LOCUS       NM_001409779             741 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus NAD(P)HX epimerase (Naxe), transcript variant 12,
            mRNA.
ACCESSION   NM_001409779
VERSION     NM_001409779.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 741)
  AUTHORS   Kim,Y.S., Choi,S.H., Kim,K.Y., Navia-Pelaez,J.M., Perkins,G.A.,
            Choi,S., Kim,J., Nazarenkov,N., Rissman,R.A., Ju,W.K.,
            Ellisman,M.H. and Miller,Y.I.
  TITLE     AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a
            mouse model of Alzheimer's disease
  JOURNAL   J Neuroinflammation 21 (1), 245 (2024)
   PUBMED   39342323
  REMARK    GeneRIF: AIBP controls TLR4 inflammarafts and mitochondrial
            dysfunction in a mouse model of Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 741)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 741)
  AUTHORS   Jiang,Y., Li,X., Liu,Q., Lei,G., Wu,C., Chen,L., Zhao,Y., Hu,Y.,
            Xian,H. and Mao,R.
  TITLE     Apolipoprotein A-I Binding Protein Inhibits the Formation of
            Infantile Hemangioma through Cholesterol-Regulated
            Hypoxia-Inducible Factor 1alpha Activation
  JOURNAL   J Invest Dermatol 144 (3), 645-658 (2024)
   PUBMED   37832842
REFERENCE   4  (bases 1 to 741)
  AUTHORS   Navia-Pelaez,J.M., Borges Paes Lemes,J., Gonzalez,L., Delay,L., Dos
            Santos Aggum Capettini,L., Lu,J.W., Goncalves Dos Santos,G.,
            Gregus,A.M., Dougherty,P.M., Yaksh,T.L. and Miller,Y.I.
  TITLE     AIBP regulates TRPV1 activation in chemotherapy-induced peripheral
            neuropathy by controlling lipid raft dynamics and proximity to TLR4
            in dorsal root ganglion neurons
  JOURNAL   Pain 164 (6), e274-e285 (2023)
   PUBMED   36719418
  REMARK    GeneRIF: AIBP regulates TRPV1 activation in chemotherapy-induced
            peripheral neuropathy by controlling lipid raft dynamics and
            proximity to TLR4 in dorsal root ganglion neurons.
REFERENCE   5  (bases 1 to 741)
  AUTHORS   Kim,J.D., Zhou,T., Zhang,A., Li,S., Gupte,A.A., Hamilton,D.J. and
            Fang,L.
  TITLE     AIBP Regulates Metabolism of Ketone and Lipids but Not
            Mitochondrial Respiration
  JOURNAL   Cells 11 (22), 3643 (2022)
   PUBMED   36429071
  REMARK    GeneRIF: AIBP Regulates Metabolism of Ketone and Lipids but Not
            Mitochondrial Respiration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 741)
  AUTHORS   Jha,K.N., Shumilin,I.A., Digilio,L.C., Chertihin,O., Zheng,H.,
            Schmitz,G., Visconti,P.E., Flickinger,C.J., Minor,W. and Herr,J.C.
  TITLE     Biochemical and structural characterization of apolipoprotein A-I
            binding protein, a novel phosphoprotein with a potential role in
            sperm capacitation
  JOURNAL   Endocrinology 149 (5), 2108-2120 (2008)
   PUBMED   18202122
  REMARK    GeneRIF: AI-BP plays an important role in capacitation possibly
            providing a link between protein phosphorylation and cholesterol
            efflux.
REFERENCE   7  (bases 1 to 741)
  AUTHORS   Suto,J.
  TITLE     Characterization of Cq3, a quantitative trait locus that controls
            plasma cholesterol and phospholipid levels in mice
  JOURNAL   J Vet Med Sci 68 (4), 303-309 (2006)
   PUBMED   16679719
REFERENCE   8  (bases 1 to 741)
  AUTHORS   Korstanje,R., Albers,J.J., Wolfbauer,G., Li,R., Tu,A.Y.,
            Churchill,G.A. and Paigen,B.J.
  TITLE     Quantitative trait locus mapping of genes that regulate
            phospholipid transfer activity in SM/J and NZB/BlNJ inbred mice
  JOURNAL   Arterioscler Thromb Vasc Biol 24 (1), 155-160 (2004)
   PUBMED   14592843
REFERENCE   9  (bases 1 to 741)
  AUTHORS   Ritter,M., Buechler,C., Boettcher,A., Barlage,S., Schmitz-Madry,A.,
            Orso,E., Bared,S.M., Schmiedeknecht,G., Baehr,C.H., Fricker,G. and
            Schmitz,G.
  TITLE     Cloning and characterization of a novel apolipoprotein A-I binding
            protein, AI-BP, secreted by cells of the kidney proximal tubules in
            response to HDL or ApoA-I
  JOURNAL   Genomics 79 (5), 693-702 (2002)
   PUBMED   11991719
REFERENCE   10 (bases 1 to 741)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137525.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ747542.1, BQ043688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC137525.3         62762-62872         c
            112-222             AC137525.3         62553-62663         c
            223-336             AC137525.3         62356-62469         c
            337-484             AC137525.3         61618-61765         c
            485-741             AC137525.3         61152-61408         c
FEATURES             Location/Qualifiers
     source          1..741
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.78 cM"
     gene            1..741
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /note="NAD(P)HX epimerase"
                     /db_xref="GeneID:246703"
                     /db_xref="MGI:MGI:2180167"
     exon            1..111
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..687
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /EC_number="5.1.99.6"
                     /note="isoform 12 is encoded by transcript variant 12;
                     apolipoprotein A-I binding protein; apolipoprotein A-I
                     interacting protein; apoA-I binding protein;
                     NAD(P)H-hydrate epimerase"
                     /codon_start=1
                     /product="NAD(P)H-hydrate epimerase isoform 12"
                     /protein_id="NP_001396708.1"
                     /db_xref="GeneID:246703"
                     /db_xref="MGI:MGI:2180167"
                     /translation="MELAGLSCATAIAKAYPPTSMSKSPPTVLVICGPGNNGGDGLVC
                     ARHLKLFGYQPTIYYPKRPNKPLFTGLVTQCQKMDIPFLGEMPPEPMMVDELYELVVD
                     AIFGFSFKGDVREPFHSILSVLSGLTVPIASIDIPSGWDVEKGNPSGIQPDLLISLTA
                     PKKSATHFTGRYHYLGGRFVPPALEKKYQLNLPSYPDTECVYRLQ"
     exon            112..222
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /inference="alignment:Splign:2.1.0"
     exon            223..336
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /inference="alignment:Splign:2.1.0"
     exon            337..484
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /inference="alignment:Splign:2.1.0"
     exon            485..741
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      712..717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /note="hexamer: AATAAA"
     polyA_site      741
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /note="major polyA site"
ORIGIN      
        1 agtcaggagg aggctcaggc cgtggaccaa gagcttttta acgagtatca gttcagcgtg
       61 gatcaactca tggagctggc cgggttgagc tgtgccacgg ctattgccaa ggcttatccc
      121 cccacgtcta tgtccaagag tcccccgact gtcttggtca tctgtggccc cggaaataac
      181 ggaggggatg ggctggtctg tgcgcgacac ctcaaacttt ttggttacca gccaactatc
      241 tattacccca aaagacctaa caagcccctc ttcactgggc tagtgactca gtgtcagaaa
      301 atggacattc ctttccttgg tgaaatgccc ccagagccca tgatggtgga cgagctgtat
      361 gagctggtgg tggacgccat cttcggcttc agtttcaagg gtgacgttcg ggagccattc
      421 cacagcatcc tgagtgtctt gagtggactc actgtgccca ttgctagcat cgacattccc
      481 tcaggatggg atgtagagaa gggaaaccct agcggaatcc aaccagactt actcatctca
      541 ctgacggcac ccaagaagtc tgcaactcac tttactggcc gatatcatta ccttgggggt
      601 cgctttgtac cacctgctct agagaagaag taccagctga acctgccatc ttaccctgac
      661 acagagtgtg tctaccgtct acagtaaggg aggtgggtag gcaggattct caataaagac
      721 ttggtacttt ctgtcttgaa a
//
