LOCUS       NM_001409767             962 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus NAD(P)HX epimerase (Naxe), transcript variant 1, mRNA.
ACCESSION   NM_001409767
VERSION     NM_001409767.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 962)
  AUTHORS   Kim,Y.S., Choi,S.H., Kim,K.Y., Navia-Pelaez,J.M., Perkins,G.A.,
            Choi,S., Kim,J., Nazarenkov,N., Rissman,R.A., Ju,W.K.,
            Ellisman,M.H. and Miller,Y.I.
  TITLE     AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a
            mouse model of Alzheimer's disease
  JOURNAL   J Neuroinflammation 21 (1), 245 (2024)
   PUBMED   39342323
  REMARK    GeneRIF: AIBP controls TLR4 inflammarafts and mitochondrial
            dysfunction in a mouse model of Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 962)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 962)
  AUTHORS   Jiang,Y., Li,X., Liu,Q., Lei,G., Wu,C., Chen,L., Zhao,Y., Hu,Y.,
            Xian,H. and Mao,R.
  TITLE     Apolipoprotein A-I Binding Protein Inhibits the Formation of
            Infantile Hemangioma through Cholesterol-Regulated
            Hypoxia-Inducible Factor 1alpha Activation
  JOURNAL   J Invest Dermatol 144 (3), 645-658 (2024)
   PUBMED   37832842
REFERENCE   4  (bases 1 to 962)
  AUTHORS   Navia-Pelaez,J.M., Borges Paes Lemes,J., Gonzalez,L., Delay,L., Dos
            Santos Aggum Capettini,L., Lu,J.W., Goncalves Dos Santos,G.,
            Gregus,A.M., Dougherty,P.M., Yaksh,T.L. and Miller,Y.I.
  TITLE     AIBP regulates TRPV1 activation in chemotherapy-induced peripheral
            neuropathy by controlling lipid raft dynamics and proximity to TLR4
            in dorsal root ganglion neurons
  JOURNAL   Pain 164 (6), e274-e285 (2023)
   PUBMED   36719418
  REMARK    GeneRIF: AIBP regulates TRPV1 activation in chemotherapy-induced
            peripheral neuropathy by controlling lipid raft dynamics and
            proximity to TLR4 in dorsal root ganglion neurons.
REFERENCE   5  (bases 1 to 962)
  AUTHORS   Kim,J.D., Zhou,T., Zhang,A., Li,S., Gupte,A.A., Hamilton,D.J. and
            Fang,L.
  TITLE     AIBP Regulates Metabolism of Ketone and Lipids but Not
            Mitochondrial Respiration
  JOURNAL   Cells 11 (22), 3643 (2022)
   PUBMED   36429071
  REMARK    GeneRIF: AIBP Regulates Metabolism of Ketone and Lipids but Not
            Mitochondrial Respiration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 962)
  AUTHORS   Jha,K.N., Shumilin,I.A., Digilio,L.C., Chertihin,O., Zheng,H.,
            Schmitz,G., Visconti,P.E., Flickinger,C.J., Minor,W. and Herr,J.C.
  TITLE     Biochemical and structural characterization of apolipoprotein A-I
            binding protein, a novel phosphoprotein with a potential role in
            sperm capacitation
  JOURNAL   Endocrinology 149 (5), 2108-2120 (2008)
   PUBMED   18202122
  REMARK    GeneRIF: AI-BP plays an important role in capacitation possibly
            providing a link between protein phosphorylation and cholesterol
            efflux.
REFERENCE   7  (bases 1 to 962)
  AUTHORS   Suto,J.
  TITLE     Characterization of Cq3, a quantitative trait locus that controls
            plasma cholesterol and phospholipid levels in mice
  JOURNAL   J Vet Med Sci 68 (4), 303-309 (2006)
   PUBMED   16679719
REFERENCE   8  (bases 1 to 962)
  AUTHORS   Korstanje,R., Albers,J.J., Wolfbauer,G., Li,R., Tu,A.Y.,
            Churchill,G.A. and Paigen,B.J.
  TITLE     Quantitative trait locus mapping of genes that regulate
            phospholipid transfer activity in SM/J and NZB/BlNJ inbred mice
  JOURNAL   Arterioscler Thromb Vasc Biol 24 (1), 155-160 (2004)
   PUBMED   14592843
REFERENCE   9  (bases 1 to 962)
  AUTHORS   Ritter,M., Buechler,C., Boettcher,A., Barlage,S., Schmitz-Madry,A.,
            Orso,E., Bared,S.M., Schmiedeknecht,G., Baehr,C.H., Fricker,G. and
            Schmitz,G.
  TITLE     Cloning and characterization of a novel apolipoprotein A-I binding
            protein, AI-BP, secreted by cells of the kidney proximal tubules in
            response to HDL or ApoA-I
  JOURNAL   Genomics 79 (5), 693-702 (2002)
   PUBMED   11991719
REFERENCE   10 (bases 1 to 962)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137525.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3082633.1,
                                           SRR13422600.2142325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC137525.3         62959-63154         c
            197-305             AC137525.3         62762-62870         c
            306-416             AC137525.3         62553-62663         c
            417-557             AC137525.3         62329-62469         c
            558-705             AC137525.3         61618-61765         c
            706-962             AC137525.3         61152-61408         c
FEATURES             Location/Qualifiers
     source          1..962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.78 cM"
     gene            1..962
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /note="NAD(P)HX epimerase"
                     /db_xref="GeneID:246703"
                     /db_xref="MGI:MGI:2180167"
     exon            1..196
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..908
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /EC_number="5.1.99.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     apolipoprotein A-I binding protein; apolipoprotein A-I
                     interacting protein; apoA-I binding protein;
                     NAD(P)H-hydrate epimerase"
                     /codon_start=1
                     /product="NAD(P)H-hydrate epimerase isoform 1"
                     /protein_id="NP_001396696.1"
                     /db_xref="GeneID:246703"
                     /db_xref="MGI:MGI:2180167"
                     /translation="MSGLRTLLGLGLLVAGSRLPRVISQQSVCRARPIWWGTQRRGSE
                     TMAGAAVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSKSP
                     PTVLVICGPGNNGGDGLVCARHLKLFGYQPTIYYPKRPNKPLFTGLVTQCQKMDIPFL
                     GEMPPEVGGLMPVSTPMMVDELYELVVDAIFGFSFKGDVREPFHSILSVLSGLTVPIA
                     SIDIPSGWDVEKGNPSGIQPDLLISLTAPKKSATHFTGRYHYLGGRFVPPALEKKYQL
                     NLPSYPDTECVYRLQ"
     exon            197..305
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /inference="alignment:Splign:2.1.0"
     exon            306..416
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /inference="alignment:Splign:2.1.0"
     exon            417..557
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /inference="alignment:Splign:2.1.0"
     exon            558..705
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /inference="alignment:Splign:2.1.0"
     exon            706..962
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      933..938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /note="hexamer: AATAAA"
     polyA_site      962
                     /gene="Naxe"
                     /gene_synonym="AI-BP; AIBP; Apoa1bp; Apoa1ip; ESTM37"
                     /note="major polyA site"
ORIGIN      
        1 atgcgccgtg cgagcggcgc tctgctagtc gaatgtccgg gctgcggacg ctgctggggc
       61 tggggctgct ggttgcgggc tcgcgcctgc cacgggtcat cagccagcag agtgtgtgtc
      121 gtgcaaggcc catctggtgg ggaacacagc gccggggctc ggagaccatg gcgggcgctg
      181 cggtgaagta cttaagtcag gaggaggctc aggccgtgga ccaagagctt tttaacgagt
      241 atcagttcag cgtggatcaa ctcatggagc tggccgggtt gagctgtgcc acggctattg
      301 ccaaggctta tccccccacg tctatgtcca agagtccccc gactgtcttg gtcatctgtg
      361 gccccggaaa taacggaggg gatgggctgg tctgtgcgcg acacctcaaa ctttttggtt
      421 accagccaac tatctattac cccaaaagac ctaacaagcc cctcttcact gggctagtga
      481 ctcagtgtca gaaaatggac attcctttcc ttggtgaaat gcccccagag gtaggtgggt
      541 tgatgcctgt ttctacaccc atgatggtgg acgagctgta tgagctggtg gtggacgcca
      601 tcttcggctt cagtttcaag ggtgacgttc gggagccatt ccacagcatc ctgagtgtct
      661 tgagtggact cactgtgccc attgctagca tcgacattcc ctcaggatgg gatgtagaga
      721 agggaaaccc tagcggaatc caaccagact tactcatctc actgacggca cccaagaagt
      781 ctgcaactca ctttactggc cgatatcatt accttggggg tcgctttgta ccacctgctc
      841 tagagaagaa gtaccagctg aacctgccat cttaccctga cacagagtgt gtctaccgtc
      901 tacagtaagg gaggtgggta ggcaggattc tcaataaaga cttggtactt tctgtcttga
      961 aa
//
