LOCUS       NP_835214               1506 aa            linear   ROD 02-MAY-2024
DEFINITION  condensin-2 complex subunit D3 isoform 1 [Mus musculus].
ACCESSION   NP_835214
VERSION     NP_835214.2
DBSOURCE    REFSEQ: accession NM_178113.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1506)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1506)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   3  (residues 1 to 1506)
  AUTHORS   Nishide,K. and Hirano,T.
  TITLE     Overlapping and non-overlapping functions of condensins I and II in
            neural stem cell divisions
  JOURNAL   PLoS Genet 10 (12), e1004847 (2014)
   PUBMED   25474630
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1506)
  AUTHORS   Lee,J., Ogushi,S., Saitou,M. and Hirano,T.
  TITLE     Condensins I and II are essential for construction of bivalent
            chromosomes in mouse oocytes
  JOURNAL   Mol Biol Cell 22 (18), 3465-3477 (2011)
   PUBMED   21795393
REFERENCE   5  (residues 1 to 1506)
  AUTHORS   Onn,I., Aono,N., Hirano,M. and Hirano,T.
  TITLE     Reconstitution and subunit geometry of human condensin complexes
  JOURNAL   EMBO J 26 (4), 1024-1034 (2007)
   PUBMED   17268547
REFERENCE   6  (residues 1 to 1506)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156163.2 and CT025660.9.
            
            On Nov 24, 2007 this sequence version replaced NP_835214.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.11072.1,
                                           SRR10223969.8689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1506
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 12.12 cM"
     Protein         1..1506
                     /product="condensin-2 complex subunit D3 isoform 1"
                     /note="condensin-2 complex subunit D3; Jacobsen syndrome
                     region 2"
                     /calculated_mol_wt=169276
     Region          154..194
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Region          442..476
                     /region_name="HEAT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Region          483..524
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          532..567
                     /region_name="HEAT 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Region          <538..603
                     /region_name="VHS_ENTH_ANTH"
                     /note="VHS, ENTH and ANTH domain superfamily; cl02544"
                     /db_xref="CDD:470608"
     Region          538..566
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            562
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42695; propagated from
                     UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Region          574..605
                     /region_name="HEAT 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Region          575..600
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          611..641
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          884..908
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Region          936..965
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          951..1127
                     /region_name="Cnd1"
                     /note="non-SMC mitotic condensation complex subunit 1;
                     pfam12717"
                     /db_xref="CDD:463677"
     Region          968..1004
                     /region_name="HEAT 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Region          973..1000
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1011..1037
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1317..1353
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Site            1359
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42695; propagated from
                     UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Site            1368
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42695; propagated from
                     UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Site            1381
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42695; propagated from
                     UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Region          1385..1412
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Site            1393
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42695; propagated from
                     UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     Region          1473..1506
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6ZQK0.3)"
     CDS             1..1506
                     /gene="Ncapd3"
                     /gene_synonym="2810487N22Rik; 4632407J06Rik;
                     B130055D15Rik; mKIAA0056"
                     /coded_by="NM_178113.4:483..5003"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS57665.1"
                     /db_xref="GeneID:78658"
                     /db_xref="MGI:MGI:2142989"
ORIGIN      
        1 malqdlgenl qpwcplglsl ewvktvwdld fteiepldps ivgeiletgr daftklygsl
       61 fpfatdesgs lesiwtffte ndissntlva lfchfvqeah kksasaqyre yglhaaglyf
      121 llleipgsvv nqvfhpvmfd kciqilkrsw pqesnltqkr kkdhsksskd nyrksrkrgk
      181 pprkedyqvd elsreeeeee eeiyfsgrdl cqirdaifnl lknflrllpk fslkekpqsi
      241 qtcievfval tsfepiphkf lisqarnlne vkhiselayy glyllcspvh geenkvigsi
      301 fhqmlnvilm levgegsrca plaitsqvin crnqavqfvs slvdelqasv ypvlgtllqh
      361 icakvvdkae yrtyaaqslv qlltklpsee yatfiawlyk ysrsskiphr vftldvalal
      421 ltlpereldd tvslehqkfl khkffvqeii fdrcldkapt vrskalssfa hclelsssnt
      481 sesileifin snlvpgiqnl sntvlnpspv ltsrngysaq srthnndeqt lpgercfmtm
      541 lrkrikdeki nvrksalqvl msilkhcdil smeqdllilq dhcrdpaisv rkqalqslte
      601 lvmaqptcvp vqkawlmgvi pvvmdcestv qekalecldq lllqnikhhk kfhsadrsqv
      661 lawsllallt ienqdlrryl nkafhiwskk dkfsstfins vishtdters apawmllski
      721 tcsspkldyt kiieswerls reqspnsntl gymlcvighi akhlpkgtrd kitgvikakl
      781 ngfqwspeli sssvdalqkl crasaktvle eqgllkqvcg dvlatceqhl snillkedgt
      841 gnmdeglvvk ciftlgdiaq lcpaivekrv flliqsilas sahsdhlpss qgttdaldsq
      901 ppfqprssam psvirahaii tlgklclqhe dlakksipal vrelevsedv avrnnviivi
      961 cdlcirytvm vdnyipnisv clkdsdpfir kqtlvlltnl lqeeyvkwkg slffrfvstl
     1021 vdshpdiasl gefclahlll krnptmffqh fiecifhfns yekhgqynkf sqsergkqlf
     1081 llkgktnkek rmriykflle hftdeqrfnv tskiclnila cftdgilpmd measellsdt
     1141 fdilnskeik llamraqtsk dlleeddval anvvmqeaqm kiisqvqkrn fieniipiii
     1201 slktvleknk ipalrelmny lrevmqdyrd eindffavdk qlaseleydm kkyneqlaqe
     1261 qaltehanat kgpedsdrvp saqvapdlea vpalaaapma aaaaaapmaa aaaaagqdna
     1321 dvpptqsrps aprsnftptl ppisengplk imsstrpmsl stiailnsvk kavasknrtr
     1381 slgalpfnve tgspenpssh esslslekes drtvnhvtkr aistpensis dvtfaagvsy
     1441 igtpatfftk ekheaqeqgs dilclslldk rppqspqwnv ksparshgst rssrrslrka
     1501 plktan
//
