LOCUS       NM_001170868            3420 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus neurocalcin delta (Ncald), transcript variant 4, mRNA.
ACCESSION   NM_001170868
VERSION     NM_001170868.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3420)
  AUTHORS   Kolesova,H., Hrabalova,P., Bohuslavova,R., Abaffy,P.,
            Fabriciova,V., Sedmera,D. and Pavlinkova,G.
  TITLE     Reprogramming of the developing heart by Hif1a-deficient
            sympathetic system and maternal diabetes exposure
  JOURNAL   Front Endocrinol (Lausanne) 15, 1344074 (2024)
   PUBMED   38505753
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3420)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3420)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 3420)
  AUTHORS   Del Aguila,A., Adam,M., Ullom,K., Shaw,N., Qin,S., Ehrman,J.,
            Nardini,D., Salomone,J., Gebelein,B., Lu,Q.R., Potter,S.S.,
            Waclaw,R., Campbell,K. and Nakafuku,M.
  TITLE     Olig2 defines a subset of neural stem cells that produce specific
            olfactory bulb interneuron subtypes in the subventricular zone of
            adult mice
  JOURNAL   Development 149 (5) (2022)
   PUBMED   35132995
REFERENCE   5  (bases 1 to 3420)
  AUTHORS   Upadhyay,A., Hosseinibarkooie,S., Schneider,S., Kaczmarek,A.,
            Torres-Benito,L., Mendoza-Ferreira,N., Overhoff,M., Rombo,R.,
            Grysko,V., Kye,M.J., Kononenko,N.L. and Wirth,B.
  TITLE     Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half
            Reduction Is Not Pathological
  JOURNAL   Front Mol Neurosci 12, 19 (2019)
   PUBMED   30853885
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3420)
  AUTHORS   Duda,T., Pertzev,A. and Sharma,R.K.
  TITLE     Ca(2+) modulation of ANF-RGC: new signaling paradigm interlocked
            with blood pressure regulation
  JOURNAL   Biochemistry 51 (46), 9394-9405 (2012)
   PUBMED   23088492
REFERENCE   7  (bases 1 to 3420)
  AUTHORS   Brouns,M.R., De Castro,S.C., Terwindt-Rouwenhorst,E.A., Massa,V.,
            Hekking,J.W., Hirst,C.S., Savery,D., Munts,C., Partridge,D.,
            Lamers,W., Kohler,E., van Straaten,H.W., Copp,A.J. and Greene,N.D.
  TITLE     Over-expression of Grhl2 causes spina bifida in the Axial defects
            mutant mouse
  JOURNAL   Hum Mol Genet 20 (8), 1536-1546 (2011)
   PUBMED   21262862
REFERENCE   8  (bases 1 to 3420)
  AUTHORS   Kotani,T., Murata,Y., Ohnishi,H., Mori,M., Kusakari,S., Saito,Y.,
            Okazawa,H., Bixby,J.L. and Matozaki,T.
  TITLE     Expression of PTPRO in the interneurons of adult mouse olfactory
            bulb
  JOURNAL   J Comp Neurol 518 (2), 119-136 (2010)
   PUBMED   19924828
REFERENCE   9  (bases 1 to 3420)
  AUTHORS   Murias,A.R., Weruaga,E., Recio,J.S., Airado,C., Diaz,D. and
            Alonso,J.R.
  TITLE     Distribution of neurocalcin-containing neurons reveals sexual
            dimorphism in the mouse olfactory bulb
  JOURNAL   Chem Senses 32 (7), 673-680 (2007)
   PUBMED   17548529
  REMARK    GeneRIF: According to their distribution in the olfactory bulb,
            neurocalcin-immunoreactive interneurons could reflect a sexually
            dimorphic regulation of specific odorants.
REFERENCE   10 (bases 1 to 3420)
  AUTHORS   Germana,A., del Valle,M.E., Laura,R., Ciriaco,E., Vega,J.A. and
            Germana,G.
  TITLE     Effects of neurotrophin-3 gene mutation in the expression of
            neurocalcin
  JOURNAL   Ital J Anat Embryol 110 (2 Suppl 1), 37-47 (2005)
   PUBMED   16101019
  REMARK    GeneRIF: Neurocalcin-containing DRG neurons include all
            proprioceptive, and a subset of mechanoreceptive and
            proprioceptive. Furthermore, NT-3 is involved in the maturation of
            motor end-plates.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121814.3, BC026979.1 and AK048440.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1 through 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026979.1, AK167313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC121814.3         17468-17513
            47-3330             BC026979.1         1-3284
            3331-3420           AK048440.1         3620-3709
FEATURES             Location/Qualifiers
     source          1..3420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.94 cM"
     gene            1..3420
                     /gene="Ncald"
                     /gene_synonym="D030020D09Rik; D15Ertd412e"
                     /note="neurocalcin delta"
                     /db_xref="GeneID:52589"
                     /db_xref="MGI:MGI:1196326"
     exon            1..166
                     /gene="Ncald"
                     /gene_synonym="D030020D09Rik; D15Ertd412e"
                     /inference="alignment:Splign:2.1.0"
     exon            167..563
                     /gene="Ncald"
                     /gene_synonym="D030020D09Rik; D15Ertd412e"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..767
                     /gene="Ncald"
                     /gene_synonym="D030020D09Rik; D15Ertd412e"
                     /codon_start=1
                     /product="neurocalcin-delta"
                     /protein_id="NP_001164339.1"
                     /db_xref="CCDS:CCDS27435.1"
                     /db_xref="GeneID:52589"
                     /db_xref="MGI:MGI:1196326"
                     /translation="MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLS
                     MEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALSVTSRGKLEQKLK
                     WAFSMYDLDGNGYISKAEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNR
                     DGKLSLEEFIRGAKSDPSIVRLLQCDPSSAGQF"
     exon            564..669
                     /gene="Ncald"
                     /gene_synonym="D030020D09Rik; D15Ertd412e"
                     /inference="alignment:Splign:2.1.0"
     exon            670..3420
                     /gene="Ncald"
                     /gene_synonym="D030020D09Rik; D15Ertd412e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3308..3313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ncald"
                     /gene_synonym="D030020D09Rik; D15Ertd412e"
                     /note="hexamer: ATTAAA"
     polyA_site      3330
                     /gene="Ncald"
                     /gene_synonym="D030020D09Rik; D15Ertd412e"
                     /note="major polyA site"
     polyA_site      3420
                     /gene="Ncald"
                     /gene_synonym="D030020D09Rik; D15Ertd412e"
ORIGIN      
        1 tgtggctgag tccgcacagt caaaggcttg tgagaatctg gtggatgctg gaccttgctg
       61 ctgctgctgc cgccgccgcc gctgttgctg tccctacagc tgtggttgtt gcttcccagg
      121 ggctgcagga gcatggacta ctaaaccccc acttcttcag cgtgagttga attcttgttg
      181 ccagaatggg gaaacagaac agcaagctgc gccctgaagt catgcaggac ttactggaaa
      241 gcacagactt cacagagcac gagatccagg agtggtacaa aggcttcttg agagactgcc
      301 ccagcggaca tttatcaatg gaagagttta agaaaatata tgggaacttt ttcccttacg
      361 gggatgcttc caaatttgca gagcatgtct tccgcacctt cgatgcaaac ggtgatggga
      421 caatagactt tagagagttc atcatagccc tgagtgtgac atcaaggggc aagctggagc
      481 agaagctgaa gtgggccttc agcatgtatg acctggatgg caatggctac atcagcaagg
      541 cagaaatgct ggagattgta caggcgatct acaaaatggt ttcctctgtc atgaaaatgc
      601 ctgaagatga atcaacccca gagaaaagga cagaaaagat cttccgccag atggatacca
      661 atagagatgg aaagctctcc ctggaagaat tcatccgagg ggccaaaagc gacccatcca
      721 ttgtgcgtct cctgcagtgt gaccccagca gtgccggcca gttctgagcc ctgcaccccc
      781 aggacgctac agctgcttgt gtccctcctg attagctttt aaacttactt cggtttttgt
      841 ttttgccaaa caatattgat ggtgacactg tgccctcttc agtcagatgt gccctcctgt
      901 gacacttttg ccccttgctt ctttcatggt ggatgtgaat gcccagagcc cacgtgcttg
      961 tggagagcat gcacagactt cgtggtgttc cccagtggat ggctttttta atcatctttt
     1021 ttttcccctt tgattctaat gtctctatct taaaacctaa gccctgaggg gcaagacaag
     1081 ggaagtacat tcagcccggg gcttcttctg caagcttcca ggggctttgt ttgaaataca
     1141 aaactcctac cctgggtctg ttgtcacaca tgccctggga gctagagcag acacctgagg
     1201 ctaagttttt aaagaacagg ttaccctctg gggagaggct attaaaggca gctgggacat
     1261 ttccccccag aggccactcc ctctcacccc agcaggctgt aatttctaag ctgtgaactt
     1321 ttcaaggtaa attaacagag atgggaaaag atggctcagc tgtttgtttt gttttgtttt
     1381 gttttgtttt tctcccacag gtttacatag ttgagctaat acaagtttct ttaaaaaaaa
     1441 aaaaaatcaa acacatattc aaatgccaga cccatcttgc tgcctactgg tgatttataa
     1501 aagactgctg tatataaaac attggatatt gcagaccaaa ttaagtgttt tgccttgtaa
     1561 aatgcatgtt tagcgagcgc taatacaatc ttactacaga agactgtttt agtagcttat
     1621 tgtgaagcca actacaatga atgtcgatgt cttgttttaa agtcatagct gtctttgcac
     1681 aaatgtacca gttagcaagt atattttata tactccataa aatcacagaa tggtgacagg
     1741 ggcccagctt tgatttcaaa tggcttccta gagtcaaggt ggctggagga cacgaggaag
     1801 ccaactgtcc aggcatcctg tccaccagag cagcacggtg agctccacaa ggacaaggga
     1861 ccaaggccca gcagcgtact ggcagcaagc gcaggtgcaa cgcttgtctc agcagatgaa
     1921 tgtcctacag acgcagaaaa acagagactt caagcagttt aacccacatc cttggtgggg
     1981 gagccacatc tagaatgttc atttttcctg cccccaggta ccctagtcag gtgtgggcta
     2041 gccaggtgat tcacccatta taagaaccag caaagggacc tgcagtgtcc aaggccaacc
     2101 atgggggtcc caagagcgct cttcctcact gtgttctttg aatgcagcaa agttgagctg
     2161 ctgcctcggc tggtcacctc atgcacacta ctttgaaatt agggctggaa ataaaaactc
     2221 ctggccacag gcaagataag gcctcacaaa cagcttacat cagaagatct aaatactcaa
     2281 gaatgttggt ggcagaccct aagaggagca gcctaagagg aggcaggaag gtctctgtct
     2341 ggcaggggcc aagccgtgtc ctgtaaaaca agaaccacaa aaagataaag acaacctgaa
     2401 ggaaagtttc ctgccagccc caggtccccc acagtgacac tcgtaactgg cagaagttta
     2461 aacttgaatg gtgaattaaa atgaatcact tagtaggttg aaatttagag acctagattt
     2521 tgtaatctta atctttccta gtgtcgtttc cttacatttt gtaccaaggt ttgccaactc
     2581 ctgtggacca aatggtaaag tctgtttttg taaagaagaa ttaactcaag tggttgagca
     2641 taaacaggtg aagggagccg acatgctggt ttgtgaggta ggctcaccta cttgggctct
     2701 gcctcaggtt gggccaaacc ctgtgtttcc tagaacttag agatggggtg ggaactagag
     2761 gtgctctcca gctattagga aatgaaagag ccagatgcaa gagttatgaa ccctgtggtc
     2821 cccagaaggc atggagagtt ccagaactgg ttacaccaca gacctaacag atatatccgt
     2881 acatcctcct cctccccacc tggccccagg aaggcactgg acctgtgtaa ttttcatgca
     2941 tgcatgttgg accaagggac ttcacagcat caagagggcc gagtgcctga agtcaactgt
     3001 cactcctgtg gctaggcatt gttttgctgt gttcagagat ctctgtggag gaaatggagc
     3061 ctgttttgtt ccaagtaaag gcagcttgtg ctgtccatgg aactggagta aatggcttat
     3121 gagttgaagg atgtttcaga atgctggact gttcatacct cgcttaggat ggaggagggg
     3181 atgctgtggg taccacccca ccccagcagt actccctggg gactttctac agatgaattt
     3241 aataatatat atgtcatact atgtggaatg gtcccgttat cagttggttg tgtagctctt
     3301 gcctggcatt aaagcatgtt tattatttaa tatcattgtc tggaacatga gattttcctt
     3361 aataaactgc ccctagcaga ctgtgtctta gggaggctcc aggttgggga tggaaaagtt
//
