LOCUS       NM_008675               1762 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus NBL1, DAN family BMP antagonist (Nbl1), mRNA.
ACCESSION   NM_008675
VERSION     NM_008675.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1762)
  AUTHORS   Liu,M., Deng,W., Tang,L., Liu,M., Bao,H., Guo,C., Zhang,C., Lu,J.,
            Wang,H., Lu,Z. and Kong,S.
  TITLE     Menin directs regionalized decidual transformation through
            epigenetically setting PTX3 to balance FGF and BMP signaling
  JOURNAL   Nat Commun 13 (1), 1006 (2022)
   PUBMED   35194044
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1762)
  AUTHORS   Bottasso-Arias,N., Leesman,L., Burra,K., Snowball,J., Shah,R.,
            Mohanakrishnan,M., Xu,Y. and Sinner,D.
  TITLE     BMP4 and Wnt signaling interact to promote mouse tracheal
            mesenchyme morphogenesis
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 322 (2), L224-L242 (2022)
   PUBMED   34851738
REFERENCE   3  (bases 1 to 1762)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1762)
  AUTHORS   Velecela,V., Torres-Cano,A., Garcia-Melero,A., Ramiro-Pareta,M.,
            Muller-Sanchez,C., Segarra-Mondejar,M., Chau,Y.Y.,
            Campos-Bonilla,B., Reina,M., Soriano,F.X., Hastie,N.D.,
            Martinez,F.O. and Martinez-Estrada,O.M.
  TITLE     Epicardial cell shape and maturation are regulated by Wt1 via
            transcriptional control of Bmp4
  JOURNAL   Development 146 (20) (2019)
   PUBMED   31624071
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1762)
  AUTHORS   Stafford,D.A., Dichmann,D.S., Chang,J.K. and Harland,R.M.
  TITLE     Deletion of the sclerotome-enriched lncRNA PEAT augments ribosomal
            protein expression
  JOURNAL   Proc Natl Acad Sci U S A 114 (1), 101-106 (2017)
   PUBMED   27986952
REFERENCE   6  (bases 1 to 1762)
  AUTHORS   Pearce,J.J., Penny,G. and Rossant,J.
  TITLE     A mouse cerberus/Dan-related gene family
  JOURNAL   Dev Biol 209 (1), 98-110 (1999)
   PUBMED   10208746
REFERENCE   7  (bases 1 to 1762)
  AUTHORS   Stanley,E., Biben,C., Kotecha,S., Fabri,L., Tajbakhsh,S.,
            Wang,C.C., Hatzistavrou,T., Roberts,B., Drinkwater,C., Lah,M.,
            Buckingham,M., Hilton,D., Nash,A., Mohun,T. and Harvey,R.P.
  TITLE     DAN is a secreted glycoprotein related to Xenopus cerberus
  JOURNAL   Mech Dev 77 (2), 173-184 (1998)
   PUBMED   9831647
REFERENCE   8  (bases 1 to 1762)
  AUTHORS   Hsu,D.R., Economides,A.N., Wang,X., Eimon,P.M. and Harland,R.M.
  TITLE     The Xenopus dorsalizing factor Gremlin identifies a novel family of
            secreted proteins that antagonize BMP activities
  JOURNAL   Mol Cell 1 (5), 673-683 (1998)
   PUBMED   9660951
REFERENCE   9  (bases 1 to 1762)
  AUTHORS   Matsuda,Y., Ozaki,T., Enomoto,H., Saito,T. and Sakiyama,S.
  TITLE     Chromosome mapping of the mouse and rat homologs of the human DAN
            gene, D1S1733E
  JOURNAL   Mamm Genome 7 (9), 709-710 (1996)
   PUBMED   8703135
REFERENCE   10 (bases 1 to 1762)
  AUTHORS   Ozaki,T., Ma,J., Takenaga,K. and Sakiyama,S.
  TITLE     Cloning of mouse DAN cDNA and its down-regulation in transformed
            cells
  JOURNAL   Jpn J Cancer Res 87 (1), 58-61 (1996)
   PUBMED   8609050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146535.1.
            
            On May 23, 2007 this sequence version replaced NM_008675.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146535.1, AK158008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1762              AK146535.1         15-1776
FEATURES             Location/Qualifiers
     source          1..1762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.57 cM"
     gene            1..1762
                     /gene="Nbl1"
                     /gene_synonym="D4H1S1733E; DAN; Dana; NO3"
                     /note="NBL1, DAN family BMP antagonist"
                     /db_xref="GeneID:17965"
                     /db_xref="MGI:MGI:104591"
     exon            1..144
                     /gene="Nbl1"
                     /gene_synonym="D4H1S1733E; DAN; Dana; NO3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..339
                     /gene="Nbl1"
                     /gene_synonym="D4H1S1733E; DAN; Dana; NO3"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..709
                     /gene="Nbl1"
                     /gene_synonym="D4H1S1733E; DAN; Dana; NO3"
                     /note="neuroblastoma suppressor of tumorigenicity 1; N03;
                     zinc finger protein DAN; neuroblastoma, suppression of
                     tumorigenicity 1"
                     /codon_start=1
                     /product="neuroblastoma suppressor of tumorigenicity 1
                     precursor"
                     /protein_id="NP_032701.2"
                     /db_xref="CCDS:CCDS18839.1"
                     /db_xref="GeneID:17965"
                     /db_xref="MGI:MGI:104591"
                     /translation="MLWVLVGAVLPVMLLAAPPPINKLALFPDKSAWCEAKNITQIVG
                     HSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHE
                     EVPRVDKLVEKIVHCSCQACGKEPSHEGLNVYVQGEDSPGSQPGPHSHAHPHPGGQTP
                     EPEEPPGAPQVEEEGAED"
     exon            340..451
                     /gene="Nbl1"
                     /gene_synonym="D4H1S1733E; DAN; Dana; NO3"
                     /inference="alignment:Splign:2.1.0"
     exon            452..1762
                     /gene="Nbl1"
                     /gene_synonym="D4H1S1733E; DAN; Dana; NO3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1741..1746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nbl1"
                     /gene_synonym="D4H1S1733E; DAN; Dana; NO3"
                     /note="putative"
     polyA_site      1762
                     /gene="Nbl1"
                     /gene_synonym="D4H1S1733E; DAN; Dana; NO3"
                     /note="putative"
ORIGIN      
        1 gcagacggcc agcagcgcag cccagccgag cctcgcgggg ccgccccagc ccgaggaccc
       61 cgggcctgcg acccccgcgg ctcgcacccc actttctagg acccccagga ggacgcgccg
      121 cgctccccgc ggccgccgcg cgcgttccag ggctccggag gtgacgggca caatgctttg
      181 ggtcctggtg ggggccgtcc tccctgtcat gttgctggct gccccgccac ctatcaacaa
      241 gctggccctg tttccggaca agagtgcctg gtgtgaagcc aagaacatca cgcagattgt
      301 gggccacagc ggctgtgagg ccaagtctat ccagaacagg gcgtgcctag gacaatgctt
      361 cagttacagc gtccccaaca ccttcccgca gtccacagag tccctggtgc actgtgactc
      421 ctgcatgccg gcccagtcca tgtgggagat tgtgaccttg gagtgccctg gccacgagga
      481 ggtgcccagg gtggacaagc tggtagagaa gattgtacac tgcagctgcc aggcttgcgg
      541 caaggagccc agtcacgagg gcctgaacgt ctatgtgcag ggtgaagaca gcccgggctc
      601 ccagcctgga ccacactccc atgcccatcc ccaccctggg ggccagaccc ctgagcccga
      661 agagcctcct ggagcccctc aggttgagga agagggggct gaggactgag ggcccccaac
      721 tcttcctccc ctcttgttcc ctgtggaatg tcggtcccac cctccaggga agagggaggg
      781 gataggcaga agcccccctc cccctttggc actggatgga cttggaatgc tgcctggttg
      841 tcatggagat ctgaagggag gggctggagc caagctgcac aatttaatat atgcaagatg
      901 ggggaggaag cagacagaca tccgcaggac ttttcttttg gaaggtgaag tgtggtcttt
      961 cctttcggcc ttctagagag atgagccccc cacccccacc cgggatagag aggaaatggg
     1021 ctgagctgct gaggatgagt gagatcctca aacagggcag gcccaggcca ggacccacac
     1081 aactgatggg ggcaggatcc ccagtgatgg gtccagagtg ggaatcaagt cctttgctga
     1141 aggacctatg tgggaagacc gcttgcagag gtcggaagct ccagtcccat aggtttccct
     1201 aacgacctcc ctcactcccc agtgccaggg aagtaacccc ttcaatggag tggcttagga
     1261 gtcaggctgg ggcaggaccc tgctgactca agtgccagag tgtcactgaa gaagaaagaa
     1321 gatccctccc atctctccct ctggagatct tagctctctg ctccccgtgt tctggaccct
     1381 ttagggaagt agctgcagcc agccctgctg tctttggggc cggtctttct gaaagaggtg
     1441 atggtccatc tccatcacct gggaccatag tggacaggag gcccctgcat agggccccca
     1501 ctgacctcag ctttctctag ctccctagtc tagccactcc tccttcccag ctgcacttta
     1561 accctagggc agggcaggtg gcaaggaagg gccctctgtc ccctgatatg ctggtaccat
     1621 tgtttgtgtc caggggatgc cagctcacct ccctgggggt gccccggccc gtggctgttc
     1681 gacgagagcc ttagagcttg taactagtag ccatctcccc tggacccgag tgttttcatg
     1741 aataaatacc ttcaatgcct ct
//
