LOCUS       NM_007789               7184 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus neurocan (Ncan), mRNA.
ACCESSION   NM_007789 XM_913832
VERSION     NM_007789.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7184)
  AUTHORS   Kaneko,N., Hirai,K., Oshima,M., Yura,K., Hattori,M., Maeda,N. and
            Ohtaka-Maruyama,C.
  TITLE     ADAMTS2 promotes radial migration by activating TGF-beta signaling
            in the developing neocortex
  JOURNAL   EMBO Rep 25 (7), 3090-3115 (2024)
   PUBMED   38871984
REFERENCE   2  (bases 1 to 7184)
  AUTHORS   Irala,D., Wang,S., Sakers,K., Nagendren,L., Ulloa Severino,F.P.,
            Bindu,D.S., Savage,J.T. and Eroglu,C.
  TITLE     Astrocyte-secreted neurocan controls inhibitory synapse formation
            and function
  JOURNAL   Neuron 112 (10), 1657-1675 (2024)
   PUBMED   38574730
REFERENCE   3  (bases 1 to 7184)
  AUTHORS   Mubuchi,A., Takechi,M., Nishio,S., Matsuda,T., Itoh,Y., Sato,C.,
            Kitajima,K., Kitagawa,H. and Miyata,S.
  TITLE     Assembly of neuron- and radial glial-cell-derived extracellular
            matrix molecules promotes radial migration of developing cortical
            neurons
  JOURNAL   Elife 12, 92342 (2024)
   PUBMED   38512724
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7184)
  AUTHORS   Reinhard,J., Mueller-Buehl,C., Wiemann,S., Roll,L., Luft,V.,
            Shabani,H., Rathbun,D.L., Gan,L., Kuo,C.C., Franzen,J.,
            Joachim,S.C. and Faissner,A.
  TITLE     Neural extracellular matrix regulates visual sensory motor
            integration
  JOURNAL   iScience 27 (2), 108846 (2024)
   PUBMED   38318351
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7184)
  AUTHORS   Hu,R., He,K., Chen,B., Chen,Y., Zhang,J., Wu,X., Shi,M., Wu,L. and
            Ma,R.
  TITLE     Electroacupuncture promotes the repair of the damaged spinal cord
            in mice by mediating neurocan-perineuronal net
  JOURNAL   CNS Neurosci Ther 30 (1), e14468 (2024)
   PUBMED   37950551
  REMARK    GeneRIF: Electroacupuncture promotes the repair of the damaged
            spinal cord in mice by mediating neurocan-perineuronal net.
REFERENCE   6  (bases 1 to 7184)
  AUTHORS   Whitmer,J.D., Koslovsky,J.S., Bahler,M. and Mercer,J.A.
  TITLE     Chromosomal location of three unconventional myosin heavy chain
            genes in the mouse
  JOURNAL   Genomics 38 (2), 235-237 (1996)
   PUBMED   8954808
REFERENCE   7  (bases 1 to 7184)
  AUTHORS   Perlick,H.A., Medghalchi,S.M., Spencer,F.A., Kendzior,R.J. Jr. and
            Dietz,H.C.
  TITLE     Mammalian orthologues of a yeast regulator of nonsense transcript
            stability
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10928-10932 (1996)
   PUBMED   8855285
REFERENCE   8  (bases 1 to 7184)
  AUTHORS   Beccari,T., Appolloni,M.G., Stirling,J.L. and Orlacchio,A.
  TITLE     Assignment of lysosomal alpha-D-mannosidase to mouse chromosome 8
  JOURNAL   Mamm Genome 7 (9), 707-708 (1996)
   PUBMED   8829553
REFERENCE   9  (bases 1 to 7184)
  AUTHORS   Rauch,U., Grimpe,B., Kulbe,G., Arnold-Ammer,I., Beier,D.R. and
            Fassler,R.
  TITLE     Structure and chromosomal localization of the mouse neurocan gene
  JOURNAL   Genomics 28 (3), 405-410 (1995)
   PUBMED   7490074
REFERENCE   10 (bases 1 to 7184)
  AUTHORS   Weisz,P.V., Solem,M. and Barnes,D.
  TITLE     Expression of a TGF beta regulated, brain-specific mRNA in
            serum-free mouse embryo (SFME) cells
  JOURNAL   Neurosci Lett 154 (1-2), 153-156 (1993)
   PUBMED   8361632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX202471.1, BC065118.1 and BQ745524.1.
            
            On Nov 15, 2007 this sequence version replaced NM_007789.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065118.1, X84727.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CX202471.1         1-34
            35-4435             BC065118.1         1-4401
            4436-5010           BQ745524.1         101-675
            5011-7184           BC065118.1         4974-7147
FEATURES             Location/Qualifiers
     source          1..7184
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..7184
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /note="neurocan"
                     /db_xref="GeneID:13004"
                     /db_xref="MGI:MGI:104694"
     exon            1..117
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            118..197
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            198..596
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            597..771
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            772..899
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1193
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1790
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..2999
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3116
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3230
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3389
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3472
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            3473..3617
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..3800
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..7166
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7146..7151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /note="hexamer: AATAAA"
     polyA_site      7166
                     /gene="Ncan"
                     /gene_synonym="C230035B04; Cspg3; Cspg3-rs; Tgfbit"
                     /note="major polyA site"
ORIGIN      
        1 ggaggctgcg cctggcgtgc tgagcgcctg ggctctaggg ctgaagaaac accgggagcg
       61 gggcgtcgcg tcctttgtgc ccggaaccgt ggggatgtgt tcgcgctaag gagccagctc
      121 cagtatgggg gccggatctg tgtgggcctc aggcctcctg ctgctgtggc tgcttctcct
      181 agtggctggg gatcaggaca cacaggacac caccgccacg gaaaaggggc ttcgcatgct
      241 gaagtcaggg tcaggacccg tccgtgctgc cctggcagag ctagtggccc tgccctgctt
      301 ctttaccctg caaccacggc taagctccct gcgagacatt cctcggatca agtggactaa
      361 ggttcagact gcatcaggcc agcgacagga tttgccaatc ttggtggcca aagacaacgt
      421 ggtgcgtgtg gccaagggct ggcagggacg ggtgtcattg cctgcttatc cccggcacag
      481 agccaatgct acccttctgc tggggccact tcgagcaagc gactctgggc tgtatcgctg
      541 ccaagtggta aagggtatcg aagatgagca ggacctggta accctggaag tgacaggcgt
      601 cgtgttccat tatcgggcgg cccgggaccg ctatgcgctg accttcgctg aggcccagga
      661 ggcttgtcgc ctaagctctg ctaccatcgc tgccccacgg cacctgcagg ctgcctttga
      721 agatggcttt gacaactgcg acgcgggctg gctctcagac cgcacggttc ggtacccgat
      781 cactcagtcg cgtcctggtt gctatggtga ccgcagcagt ctcccgggtg ttcggagcta
      841 cgggagacgc gacccgcagg aactctacga tgtctactgc tttgcccgcg agctaggggg
      901 tgaagtcttt tacgtgggcc cggcccgccg actgaccctg gcgggcgcgc gggcacaatg
      961 tcagcggcag ggtgcagcgc tggcctcggt ggggcagttg cacctggcct ggcacgaggg
     1021 cctggaccag tgcgacccgg gctggctggc agacggcagc gtgcgctacc ccatccagac
     1081 tccgcgccgg cgttgcgggg gccccgcccc aggtgtgcgc actgtgtacc gcttcgccaa
     1141 ccgcaccggc tttcctgcgc caggagcacg cttcgacgcc tactgcttcc gagctcatca
     1201 ccatacagca caacatggag attctgagat cccctcatct ggagatgagg gggagattgt
     1261 gtcagcagag gggcctccag gccgagaact aaagcccagc ttgggggaac aggaggtgat
     1321 agcacctgac ttccaggaac ctctcatgtc cagtggagaa ggcgaacccc cagacttgac
     1381 ttggacacaa gcacctgagg agacccttgg ttctactcca gggggtccca cgctggcctc
     1441 atggccctct tcagaaaagt ggctctttac gggtgcccca agctccatgg gtgtctccag
     1501 tcccagcgac atgggagtag atatggaagc gacaacaccc ttgggcacac aggtagcacc
     1561 cacccccacg atgaggaggg gccgctttaa agggttgaat ggtcgacact tccagcagca
     1621 gggcccagaa gaccagctgc ctgaggtagc agagcccagt gcccagcctc ccaccctggg
     1681 agctactgcc aaccacatga ggccttctgc agccacagag gcttcagaga gtgaccagag
     1741 ccacagtcct tgggccattc tgaccaacga agtggatgag ccaggagcag gctctcttgg
     1801 cagcaggagt ctcccagagt ccctgatgtg gtccccgtcg ttgatctcac ccagtgtccc
     1861 aagcaccgac agtactccta gcgcgaagcc aggggcagcc gaggcaccca gtgtgaagtc
     1921 agccatcccc cacctgcccc ggctgccctc agagccccct gctccctctc ccgggccctc
     1981 agaggcccta agtgctgtct ccctccaggc atcctctgct gatggctccc ctgacttccc
     2041 cattgtagcc atgcttcgag cccccaaact gtggcttctg ccacgctcta cacttgtccc
     2101 caatatgacc ccagtcccac tgtccccagc ttctccactt ccctcctggg tcccagaaga
     2161 acaggctgtc aggcctgtca gccttggagc ggaagacctc gaaaccccat ttcagaccac
     2221 catagctgcc ccagttgaag ccagccacag atcccctgat gcagattcta tagaaatcga
     2281 ggggaccagc tccatgcggg ctacaaagca ccccatctct ggcccatggg cttctttgga
     2341 ctctagtaat gtgacgatga atcctgtccc ttctgatgct ggcatcctag ggactgagtc
     2401 tggggtcttg gacttaccag ggagtcccac atcaggcgga caggccactg tggagaaggt
     2461 gctggccacc tggctaccac tgcctggcca aggactagac cctggctccc agtccacacc
     2521 catggaagcc catggggttg ccgtgagcat ggaacctaca gtggctttgg agggaggtgc
     2581 caccgagggc cctatggagg ccaccaggga ggtggtcccc agcactgctg atgccacttg
     2641 ggagtctgaa tccagaagtg ccatttctag cacccacata gctgtgacca tggctagggc
     2701 tcagggcatg cccacactga cctctacaag ctccgaaggc cacccagagc ctaagggcca
     2761 gatggtggcc caggagtcac tggagcctct caacactctg ccttcgcacc cctggtcatc
     2821 cctggtggtc cccatggatg aagtggcctc agtttcctca ggggaaccca caggactgtg
     2881 ggacataccc agcactctga tacctgtatc cttgggcttg gatgaatcag acctgaatgt
     2941 tgtggctgag agtccaagcg tgaagggctt ctgggaagag gtggccagcg ggcaggaaga
     3001 tcccacagat ccctgcgaga acaacccctg cctgcatggg ggcacctgcc acaccaacgg
     3061 caccgtgtat ggctgtagtt gtgaccaggg ctatgctggg gagaattgtg aaattgacat
     3121 tgatgactgc ttatgcagcc cttgcgagaa tgggggcacc tgcatcgacg aggtgaatgg
     3181 tttcatctgc ctctgcctcc ccagctatgg gggcagcctg tgtgagaagg acacagaagg
     3241 ctgcgaccgt ggctggcaca aattccaggg acactgctac cggtactttg cccatcgccg
     3301 ggcctgggag gatgcagaga gagattgcag gcgccgagct ggtcacctga caagcgtcca
     3361 ttcgccagaa gagcacaagt tcattaacag ttttggacat gagaattcgt ggatcggcct
     3421 gaatgaccgg acagtagaga gggacttcca gtggacagac aacacaggac tgcaatatga
     3481 gaactggagg gagaagcagc cggataattt cttcgcaggt ggggaggatt gtgtggtgat
     3541 ggtggcacat gagagtgggc gctggaatga tgtcccctgc aactacaacc taccctatgt
     3601 ctgcaagaag ggtacagtgc tgtgtggtcc ccctccagca gtggagaatg cctctcttgt
     3661 tggtgtgcgc aagatcaagt acaatgtcca tgccactgtg cgataccagt gtgatgaagg
     3721 attctcccag caccgagtgg ccactatccg ctgccgtaac aatgggaagt gggaccggcc
     3781 tcagatcatg tgcatcaaac ccaggcggtc acatcggatg cgtagacacc accaccatcc
     3841 acaccgacat cacaagcctc gcaaggagca cagaaaacac aagagacacc cagcggaaga
     3901 ctgggagaaa gacgaagggg atttctgcta aagatccagg ctaatcaagc acaagccccc
     3961 acaccttctc cagagtgttt ccttggggac ccagaaccca gcatccacca gagagggtgg
     4021 ggacactgca gagccccaca cccctgcggt aggtcctctg ttactgaggt cctcctggaa
     4081 ggggtggctg agcctgagag gccatgctgg tctggctgag cctctaggtc acttcccagc
     4141 cattaaaggg ggtcctgaag tctgcatcca caaggggcaa cagtatgtct gtgtgtgctg
     4201 gggagtggct ttcgcaccag agattcaggc ttaggaaaca gtggaccatc ctgaatctat
     4261 ggtgaaggtt tggctaaagt cactgtatct gagtggagga ccagcagagc aaacatgatg
     4321 gcctgccatc tcctgggatc ccccaagggt gacttccact cctctggttt tctttttttt
     4381 tcccctttct tcttcctccc tcccaattcc aacacctcca acccccaaac taggctggcc
     4441 tcgaactcac tattgtagaa agatgtcctt gaagtctcaa tcctcctgcc tctgcaccac
     4501 catgcctacc tggtttattt ggtgctggac atggcaccta gtactgagca gggctctctc
     4561 tgctaaccag ccctagtctt tggtcttggt tcagaccact aaatctagtg tggaactctt
     4621 atatactgat tttagtgatg tctcttagag ccactggcct ccttggcttc ctaggggagg
     4681 ttactccgag cgatgggggt ggggagggct agtgtcttgc tgactcccca ggtctagtgc
     4741 agtgctaaga tctggtggtt ctgttttggg ttgtttttgt tttgagacag ggcctcactg
     4801 tgcggccctg gctggcctgg aacttgctat atagaccagg ctaacctgga actcagcgaa
     4861 ctgtctgccc agccttcttt ggttttattg acgtaagatc tccagagcct aggctgggtt
     4921 tcaggccaca gcaatcatcc tttctcaacc acctgaaggt gacaggcata cgccgtcgtg
     4981 tgtggcagtt tcgtggcttt gtgatgaaaa atctcccaca cccgtgtgca cagaagtgag
     5041 atcagtggag tacaatgtgc tggatgctgc tgtatcctcc ccctccatct ctcagggaga
     5101 cagacaacct tctgcctgaa ccaagatggt gccatgtttt ctaacccaga gcctgtcttt
     5161 ttagcagacc tcaataaatc tcctgcctca gattccatcc ctgccccacc ccacttctgt
     5221 ttccacatcc tgcctgatgg actttatgct tacagtgttc atggtcctat ggtagaaaga
     5281 agaattctct tagaattaac acacacacat acacacacac acatgcatgt acacacacta
     5341 acacaccttc tcgcctggtt ttacattttt ctttttcttt tccttttccc cgtttccttt
     5401 tcttttttct tttttttttt tttttttttt tttttgaaac agggtttctc tgtgtagccc
     5461 tggctgtcct ggaactcact ttgtagacca ggctagcctc gcactcagaa atctgcctgc
     5521 cgctgcctcc caagagctgg gattaaaggt gtgcgccacc acgcccggtt ctacattttt
     5581 caaaatgtga aataatccac tttggattcc ctcttcccat ctacactcca gaaaagactt
     5641 cccaagccag ggacagggtc cctcacagag cccatgcagt gtgggtagaa tctatgaatt
     5701 tgtgttaaag ccacagtgga gcctgagctt agccctgtgg gtaaagatgc tgcataagcc
     5761 tgaagaagtc cgtttaagcc ctgggaccca tgttttaaaa gtgaaaagcc aggtagggtg
     5821 tgaaccctgg tgccagcatc cctgtgctga gactatagga agctcatgag ccagctagcc
     5881 tggaggatca cggcaaaccc ttaaagggta gcatttgacc tccactgcac actacaatgt
     5941 gggtgattct ccaacacacg cacaaccctc tccccccaca cacactgcac aagcacaaaa
     6001 taaataagta aaaatttcaa aaactgtagg attgggtggg tcagggcagg gatgggtgca
     6061 caggttctgg ggtccatgcc cagctcttcc taagtgttta ctgagctgca ttgctcacag
     6121 gaggtaatga aagcctgggg cagttactga atagaagccg tgtaaagcct tgtgagatgc
     6181 ccttgaatcc tctcagcagc ccacgtggtc cttagtctcc catttccact tgattgtaag
     6241 agaaagacaa agttacagac tacgatagag gagctagagc aagaatttcc ttctgtgcgt
     6301 tataattact gtaagtgttg attttttgga cagggcctca gtctggcctt gaattcactc
     6361 agtagctgag gataacctta aagtcctgat ccttctgcct cagtttccca agtactaaaa
     6421 cggcaggtat gcactatgac tggtgtatac aatgctaggg atggaaccca gagatttgtg
     6481 catactaagt aaatgttcta cacctgagct ccaagtactc tgtcaactga gctccaagca
     6541 ctctgtcaac tgagctccaa gcactcttat ctgtgcttcg aacgctacca acttagttcg
     6601 attcgcaaac cctggtcttg atttgtgctc caaattttgc tttatgttta agggaagaga
     6661 cctaaaatcc ttacctgctg tcacacacac acacacacac acacacacac acacacacac
     6721 acacacacac acgagcagac ttgggaaatg gttgagaaaa gcaaactgga ccctgatccg
     6781 taaaggtccc tgtgactggg gacaaagctt cttggtaaca ttttctaatt cagaaggaac
     6841 cacaccaatc ccctgctggg gattgagggc gaggcctgct ggggctcaga ggttcttcct
     6901 agcccctgaa ctgcctgctc catggagggg catgctttag gcttttctgg actggagcct
     6961 catctccagc tttccccctc cctggtgtgt ctgcttgggc cagtatgcgg gaggagtgtg
     7021 tatgtgcgag aatggctaca ggttctgctg ggttttgttt tgtttttgtt tttctgggag
     7081 ctttgatgtt ccgtggatct gtgctatctg acactgtgga tgttaatgga cttattggac
     7141 attttaataa aaatttttta acagttaaaa aaaaaaaaaa aaaa
//
