagct ctgggagcaa gtttctggcc ctgctcgtga atctagcgtg cgtggaggta
     1381 cggctggctc tcgaggagac aggcacagag gtgaaagaag acgtggtaac agcctgctat
     1441 gcccttatgg aattggggat ccaggagtgc acccgctgtg agcagtccct gcttaaggag
     1501 ccacagaagg ttcagctcgt gagcattatg aaagaggcca ttggcgctgt catccactac
     1561 ctgctgcagg tggggccaga gaagcagaaa gagccctttg tgtttgcctc ggtgcggatc
     1621 ctgggtgcct ggctggcgga ggagacctca tccctgcgta aggaggtgtg ccaactgctg
     1681 cccttccttg tccgatatgc caagacactc tatgaggagg ctgaggaggc cagtgacatt
     1741 tcgcagcagg tggccaactt ggccatctct cctactacac cagggccttc atggccaggg
     1801 gatgctctcc ggctcctcct tcccggctgg tgtcacctga ctgttgaaga tggtccccgg
     1861 gagattctga tcaaggaagg agccccctca cttctgtgca agtacttcct gcagcagtgg
     1921 gaactcacat ccccgggcca tgatacctcg gtgctgccag acagcgtgga gatcggcctt
     1981 cagacctgtt gccacatctt cctcaacctg gtggtcaccg ctccagggct gatcaaacgc
     2041 gatgcctgct tcacatctct tatgaacacc ctgatgacgt cactgccctc actagtgcag
     2101 caacaaggga gactgcttct agctgccaac gtggccactt tggggctcct aatggcccgg
     2161 ctccttagca cctctccagc tctccaagga accccagcct cccgaggttt cttcgcagct
     2221 gccatcctct ttctgtcaca gtcccatgtg gcacgagcca cccctggctc tgaccaggca
     2281 gtgttggccc tgtcccctga ctatgaaggc atctgggctg acttgcaaga gctctggttc
     2341 ctgggcatgc aggccttcac gggttgtgtg ccgctgctgc cctggctggc ccctgccgcc
     2401 ctgcgctccc gctggccaca ggagctgcta caactgctag gtagtgtaag ccccaactcc
     2461 gtcaagcctg agatggtggc tgcctaccag ggcgtgctgg tggaattggc acgggctaac
     2521 cggctatgcc gggaggccat gaggctgcag gcgggtgaag aaacggccag ccattaccga
     2581 atggctgctt tggagcagtg cctgtcagag ccctgagggg catccagtgg gtacagaccc
     2641 aggcgggcag cgagggaagg agggaggagg catcttccct gaagccccca aactggaccc
     2701 cttcttcaga cccccacaaa caccccagct ttctggcttt tctgagggct agggcatggt
     2761 gcccacctct caagtataag aaactgcatc ctgcctccag cccccttggg gcagggattg
     2821 gcttggaaca gaggttggcc ccgccaggcc ggggaaggtt ggagaagccc ccaggaggag
     2881 ggcaactaag tgtcattata cccagtgtct ggctccctga taggagggag gtcccagggt
     2941 aggagcgggc tggcaggcgc tgactgcctc agcccatgtg ccctgccggc cagggcgtgg
     3001 cctccccaag gctgtggtgc cccttctggc tcccccaggt caggtccgcg ccctttaaat
     3061 tggccgcttg gcttttgcct ttggtcctct tggacagaga gcaggctcag gccattgaca
     3121 tcacagttct tccttttaac tctagtgacc cggggtccga gttgccccta tgcttccagg
     3181 gcaatttgga gcagacagac cagtgggggg tggggaacct ccttccacct gcgcttcctt
     3241 gaggggacca gagagccctt ggtcccaggt ctcttgagct tttgtgtcat gttgcagcag
     3301 agtgaagatg gggggttggg ggttatttat tttgcttgtc cttatccctg cttggacacc
     3361 tgagcatcag atccctgtgc ccctggtgcc atctggcctg gctggagcca ggaacaagag
     3421 gtcaccccac cctagaatcc gcatggtttc cctgtgattg cactccactg ccaccgtggt
     3481 gcctggcttc agctcccctc ccccaatccc tgctaagcct ctactctgca gggagacgcg
     3541 actggcggct ccagcaggaa ctacctttct gaacccgcgg agacccgcat aagcctgacc
     3601 ccttgcttcc tccccgcccc ccagtgcgtt ctgtgatcgc caagttcaaa gctgtgcaca
     3661 tgtggacact caataaatgt ttattggtga tgagaagcct c
//
