LOCUS       NM_027327                856 bp    mRNA    linear   ROD 06-MAR-2025
DEFINITION  Mus musculus negative regulator of P-body association (Nbdy), mRNA.
ACCESSION   NM_027327 NR_028432 XM_001475273 XM_489371 XM_898756 XM_979021
            XM_982708
VERSION     NM_027327.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 856)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   2  (bases 1 to 856)
  AUTHORS   Khan,M.M., Chatterjee,S., Dwivedi,V.P., Pandey,N.K., Singh,Y.,
            Tousif,S., Bhavesh,N.S., Van Kaer,L., Das,J. and Das,G.
  TITLE     CD4+ T cell-derived novel peptide Thp5 induces interleukin-4
            production in CD4+ T cells to direct T helper 2 cell
            differentiation
  JOURNAL   J Biol Chem 287 (4), 2830-2835 (2012)
   PUBMED   22130674
  REMARK    GeneRIF: CD4+ T cell-derived novel peptide Thp5 induces
            interleukin-4 production in CD4+ T cells to direct T helper 2 cell
            differentiation.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL831725.5 and AK008724.1.
            
            On Jun 26, 2012 this sequence version replaced NR_028432.1.
            
            Summary: The protein encoded by this gene is a 43 aa peptide
            produced by early activated CD4+ T cells. The encoded protein helps
            regulate the differentiation of these cells into T helper 2 (Th2)
            cells. The solution structure of this protein is similar to that of
            vasoactive intestinal peptide, which plays a role in the
            differentiation of Th2 cells and Treg cells. [provided by RefSeq,
            Jun 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI109108.1, KY467461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AL831725.5         55248-55509
            263-824             AK008724.1         229-790
            825-856             AL831725.5         72959-72990
FEATURES             Location/Qualifiers
     source          1..856
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.38 cM"
     gene            1..856
                     /gene="Nbdy"
                     /gene_synonym="2210013O21Rik; Thp5"
                     /note="negative regulator of P-body association"
                     /db_xref="GeneID:70123"
                     /db_xref="MGI:MGI:1917373"
     exon            1..384
                     /gene="Nbdy"
                     /gene_synonym="2210013O21Rik; Thp5"
                     /inference="alignment:Splign:2.1.0"
     exon            385..521
                     /gene="Nbdy"
                     /gene_synonym="2210013O21Rik; Thp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             513..644
                     /gene="Nbdy"
                     /gene_synonym="2210013O21Rik; Thp5"
                     /codon_start=1
                     /product="T helper cell-induced peptide 5"
                     /protein_id="NP_081603.1"
                     /db_xref="CCDS:CCDS85820.1"
                     /db_xref="GeneID:70123"
                     /db_xref="MGI:MGI:1917373"
                     /translation="MLKAHLIFSTPLTISLFDCATWRPYLQTEYYDVMTVISPPEFG"
     exon            522..599
                     /gene="Nbdy"
                     /gene_synonym="2210013O21Rik; Thp5"
                     /inference="alignment:Splign:2.1.0"
     exon            600..856
                     /gene="Nbdy"
                     /gene_synonym="2210013O21Rik; Thp5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      806..811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nbdy"
                     /gene_synonym="2210013O21Rik; Thp5"
                     /note="hexamer: ATTAAA"
     polyA_site      825
                     /gene="Nbdy"
                     /gene_synonym="2210013O21Rik; Thp5"
                     /note="major polyA site"
     regulatory      836..841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nbdy"
                     /gene_synonym="2210013O21Rik; Thp5"
                     /note="hexamer: AATAAA"
     polyA_site      856
                     /gene="Nbdy"
                     /gene_synonym="2210013O21Rik; Thp5"
ORIGIN      
        1 gggatatacg tctcaggata caggaaatac ggtaacagcg aaaccaggag gaagccagcc
       61 ccgtgcctgg aggggatccg ccatctcaga tctcggcctt gccagggccc accagagaaa
      121 actaacgctc tggtcctgtc atacctatgg gggaccaacc ttgtgcctcc gggagatcca
      181 cgctcccacc aggaaatacg cgggaaccca agcctccaaa aaagcgctgt gtcctggctc
      241 cgcggtggga ttatcccgaa gggactccca gtggaggtag tagcactctc ccctcggcgc
      301 ctcctcctgc atctgctgga ctcaagtcgc accctcctcc tccggagaag tagtgaaata
      361 gatttttttc ccagccgaaa tcagtttgtg agggactgca gtatggcttc atttccttgg
      421 tgcgtttgta aaatagttca cccattgaag accatgaagg ttctttccaa tgctgccctg
      481 cttttgctgg tgtcttgctc ctggaagttg tgatgctaaa ggctcatctt atattttcta
      541 ccccattgac catttctcta tttgactgtg ccacttggag accgtattta caaactgagt
      601 attatgatgt aatgactgtg atttcacctc cagaatttgg atgactctag gacattggca
      661 agatcaggtg gtagacttct aggactgaag gccatggtgt gtgtggatca tggtaaactc
      721 accaaagcaa gtaatgccct tgagatgatc ctgcagaagc ttgtcattgc actcttttgt
      781 tgacacccag tctttgctgt attacattaa agttgcataa acccattaat gtccaaataa
      841 attttgtctt atggca
//
