LOCUS       NM_001113208            3590 bp    mRNA    linear   ROD 30-DEC-2024
DEFINITION  Mus musculus neural cell adhesion molecule 2 (Ncam2), transcript
            variant 1, mRNA.
ACCESSION   NM_001113208
VERSION     NM_001113208.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3590)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3590)
  AUTHORS   Ortega-Gasco,A., Parcerisas,A., Hino,K., Herranz-Perez,V.,
            Ulloa,F., Elias-Tersa,A., Bosch,M., Garcia-Verdugo,J.M., Simo,S.,
            Pujadas,L. and Soriano,E.
  TITLE     Regulation of young-adult neurogenesis and neuronal differentiation
            by neural cell adhesion molecule 2 (NCAM2)
  JOURNAL   Cereb Cortex 33 (21), 10931-10948 (2023)
   PUBMED   37724425
  REMARK    GeneRIF: Regulation of young-adult neurogenesis and neuronal
            differentiation by neural cell adhesion molecule 2 (NCAM2).
REFERENCE   3  (bases 1 to 3590)
  AUTHORS   Sah,S., Keable,R., Pfundstein,G., Clemens,K.J., Begg,D.,
            Schachner,M., Leshchyns'ka,I. and Sytnyk,V.
  TITLE     Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces
            axonal levels of beta-site amyloid precursor protein cleaving
            enzyme 1 (BACE1), affects axonal organization in the hippocampus,
            and leads to behavioral deficits
  JOURNAL   Cereb Cortex 33 (18), 10047-10065 (2023)
   PUBMED   37522285
  REMARK    GeneRIF: Deficiency in the neural cell adhesion molecule 2 (NCAM2)
            reduces axonal levels of beta-site amyloid precursor protein
            cleaving enzyme 1 (BACE1), affects axonal organization in the
            hippocampus, and leads to behavioral deficits.
REFERENCE   4  (bases 1 to 3590)
  AUTHORS   Keable,R., Hu,S., Pfundstein,G., Kozlova,I., Su,F., Du,X., Yang,H.,
            Gunnersen,J., Schachner,M., Leshchyns'ka,I. and Sytnyk,V.
  TITLE     The BACE1-generated C-terminal fragment of the neural cell adhesion
            molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive
            endosomes
  JOURNAL   Cell Mol Life Sci 79 (11), 555 (2022)
   PUBMED   36251052
  REMARK    GeneRIF: The BACE1-generated C-terminal fragment of the neural cell
            adhesion molecule 2 (NCAM2) promotes BACE1 targeting to
            Rab11-positive endosomes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3590)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3590)
  AUTHORS   Yang,A., Walker,N., Bronson,R., Kaghad,M., Oosterwegel,M.,
            Bonnin,J., Vagner,C., Bonnet,H., Dikkes,P., Sharpe,A., McKeon,F.
            and Caput,D.
  TITLE     p73-deficient mice have neurological, pheromonal and inflammatory
            defects but lack spontaneous tumours
  JOURNAL   Nature 404 (6773), 99-103 (2000)
   PUBMED   10716451
REFERENCE   7  (bases 1 to 3590)
  AUTHORS   O'Leary,D.D., Yates,P.A. and McLaughlin,T.
  TITLE     Molecular development of sensory maps: representing sights and
            smells in the brain
  JOURNAL   Cell 96 (2), 255-269 (1999)
   PUBMED   9988220
  REMARK    Review article
REFERENCE   8  (bases 1 to 3590)
  AUTHORS   Alenius,M. and Bohm,S.
  TITLE     Identification of a novel neural cell adhesion molecule-related
            gene with a potential role in selective axonal projection
  JOURNAL   J Biol Chem 272 (42), 26083-26086 (1997)
   PUBMED   9334170
REFERENCE   9  (bases 1 to 3590)
  AUTHORS   Yoshihara,Y., Kawasaki,M., Tamada,A., Fujita,H., Hayashi,H.,
            Kagamiyama,H. and Mori,K.
  TITLE     OCAM: A new member of the neural cell adhesion molecule family
            related to zone-to-zone projection of olfactory and vomeronasal
            axons
  JOURNAL   J Neurosci 17 (15), 5830-5842 (1997)
   PUBMED   9221781
REFERENCE   10 (bases 1 to 3590)
  AUTHORS   Reeves,R.H., Rue,E.E., Citron,M.P. and Cabin,D.E.
  TITLE     High-resolution recombinational map of mouse chromosome 16
  JOURNAL   Genomics 43 (2), 202-208 (1997)
   PUBMED   9244437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW121550.1, BC119027.1, AF016620.1, BB663005.1 and BM933307.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF001287.1, SRR1660811.94494.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AW121550.1         1-142
            143-2048            BC119027.1         1-1906
            2049-2890           AF016620.1         1-842
            2891-3308           BB663005.1         137-554
            3309-3590           BM933307.1         6-287               c
FEATURES             Location/Qualifiers
     source          1..3590
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 45.89 cM"
     gene            1..3590
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /note="neural cell adhesion molecule 2"
                     /db_xref="GeneID:17968"
                     /db_xref="MGI:MGI:97282"
     exon            1..272
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..2731
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; neural cell adhesion molecule RB-8; olfactory
                     axon cell adhesion molecule; R4B12 antigen"
                     /codon_start=1
                     /product="neural cell adhesion molecule 2 isoform a
                     precursor"
                     /protein_id="NP_001106679.1"
                     /db_xref="CCDS:CCDS49888.1"
                     /db_xref="GeneID:17968"
                     /db_xref="MGI:MGI:97282"
                     /translation="MSLLLSFYLLGLLVRSGQALLQVTISLSKVELSVGESKFFTCTA
                     IGEPESIDWYNPQGEKIISTQRVMLQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQT
                     QEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTIPD
                     NRFAVLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAIMMPQKSF
                     NATAERGEEMTLTCKASGSPDPTISWFRNGKLIEENEKYILKGSNTELTVRNIINKDG
                     GSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNETTSENGHVTLVCEAEGEPVPEITW
                     KRAIDGVMFSEGDKSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAASRIGGHQRS
                     MHLDIEYAPKFVSNQTMYYSWEGNPINISCDVTANPPASIHWRREKLLLPAKNTTHLK
                     THSVGRKMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSPHGVKIIELS
                     QTTAKISFNKPESHGGVPIHHYQVDVKEVASETWKIVRSHGVQTMVVLSSLEPNTTYE
                     IRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHGQPSSGKSFKISITKQDDGGAPIL
                     EYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEF
                     SMPPKPNIIKDTLFNGLGLGAIIGLGVAALLLILVVTDVSCFFIRQCGLLMCITRRMC
                     GKKSGSSGKSKELEEGKAAYLKDGSKEPIVEMRTEDERITNHEDGSPVNEPNETTPLT
                     EPEKLPLKEENGKEVLNAETIEIKVSNDIIQSKEDDIKA"
     exon            273..347
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            348..554
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            555..698
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            699..836
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            837..954
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1115
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1261
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1412
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1600
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1697
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1871
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1991
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2113
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2294
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2499
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2619
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..3568
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3543..3548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /note="hexamer: AATAAA"
     polyA_site      3568
                     /gene="Ncam2"
                     /gene_synonym="Ncam-2; Ocam; RNCAM"
                     /note="major polyA site"
ORIGIN      
        1 cggccgctgc tgccgccgcc gccgccgcct ggatatagtg cggcaaggcg cggagcttgc
       61 agtcactttg cgaggaggag cgcgcggcgg gctgcgggcg gctggggcac ccgggagcgg
      121 cggcgggcta gcagaggcgg ccgtggcagc ggaaggttct ctctccgggg ctggacttaa
      181 taactttgga actgtccgcc ggtgtcacgt cctgaacatg agcctcctcc tctccttcta
      241 cctgctcggg ttgcttgtca ggagcgggca agctcttctt caagtgacaa tttcacttag
      301 caaagtagag cttagtgtgg gtgagtctaa attcttcaca tgtacagcca ttggtgagcc
      361 tgagagtatc gactggtata accctcaagg agagaagatc atttcaacgc agagggttat
      421 gctacagaag gagggtgtca ggtcacgact caccatctac aatgcaaaca tagaagatgc
      481 agggatatat cgctgtcaag cgacagatgc caaaggacag acacaagaag ctacagtagt
      541 tttggaaatt taccaaaaac tcaccttcag agaagtggtg tcccctcaag agttcaagca
      601 aggggaggat gcagaagtgg tttgcagagt gagcagttcc ccagcccctg cggtcagctg
      661 gttgtaccac aatgaggaag tcaccaccat ccccgacaat cggtttgcag tgcttgcaaa
      721 caataatttg cagatcctca atatcaataa aagtgatgaa ggtatataca gatgtgaagg
      781 aagagtggag gcgaggggag agattgactt ccgggatatc attgttattg ttaacgttcc
      841 accagcaatc atgatgcccc agaagtcctt caatgctaca gcagagagag gagaagagat
      901 gaccttaaca tgcaaggcct cgggctcccc agatccaacc atctcttggt tcaggaacgg
      961 caaactcatt gaagaaaatg aaaagtatat tttaaagggc agtaatacag agctcactgt
     1021 caggaacata atcaataaag acgggggctc ttatgtctgc aaagcaacaa acaaggcagg
     1081 agaagatcaa aagcaggcct tccttcaagt ctttgtacag cctcatatat tacaacttaa
     1141 aaatgagaca acatctgaga atggtcatgt cacactcgta tgtgaagcag aaggggagcc
     1201 tgttccagaa atcacatgga aaagagccat agatggagtc atgttttctg aaggtgataa
     1261 gagtccggat ggccgcatcg aagttaaagg gcagcatgga cgctcttcac tgcacattag
     1321 agatgtgaag ttgtcagatt cggggagata tgactgtgag gccgctagtc ggattggtgg
     1381 gcaccagagg agcatgcacc tggacatcga atatgctcct aagtttgttt caaatcagac
     1441 aatgtattac tcttgggaag gaaatccaat caacataagt tgtgatgtga cagcaaaccc
     1501 acctgcgtca atccactgga gaagagagaa actgctctta ccagctaaga atacgactca
     1561 tttaaaaact cacagtgtag gaagaaagat gatactcgag attgccccca catcagacaa
     1621 tgactttgga cgatataact gcacagctac taaccgtata ggcacaagat ttcaggaata
     1681 tattcttgaa ttagcagatg tcccctctag tccccatgga gtgaagatta tagagctgtc
     1741 acagaccaca gccaagatct ctttcaataa acccgaatcc catggaggtg tgcctattca
     1801 tcactatcaa gtggatgtca aagaagtggc atcagaaacc tggaaaatag tacgctccca
     1861 tggagttcaa acgatggttg ttttgagcag tctggaacca aatacgactt acgaaattag
     1921 ggttgcagca gtgaatggca aaggtcaagg agactacagt aaaatagaaa tattccagac
     1981 actgccagtc cgtgagccaa gtcccccttc catacatgga cagccaagca gtggcaagag
     2041 ttttaaaatc agcatcacca agcaagatga tggaggggct cctattttag aatacattgt
     2101 aaaatacaga agtaaagaca aggaagatca gtggctagag aagaaggtac agggaaataa
     2161 agaccacatt atcttggagc atctgcagtg gacaatgggc tacgaagtgc aaatcacagc
     2221 tgccaacaga ctgggatatt ctgagcctac tgtatatgag ttcagcatgc ccccaaaacc
     2281 caacattatt aaagacacac tttttaatgg ccttggccta ggagccatca ttggccttgg
     2341 agttgctgcc cttttgctaa tccttgtggt aacagacgtc agctgcttct tcattcgaca
     2401 atgtgggtta ctaatgtgca tcaccaggag aatgtgcggg aaaaagagtg gctccagtgg
     2461 gaaaagtaaa gaacttgaag aaggaaaagc agcttacctg aaagatggat caaaagaacc
     2521 gatagtggaa atgagaacag aagatgaaag aatcactaac catgaagatg ggagtccagt
     2581 aaatgagcca aatgaaacca caccgctaac agaacctgaa aaattgcctt taaaagaaga
     2641 aaacggaaag gaagttttaa acgcagaaac tatagaaatt aaagtgtcca atgacatcat
     2701 ccagtctaaa gaagatgaca taaaggcatg acaacaagtt tcagcacctt ggtcagcacc
     2761 tcaaggagca tttggtttgg agtgacacta tgaccaaaac tattccattg accttaattt
     2821 ctcgggaaaa gtctagcttg gaatagcttg tacacatata catacgacaa actcctctgg
     2881 ccacaaccca tttctttctg ttattgtggt ggtggttgtt tattttgtta agaattcggt
     2941 ataaagactt gattggcacc aattttgggg tttcagttcg attctataat tgaagtactg
     3001 caatttatta gatggctaaa gtgggttttt tttttttgtc ttatataaca caaacaaata
     3061 tgtttctctc taaaatatta ggttgtaatg gaaggcagag aaaaacgttg tgagctaaat
     3121 gtgggaagtg tatgaaagcc ctgcatgttt ataaatctta tcttgggcaa acacactatt
     3181 gtgagggctt tcagactaag acgaaggcac ataataaagg gtatgctttt tatcagggga
     3241 atttcaggga acccaggctt gaaagggcca gtcagttatc ttttgcagat attagaaatt
     3301 gaaacattgt tggagaactc ttttcacctt atgaccacac tgcatttttc gacattgatc
     3361 ttacgtacac tgataccagg acaaaattgt tacacatttg aaagaagatt agttgtgtgt
     3421 aaaattagat tagaaagatc cctaaatctc tttttatgta taccatattc acccacagtg
     3481 gattacacaa aaagtaaatg tattacaagt aaaaatggta ttgatttctg ccctcagctt
     3541 caaataaagt gaatttaaat gggaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
