LOCUS       NM_008676               4682 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus NBR1, autophagy cargo receptor (Nbr1), transcript
            variant 1, mRNA.
ACCESSION   NM_008676
VERSION     NM_008676.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4682)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4682)
  AUTHORS   Trapannone,R., Romanov,J. and Martens,S.
  TITLE     p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs
            and ESC-derived neurons
  JOURNAL   Life Sci Alliance 6 (11), e202301936 (2023)
   PUBMED   37620146
  REMARK    GeneRIF: p62 and NBR1 functions are dispensable for aggrephagy in
            mouse ESCs and ESC-derived neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4682)
  AUTHORS   Merkley,S.D., Goodfellow,S.M., Guo,Y., Wilton,Z.E.R., Byrum,J.R.,
            Schwalm,K.C., Dinwiddie,D.L., Gullapalli,R.R., Deretic,V., Jimenez
            Hernandez,A., Bradfute,S.B., In,J.G. and Castillo,E.F.
  TITLE     Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of
            IL-12 Prevents Gut Dysbiosis and Inflammation
  JOURNAL   J Crohns Colitis 16 (2), 259-274 (2022)
   PUBMED   34374750
  REMARK    GeneRIF: Non-autophagy Role of Atg5 and NBR1 in Unconventional
            Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation.
REFERENCE   4  (bases 1 to 4682)
  AUTHORS   Huang,J., Linares,J.F., Duran,A., Xia,W., Saltiel,A.R.,
            Muller,T.D., Diaz-Meco,M.T. and Moscat,J.
  TITLE     NBR1 is a critical step in the repression of thermogenesis of
            p62-deficient adipocytes through PPARgamma
  JOURNAL   Nat Commun 12 (1), 2876 (2021)
   PUBMED   34001883
  REMARK    GeneRIF: NBR1 is a critical step in the repression of thermogenesis
            of p62-deficient adipocytes through PPARgamma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4682)
  AUTHORS   Li,X., Xia,Q., Mao,M., Zhou,H., Zheng,L., Wang,Y., Zeng,Z., Yan,L.,
            Zhao,Y. and Shi,J.
  TITLE     Annexin-A1 SUMOylation regulates microglial polarization after
            cerebral ischemia by modulating IKKalpha stability via selective
            autophagy
  JOURNAL   Sci Adv 7 (4) (2021)
   PUBMED   33523920
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4682)
  AUTHORS   Dimitrov,S., Brennerova,M. and Forejt,J.
  TITLE     Expression profiles and intergenic structure of head-to-head
            oriented Brca1 and Nbr1 genes
  JOURNAL   Gene 262 (1-2), 89-98 (2001)
   PUBMED   11179671
REFERENCE   7  (bases 1 to 4682)
  AUTHORS   Pershouse,M., Li,J., Yang,C., Su,H., Brundage,E., Di,W.,
            Biggs,P.J., Bradley,A. and Chinault,A.C.
  TITLE     BAC contig from a 3-cM region of mouse chromosome 11 surrounding
            Brca1
  JOURNAL   Genomics 69 (1), 139-142 (2000)
   PUBMED   11013085
REFERENCE   8  (bases 1 to 4682)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 4682)
  AUTHORS   Bennett,L.M., Brownlee,H.A., Hagavik,S. and Wiseman,R.W.
  TITLE     Sequence analysis of the rat Brca1 homolog and its promoter region
  JOURNAL   Mamm Genome 10 (1), 19-25 (1999)
   PUBMED   9892727
REFERENCE   10 (bases 1 to 4682)
  AUTHORS   Chambers,J.A. and Solomon,E.
  TITLE     Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene
  JOURNAL   Genomics 38 (3), 305-313 (1996)
   PUBMED   8975707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV558786.1, BC129867.1, BC052709.1 and CJ303949.1.
            
            On Nov 9, 2011 this sequence version replaced NM_008676.2.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.202451.1, U73039.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               CV558786.1         1-348
            349-3715            BC129867.1         1-3367
            3716-4649           BC052709.1         3448-4381
            4650-4682           CJ303949.1         370-402
FEATURES             Location/Qualifiers
     source          1..4682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 65.36 cM"
     gene            1..4682
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /note="NBR1, autophagy cargo receptor"
                     /db_xref="GeneID:17966"
                     /db_xref="MGI:MGI:108498"
     exon            1..302
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            303..413
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            414..479
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            480..596
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            597..659
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            660..678
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            679..701
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            702..899
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            900..977
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1192
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1360
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1570
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1730
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..2021
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2171
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2247
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2358
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2523
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2598
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..3016
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3123
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..3181
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3287
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..4654
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4626..4631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /note="hexamer: AATAAA"
     polyA_site      4649
                     /gene="Nbr1"
                     /gene_synonym="mKIAA0049"
                     /note="major polyA site"
ORIGIN      
        1 atccaaccag ctgacttctg cgcgctagtt ccgcccctcg gcctgggtgt ttgttattgt
       61 tatgcggttc agagagcttc tgtccctccc ttgccaacgc agcactgacc aatcggtaga
      121 gaggttattt tgaggggcag atagaaagag ccaatcatct tgtggaaaac tccgggaaac
      181 atgggactag gcccggtctc tgtccgccat gttagattca ccccgcaggg atagcaggcg
      241 agctggccgc gaacggtcct tgcactggcc actggcaagc gccccccgtg ggcggaaagc
      301 tgaaaaaaca aacaaaccaa ccaacttgaa cgtgctgggg agttgctggg gagttgatga
      361 gccagcgtct gcctaaattt tacagctcct aagaaggaag aattgcattt caggctgacc
      421 tagaactctt ggacttccat taccatcctg catcaacttc tgagtaactg ggactacagc
      481 tccagccaga cagcatggaa ccacaggtta ctctaaatgt gacttttaaa aatgaaactc
      541 aaagctttct ggtttcggat ccagaaaata caacctgggc tgatgttgaa gctatggtaa
      601 aagtttcatt tgatctgaat actatccaga taaaatacct ggatgaggag aacgaggaga
      661 tatccatcaa tagtcaaggt gaatatgaag aagcacttaa gatggctaac attaagcaag
      721 gaaatcagct acagatgcaa gtccacgaag ggtaccatgt tgtagatgaa gcactcccca
      781 aaaatgtggt agaaaaccaa gcggctgcca ggacagggaa gaagccactt gcacattatt
      841 cttcactggt gagagtcttg ggatcagaca tgaagaccac agaggagcct gcaccagagc
      901 aatgttcttc tgctccttgt gacacagacc agcctcaaga caagccccca gattggttta
      961 caagctacct ggagatgttc cgagaacaag tggttaagga aacggtggag aaacttgaac
     1021 agaggttgca ggagaagctt gtcctccaga agccactcct gagttcctca cccacagaag
     1081 tctcaatgcc tatttcagag gaaaccctgt ttttgccaga gaaccagttc agctggcata
     1141 ttgcttgtag ccactgccag aagaggatcg ttggagtgcg ctaccagtgt agcctatgcc
     1201 catcctacaa catttgtgaa gattgtgaag ctggaccata cacccatgac actaaccatg
     1261 ttttgttaaa gctgcggaga cctgttgtga tatcctctga gccatttttc tactccaagt
     1321 attccgctcc tcgtctgcct gctgctttgg aacaagtcag gctccaaaaa caggtggaca
     1381 agaactttgt gaaagcagaa aagcaaaggt tgcgggctga gaagaaacag cggaaggcag
     1441 aggtcaaaga gcttaaaaag cagcttaaac tccacaggaa gattcattta tggaattcaa
     1501 tccatggact tcagagtccc aagtcccctt tgggccgacc tgagagcttg ctgcagtcta
     1561 acaccctgat gcttcctttg cagccctgtg ccccagttat gccaacactc agtgcagcat
     1621 ttgtggatga gaatttgcct gatgggactc atcttcagcc aggaaccaag tttattaaac
     1681 actggaggat gaaaaacacg gggaatgtga agtggaacac agacacaaag ctcaagttca
     1741 tgtggggaaa cttgactctg gcttctacag agaagaaaga tgttttggtt ccctgcttga
     1801 aggctggcca cgttggggtc gtgtctgtgg agttcatcgc tccaaccttg gaggggacat
     1861 acacttcgca ctggcgtctc tctcacaaag gccagcagtt tgggcctcgg gtttggtgca
     1921 gtatcatagt ggatcctttt ccttcctctg agagccctga taatgttgaa ggggacagga
     1981 tcagctcaag caaagctgac gatttctcct gtgagcaaga ggaagctttt cttctagctg
     2041 aagaagagat tccattgggt gaggtgacaa agcagacaga agggacagga gccagtgcct
     2101 cacagaagac aagacgcgct gccagtgaaa gggagctgta cattccatct gtggacctcc
     2161 tgactgccca ggacctgctg tcctttgagc tgctggatat aaacattgtc caagaattgg
     2221 agagagtgcc acacaacacc cctgtggata tgactccctg catgtctcct ctgccacatg
     2281 acagtccttt aatagagaag ccaggcttgg ggcagataca ggaagagagt gaaggggcgg
     2341 gatttaaagc acctcctgat tccactgtat cagcaaagag gaaagctgag acccctgctt
     2401 cggtcgaaga aacagaagaa gacctgagtg ggacccaatt tgtatgtgag actgtaattc
     2461 gatcccttac cttggatgct gctccagacc acaaccctcc ttgcaggcag aggtccccac
     2521 agagggaatt acagctgtat tccaccgagg gacagcagcc acttgtgctg cctggattct
     2581 gcagaaagga ttcttccttg aaatttgcct tgcctgaaga aggaccgcgt ggagatgaga
     2641 gggaggagat tgtccacatt gttgaggaag aagtcgttga ggaagaggag gaagtccaag
     2701 atgaagaagt ccaaagtcag tcttctgctt cctctgaaga ttatatcatc atccttcctg
     2761 agtgctttga taccagccgc cccctggggg actccatgta cagctctgcg ctctcccagc
     2821 caggcctgga gcgaggggct gaaggcgaac ctgggatcga gtctgggctg gaaccaactg
     2881 aggctagaga gagactccca gagagggaga gccagccaca ggagcagagc atcagcgaca
     2941 tcctcacaac ctcacagcct ctggacacgg tgcctctagt ccccgaggtg gcaggacttc
     3001 cagcagcatt gtccaggagc gccccttgtg gacagtgtga gtcatcagga gtggattcac
     3061 caggagtgga ttcaccagct accatgcacg aagttccccc agcccctgat gacatcagag
     3121 gagagcccag aggctcaaca ggactcgcaa acagcagaca gaggagctgt gaccactcaa
     3181 ggcaccacaa tgggagcagc attgctggag gactggtgaa gggggctttg tctgttgctg
     3241 cctctgcgta caaggccctg ttttctgggc caccagtcac tgcacagccc atcgtttctg
     3301 aagatcagac cacagccctg atggcccatc tctttgaaat gggattctgc gacaggcagc
     3361 tgaacctaag gctgctgaga aaacacaatt acaatatcct gcaggttgtg acagagctcc
     3421 ttcaagtgaa taacaacgac tggtacagcc accgctattg aggactgacc ttgtattaaa
     3481 taactgcctg ccgctcagag gtggtctctc tgctgtcatt gagtgtgggt ggaagccctt
     3541 gcttgctttt taatctgatg aatctatgtc tctgaattgt caaaacagta cctgttacag
     3601 tattttttgg agcaaatcaa aggccagaac ttaaattttc actgtagaaa tgggatgaat
     3661 ggtaggaaga cagttttcaa ctcagctgga cagaactctc gccgctgtag tccgtggaag
     3721 cgagtaactt ggacttcctt agatcgcttt tccttctgct tgtattgaaa ttgagtattt
     3781 tcctttggtt catgtggatg tttttaatgg gctgttaaat attagtttgg tttttgtttt
     3841 ttaaagatta accttgaatg tttccaagaa ttattcacct agtttctata accaatcgca
     3901 agcctcatag ctacataaag acagcagatc aagaaagtca tgttcctcaa agacttagaa
     3961 atgaggaaca ctttgctttc agaaggccta gcaggaacct ggaaggacag gaggcattcg
     4021 ggttaaccca cagcacccac tgagcagtgt ctgtcaaagt aattttgcat aaattttatt
     4081 taaggagaat cctgggtagt gtgaaatatt ttgctaatcc tatggggggg gcacctgtta
     4141 cagaaaggga aagttagtag tcgtcctttt actgactgtc acagtggatt ggaaggacaa
     4201 gcatgtgcaa atactcatct cagtaaggtc gggtgtgggt gaaaggacac agaactgctg
     4261 ctgactttcc gaatgtgtgg aatccccttg tgaggtatcc agccctagaa agccgagaac
     4321 aggaagtaat gctttggggc taacccacag aaaggttagt ttaccattag aatagatggg
     4381 aagaaggctc tgtcaagagt tctaggtctc atttagttta taaagggaag ctttgggtcc
     4441 agatggtgaa agaaaaggca acacaacact aaagatttta ttcatgtttg agaaaaggta
     4501 tctgaactcc agctcaaagg ggatagttaa aatagtatta tttaacttag ttggtattta
     4561 taataaatgg cgatcttaat tactcataat atgtttattt acaatctaac tcttgaatgc
     4621 ttctaaataa accacaattc aaactgcaag ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4681 aa
//
